| 1. |
-
- 2017
-
Ingår i: Physical Review D. - 2470-0010 .- 2470-0029. ; 96:2
-
Tidskriftsartikel (refereegranskat)
|
|
| 2. |
- Ade, Peter, et al.
(författare)
-
The Simons Observatory : science goals and forecasts
- 2019
-
Ingår i: Journal of Cosmology and Astroparticle Physics. - : IOP Publishing. - 1475-7516. ; :2
-
Tidskriftsartikel (refereegranskat)abstract
- The Simons Observatory (SO) is a new cosmic microwave background experiment being built on Cerro Toco in Chile, due to begin observations in the early 2020s. We describe the scientific goals of the experiment, motivate the design, and forecast its performance. SO will measure the temperature and polarization anisotropy of the cosmic microwave background in six frequency bands centered at: 27, 39, 93, 145, 225 and 280 GHz. The initial con figuration of SO will have three small-aperture 0.5-m telescopes and one large-aperture 6-m telescope, with a total of 60,000 cryogenic bolometers. Our key science goals are to characterize the primordial perturbations, measure the number of relativistic species and the mass of neutrinos, test for deviations from a cosmological constant, improve our understanding of galaxy evolution, and constrain the duration of reionization. The small aperture telescopes will target the largest angular scales observable from Chile, mapping approximate to 10% of the sky to a white noise level of 2 mu K-arcmin in combined 93 and 145 GHz bands, to measure the primordial tensor-to-scalar ratio, r, at a target level of sigma(r) = 0.003. The large aperture telescope will map approximate to 40% of the sky at arcminute angular resolution to an expected white noise level of 6 mu K-arcmin in combined 93 and 145 GHz bands, overlapping with the majority of the Large Synoptic Survey Telescope sky region and partially with the Dark Energy Spectroscopic Instrument. With up to an order of magnitude lower polarization noise than maps from the Planck satellite, the high-resolution sky maps will constrain cosmological parameters derived from the damping tail, gravitational lensing of the microwave background, the primordial bispectrum, and the thermal and kinematic Sunyaev-Zel'dovich effects, and will aid in delensing the large-angle polarization signal to measure the tensor-to-scalar ratio. The survey will also provide a legacy catalog of 16,000 galaxy clusters and more than 20,000 extragalactic sources.
|
|
| 3. |
- Lee, Kibeom, et al.
(författare)
-
Personality, Religion, and Politics : An Investigation in 33 Countries
- 2018
-
Ingår i: European Journal of Personality. - : SAGE Publications. - 0890-2070 .- 1099-0984. ; 32:2, s. 100-115
-
Tidskriftsartikel (refereegranskat)abstract
- The relations of HEXACO personality factors and religiosity with political orientation were examined in responses collected online from participants in 33 countries (N=141 492). Endorsement of a right-wing political orientation was negatively associated with Honesty-Humility and Openness to Experience and positively associated with religiosity. The strength of these associations varied widely across countries, such that the religiosity-politics correlations were stronger in more religious countries, whereas the personality-politics correlations were stronger in more developed countries. We also investigated the utility of the narrower traits (i.e. facets) that define the HEXACO factors. The Altruism facet (interstitially located between the Honesty-Humility, Agreeableness, and Emotionality axes) was negatively associated with right-wing political orientation, but religiosity was found to suppress this relationship, especially in religious countries. In addition to Altruism, the Greed Avoidance and Modesty facets of the Honesty-Humility factor and the Unconventionality and Aesthetic Appreciation facets of the Openness to Experience factor were also negatively associated with right-wing political orientation. We discuss the utility of examining facet-level personality traits, along with religiosity, in research on the individual difference correlates of political orientation.
|
|
| 4. |
- Timmermann, C., et al.
(författare)
-
Neural correlates of the DMT experience assessed with multivariate EEG
- 2019
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- Studying transitions in and out of the altered state of consciousness caused by intravenous (IV) N,N-Dimethyltryptamine (DMT - a fast-acting tryptamine psychedelic) offers a safe and powerful means of advancing knowledge on the neurobiology of conscious states. Here we sought to investigate the effects of IV DMT on the power spectrum and signal diversity of human brain activity (6 female, 7 male) recorded via multivariate EEG, and plot relationships between subjective experience, brain activity and drug plasma concentrations across time. Compared with placebo, DMT markedly reduced oscillatory power in the alpha and beta bands and robustly increased spontaneous signal diversity. Time-referenced and neurophenomenological analyses revealed close relationships between changes in various aspects of subjective experience and changes in brain activity. Importantly, the emergence of oscillatory activity within the delta and theta frequency bands was found to correlate with the peak of the experience - particularly its eyes-closed visual component. These findings highlight marked changes in oscillatory activity and signal diversity with DMT that parallel broad and specific components of the subjective experience, thus advancing our understanding of the neurobiological underpinnings of immersive states of consciousness.
|
|
| 5. |
- Adie, Bailey Ashton, et al.
