| 1. |
- Hillier, Ladeana W, et al.
(författare)
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Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
- 2004
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Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 432:7018, s. 695-716
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Tidskriftsartikel (refereegranskat)abstract
- We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genome sequenced, the draft sequence of its genome--composed of approximately one billion base pairs of sequence and an estimated 20,000-23,000 genes--provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes. For example, the evolutionary distance between chicken and human provides high specificity in detecting functional elements, both non-coding and coding. Notably, many conserved non-coding sequences are far from genes and cannot be assigned to defined functional classes. In coding regions the evolutionary dynamics of protein domains and orthologous groups illustrate processes that distinguish the lineages leading to birds and mammals. The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture.
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| 2. |
- Markenroth, Karin, 1973, et al.
(författare)
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Crossing the dripline to N-11 using elastic resonance scattering
- 2000
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Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 6203:3
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Tidskriftsartikel (refereegranskat)abstract
- The level structure of the unbound nucleus N-11 has been studied by C-10+p elastic resonance scattering in inverse geometry with the LISE3 spectrometer at GANIL, using a C-10 beam with an energy of 9.0 MeV/ nucleon. An additional measurement was done at the A1200 spectrometer at MSU. The excitation function above the C-10+p threshold has been determined up to 5 MeV. A potential-model analysis revealed three resonance states at energies 1.27(-0.05)(+0.18) MeV (Gamma = 1.44 +/- 0.2 MeV), 2.01(-0.05)(+0.15) MeV (Gamma = 0.84 +/- 0.2 MeV), and 3.75 +/- 0.05 MeV (Gamma = 0.60 +/- 0.05 MeV) with the spin-parity assignments I-pi=1/2+,1/2,-,5/2+, respectively. Hence, N-11 is shown to have a ground state parity inversion completely analogous to its mirror partner Be-11. A narrow resonance in the excitation function at 4.33 +/- 0.05 MeV was also observed and assigned spin parity 3/2-.
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| 3. |
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| 4. |
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| 5. |
- Bracco, A, et al.
(författare)
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Search for the GDR built on superdeformed nuclei
- 2000
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Ingår i: PHYSICA SCRIPTA. - : ROYAL SWEDISH ACAD SCIENCES. - 0281-1847. ; T88, s. 182-188
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Tidskriftsartikel (refereegranskat)abstract
- An experiment aiming at finding evidence for gamma-decay of the giant dipole resonance built on superdeformed nuclear states has been made using the EUROBALL gamma-detector array coupled to the large BaF2 detectors of the HECTOR system. The reaction Pd-11
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| 6. |
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| 7. |
- Ringqvist, Ann, et al.
(författare)
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Atomic Force Microscopy Analysis and Confocal Raman Microimaging of Coated Pellets
- 2003
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Ingår i: International Journal of Pharmaceutics. - : Elsevier BV. - 1873-3476 .- 0378-5173. ; 267:1-2, s. 35-47
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Tidskriftsartikel (refereegranskat)abstract
- Polymer-coated pellets with different coating thicknesses have been studied regarding coating morphology and drug release properties with atomic force microscopy (AFM) and confocal Raman microscopy. The results were compared with those from scanning electron microscopy (SEM) and drug release profiles, which have been measured previously for these systems and found to vary depending on coating thickness. Results from AFM studies indicated that these pellets differ in the amount of crystalline material on the surface of the coating. The amount was found to be highest on the pellet with the thinnest coating. Confocal Raman microscopy studies confirmed that the active component (remoxipride hydrochloride monohydrate) is present at or close to the surface and that the amount is higher for the thinnest coating. AFM studies in aqueous media showed that the crystalline material on the surface was almost instantaneously dissolved and released into the liquid. AFM has proven to be a powerful tool in the study of the surface of dry formulations and in the study of the controlled release mechanism of a pharmaceutical in a liquid cell. The method can be combined with Raman, giving the added possibility to identify the chemical composition in selected small areas of the coating surface.
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| 8. |
- Weiszflog, M., et al.
(författare)
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High-spin Spectroscopy of 63Ga and 65Ga
- 2001
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Ingår i: European Physical Journal A. Hadrons and Nuclei. - 1434-6001. ; 11, s. 25-38
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in the nuclei Ga-63 and Ga-65 were studied following the reaction S-32 + Ca-40 at a reaction energy of 125 MeV and using the GASP gamma -ray spectrometer in combination with the ISIS charged-particle detector system. In addition to low-lying negative-parity states with single-particle character, rotational-like cascades built on the 9/2(+) and 19/2(-) states have been observed in both nuclei. Sidebands with negative parity in Ga-63 and positive parity in Ga-65 could be established. The experimental results are compared with Total Routhian Surface calculations which describe the nuclei as moderately deformed (beta (2) approximate to 0.25) and gamma soft at low rotational frequencies. The highest experimentally observed positive-parity state in Ga-65 (41/2(+)) is in good agreement with the calculated crossing of the collective band with a non-collective one terminating at this spin.
