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- Björk, Göran, 1956, et al.
(författare)
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Bathymetry and deep-water exchange across the central Lomonosov Ridge at 88°-89°N
- 2007
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Ingår i: Deep-Sea Research I. - : Elsevier BV. ; 54, s. 1197-1208
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Tidskriftsartikel (refereegranskat)abstract
- Seafloor mapping of the central Lomonosov Ridge using a multibeam echo-sounder during the Beringia/Healy–Oden Trans-Arctic Expedition (HOTRAX) 2005 shows that a channel across the ridge has a substantially shallower sill depth than the 2500 m indicated in present bathymetric maps. The multibeam survey along the ridge crest shows a maximum sill depth of about 1870 m. A previously hypothesized exchange of deep water from the Amundsen Basin to the Makarov Basin in this area is not confirmed. On the contrary, evidence of a deep-water flow from the Makarov to the Amundsen Basin was observed, indicating the existence of a new pathway for Canadian Basin Deep Water toward the Atlantic Ocean. Sediment data show extensive current activity along the ridge crest and along the rim of a local Intra Basin within the ridge structure.
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- Arnetz, Bengt B, et al.
(författare)
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Trauma resiliency training for police : psychophysiological and performance effects
- 2009
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Ingår i: Journal of Police and Criminal Psychology. - : Springer Science and Business Media LLC. - 0882-0783 .- 1936-6469. ; 24:1, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this study is to test the effects of police trauma resilience training on stress and performance during a critical incident police work simulation. Rookie police officers (N = 18) participated in a randomized trial of a 10-week imagery and skills training program versus training as usual. Twelve months later, psychophysiological stress and police work performance were assessed during a live critical incident simulation. Training resulted in significantly less negative mood, less heart rate reactivity, a larger increase in antithrombin, and better police performance compared to controls. Trends for cortisol and self-reported stress also suggested benefits of training. This novel training program is a promising paradigm for improving police well-being, stress resiliency, and optimizing job performance.
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| 8. |
- Ihse, E, et al.
(författare)
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Amyloid fibril composition is related to the phenotype of hereditary transthyretin V30M amyloidosis
- 2008
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Ingår i: Journal of Pathology. - : Wiley. - 0022-3417 .- 1096-9896. ; 216:2, s. 253-61
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Tidskriftsartikel (refereegranskat)abstract
- Swedish familial systemic amyloidosis with polyneuropathy (FAP) depends on a mutation leading to a methionine-for-valine substitution in transthyretin. The disease appears with different clinical manifestations, including age of onset and involvement of the heart. Liver transplantation is currently the only curative treatment, but progressive cardiomyopathy may occur post-transplant. Two amyloid deposition patterns have previously been described in the heart. In one, the amyloid consists partially of transthyretin fragments and is weakly stainable by Congo red, while in the other, only full-length molecules are found and the fibrils have a strong affinity for Congo red. The present study aimed to see whether these morphological and biochemical variations have clinical implications. Subcutaneous adipose tissue biopsies were taken from 33 patients with Val30Met FAP and examined by microscopy, electrophoresis and western blot. Clinical data included age, sex, duration of disease and echocardiographic determination of the interventricular septum (IVS) thickness. It was found that fibrils composed of only full-length transthyretin were associated with early age of onset (44.8 +/- 12.9 years), no clinical cardiac involvement and a strong affinity for Congo red. In contrast, presence of transthyretin fragments in the amyloid was associated with late age of onset (67.3 +/- 7.0 years), signs of cardiac involvement and weak Congo red staining. For each individual, the same molecular type of amyloid was found in different organs. This is the first report showing that variations in clinical appearance of familial ATTR amyloidosis are associated with specific structural differences in the amyloid fibrils, and therefore may have a molecular cause. The molecular type of amyloid can be determined from a subcutaneous fat tissue biopsy.
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- Ilev, I K, et al.
