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- Antonsson, S., et al.
(författare)
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A comparative study of the impact of the cooking process on oxygen delignification
- 2003
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Ingår i: Nordic Pulp & Paper Research Journal. - : Walter de Gruyter GmbH. - 0283-2631 .- 2000-0669. ; 18:4, s. 388-394
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Tidskriftsartikel (refereegranskat)abstract
- The impact of oxygen delignification on chemical pulps of a given kappa number manufactured in different ways (using kraft, prehydrolysis kraft and magnesium sulphite cooking) has been investigated. The prehistory of the pulps proves to be a very important factor in determining the response to oxygen delignification, i.e. the degree of delignification. It is shown that this is not due to different amounts of hexenuronic acid (HexA) in the different pulps, although this is an important factor behind the high residual kappa number after oxygen delignification of birch kraft pulp. Oxygen delignification of sulphite pulps proves to be efficient even at kappa numbers significantly lower than 10. These pulps show the greatest yield loss over the oxygen delignification. It is likely that Lignin Carbohydrate Complexes (LCC) complexes play a very important role in limiting the speed of reaction of oxygen delignification. Due to the very different prehistories of the pulps investigated, it is probable that the LCC:s are native and not formed during cooking.
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- Dhindaw, B. K., et al.
(författare)
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Characterization of the peritectic reaction in medium-alloy steel through microsegregation and heat-of-transformation studies
- 2004
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Ingår i: Metallurgical and Materials Transactions. A. - : Springer Science and Business Media LLC. - 1073-5623 .- 1543-1940. ; 35A:9, s. 2869-2879
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Tidskriftsartikel (refereegranskat)abstract
- In the present work, the phenomenon of the peritectic reaction was characterized in a medium-ailoy steel. Several directional solidification and thermal-analysis experiments were done to investigate the reaction process. Directional solidification experiments carried out did not tend to show any direct evidence of a peritectic reaction. Microsegregation studies on the directionally solidified samples and those solidified under isothermal conditions bring out some interesting features. It has been documented that if the segregation ratio for Ni is higher than that for Cr, there is a correlation that the peritectic reaction had occurred in that region. On the other hand, a higher Cr segregation ratio as compared to Ni showed the possibility that the liquid had directly transformed to gamma-austenite without undergoing a peritectic reaction. Measurement of energies of transformations and the analysis of their values in different segments of the cooling-curve differential thermal analysis (DTA) experiments have helped in understanding the peritectic reaction. It is revealed that the transformation is more like diffusionless transformation, where gamma-austenite directly precipitates from delta-ferrite. Indeed, this proposition is also supported by the segregation patterns for Cr and Ni obtained in the solidified samples of this steel during directional solidification and DTA experiments and also by calculations to show the presence of enough lattice defects or vacancies to aid the aforementioned transformation.
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- Hughes, K, et al.
(författare)
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Calmodulin-dependent kinase II mediates T cell receptor/CD3- and phorbol ester-induced activation of IkappaB kinase.
- 2001
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Ingår i: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 276:38, s. 36008-36013
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Tidskriftsartikel (refereegranskat)abstract
- Numerous fundamental biological processes involve the NFkappaB family of transcription factors. The mechanisms by which this family of proteins is regulated are therefore of widespread importance. In most cells, NFkappaB is bound to inhibitory IkappaB proteins and sequestered in the cytoplasm. NFkappaB-inducing signals result in activation of a large multisubunit kinase complex, IKK, which phosphorylates IkappaB. IkappaB is subsequently degraded, releasing NFkappaB, which translocates to the nucleus. We previously reported that inhibitors of the calcium-binding protein calmodulin (CaM) prevent phorbol ester-induced phosphorylation of IkappaB. Here we show that KN93, an inhibitor of CaM-dependent kinases (CaMKs), also inhibits the phosphorylation of IkappaB. The effect of both CaM and CaMK inhibitors on IkappaB phosphorylation is due to the inhibition of the activity of CaMK II because neither drug has any effect when a derivative of CaMK II that is insensitive to these inhibitors is expressed. When CaMK II is inhibited, phorbol ester is no longer able to activate IKK, placing CaMK II in the signaling pathway that leads to IKK activation. CaM and CaMK inhibitors also block T cell receptor/CD3-induced activation but have no effect on the ability of the cytokine tumor necrosis factor alpha or the phosphatase inhibitor calyculin A to induce degradation of IkappaB. Finally we show that expression of a constitutively active CaMK II results in the activation of NFkappaB. The results identify CaMK II as a mediator of IKK activation specifically in response to T cell receptor/CD3 and phorbol ester stimulation.
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