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- Wang, Li-San, et al.
(författare)
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Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States.
- 2015
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Ingår i: JAMA neurology. - : American Medical Association (AMA). - 2168-6157 .- 2168-6149. ; 72:2
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Tidskriftsartikel (refereegranskat)abstract
- Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a population from Iceland. This variant, in which alanine is replaced by threonine at position 673 (A673T), appears to protect against late-onset Alzheimer disease (AD). We evaluated the frequency of this variant in AD cases and cognitively normal controls to determine whether this variant will significantly contribute to risk assessment in individuals in the United States.
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| 5. |
- Lagerström, Robert, 1981-, et al.
(författare)
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A Methodology for Operationalizing Enterprise IT Architecture and Evaluating its Modifiability
- 2019
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Ingår i: Complex Systems Informatics and Modeling Quarterly. - : Riga Technical University. - 2255-9922. ; 19, s. 75-98
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Tidskriftsartikel (refereegranskat)abstract
- Recent contributions to information systems theory suggest that the primary role of a firm’s information technology (IT) architecture is to facilitate, and therefore ensure the continued alignment of a firm’s IT investments with a constantly changing business environment. Despite the advances we lack robust methods with which to operationalize enterprise IT architecture, in a way that allows us to analyze performance, in terms of the ability to adapt and evolve over time. We develop a methodology for analyzing enterprise IT architecture based on “Design Structure Matrices” (DSMs), which capture the coupling between all components in the architecture. Our method addresses the limitations of prior work, in that it i) captures the architecture “in-use” as opposed to high level plans or conceptual models; ii) identifies discrete layers in the architecture associated with different technologies; iii) reveals the “flow of control” within the architecture; and iv) generates measures that can be used to analyze performance. We apply our methodology to a dataset from a large pharmaceutical firm. We show that measures of coupling derived from an IT architecture DSM predict IT modifiability – defined as the cost to change software applications. Specifically, applications that are tightly coupled cost significantly more to change.
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| 6. |
- Lagerström, Robert, 1981-, et al.
(författare)
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Exploring the Relationship Between Architecture Coupling and Software Vulnerabilities
- 2017
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Ingår i: 9th International Symposium on Engineering Secure Software and Systems, ESSoS 2017. - Cham : Springer. - 9783319621043 ; , s. 53-69
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Konferensbidrag (refereegranskat)abstract
- Employing software metrics, such as size and complexity, for predicting defects has been given a lot of attention over the years and proven very useful. However, the few studies looking at software architecture and vulnerabilities are limited in scope and findings. We explore the relationship between software vulnerabilities and component metrics (like code churn and cyclomatic complexity), as well as architecture coupling metrics (direct, indirect, and cyclic coupling). Our case is based on the Google Chromium project, an open source project that has not been studied for this topic yet. Our findings show a strong relationship between vulnerabilities and both component level metrics and architecture coupling metrics. 68% of the files associated with a vulnerability are cyclically coupled, compared to 43% of the non-vulnerable files. Our best regression model is a combination of low commenting, high code churn, high direct fan-out within the main cyclic group, and high direct fan-in outside of the main cyclic group.
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| 7. |
- Lagerström, Robert, 1981-, et al.
(författare)
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Visualizing and Measuring Software Portfolio Architecture : A Power Utility Case
- 2015
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Ingår i: Journal of Modern Project Management. - : Editora Mundos Sociais. - 2317-3963. ; 3:2, s. 114-121
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we test a Design Structure Matrix (DSM) based method for visualizing and measuring software portfolio architectures. Our data is drawn from a power utility company, comprising 192 software applications with 614 dependencies between them. We show that the architecture of this system can be classified as a “core-periphery” system, meaning it contains a single large dominant cluster of interconnected components (the “Core”) representing 40% of the system. The system has a propagation cost of 44% and architecture flow through of 93%. This case and these findings add another piece of the puzzle suggesting that the method could be effective in uncovering the hidden structure in software portfolio architectures.
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| 8. |
- ODonnell, Michael, et al.
(författare)
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Registered Replication Report: Dijksterhuis and van Knippenberg (1998)
- 2018
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Ingår i: Perspectives on Psychological Science. - : SAGE PUBLICATIONS LTD. - 1745-6916 .- 1745-6924. ; 13:2, s. 268-294
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Tidskriftsartikel (refereegranskat)abstract
- Dijksterhuis and van Knippenberg (1998) reported that participants primed with a category associated with intelligence (professor) subsequently performed 13% better on a trivia test than participants primed with a category associated with a lack of intelligence (soccer hooligans). In two unpublished replications of this study designed to verify the appropriate testing procedures, Dijksterhuis, van Knippenberg, and Holland observed a smaller difference between conditions (2%-3%) as well as a gender difference: Men showed the effect (9.3% and 7.6%), but women did not (0.3% and -0.3%). The procedure used in those replications served as the basis for this multilab Registered Replication Report. A total of 40 laboratories collected data for this project, and 23 of these laboratories met all inclusion criteria. Here we report the meta-analytic results for those 23 direct replications (total N = 4,493), which tested whether performance on a 30-item general-knowledge trivia task differed between these two priming conditions (results of supplementary analyses of the data from all 40 labs, N = 6,454, are also reported). We observed no overall difference in trivia performance between participants primed with the professor category and those primed with the hooligan category (0.14%) and no moderation by gender.
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