(författare)
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Introduction to the special issue on biophotonics - Part 2
- 2008
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Ingår i: IEEE Journal of Selected Topics in Quantum Electronics. - 1077-260X. ; 14:1, s. 1-3
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The 30 articles in this special section cover a broad range among the following areas: advanced bioimaging; multifunctional endoscopy; novel approaches in biophotonic diagnostics and therapeutics; advanced biophotonic sensing techniques; laser-cell interactions; photoacoustics and terahertz biophotonics; nanobiophotonics; and novel laser, fiber-optics and electrooptics biophotonic tools, and devices.
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| 11. |
- Lindqvist, Per, et al.
(författare)
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Pulsed tissue Doppler and strain imaging discloses early signs of infiltrative cardiac disease: a study on patients with familial amyloidotic polyneuropathy.
- 2006
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Ingår i: Eur J Echocardiogr. ; 7:1, s. 22-30
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Familial amyloidotic polyneuropathy (FAP) is a hereditary systemic amyloidosis with cardiac involvement. As early identification of the cardiac involvement is of major clinical interest we performed this study to test the hypothesis that tissue Doppler imaging (TDI) and strain imaging (SI) might disclose cardiac involvement in patients with early stages of FAP. METHODS: Twenty-two patients with FAP and 36 healthy controls were studied. Standard M-mode and Doppler echocardiography were performed. TDI and SI were used to assess the regional longitudinal left ventricular (LV) lateral and septal and right ventricular (RV) wall functions. All time intervals were corrected for heart rate by dividing with R-R interval and presented as percentage. RESULTS: We found that patients in comparison with controls had increased LV and RV wall thickness and by using TDI a prolonged isovolumic relaxation time (IVRt) at the septal segment (15.0+/-7.0 vs 10.7+/-4.1%, p<0.05) and prolonged isovolumic contraction time (IVCt) at LV lateral (12.8+/-4.3 vs 10.1+/-3.3%, p<0.05), septal (12.5+/-3.5 vs 8.9+/-1.9%, p<0.001) and RV free wall segments (12.0+/-3.6 vs 8.3+/-2.1%, p<0.001). Strain was reduced at LV lateral basal segment (-4.6+/-14.0 vs -20.2+9.1, p<0.001), RV free wall mid segment (-16.2+/-12.8 vs -29.4+/-15.2) as well as both septal segments (-4.1+/-11.7 vs -16.2+/-9.0%, p<0.001, -8.8+/-11.5 vs -19.4+/-8.4%, p<0.001 for septal basal and mid-segment). Even in the absence of septal hypertrophy the septal strain was reduced and the regional IVCt was prolonged. CONCLUSIONS: This is the first clinical study using TDI and strain in patients with FAP showing functional abnormalities before any morphological echocardiographic abnormalities were present. Both the left and right heart functions are involved and the disease should therefore be regarded as biventricular.
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- Wiberg, Mikael, et al.
(författare)
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Plexus brachialis-skador hos vuxna : Tidig nervreparation ger bättre kliniskt slutresultat
- 2009
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Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 106:9, s. 586-590
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Tidskriftsartikel (refereegranskat)abstract
- Unga personer kan drabbas av skador på plexus brachialis – armens nervfläta – vid högenergitrauma. Medicinsk prioritering av patientens samtliga skador för adekvata åtgärder ska alltid göras vid stort trauma. Noggrann och tidig, eventuellt upprepad, klinisk neurologisk diagnostik kompletterad med tex MRI, DT-myelografi och neurofysiologiska undersökningar ska göras för att kartlägga plexusskadan. Neurobiologisk forskning visar att celldöd kan minskas och nervutväxt förbättras vid tidig nervreparation. Olika reparations- och rekonstruktionstekniker används beroende på plexusskadans omfattning och lokalisation. Tidig kirurgi och rekonstruktion vid plexusskador förbättrar det kliniska slutresultatet. Rehabiliteringen är omfattande och inkluderar ett adekvat omhändertagande av smärtproblematik.
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