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| 9. |
- Weiszflog, M., et al.
(författare)
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High-spin spectroscopy of Ga-63(31)32 and Ga-65(31)34
- 2001
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Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 11:1, s. 25-38
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in the nuclei Ga-63 and Ga-65 were studied following the reaction S-32 + Ca-40 at a reaction energy of 125 MeV and using the GASP gamma -ray spectrometer in combination with the ISIS charged-particle detector system. In addition to low-lying negative-parity states with single-particle character, rotational-like cascades built on the 9/2(+) and 19/2(-) states have been observed in both nuclei. Sidebands with negative parity in Ga-63 and positive parity in Ga-65 could be established. The experimental results are compared with Total Routhian Surface calculations which describe the nuclei as moderately deformed (beta (2) approximate to 0.25) and gamma soft at low rotational frequencies. The highest experimentally observed positive-parity state in Ga-65 (41/2(+)) is in good agreement with the calculated crossing of the collective band with a non-collective one terminating at this spin.
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| 10. |
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| 11. |
- Axelsson, L., et al.
(författare)
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Deriving the angular variation of p(parallel to)-distributions for halo neutrons with robust statistics
- 2001
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Ingår i: Nuclear Physics A. - 0375-9474. ; 679:3-4, s. 215-230
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Tidskriftsartikel (refereegranskat)abstract
- The longitudinal neutron momentum distribution from core breakup of Li-11 and Be-11 have been measured at 29.9 MeV/u and 38.5 MeV/u, respectively. Separate measurements on Li-9 and Be-10 allowed extraction of the halo neutron distribution. The shapes of the distributions are analyzed using robust and descriptive statistics, For both isotopes the shape is changing with angle. (C) 2001 Elsevier Science B.V. All rights reserved.
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| 12. |
- Axelsson, Å, et al.
(författare)
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Attitudes of trained lay rescuers toward cardiopulmonary resuscitation performance in an actual emergency. A survery of 1012 recently trained CPR rescuers
- 2000
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Ingår i: Resuscitation. - : Elsevier Ireland Ltd. - 0300-9572 .- 1873-1570. ; 44:1, s. 27-36
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Tidskriftsartikel (refereegranskat)abstract
- There are currently 1.5 million trained cardiopulmonary resuscitation (CPR) rescuers in Sweden. Bystander CPR is performed on ≈30% of out-of-hospital cardiac arrests. The aim of this study was to analyse trained CPR rescuers’ attitudes and beliefs in terms of CPR performance in an emergency and differences with regard to gender, age, residential area and occupation. In a nation wide survey 1410, randomly selected, recently trained CPR rescuers were approached with a postal questionnaire, resulting in 1012 respondents. The mean age was 36.9 years and only 3% of the respondents were >59 years old. Only 1% had attended the course because of their own or a relative’s cardiac disease. Ninety-four per cent believed there was a minor to major risk of serious disease transmission while performing CPR. When predicting their willingness to perform CPR in six scenarios, 17% would not start CPR on a young drug addict, 7% would not perform CPR on an unkempt man, while 97% were sure about starting CPR on a relative and 91% on a known person. In four of six scenarios, respondents from rural areas were significantly more positive than respondents from metropolitan areas about starting CPR. In conclusion, readiness to perform CPR on a known person is high among trained CPR rescuers, while hesitation about performing CPR on a stranger is evident. Respondents from rural areas are more frequently positive about starting CPR than those from metropolitan areas.
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| 13. |
- Axelsson, Åsa B., 1955, et al.
(författare)
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Attitudes of trained Swedish lay rescuers toward CPR performance in an emergency. A survey of 1012 recently trained CPR rescuers.
