| 1. |
- Ali, Salamat, et al.
(författare)
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Experimental and Theoretical Aspects of MXenes-Based Energy Storage and Energy Conversion Devices
- 2023
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Ingår i: Journal of Chemistry and Environment. - : Science Research Publishers (SRP). - 2959-0132. ; 2:2, s. 54-81
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Forskningsöversikt (refereegranskat)abstract
- Transition metal carbides, nitrides, and carbonitrides (MXenes) have become an appealing framework for developing various energy applications. MXenes with van der Waals (vdW) interactions are facile, highly efficient, affordable, and self-assembled features that improve energy density. MXenes exhibit large surface area, high electric conductivity, and excellent electrochemical characteristics for various energy applications. This review summarizes and emphasizes the current developments in MXene with improved performance for energy storage or conversion devices, including supercapacitors (SCs), various types of rechargeable batteries (RBs), solar cells, and fuel cells. We discuss the crystal structures of MXenes properties of MXenes and briefly discuss them for different types of energy applications. Finally, the critical outlook and perspective for the MXene progress for applications in energy applications are also described.
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| 2. |
- Callen, Michael, et al.
(författare)
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COVID-19 vaccine acceptance and hesitancy in low- and middle-income countries
- 2021
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Ingår i: Nature Medicine. - : Springer Nature. - 1546-170X .- 1078-8956. ; 27:8, s. 1385-1394
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Tidskriftsartikel (refereegranskat)abstract
- Widespread acceptance of COVID-19 vaccines is crucial for achieving sufficient immunization coverage to end the global pandemic, yet few studies have investigated COVID-19 vaccination attitudes in lower-income countries, where large-scale vaccination is just beginning. We analyze COVID-19 vaccine acceptance across 15 survey samples covering 10 low- and middle-income countries (LMICs) in Asia, Africa and South America, Russia (an upper-middle-income country) and the United States, including a total of 44,260 individuals. We find considerably higher willingness to take a COVID-19 vaccine in our LMIC samples (mean 80.3%; median 78%; range 30.1 percentage points) compared with the United States (mean 64.6%) and Russia (mean 30.4%). Vaccine acceptance in LMICs is primarily explained by an interest in personal protection against COVID-19, while concern about side effects is the most common reason for hesitancy. Health workers are the most trusted sources of guidance about COVID-19 vaccines. Evidence from this sample of LMICs suggests that prioritizing vaccine distribution to the Global South should yield high returns in advancing global immunization coverage. Vaccination campaigns should focus on translating the high levels of stated acceptance into actual uptake. Messages highlighting vaccine efficacy and safety, delivered by healthcare workers, could be effective for addressing any remaining hesitancy in the analyzed LMICs. © 2021, The Author(s).
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| 3. |
- Asif, Muhammad, et al.
(författare)
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Diagnostic Performance and Appropriate Cut-Offs of Different Anthropometric Indicators for Detecting Children with Overweight and Obesity
- 2021
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Ingår i: BioMed Research International. - : Hindawi Publishing Corporation. - 2314-6133 .- 2314-6141.
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Tidskriftsartikel (refereegranskat)abstract
- In the clinical settings, different anthropometric indicators like neck circumference (NC), waist circumference (WC), midupper arm circumference (MUAC), waist-to-height ratio (WHtR), and arm-to-height ratio (AHtR) have been suggested for evaluating overweight and obesity in children. The comparative ability of these indicators in Pakistan is yet unknown. This study is aimed at examining the validity of different anthropometric indicators of overweight and obesity simultaneously and at determining their superlative cut-off values that would correctly detect overweight and obesity in children. For this purpose, the dataset of anthropometric measurements height, weight, WC, MUAC, and NC of 5,964 Pakistani children, aged 5-12 years collected in a cross-sectional multiethnic anthropometric survey (MEAS), was used. Receiver operating characteristic (ROC) curve analysis was performed to assess the validity of different anthropometric indicators. The most sensitive and specific cut-off points, positive and negative predictive values of each indicator were also calculated. The results of the ROC curve indicated that all the studied indicators had a good performance but the indicators AHtR and WHtR had the highest value of the area under the curve (AUC) for the screening of children with overweight and obesity (AUC > 0.80). In the overall sample, AHtR, WHtR, MUAC, WC, and NC cut-off points indicative of overweight, in both boys and girls, were 0.14, 0.46, 18.41 cm, 62.86 cm, and 26.36 cm and 0.14, 0.47, 18.16 cm, 64.39 cm, and 26.54 cm, respectively; the corresponding values for obesity were 0.14, 0.47, 18.67 cm, 62.10 cm, and 26.36 cm and 0.14, 0.48, 20.19 cm, 64.39 cm, and 25.27 cm. We concluded that the sex-specific cut-off points for AHtR, WHtR, MUAC, WC, and NC can be used to diagnose overweight and obesity in Pakistani children.