(författare)
-
Urban tourism and urban socialist and communist heritage : beyond tragedy and farce?
- 2017
-
Ingår i: International Journal of Tourism Cities. - : Emerald Group Publishing Limited. - 2056-5607 .- 2056-5615. ; 3:3, s. 291-304
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose - Existing literature on state socialist and communist heritage as a form of tourist consumption predominately focuses on destination contexts, such as the former Soviet countries and the few remaining state communist countries (i.e. China, North Korea and Cuba). As a result, the visitation to places linked to the history of socialism and communism in the so-called western pluralist democracies has often been overlooked and, at most, unacknowledged, especially as most research on "socialist" heritage focuses on sites connected to statist heritage rather than sites connected to socialist movements. The paper aims to discuss these issues. Design/methodology/approach - This paper aims to fill the gap in terms of research focusing on these types of sites, with evidence from a range of countries in Europe and the Americas. It does so by illustrating the presence and engagement with official and non-official communist/socialist heritage at varying levels of commodification. Findings - The paper concludes that not only is there a need to broaden the concept of socialist heritage but that its framing needs to continue to be understood from present day ideological discourses and struggles with respect to the marking of urban heritage tourist locations. Originality/value - This contribution advocates the broadening of the concept of socialist heritage by acknowledging the relevance of "hidden" urban sites related to key socialist thinkers, socialist opposition to fascism, and civil wars in which the socialist movement was involved, while also drawing parallels between the levels of socialist/heritage recognition and use as a commodity in relation to the historical narrative within the studied countries.
|
|
| 6. |
- Adie, Bailey Ashton, et al.
(författare)
-
Who visits World Heritage? : A comparative analysis of three cultural sites
- 2017
-
Ingår i: Journal of Heritage Tourism. - : Taylor & Francis. - 1743-873X .- 1747-6631. ; 12:1, s. 67-80
-
Tidskriftsartikel (refereegranskat)abstract
- Heritage tourism is a growing segment of the modern tourism industry, and several studies have been undertaken to identify the individuals who participate in this type of tourism. These have indicated that heritage tourists, generally, are middle class, middle age, and well educated. However, despite their iconic role, there has been relatively little attention paid to profile of visitors to World Heritage Sites. This study aims to better understand the demography of this specific tourism segment through the use of survey-based research at three geographically diverse World Heritage Sites: Independence Hall in the USA, Studenica Monastery in Serbia, and the Archaeological Site of Volubilis in Morocco. Through the use of descriptive statistics, several over-arching trends were noted among the three sites. World Heritage Site visitors were found to be very well educated, but they did not have any similarities in relation to age, income, or residence, which contrasts the "general" heritage tourist typology. However, there were several World Heritage specific trends. While this work is a snapshot of the three sites under study and thus is difficult to generalize, it provides the basis for more comprehensive demographic research on visitors to World Heritage Sites.
|
|
| 7. |
- Adie, Bailey Ashton, et al.
(författare)
-
World Heritage as a placebo brand : a comparative analysis of three sites and marketing implications
- 2018
-
Ingår i: Journal of Sustainable Tourism. - : Routledge. - 0966-9582 .- 1747-7646. ; 26:3, s. 399-415
-
Tidskriftsartikel (refereegranskat)abstract
- The UNESCO World Heritage (WH) List is often regarded as a successful tourism brand that motivates site nominations. However, there is relatively little research dealing specifically with WH brand attraction effects, and what does exist shows conflicting results. There is a significant research gap in terms of awareness of the WH brand and its potential impact on visitation, which this study seeks to fill through a comparative analysis of three diverse case studies: Independence Hall, USA; Studenica Monastery, Serbia; and the Archaeological Site of Volubilis, Morocco. Survey data (n = 771) from these three sites were collected and analyzed resulting in three distinct clusters of visitors. One of the clusters does exhibit higher levels of awareness of the WH brand, but members of this group were not motivated by this knowledge when planning their site visit. It is concluded that the WH brand may function as a placebo, and that its importance may be tied more to political interests than economic advancement. Thus, dependency on the WH List for tourism development may potentially be detrimental for locations in the long term. The WH brand's placebo effect could result in long-term problems for both the site and those whose livelihoods depend on tourism.
|
|
| 8. |
- Ashton, Nicholas J., et al.
(författare)
-
A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer's disease.
