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- Rabbitts, T H, et al.
(författare)
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Chromosomal translocations and leukaemia : a role for LMO2 in T cell acute leukaemia, in transcription and in erythropoiesis
- 1997
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Ingår i: Leukemia. - 0887-6924. ; 11:Suppl 3, s. 2-271
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Tidskriftsartikel (refereegranskat)abstract
- The LMO2 gene associated with T cell acute leukaemia has been used as an example of a gene activated by association with the T cell receptor genes after chromosomal translocations. The gene is shown to encode a LIM protein which is involved in protein interactions and during normal haematopoiesis is necessary for erythroid development. LMO2 has been shown to cause tumours when aberrantly expressed and to be able to heterodimerise with TAL1 to facilitate tumour development.
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- Fredriksson, A, et al.
(författare)
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MPTP-induced deficits in motor activity: neuroprotective effects of the spintrapping agent, alpha-phenyl-tert-butyl-nitrone (PBN)
- 1997
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Ingår i: JOURNAL OF NEURAL TRANSMISSION. - : SPRINGER-VERLAG WIEN. - 0300-9564. ; 104:6-7, s. 579-592
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In Experiment 1, groups of mice were administered either saline or MPTP (2 x 30 mg/kg, s.c., separated by a 24-hr interval) 30 min after being injected either PBN (15, 50 or 150 mg/kg, s.c., low, medium and high doses, respectively) or L-Deprenyl (0.25 or
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- Fredriksson, A, et al.
(författare)
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Neonatal iron exposure induces neurobehavioural dysfunctions in adult mice
- 1999
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Ingår i: TOXICOLOGY AND APPLIED PHARMACOLOGY. - : ACADEMIC PRESS INC. - 0041-008X. ; 159:1, s. 25-30
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Excess iron in the brain has been implicated in the pathogenesis of several human neurodegenerative disorders, i.e., Parkinson's and Alzheimer's disease. The neonatal period is critical for the establishment of normal iron content in the adult brain. In t
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