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| 4. |
- Abdal, Noman, et al.
(författare)
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Salinity mitigates cadmium-induced phytotoxicity in quinoa (Chenopodium quinoa Willd.) by limiting the Cd uptake and improved responses to oxidative stress : implications for phytoremediation
- 2023
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Ingår i: Environmental Geochemistry and Health. - : Springer Science and Business Media LLC. - 0269-4042 .- 1573-2983. ; 45:1, s. 171-185
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Tidskriftsartikel (refereegranskat)abstract
- Cadmium (Cd) contamination and soil salinity are the main environmental issues reducing crop productivity. This study aimed to examine the combined effects of salinity (NaCl) and Cd on the physiological and biochemical attributes of quinoa (Chenopodium quinoa Willd.). For this purpose, 30-day-old plants of quinoa genotype “Puno” were transplanted in Hoagland's nutrient solution containing diverse concentrations of Cd: 0, 50, 100, 200 µM Cd, and salinity: 0, 150, and 300 mM NaCl. Results demonstrated that plant growth, stomatal conductance, and pigment contents were significantly lower at all Cd concentrations than the control plants. Quinoa plants exhibited improved growth and tolerance against Cd when grown at a lower level of salinity (150 mM NaCl) combined with Cd. In contrast, the elevated concentration of salinity (300 mM NaCl) combined with Cd reduced shoot and root growth of experimental plants more than 50%. Combined application of salinity and Cd increased Na (25-fold), while lessened the Cd (twofold) and K (1.5-fold) uptake. A blend of high concentrations of Na and Cd caused overproduction of H2O2 (eightfold higher than control) contents and triggered lipid peroxidation. The activities of antioxidant enzymes: ascorbate peroxidase (APX), catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) were 13, 12, 7 and ninefold higher than control to mitigate the oxidative stress. Due to restricted root to shoot translocation, and greater tolerance potential against Cd, the quinoa genotype, Puno, is suitable for phytostabilization of Cd in saline soils.
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| 5. |
- Ali, Asad, et al.
(författare)
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Emerging strategies and developments in oxygen reduction reaction using high-performance platinum-based electrocatalysts
- 2024
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Ingår i: Nano Reseach. - : Tsinghua University Press. - 1998-0124 .- 1998-0000. ; 17:5, s. 3516-3532
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Forskningsöversikt (refereegranskat)abstract
- The global practical implementation of proton exchange membrane fuel cells (PEMFCs) heavily relies on the advancement of highly effective platinum (Pt)-based electrocatalysts for the oxygen reduction reaction (ORR). To achieve high ORR performance, electrocatalysts with highly accessible reactive surfaces are needed to promote the uncovering of active positions for easy mass transportation. In this critical review, we introduce different approaches for the emerging development of effective ORR electrocatalysts, which offer high activity and durability. The strategies, including morphological engineering, geometric configuration modification via supporting materials, alloys regulation, core-shell, and confinement engineering of single atom electrocatalysts (SAEs), are discussed in line with the goals and requirements of ORR performance enhancement. We review the ongoing development of Pt electrocatalysts based on the syntheses, nanoarchitecture, electrochemical performances, and stability. We eventually explore the obstacles and research directions on further developing more effective electrocatalysts.
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| 6. |
- Ali, Asad, et al.