- 2019
-
Ingår i: Science advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 5:2
-
Tidskriftsartikel (refereegranskat)abstract
- A blood-based assessment of preclinical disease would have huge potential in the enrichment of participants for Alzheimer's disease (AD) therapeutic trials. In this study, cognitively unimpaired individuals from the AIBL and KARVIAH cohorts were defined as Aβ negative or Aβ positive by positron emission tomography. Nontargeted proteomic analysis that incorporated peptide fractionation and high-resolution mass spectrometry quantified relative protein abundances in plasma samples from all participants. A protein classifier model was trained to predict Aβ-positive participants using feature selection and machine learning in AIBL and independently assessed in KARVIAH. A 12-feature model for predicting Aβ-positive participants was established and demonstrated high accuracy (testing area under the receiver operator characteristic curve = 0.891, sensitivity = 0.78, and specificity = 0.77). This extensive plasma proteomic study has unbiasedly highlighted putative and novel candidates for AD pathology that should be further validated with automated methodologies.
|
|
| 9. |
- Kloprogge, F., et al.
(författare)
-
Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis
- 2018
-
Ingår i: Plos Medicine. - : Public Library of Science (PLoS). - 1549-1676 .- 1549-1277. ; 15:6
-
Tidskriftsartikel (refereegranskat)abstract
- Background The fixed dose combination of artemether-lumefantrine (AL) is the most widely used treatment for uncomplicated Plasmodium falciparum malaria. Relatively lower cure rates and lumefantrine levels have been reported in young children and in pregnant women during their second and third trimester. The aim of this study was to investigate the pharmacokinetic and pharmacodynamic properties of lumefantrine and the pharmacokinetic properties of its metabolite, desbutyl-lumefantrine, in order to inform optimal dosing regimens in all patient populations. A search in PubMed, Embase, ClinicalTrials. gov, Google Scholar, conference proceedings, and the WorldWide Antimalarial Resistance Network (WWARN) pharmacology database identified 31 relevant clinical studies published between 1 January 1990 and 31 December 2012, with 4,546 patients in whom lumefantrine concentrations were measured. Under the auspices of WWARN, relevant individual concentration-time data, clinical covariates, and outcome data from 4,122 patients were made available and pooled for the meta-analysis. The developed lumefantrine population pharmacokinetic model was used for dose optimisation through in silico simulations. Venous plasma lumefantrine concentrations 7 days after starting standard AL treatment were 24.2% and 13.4% lower in children weighing < 15 kg and 15-25 kg, respectively, and 20.2% lower in pregnant women compared with non-pregnant adults. Lumefantrine exposure decreased with increasing pre-treatment parasitaemia, and the dose limitation on absorption of lumefantrine was substantial. Simulations using the lumefantrine pharmacokinetic model suggest that, in young children and pregnant women beyond the first trimester, lengthening the dose regimen (twice daily for 5 days) and, to a lesser extent, intensifying the frequency of dosing (3 times daily for 3 days) would be more efficacious than using higher individual doses in the current standard treatment regimen (twice daily for 3 days). The model was developed using venous plasma data from patients receiving intact tablets with fat, and evaluations of alternative dosing regimens were consequently only representative for venous plasma after administration of intact tablets with fat. The absence of artemether-dihydroartemisinin data limited the prediction of parasite killing rates and recrudescent infections. Thus, the suggested optimised dosing schedule was based on the pharmacokinetic endpoint of lumefantrine plasma exposure at day 7. Our findings suggest that revised AL dosing regimens for young children and pregnant women would improve drug exposure but would require longer or more complex schedules. These dosing regimens should be evaluated in prospective clinical studies to determine whether they would improve cure rates, demonstrate adequate safety, and thereby prolong the useful therapeutic life of this valuable antimalarial treatment.
|
|
| 10. |
- Vos, K., et al.
(författare)
-
MRP2/ABCC2 C1515Y polymorphism modulates exposure to lumefantrine during artemether-lumefantrine antimalarial therapy
- 2017
-
Ingår i: Pharmacogenomics. - : Future Medicine Ltd. - 1462-2416 .- 1744-8042. ; 18:10, s. 981-985
-
Tidskriftsartikel (refereegranskat)abstract
- Aim: To investigate the potential involvement of the hepatic ATP-binding cassette transporters MRP2 and MDR1 in the disposition of lumefantrine (LUM) among patients with uncomplicated Plasmodium falciparum malaria. Materials & methods: The tag SNPs MDR1/ABCB1 C3435T and MRP2/ABCC2 C1515Y were determined in two artemether-LUM clinical trials, including a pharmacokinetic/pharmacodynamic study focused on the treatment phase (72 h), and an efficacy trial where day 7 (D-7) LUM levels were measured. Results: The 1515YY genotype was significantly associated with higher (p < 0.01) LUM D-7 concentrations (median 1.42 mu M), compared with 0.77 mu M for 1515CY and 0.59 mu M for 1515CC. No significant influence of the MDR1/ABCB1 C3435T was found. Conclusion: LUM body disposition may be influenced by MRP2/ABCC2 genotype.
|
|
