| 1. |
- Postmus, Iris, et al.
(författare)
-
Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
- 2014
-
Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 5
-
Tidskriftsartikel (refereegranskat)abstract
- Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response.
|
|
| 2. |
- Stankunas, Mindaugas, et al.
(författare)
-
Factors associated with refraining from buying prescribed medications among older people in Europe
- 2014
-
Ingår i: Australasian Journal on Ageing. - : Wiley. - 1440-6381 .- 1741-6612. ; 33:4, s. 25-36
-
Tidskriftsartikel (refereegranskat)abstract
- AimTo evaluate the associations between refraining from buying prescribed medications and selected factors among older persons.MethodsA total of 4467 people aged 60–84 years from seven European countries answered a questionnaire (response rate 45.2%). Refraining from buying prescribed medications was measured with the question: ‘Have you ever refrained from buying prescribed medication and care?’ResultsAbout 11.9% of older people refrained from buying prescribed medications. The multiple regression analysis showed that ages 60–64 (odds ratio (OR) = 2.08; 95% confidence interval (95%CI): 1.38–3.13) and 65–69 (OR = 1.73; 95%CI: 1.16–2.57) years, experience of financial strain (OR = 1.59; 95%CI: 1.27–2.01), as well as exposure to abuse (OR = 1.64; 95%CI: 1.31–2.06) when taking into account country of participant were independently associated with refraining from buying medications, while an opposite association was observed for being male (OR = 0.72; 95%CI: 0.58–0.91).ConclusionsThe study has revealed that refraining from buying prescription medications is a problem among older people and it has identified a number of factors associated with this.
|
|
| 3. |
- Stankunien, Aurima, et al.
(författare)
-
Somatic complaints and refrain from buying prescribed medications. Results from a cross-sectional study on people 60 years and older living in Kaunas (Lithuania)
- 2012
-
Ingår i: DARU. - : Springer Science and Business Media LLC. - 1560-8115 .- 2008-2231. ; 20:78, s. 1-6
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundThe use of medicines by elderly people is a growing area of concern in social pharmacy. A significant proportion of older people do not follow the recommendations from physicians and refrain from buying prescribed medications. The aim of this study is to evaluate associations between self-rated health, somatic complaints and refraining from buying prescribed medications by elderly people.FindingsData was collected in a cross-sectional study in 2009. We received 624 completed questionnaires (response rate -- 48.9%) from persons aged 60--84 years living in Kaunas (Lithuania). Somatic complaints were measured with the 24 item version of the Giessen Complaint List (GBB-24). Logistic regression (Enter model) was used for evaluation of the associations between refraining from buying medications and somatic complaints. These associations were measured using odds ratio (OR) and calculating the 95% confidence interval (CI).The mean scores in total for the GBB scale and sub-scales (exhaustion, gastrointestinal and cardiovascular) were lowest among respondents who did not refrain from buying prescribed medications (means for GBB-24 scale: 21.04 vs. 24.82; p=0.001). Logistic regression suggests that somatic complaints were associated with a increased risk of refraining from buying prescribed medications (OR=1.35, 95% CI=1.15-1.60).ConclusionsSomatic complaints were significantly associated with the decision to refrain from buying prescribed medications.
|
|
| 4. |
- Stankuniene, Aurima, et al.
(författare)
-
Use of medications amongst older persons in Kaunas, Lithuania
- 2013
-
Ingår i: Open Medicine. - : Walter de Gruyter GmbH. - 1911-2092 .- 2391-5463. ; 8:6, s. 855-860
-
Tidskriftsartikel (refereegranskat)abstract
- Aim: To evaluate the associations between socio-economical factors and the use of medications in the elderly. Methods: The data was collected in a cross-sectional study in 2009. We received 624 completed questionnaires (response rate - 48.9%) from elderly people aged 60-84 years living in Kaunas (Lithuania). For an evaluation of the impact of explanatory variables on the analyzed events (binary dependent variable), an Enter model of logistic regression was used. Results: Our findings suggest that 50.8% (n=317) of respondents used at least one drug daily. 18.3% (n=114) of respondents indicated that they use medications regularly, but not on a day-by-day basis. One quarter (25.6%; n=160) used medication only on an "at need" basis. Only 5.3% (n=33) of older persons did not use any medications at all. Logistic regression showed that being male (OR=0.67; 95%CI:0.45-0.98) was associated with using medications "regularly + daily." For the use of "daily" medications, older age (OR=1.33; 95%CI:1.15-1.53) was associated with using medications daily. An opposite association was observed for respondents having no paid work (OR=0.48; 95%CI:0.26-0.82). Conclusions: Our study suggests that more than half of older persons in Lithuania use medications every day. Use was associated with socioeconomic factors (gender, age, and employment status).
|
|