(författare)
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Gram-scale production of in-situ generated iron carbide nanoparticles encapsulated via nitrogen and phosphorous co-doped bamboo-like carbon nanotubes for oxygen evolution reaction
- 2023
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Ingår i: Materials Science for Energy Technologies. - : Elsevier. - 2589-2991. ; 6, s. 301-309
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Tidskriftsartikel (refereegranskat)abstract
- Optimizing electrocatalytic activity and recognizing the most reactive sites for oxygen evolution reaction (OER) electrocatalysts are valuable to the order of renewable power. In this research article, we explored an innovative in-situ annealing technique for constructing iron carbide nanoparticles (Fe3C NPs) encapsulated via nitrogen and phosphorous doped bamboo-shape carbon nanotubes (NP-CNTs) for OER. Interestingly, the constructed Fe3C NPs@NP-CNT-800 composite exhibited remarkable electrochemical operation and offered a stable current density of 10 mA/cm2 at a lower overpotential (280 mV) in an alkaline solution. Furthermore, an innovative Fe3C NPs@N,P-CNT-800 hybrid surpassed the standard RuO2 electrocatalyst in terms of OER performance and showed negligible degradation in chronoamperometric (21 h) and chronopotentiometry (3000 cycles) analyses. The remarkable performance and stability are ascribed to the Fe3C NPs, novel tubular bamboo-like morphology of its carbon materials, and heteroatom doping, which contribute to the electrochemical interfaces, large surface area, active catalytic sites, and rapid charge transfer kinetics.
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| 7. |
- Anjum, Asad Ur Rehman, et al.
(författare)
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Sensitivity Analysis of Mathematical Model to Study the Effect of T Cells Infusion in Treatment of CLL
- 2020
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Ingår i: Mathematics. - : MDPI AG. - 2227-7390. ; 8:4
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we considered a mathematical model concerned with the treatment of Chronic Lymphocytic Leukemia (CLL) taking into account the effect of superficially infused T cells in this particular type of tumor. The model is described thoroughly by the system of non-linear differential equations explaining the interaction of naive, infected, cancer and immune cell population. The detailed sensitivity analysis with the application is the major part of this paper. The basic objective is to provide insight to how parameters' behavior varies model results by elaborating the results obtained from the application of sensitivity analysis. The sensitivity of the model was evaluated not only theoretically, but also with the help of a numerical approach, producing graphs providing better imminent of results. We argue that the application of the sensitivity analysis method endows an insight into how and which parameters are of primary significance in controlling the spread of leukemia.
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| 8. |
- Gowin, Krisstina, et al.
(författare)
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Survival following allogeneic transplant in patients with myelofibrosis
- 2020
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Ingår i: Blood Advances. - : AMER SOC HEMATOLOGY. - 2473-9529 .- 2473-9537. ; 4:9, s. 1965-1973
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Tidskriftsartikel (refereegranskat)abstract
- Allogeneic hematopoietic cell transplantation (HCT) is the only curative therapy for myelofibrosis (MF). In this large multicenter retrospective study, overall survival (OS) in MF patients treated with allogeneic HCT (551 patients) and without HCT (non-HCT) (1377 patients) was analyzed with Cox proportional hazards model. Survival analysis stratified by the Dynamic International Prognostic Scoring System (DIPSS) revealed that the first year of treatment arm assignment, due to upfront risk of transplant-related mortality (TRM), HCT was associated with inferior OS compared with non-HCT (non-HCT vs HCT: DIPSS intermediate 1 [Int-1]: hazard ratio [HR] = 0.26, P < .0001; DIPSS-Int-2 and higher: HR, 0.39, P < .0001). Similarly, in the DIPSS low-risk MF group, due to upfront TRM risk, OS was superior with non-HCT therapies compared with HCT in the first-year post treatment arm assignment (HR, 0.16, P = .006). However, after 1 year, OS was not significantly different (HR, 1.38, P = .451). Beyond 1 year of treatment arm assignment, an OS advantage with HCT therapy in Int-1 and higher DIPSS score patients was observed (non-HCT vs HCT: DIPSS-Int-1: HR, 2.64, P < .0001; DIPSS-Int-2 and higher: HR, 2.55, P < .0001). In conclusion, long-term OS advantage with HCT was observed for patients with Int-1 or higher risk MF, but at the cost of early TRM. The magnitude of OS benefit with HCT increased as DIPSS risk score increased and became apparent with longer follow-up.
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| 9. |
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| 10. |
- Khan, Adil, et al.
