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Dendritic Nanogels ...
Dendritic Nanogels Directed Dual-Encapsulation Topical Delivery System of Antimicrobial Peptides Targeting Skin Infections
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- Zhang, Yuning (författare)
- KTH,Ytbehandlingsteknik,Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, 130061, P. R. China
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- Håkansson, Joakim (författare)
- Gothenburg University,Göteborgs universitet,RISE,Kemi, biomaterial och textil,Biological Function Unit, RISE Research Institutes of Sweden, Methodology, Textile and Medical Devices, Borås, SE-501 15, Sweden; Department of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, P.O. Box 440, Gothenburg, SE-40530, Sweden, P.O. Box 440,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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- Fan, Yanmiao (författare)
- KTH,Ytbehandlingsteknik
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- Andrén, Oliver C. J. (författare)
- KTH,Ytbehandlingsteknik
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- San Jacinto García, Jorge (författare)
- KTH,Ytbehandlingsteknik
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- Qin, Liguo (författare)
- KTH,Fiber- och polymerteknologi,Institute of Design Science and Basic Components, School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an, 710049, P. R. China
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- Umerska, Anita (författare)
- RISE,Kemi, biomaterial och textil,Biological Function Unit, RISE Research Institutes of Sweden, Methodology, Textile and Medical Devices, Borås, SE-501 15, Sweden
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- Hutchinson, Daniel (författare)
- KTH,Ytbehandlingsteknik
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- Lüchow, Mads (författare)
- KTH,Ytbehandlingsteknik
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- Mahlapuu, M. (författare)
- Promore Pharma AB, Solna, SE-171 65, Sweden
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- Malkoch, Michael, 1974- (författare)
- KTH,Ytbehandlingsteknik
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(creator_code:org_t)
- 2023-01-22
- 2023
- Engelska.
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Ingår i: Macromolecular Bioscience. - : John Wiley and Sons Inc. - 1616-5187 .- 1616-5195. ; 23
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Antimicrobial peptides (AMPs) are promising antibacterial agents in the fight against multidrug resistant pathogens. However, their application to skin infections is limited by the absence of a realizable topical delivery strategy. Herein, a hybrid hierarchical delivery system for topical delivery of AMPs is accomplished through the incorporation of AMPs into dendritic nanogels (DNGs) and their subsequent embedding into poloxamer gel. The high level of control over the crosslink density and the number of chosen functionalities makes DNGs ideal capsules with tunable loading capacity for DPK-060, a human kininogen-derived AMP. Once embedded into the poloxamer gel, DPK-060 encapsulated in DNGs displays a slower release rate compared to those entrapped directly in the gels. In vitro EpiDerm Skin Irritation Tests show good biocompatibility, while MIC and time-kill curves reveal the potency of the peptide toward Staphylococcus aureus. Anti-infection tests on ex vivo pig skin and in vivo mouse infection models demonstrate that formulations with 0.5% and 1% AMPs significantly inhibit the growth of S. aureus. Similar outcomes are observed for an in vivo mouse surgical site infection model. Importantly, when normalizing the bacteria inhibition to released/free DPK-060 at the wound site, all formulations display superior efficacy compared to DPK-060 in solution. © 2023 The Authors.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik -- Polymerteknologi (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering -- Polymer Technologies (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- antimicrobial peptide delivery
- dendritic nanogel
- DPK-060
- poloxamer gel
- Antimicrobial agents
- Bacteria
- Biocompatibility
- Mammals
- Nanostructured materials
- Peptides
- Antimicrobial peptide
- Dendritics
- Nanogels
- Peptide delivery
- Poloxamer
- Topical delivery
- antimicrobial peptide delivery
- dendritic nanogel
- DPK-060
- poloxamer gel
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Zhang, Yuning
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Håkansson, Joaki ...
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Fan, Yanmiao
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Andrén, Oliver C ...
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San Jacinto Garc ...
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Qin, Liguo
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Umerska, Anita
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Hutchinson, Dani ...
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Lüchow, Mads
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Mahlapuu, M.
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Malkoch, Michael ...
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- Om ämnet
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Kemiteknik
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och Polymerteknologi
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biokemi och mole ...
- Artiklar i publikationen
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Macromolecular B ...
- Av lärosätet
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RISE
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Kungliga Tekniska Högskolan
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Göteborgs universitet