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Transcriptional lan...
Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases
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- Li, Jian Feng (författare)
- Shanghai Jiao Tong University,Ruijin Hospital
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- Dai, Yu Ting (författare)
- Shanghai Jiao Tong University,Ruijin Hospital
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- Lilljebjörn, Henrik (författare)
- Lund University,Lunds universitet,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups
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- Shen, Shu Hong (författare)
- Shanghai Jiao Tong University,Shanghai Children’s Medical Center
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- Cui, Bo Wen (författare)
- Shanghai Jiao Tong University,Ruijin Hospital
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- Bai, Ling (författare)
- Ruijin Hospital,Shanghai Jiao Tong University
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- Liu, Yuan Fang (författare)
- Shanghai Jiao Tong University,Ruijin Hospital
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- Qian, Mao Xiang (författare)
- St Jude Children´s Research Hospital, Memphis
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- Kubota, Yasuo (författare)
- University of Tokyo
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- Kiyoi, Hitoshi (författare)
- Nagoya University
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- Matsumura, Itaru (författare)
- Kindai University
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- Miyazaki, Yasushi (författare)
- Nagasaki University
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- Olsson, Linda (författare)
- Lund University,Lunds universitet,Genetiska och epigenetiska studier av barnleukemi,Forskargrupper vid Lunds universitet,Genetic and epigenetic studies of pediatric leukemia,Lund University Research Groups
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- Tan, Ah Moy (författare)
- KK Women’s and Children’s Hospital
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- Ariffin, Hany (författare)
- University of Malaya
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- Chen, Jing (författare)
- Shanghai Children’s Medical Center,Shanghai Jiao Tong University
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- Takita, Junko (författare)
- Kyoto University
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- Yasuda, Takahiko (författare)
- National Hospital Organization, Japan
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- Mano, Hiroyuki (författare)
- National Cancer Center Research Institute, Japan
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- Johansson, Bertil (författare)
- Lund University,Lunds universitet,Genetiska och epigenetiska studier av barnleukemi,Forskargrupper vid Lunds universitet,Genetic and epigenetic studies of pediatric leukemia,Lund University Research Groups,Regional Laboratories Region Skåne
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- Yang, Jun J. (författare)
- St Jude Children´s Research Hospital, Memphis
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- Yeoh, Allen Eng Juh (författare)
- National University of Singapore
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- Hayakawa, Fumihiko (författare)
- Nagoya University
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- Chen, Zhu (författare)
- Shanghai Jiao Tong University,Ruijin Hospital
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- Pui, Ching Hon (författare)
- St Jude Children´s Research Hospital, Memphis
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- Fioretos, Thoas (författare)
- Lund University,Lunds universitet,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups,Regional Laboratories Region Skåne
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- Chen, Sai Juan (författare)
- Ruijin Hospital,Shanghai Jiao Tong University
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- Huang, Jin Yan (författare)
- Ruijin Hospital,Shanghai Jiao Tong University
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(creator_code:org_t)
- 2018-11-28
- 2018
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 115:50, s. 11711-11720
- Relaterad länk:
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http://dx.doi.org/10...
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https://www.pnas.org...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Most B cell precursor acute lymphoblastic leukemia (BCP ALL) can be classified into known major genetic subtypes, while a substantial proportion of BCP ALL remains poorly characterized in relation to its underlying genomic abnormalities. We therefore initiated a large-scale international study to reanalyze and delineate the transcriptome landscape of 1,223 BCP ALL cases using RNA sequencing. Fourteen BCP ALL gene expression subgroups (G1 to G14) were identified. Apart from extending eight previously described subgroups (G1 to G8 associated with MEF2D fusions, TCF3–PBX1 fusions, ETV6–RUNX1–positive/ETV6–RUNX1–like, DUX4 fusions, ZNF384 fusions, BCR–ABL1/Ph–like, high hyperdiploidy, and KMT2A fusions), we defined six additional gene expression subgroups: G9 was associated with both PAX5 and CRLF2 fusions; G10 and G11 with mutations in PAX5 (p.P80R) and IKZF1 (p.N159Y), respectively; G12 with IGH–CEBPE fusion and mutations in ZEB2 (p.H1038R); and G13 and G14 with TCF3/4–HLF and NUTM1 fusions, respectively. In pediatric BCP ALL, subgroups G2 to G5 and G7 (51 to 65/67 chromosomes) were associated with low-risk, G7 (with ≤50 chromosomes) and G9 were intermediate-risk, whereas G1, G6, and G8 were defined as high-risk subgroups. In adult BCP ALL, G1, G2, G6, and G8 were associated with high risk, while G4, G5, and G7 had relatively favorable outcomes. This large-scale transcriptome sequence analysis of BCP ALL revealed distinct molecular subgroups that reflect discrete pathways of BCP ALL, informing disease classification and prognostic stratification. The combined results strongly advocate that RNA sequencing be introduced into the clinical diagnostic workup of BCP ALL. four decades, most of the recurring chromosomal abnormalities, including aneuploidy, chromosomal rearrangements/gene fusions (e.g., ETV6–RUNX1, BCR–ABL1, and TCF3–PBX1), and rearrangements of KMT2A (previously MLL), were identified by.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- BCP ALL
- Gene fusion
- Gene mutation
- RNA-seq
- Subtypes
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
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Li, Jian Feng
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Dai, Yu Ting
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Lilljebjörn, Hen ...
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Shen, Shu Hong
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Cui, Bo Wen
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Bai, Ling
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visa fler...
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Liu, Yuan Fang
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Qian, Mao Xiang
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Kubota, Yasuo
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Kiyoi, Hitoshi
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Matsumura, Itaru
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Miyazaki, Yasush ...
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Olsson, Linda
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Tan, Ah Moy
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Ariffin, Hany
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Chen, Jing
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Takita, Junko
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Yasuda, Takahiko
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Mano, Hiroyuki
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Johansson, Berti ...
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Yang, Jun J.
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Yeoh, Allen Eng ...
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Hayakawa, Fumihi ...
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Chen, Zhu
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Pui, Ching Hon
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Fioretos, Thoas
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Chen, Sai Juan
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Huang, Jin Yan
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