(författare)
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Predictive modeling for depth of wear of concrete modified with fly ash : A comparative analysis of genetic programming-based algorithms
- 2024
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Ingår i: Case Studies in Construction Materials. - : Elsevier. - 2214-5095. ; 20
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Tidskriftsartikel (refereegranskat)abstract
- There has been increasing growth in incorporating fly ash as a supplementary cementitious material in concrete mixtures due to its potential to enhance the durability and strength properties of concrete. However, there is a lack of research on predicting the depth of wear of fly ash-based concrete. The laboratory methods available for estimating the depth of wear often involve destructive and expensive tests. Therefore, to avoid costly and laborious tests, this study utilized two machine learning methods, including multi-expression programming (MEP) and gene expression programming (GEP), to predict the depth of wear of fly ash-modified concrete. A comprehensive dataset of 216 experimental records was compiled from published studies for model training and validation. This extensive dataset encompasses the depth of wear as the target variable, along with nine explanatory parameters, namely fly ash, cement content, fine and coarse aggregate, water content, plasticizer, age of concrete, air-entraining agent, and testing time. The models were trained with 70% of the data, and the remaining 30% of data was used for validating the models. The models were developed by a continuous trial-and-error process and iterative refinement of hyperparameters until optimal results were achieved. The efficacy of the models was assessed via multiple statistical indicators. Furthermore, the SHapley Additive exPlanation (SHAP) was utilized for the interpretability of the model prediction from both global and local perspectives. The GEP model exhibited excellent accuracy with a correlation coefficient (R) of 0.989 (training) and 0.992 (validation). Similarly, the MEP model provided prediction accuracy with R values of 0.965 and 0.968 for training and validation sets, respectively. In addition, the MEP and GEP models outperformed the traditional multi-linear regression model. The SHAP interpretation revealed that testing time and age have a higher contribution in determining the depth of wear. The findings of this study can assist practitioners and designers in avoiding costly and laborious tests for durability assessment and promoting sustainable use of fly ash in the construction sector.
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| 11. |
- Khan, Wali Ullah, et al.
(författare)
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Integration of NOMA with Reflecting Intelligent Surfaces : A Multi-cell Optimization with SIC Decoding Errors
- 2023
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Ingår i: IEEE Transactions on Green Communications and Networking. - : Institute of Electrical and Electronics Engineers (IEEE). - 2473-2400. ; 7:3, s. 1554-1565
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Tidskriftsartikel (refereegranskat)abstract
- Reflecting intelligent surfaces (RIS) has gained significant attention due to its high energy and spectral efficiency in next-generation wireless networks. By using low-cost passive reflecting elements, RIS can smartly reconfigure the signal propagation to extend the wireless communication coverage. On the other hand, non-orthogonal multiple access (NOMA) has been proven as a key air interface technique for supporting massive connections over limited resources. Utilizing the superposition coding and successive interference cancellation (SIC) techniques, NOMA can multiplex multiple users over the same spectrum and time resources by allocating different power levels. This paper proposes a new optimization scheme in a multi-cell RIS-NOMA network to enhance the spectral efficiency under SIC decoding errors. In particular, the power budget of the base station and the transmit power of NOMA users while the passive beamforming of RIS is simultaneously optimized in each cell. Due to objective function and quality of service constraints, the joint problem is formulated as non-convex, which is very complex and challenging to obtain the optimal global solution. To reduce the complexity and make the problem tractable, we first decouple the original problem into two sub-problems for power allocation and passive beamforming. Then, the efficient solution of each sub-problem is obtained in two-steps. In the first-step of For power allocation sub-problem, we transform it to a convex problem by the inner approximation method and then solve it through a standard convex optimization solver in the second-step. Accordingly, in the first-step of passive beamforming, it is transformed into a standard semi-definite programming problem by successive convex approximation and different of convex programming methods. Then, penalty based method is used to achieve a Rank-1 solution for passive beamforming in second-step. Numerical results demonstrate the benefits of the proposed optimization scheme in the multi-cell RIS-NOMA network.
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| 12. |
- Khan, Wali Ullah, et al.
