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- Roy, Alan, et al.
(författare)
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VLBI at APEX: First Fringes
- 2012
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Ingår i: Proceedings of Science. - 1824-8039. ; 2012-October
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Konferensbidrag (refereegranskat)
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- Darby, S, et al.
(författare)
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Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death : meta-analysis of individual patient data for 10,801 women in 17 randomised trials
- 2011
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Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 378:9804, s. 16-1707
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk.METHODS: We undertook a meta-analysis of individual patient data for 10,801 women in 17 randomised trials of radiotherapy versus no radiotherapy after breast-conserving surgery, 8337 of whom had pathologically confirmed node-negative (pN0) or node-positive (pN+) disease.FINDINGS: Overall, radiotherapy reduced the 10-year risk of any (ie, locoregional or distant) first recurrence from 35·0% to 19·3% (absolute reduction 15·7%, 95% CI 13·7-17·7, 2p<0·00001) and reduced the 15-year risk of breast cancer death from 25·2% to 21·4% (absolute reduction 3·8%, 1·6-6·0, 2p=0·00005). In women with pN0 disease (n=7287), radiotherapy reduced these risks from 31·0% to 15·6% (absolute recurrence reduction 15·4%, 13·2-17·6, 2p<0·00001) and from 20·5% to 17·2% (absolute mortality reduction 3·3%, 0·8-5·8, 2p=0·005), respectively. In these women with pN0 disease, the absolute recurrence reduction varied according to age, grade, oestrogen-receptor status, tamoxifen use, and extent of surgery, and these characteristics were used to predict large (≥20%), intermediate (10-19%), or lower (<10%) absolute reductions in the 10-year recurrence risk. Absolute reductions in 15-year risk of breast cancer death in these three prediction categories were 7·8% (95% CI 3·1-12·5), 1·1% (-2·0 to 4·2), and 0·1% (-7·5 to 7·7) respectively (trend in absolute mortality reduction 2p=0·03). In the few women with pN+ disease (n=1050), radiotherapy reduced the 10-year recurrence risk from 63·7% to 42·5% (absolute reduction 21·2%, 95% CI 14·5-27·9, 2p<0·00001) and the 15-year risk of breast cancer death from 51·3% to 42·8% (absolute reduction 8·5%, 1·8-15·2, 2p=0·01). Overall, about one breast cancer death was avoided by year 15 for every four recurrences avoided by year 10, and the mortality reduction did not differ significantly from this overall relationship in any of the three prediction categories for pN0 disease or for pN+ disease.INTERPRETATION: After breast-conserving surgery, radiotherapy to the conserved breast halves the rate at which the disease recurs and reduces the breast cancer death rate by about a sixth. These proportional benefits vary little between different groups of women. By contrast, the absolute benefits from radiotherapy vary substantially according to the characteristics of the patient and they can be predicted at the time when treatment decisions need to be made.FUNDING: Cancer Research UK, British Heart Foundation, and UK Medical Research Council.
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- Rojas-Arriagada, A., et al.
(författare)
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The Gaia-ESO Survey: metallicity and kinematic trends in the Milky Way bulge
- 2014
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Ingår i: Astronomy & Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 569
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Tidskriftsartikel (refereegranskat)abstract
- Aims. Observational studies of the Milky Way bulge are providing increasing evidence of its complex chemo-dynamical patterns and morphology. Our intent is to use the iDR1 Gaia-ESO Survey (GES) data set to provide new constraints on the metallicity and kinematic trends of the Galactic bulge, exploring the viability of the currently proposed formation scenarios. Methods. We analyzed the stellar parameters and radial velocities of similar to 1200 stars in five bulge fields wich are located in the region -10 degrees < / < 7 degrees and -10 degrees < b < -4 degrees. We use VISTA Variables in the Via Lactea (VVV) photometry to verify the internal consistency of the atmospheric parameters recommended by the consortium. As a by-product, we obtained reddening values using a semi-empirical Tdf -color calibration. We constructed the metallicity distribution functions and combined them with photometric and radial velocity data to analyze the properties of the stellar populations in the observed fields. Results. From a Gaussian decomposition of the metallicity distribution functions, we unveil a clear bimodality in all fields, with the relative size of components depending of the specific position on the sky. In agreement with some previous studies, we find a mild gradient along the minor axis (-0.05 dex/deg between b = -6 degrees and b = -10 degrees) that arises from the varying proportion of metal-rich and metal-poor components. The number of metal-rich stars fades in favor of the metal-poor stars with increasing b. The K-magnitude distribution of the metal-rich population splits into two peaks for two of the analyzed fields that intersects the near and far branches of the X-shaped bulge structure. In addition, two lateral fields at (l,b) = (7, -9) and (l, b) = (-10, 8) present contrasting characteristics. In the former, the metallicity distribution is dominated by metal-rich stars, while in the latter it presents a mix of a metal-poor population and and a metal-intermediate one, of nearly equal sizes. Finally, we find systematic differences in the velocity dispersion between the metal-rich and the metal-poor components of each field. Conclusions. The iDR I bulge data show chemo-dynamical distributions that are consistent with varying proportions of stars belonging to (i) a metal-rich boxy/peanut X-shaped component, with bar-like kinematics; and (ii) a metal-poor more extended rotating structure with a higher velocity dispersion that dominates far from the Galactic plane. These first GES data already allow studying the detailed spatial dependence of the Galactic bulge populations, thanks to the analysis of individual fields with relatively high statistics.
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