- 2000
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Ingår i: Resuscitation. - 0300-9572. ; 44:1, s. 27-36
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Tidskriftsartikel (refereegranskat)abstract
- 59 years old. Only 1% had attended the course because of their own or a relative's cardiac disease. Ninety-four per cent believed there was a minor to major risk of serious disease transmission while performing CPR. When predicting their willingness to perform CPR in six scenarios, 17% would not start CPR on a young drug addict, 7% would not perform CPR on an unkempt man, while 97% were sure about starting CPR on a relative and 91% on a known person. In four of six scenarios, respondents from rural areas were significantly more positive than respondents from metropolitan areas about starting CPR. In conclusion, readiness to perform CPR on a known person is high among trained CPR rescuers, while hesitation about performing CPR on a stranger is evident. Respondents from rural areas are more frequently positive about starting CPR than those from metropolitan areas.
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| 14. |
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| 15. |
- Carlsson, Annelie, et al.
(författare)
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Serological screening for celiac disease in healthy 2.5-year-old children in Sweden
- 2001
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Ingår i: Pediatrics. - : American Academy of Pediatrics (AAP). - 1098-4275 .- 0031-4005. ; 107:1, s. 42-45
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The study was designed to investigate the prevalence of celiac disease (CD) among 2.5-year-old children in a Swedish urban population with a high incidence of CD.MATERIAL AND METHODS: Six hundred ninety apparently healthy children, born in the 12-month period of July 1992 through June 1993, were screened for immunoglobulin A (IgA) antigliadin antibodies and IgA antiendomysium antibodies, and those antibody-positive at repeated testing were further investigated with intestinal biopsy.RESULTS: Of the 690 children, 6 were both IgA antigliadin antibody- and IgA antiendomysium antibody-positive, and 7 were antiendomysium antibody-positive but antigliadin antibody-negative. Jejunal biopsy, performed in 12 cases, manifested partial or total villous atrophy in 8 cases. Thus, together with an additional child whose parents declined the offered biopsy, but whose response to a gluten-free diet confirmed the presence of CD, the prevalence of CD in the study series was 1.3% (9/690; 95% confidence interval:.4-2.2). However, independent of the study, an additional 22 cases of symptomatic, biopsy-verified CD have already been detected in the birth cohort of 3004 children.CONCLUSIONS: The prevalence of CD in our study series was high, at least 1.0%, but may be as high as 2.0% if the frequency of silent CD is as high as we have found in the remaining unscreened cohort. These findings confirm that CD is one of the most common chronic disorders.
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| 16. |
- Dobrydnjov, Igor, et al.
(författare)
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Clonidine combined with small-dose bupivacaine during spinal anesthesia for inguinal herniorrhaphy : a randomized double-blinded study
- 2003
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Ingår i: Anesthesia and Analgesia. - 0003-2999 .- 1526-7598. ; 96:5, s. 1496-1503
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this randomized double-blinded study was to see whether the addition of small-dose clonidine to small-dose bupivacaine for spinal anesthesia prolonged the duration of postoperative analgesia and also provided a sufficient block duration that would be adequate for inguinal herniorrhaphy. We randomized 45 patients to 3 groups receiving intrathecal hyperbaric bupivacaine 6 mg combined with saline (Group B), clonidine 15 μg (Group BC15), or clonidine 30 μg (Group BC30); all solutions were diluted with saline to 3 mL. The sensory block level was insufficient for surgery in five patients in Group B, and these patients were given general anesthesia. Patients in Groups BC15 and BC30 had a significantly higher spread of analgesia (two to four dermatomes) than those in Group B. Two-segment regression, return of S1 sensation, and regression of motor block were significantly longer in Group BC30 than in Group B. The addition of clonidine 15 and 30 μg to bupivacaine prolonged time to first analgesic request and decreased postoperative pain with minimal risk of hypotension. We conclude that clonidine 15 μg with bupivacaine 6 mg produced an effective spinal anesthesia and recommend this dose for inguinal herniorrhaphy, because it did not prolong the motor block.
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| 17. |
- Helgason, AR, et al.
(författare)
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Tobacco prevention in Swedish dental care
- 2003
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Ingår i: Community dentistry and oral epidemiology. - : Wiley. - 0301-5661. ; 31:5, s. 378-385
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Tidskriftsartikel (refereegranskat)
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| 18. |
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| 19. |
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| 21. |
- Kieler, H, et al.
(författare)
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Ultrasound and adverse effects
- 2002
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Ingår i: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. - : Wiley. - 0960-7692. ; 20
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Forskningsöversikt (refereegranskat)
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| 22. |
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| 24. |
- Modigh, C M, et al.