(författare)
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Rate Splitting Multiple Access for Next Generation Cognitive Radio Enabled LEO Satellite Networks
- 2023
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Ingår i: IEEE Transactions on Wireless Communications. - : Institute of Electrical and Electronics Engineers (IEEE). - 1536-1276. ; , s. 1-
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Tidskriftsartikel (refereegranskat)abstract
- Low Earth Orbit (LEO) satellite communication (SatCom) has drawn particular attention recently due to its high data rate services and low round-trip latency. It has low launching and manufacturing costs than Medium Earth Orbit (MEO) and Geostationary Earth Orbit (GEO) satellites. Moreover, LEO SatCom has the potential to provide global coverage with a high-speed data rate and low transmission latency. However, the spectrum scarcity might be one of the challenges in the growth of LEO satellites, impacting severe restrictions on developing ground-space integrated networks. To address this issue, cognitive radio and rate splitting multiple access (RSMA) are the two emerging technologies for high spectral efficiency and massive connectivity. This paper proposes a cognitive radio enabled LEO SatCom using RSMA radio access technique with the coexistence of GEO SatCom network. In particular, this work aims to maximize the sum rate of LEO SatCom by simultaneously optimizing the power budget over different beams, RSMA power allocation for users over each beam, and subcarrier user assignment while restricting the interference temperature to GEO SatCom. The problem of sum rate maximization is formulated as non-convex, where the global optimal solution is challenging to obtain. Thus, an efficient solution can be obtained in three steps: first we employ a successive convex approximation technique to reduce the complexity and make the problem more tractable. Second, for any given resource block user assignment, we adopt KarushKuhnTucker (KKT) conditions to calculate the transmit power over different beams and RSMA power allocation of users over each beam. Third, using the allocated power, we design an efficient algorithm based on the greedy approach for resource block user assignment. For comparison, we propose two suboptimal schemes with fixed power allocation over different beams and random resource block user assignment as the benchmark. Numerical results provided in this work are obtained based on the Monte Carlo simulations, which demonstrate the benefits of the proposed optimization scheme compared to the benchmark schemes.
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| 13. |
- Nawaz, Muhammad Ul Saqlain, et al.
(författare)
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Efficient resource prediction framework for software-defined heterogeneous radio environmental infrastructures
- 2023
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Ingår i: Advanced Engineering Informatics. - : Elsevier Ltd.. - 1474-0346. ; 56
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Tidskriftsartikel (refereegranskat)abstract
- Artificial Intelligence (AI) is defining the future of next-generation infrastructures as proactive and data-driven systems. AI-empowered radio systems are replacing the existing command and control radio networks due to their intelligence and capabilities to adapt to the radio environmental infrastructures that include intelligent networks, smart cities and AV/VR enabled factory premises or localities. An efficient resource prediction framework (ERPF) is proposed to provide proactive knowledge about the availability of radio resources in such software-defined heterogeneous radio environmental infrastructures (SD-HREIs). That prior information enables the coexistence of radio users in SD-HREIs. In a proposed framework, the radio activity is measured in both the unlicensed bands that include 2.4 and 5 GHz, respectively. The clustering algorithms k- means and DBSCAN are implemented to segregate the already measured radioactivity as signal (radio occupancy) and noise (radio opportunity). Machine learning techniques CNN and LRN are then trained and tested using the segregated data to predict the radio occupancy and radio opportunity in SD-HREIs. Finally, the performance of CNN and LRN is validated using the cross-validation metrics.
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| 14. |
- Petty, Alice, et al.
(författare)
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Positive symptom phenotypes appear progressively in “EDiPS”, a new animal model of the schizophrenia prodrome
- 2021
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- An increase in dopamine (DA) synthesis capacity in the dorsal striatum (DS) during the prodromal stage of schizophrenia becomes more pronounced as patients progress to the full disorder. Understanding this progression is critical to intervening in disease course. We developed an animal model—Enhanced Dopamine in Prodromal Schizophrenia (EDiPS)—which uses a genetic construct to increase DA synthesis capacity in the DS of male rats. We assessed pre-pulse inhibition (PPI) and amphetamine (AMPH)-induced locomotion (0.6 mg/kg) in EDiPS animals longitudinally after post-natal day 35 (when the EDiPS construct is administered). We also assessed their response to repeated acute restraint stress. In adult EDiPS animals, we measured baseline and evoked extracellular DA levels, and their stereotyped responses to 5 mg/kg AMPH. AMPH-induced hyperlocomotion was apparent in EDiPS animals 6-weeks after construct administration. There was an overall PPI deficit in EDiPS animals across all timepoints, however the stress response of EDiPS animals was unaltered. Adult EDiPS animals show normal baseline and potassium-evoked DA release in the DS. These findings suggest that key behavioural phenotypes in EDiPS animals show a progressive onset, similar to that demonstrated by patients as they transition to schizophrenia. The EDiPS model could therefore be used to investigate the molecular mechanisms underlying the prodrome of schizophrenia.
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| 15. |
- Rasheed, Usman, et al.
(författare)
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One stone two birds: Recycling of an agri-waste to synthesize laccase-immobilized hierarchically porous magnetic biochar for efficient degradation of aflatoxin B1 in aqueous solutions and corn oil
- 2024
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Ingår i: International Journal of Biological Macromolecules. - : Elsevier B.V.. - 0141-8130 .- 1879-0003. ; 273
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Tidskriftsartikel (refereegranskat)abstract
- Aflatoxin B1 (AFB1) contamination of oils is a serious concern for the safety of edible oil consumers. Enzyme-assisted detoxification of AFB1 is an efficient and safe method for decontaminating oils, but pristine enzymes are unstable in oils and require modifications before use. Therefore, we designed a novel and magnetically separable laccase-carrying biocatalyst containing spent-mushroom-substrate (SMS)-derived biochar (BF). Laccase was immobilized on NH2-activated magnetic biochar (BF-NH2) through covalent crosslinking, which provided physicochemical stability to the immobilized enzyme. After 30 days of storage at 4 °C, the immobilized laccase (product named “BF-NH2-Lac”) retained ~95 % of its initial activity, while after five repeated cycles of ABTS oxidation, ~85 % activity retention was observed. BF-NH2-Lac was investigated for the oxidative degradation of AFB1, which exhibited superior performance compared to free laccase. Among many tested natural compounds as mediators, p-coumaric acid proved the most efficient in activating laccase for AFB1 degradation. BF-NH2-Lac demonstrated >90 % removal of AFB1 within 5.0 h, while the observed degradation efficiency in corn oil and buffer was comparable. An insight into the adsorptive and degradative removal of AFB1 revealed that AFB1 removal was governed mainly by degradation. The coexistence of multi-mycotoxins did not significantly affect the AFB1 degradation capability of BF-NH2-Lac. Investigation of the degradation products revealed the transformation of AFB1 into non-toxic AFQ1 while corn oil quality remained unaffected after BF-NH2-Lac treatment. Hence, this study holds practical importance for the research, knowledge-base and industrial application of newly proposed immobilized enzyme products.
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| 16. |
- Sunn Pedersen, Thomas, et al.
(författare)
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Experimental confirmation of efficient island divertor operation and successful neoclassical transport optimization in Wendelstein 7-X
- 2022
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 62:4, s. 042022-042022
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Tidskriftsartikel (refereegranskat)abstract
- We present recent highlights from the most recent operation phases of Wendelstein 7-X, the most advanced stellarator in the world. Stable detachment with good particle exhaust, low impurity content, and energy confinement times exceeding 100 ms, have been maintained for tens of seconds. Pellet fueling allows for plasma phases with reduced ion-temperature-gradient turbulence, and during such phases, the overall confinement is so good (energy confinement times often exceeding 200 ms) that the attained density and temperature profiles would not have been possible in less optimized devices, since they would have had neoclassical transport losses exceeding the heating applied in W7-X. This provides proof that the reduction of neoclassical transport through magnetic field optimization is successful. W7-X plasmas generally show good impurity screening and high plasma purity, but there is evidence of longer impurity confinement times during turbulence-suppressed phases.
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| 17. |
- Ullah, Kaleem, et al.
(författare)
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Cerebral phaeohyphomycosis in liver transplant recipient : A case report
- 2022
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Ingår i: Clinical Case Reports. - : Wiley. - 2050-0904. ; 10:12
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Tidskriftsartikel (refereegranskat)abstract
- Cerebral phaeohyphomycosis is a fungal brain infection with a high fatality rate. It is caused by dematiaceous fungi and is increasingly recognized as a cause of serious illness in both immunocompetent and immunocompromised patients. We report cerebral phaeohyphomycosis in a liver transplant recipient. He was treated with multiple surgeries and antifungals and made a complete recovery. This report highlights that early and aggressive surgical intervention and extended antifungal coverage can have a positive outcome even in immunocompromised patients. The fungal infection in immunocompromised patients should be considered and treated aggressively.