(författare)
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Time to pregnancy among partners of men exposed to di(2-ethylhexyl)phthalate
- 2002
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Ingår i: Scandinavian Journal of Work, Environment and Health. - 0355-3140. ; 28:6, s. 418-428
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Tidskriftsartikel (refereegranskat)abstract
- Objectives This study assessed paternal occupational exposure to di(2-ethylhexyl)phthalate (DEHP) in association with reduced fertility. Methods Men working in three plants with DEHP exposure were studied retrospectively. Male and female employees and their partners were invited to participate if they had reported a pregnancy or an attempt to achieve a pregnancy. Postal questionnaires and telephone interviews were used to collect additional data from the men and women, respectively. Information on time to pregnancy was eligible for 326 pregnancies fathered by 193 men. Male exposure to DEHP during every month of their time to pregnancy was classified into one of three exposure categories. The exposure ranged from <0.1 to 2.1 mg/ml(3). The fathers of only four pregnancies had DEHP exposure of >0.5 mg/m(3) during the time to pregnancy. The pregnancies of employed women with unexposed partners or pregnancies of employed men unexposed during the time to pregnancy formed the reference group. Results The fecundability ratio for time to pregnancy was 1.07 [95% confidence interval (95% Cl) 0.84-1.351 for those with low exposure and 0.97 (95% CI 0.70-1.33) for the highly exposed after adjustment for the father's age, mother's age, and length of recall. When the analyses were restricted to first pregnancy, the fecundability ratio was 1.13 (95% Cl 0.83-1.56) for low exposure and 1.02 (95% Cl 0.66-1.59) for high exposure. Conclusions Time to pregnancy is not prolonged among couples with paternal exposure to DEHP at a mean exposure level of <0.5 mg/ml.
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| 25. |
- Olofsson, Rickard S., et al.
(författare)
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Performance characteristics of a tandem spray chamber arrangement in double focusing sector field ICP-MS
- 2000
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Ingår i: Journal of Analytical Atomic Spectrometry. - : Royal Society of Chemistry (RSC). - 0267-9477 .- 1364-5544. ; 15:6, s. 727-729
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Tidskriftsartikel (refereegranskat)abstract
- A tandem cyclone-Scott type spray chamber configuration combined with infrared heating and a low-flow Micromist nebulizer was evaluated for the use in a ICP-SFMS sample introduction system. The system provides about a 3-fold sensitivity gain and lower oxide formation compared to the standard introduction system, although matrix-induced signal suppression is more pronounced, especially for elements with high ionization potential. The technique was evaluated by accurate analysis of riverine water reference material SLRS-3 with generally good agreement with certified and literature values. Long-term precision at a 20rµgrlm1 concentration level was 0.7% RSD in low resolution and 1.6% RSD in medium resolution. Precision in the range 0.03-0.09% RSD for lead isotope ratios at 1rµgrlm1 was obtained.
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| 26. |
- Pausch, G., et al.
(författare)
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RoSiB - a 4 pi silicon ball for charged-particle detection in EUROBALL
- 2000
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - 0168-9002 .- 1872-9576. ; 443:03-feb, s. 304-318
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Tidskriftsartikel (refereegranskat)abstract
- A 4 pi silicon bail for detection and identification of light charged particles in large multidetector gamma-arrays as EUROBALL is presented. The design is based on a N = 42 ball with 12 pentagons and 30 hexagons as used in the GASP array. The absorptive material for gamma-rays is minimized to the detector thickness of 300 or 500 mu m and a 0.63 mm ceramic backing. The geometrical coverage is designed for about 90% of 4 pi. A pulse shape discrimination method with totally depleted detectors working in the reverse mount allows identifying protons and alpha-particles above an energy threshold of about 2 MeV. The performances of the ball were rested at the tandem - booster accelerator combination of the MPI Heidelberg in two experiments using the high-recoil reaction of 228 MeV Ni-58 + Ti-46 and the low-recoil reaction of 95 MeV O-16 + Ni-58. The two-dimensional spectra of zero-crossing (ZC) versus energy confirmed an excellent discrimination of protons and alpha-particles in all the detectors at different angles. The energy spectra of protons and alpha-particles measured in the experiments are presented. too. The gamma-spectra measured in coincidence with various combinations of emitted particles showed a high selectivity of the ball. The reduced total efficiency for protons of 59% and 55% and alpha-particles of 44% and 32% measured in a nuclear spectroscopy application is analyzed in a Monte-Carlo simulation (GEANT). It is due to a combined influence of a thick target needed to stop the recoiling residual nuclei and thick absorbers needed to protect the Si-detectors from scattered beam. The results along with the GEANT extrapolation to optimum experimental conditions confirm that RoSiB is a highly efficient and selective device for identification of rare reaction channels with heavy ions.
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