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| 18. |
- Ullah, Syed Asad, et al.
(författare)
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Opportunistic CR-NOMA Transmissions for Zero-Energy Devices : A DRL-driven Optimization Strategy
- 2023
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Ingår i: IEEE Wireless Communications Letters. - 2162-2337 .- 2162-2345. ; 12:5, s. 893-897
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Tidskriftsartikel (refereegranskat)abstract
- To efficiently accommodate RF energy-harvesting (EH) capable device in a wireless network with prescheduled devices, this letter designs the deep reinforcement learning (DRL)-driven energy-efficient transmission strategy. The transmission strategy handles the EH-device uplink transmissions opportunistically using cognitive radio-inspired non-orthogonal multiple access (CR-NOMA) scheme while maximizing energy efficiency (EE). In this respect, firstly, we formulate the EE optimization problem of the EH-device while considering its RF circuit power consumption. Secondly, we divide the original, non-convex problem into a two-layer optimization problem, and solve it sequentially as i) we theoretically derive the optimal transmit power and time-sharing coefficient parameters from the first layer, and ii) using the derived parameters in the second layer, we solve the one-dimensional continuous space optimization problem through a DRL technique, recognized as a combined experience replay deep deterministic policy gradient (CER-DDPG). Finally, the numerical results show that, under different operational scenarios, the proposed approach outperforms benchmark DDPG and Stochastic algorithms in terms of EE.
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| 19. |
- Wang, Xin, et al.
(författare)
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Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018 : a systematic review and modelling study
- 2020
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Ingår i: The Lancet Global Health. - : Elsevier. - 2214-109X. ; 8:4, s. E497-E510
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Forskningsöversikt (refereegranskat)abstract
- Background: Seasonal influenza virus is a common cause of acute lower respiratory infection (ALRI) in ung children. In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million fluenza-virus-associated severe ALRI occurred in children under 5 years globally. Despite this bstantial burden, only a few low-income and middle-income countries have adopted routine influenza ccination policies for children and, where present, these have achieved only low or unknown levels of ccine uptake. Moreover, the influenza burden might have changed due to the emergence and rculation of influenza A/H1N1pdm09. We aimed to incorporate new data to update estimates of the obal number of cases, hospital admissions, and mortality from influenza-virus-associated respiratory fections in children under 5 years in 2018.Methods: We estimated the regional and global burden of influenza-associated respiratory infections in ildren under 5 years from a systematic review of 100 studies published between Jan 1, 1995, and Dec , 2018, and a further 57 high-quality unpublished studies. We adapted the Newcastle-Ottawa Scale to sess the risk of bias. We estimated incidence and hospitalisation rates of influenza-virus-associated spiratory infections by severity, case ascertainment, region, and age. We estimated in-hospital deaths om influenza virus ALRI by combining hospital admissions and in-hospital case-fatality ratios of fluenza virus ALRI. We estimated the upper bound of influenza virus-associated ALRI deaths based on e number of in-hospital deaths, US paediatric influenza-associated death data, and population-based ildhood all-cause pneumonia mortality data in six sites in low-income and lower-middle-income untries.Findings: In 2018, among children under 5 years globally, there were an estimated 109.5 million fluenza virus episodes (uncertainty range [UR] 63.1-190.6), 10.1 million influenza-virus-associated ALRI ses (6.8-15.1); 870 000 influenza-virus-associated ALRI hospital admissions (543 000-1 415 000), 15 300 -hospital deaths (5800-43 800), and up to 34 800 (13 200-97 200) overall influenza-virus-associated ALRI deaths. Influenza virus accounted for 7% of ALRI cases, 5% of ALRI hospital admissions, and 4% of ALRI deaths in children under 5 years. About 23% of the hospital admissions and 36% of the in-hospital deaths were in infants under 6 months. About 82% of the in-hospital deaths occurred in low-income and lower-middle-income countries.Interpretation: A large proportion of the influenza-associated burden occurs among young infants and in low-income and lower middle-income countries. Our findings provide new and important evidence for maternal and paediatric influenza immunisation, and should inform future immunisation policy particularly in low-income and middle-income countries.
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| 20. |
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