| 1. |
- Engert, Andreas, et al.
(författare)
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The European Hematology Association Roadmap for European Hematology Research : a consensus document
- 2016
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Ingår i: Haematologica. - Pavia, Italy : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 101:2, s. 115-208
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Tidskriftsartikel (refereegranskat)abstract
- The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at (sic)23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.
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| 2. |
- Di Orio, Giovanni, et al.
(författare)
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The PRIME Semantic Language: Plug and Produce in Standard- based Manufacturing Production Systems
- 2015
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Ingår i: Proceedings of the Flexible Automation and Intelligent Manufacturing Conference.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Nowadays manufacturing production systems are becoming more and more responsive in order to succeed in ahighly unstable environment. The capability of a production system to effectively and efficiently adapt and evolveto face the changing requirements – imposed by volatile and dynamic global markets – is a necessary conditionto enable manufacturing enterprises to be agile. Since the agility of a manufacturing enterprise is always limitedby the agility of its own building blocks than it needs to be spread over the whole enterprise including the operationand information technologies (OT/IT). Turning to production systems, one of the significant challenges isrepresented by the possibility to provide easy and rapid (re-)configuration of their internal components and/orprocesses. Innovative technologies and paradigms have been explored during the years that combined with theincreasing advancement in manufacturing technologies enable the implementation of the “plug and produce”paradigm. The “plug and produce” paradigm is the foundation of any agile production system, since to be agile itis inevitably required to reduce the installation and (re-)engineering activities time – changing/adapting the systemto new requirements – while promoting configuration rather than programming. Therefore, the “plug andproduce” paradigm is a necessary but not sufficient condition for implementing agile production systems. Modernproduction systems are typically known for their plethora of heterogeneous component/equipment. In this complexscenario, the implementation of the “plug and produce” paradigm implies the existence of a well-definedontological model to support components/equipment abstraction with the objective to allow interactions,collaboration and knowledge sharing between them. The PRIME semantic language specifies the semanticstructure for the knowledge models and overall system communication language.
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| 3. |
- Hasan, Baha, 1977-
(författare)
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An Ontological Approach to support Knowledge Sharing between Product Design and Assembly Process Planning (APP)
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Modern manufacturing organizations have to cope with several critical issues arising from the need for mass customization such as short product life-cycles, an increasing number of product variants and frequently changing customer requirements. One of the main factors that could aid overcoming those challenges is the use of information and communication technology (ICT) applications over a collaborative manufacturing environment, in which all stakeholders share and exchange knowledge across different manufacturing domains and applications. However, the use of ICT applications over a collaborative manufacturing environment is limited at the domain level by semantic conflicts arising from the use of different ways to describe the same objects and facts arising from different conceptualizations. Similarly, ICT usage is limited on the application level by interoperability problems arising from diverse heterogeneity between different ICT applications and tools.This research presents a semantic approach to support knowledge sharing within the assembly domain. More specifically, this research is focusing on capturing and sharing assembly design knowledge and integrating the assembly design domain and the Assembly Process Planning (APP) domain. Assembly design and APP are very important engineering domains for successful manufacturing system design, which requires an efficient collaborative environment for best utilization of the assembly resources. However, though these domains represent different perspectives in understanding of the same concepts, both domains use different software applications, which might cause interoperability issues.In this thesis, a novel integration approach has been proposed; this approach is composed of two stages: the first stage includes modelling and recognition of assembly knowledge semantics from SolidWorks (SW) CAD software by using SolidWorks’ Application Programmable Interface (SW-API). The second stage includes sharing the recognized assembly knowledge semantics by using a knowledge-based system in the form of a three-layer ontology architecture which provides a common semantic base to support knowledge sharing across assembly design and APP both on the domain and the application level. Each ontology layer shares a set of concepts from the most generic level to the most specialized level. The foundation ontology layer represents the general key concepts in the assembly design and APP domains. More specialized assembly design concepts and APP concepts are represented both in the domain ontology layer, and the application ontology layer. In the latter, concepts related to SolidWorks CAD software and to assembly robotic devices are represented.
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| 4. |
- Kärrholm, Mattias, et al.
(författare)
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Time-space complexity and the opening hours of commerce : A study of four European cities
- 2017
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Ingår i: Revista de Geografia e Ordenamento do Território (Journal of Geography and Spatial Planning). - : CEGOT - Center of Studies on Geography and Spatial Planning. - 2182-1267. ; 2017:12, s. 153-177
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this article is to develop the concept of time-space complexity as a way of discussing how territorial time-space production affects urban life and use. The discussion is based on a comparative study of opening hours in four centrally located European retail areas: Angers, Lisbon, Malmö and Porto. Following a comparative study of these areas, we discuss tendencies of temporal and spatial homogenisation, the production of ever-more distinctive time-spaces, and also initiate a discussion on the trend of city á la carte. Finally we argue that discussions of time-space complexity need to be taken more seriously in research on urban development, and that the issue of spatio-temporal homogenisation need to be handled more actively in urban planning and design.
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| 5. |
- Leitão, Paulo, et al.
(författare)
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Summer school on intelligent agents in automation : Hands-on educational experience on deploying industrial agents
- 2016
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Ingår i: IECON 2016 - 42nd Annual Conference of the IEEE Industrial Electronics Society. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781509034758 - 9781509034741 ; , s. 6602-6607
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Konferensbidrag (refereegranskat)abstract
- Cyber-physical systems constitutes a framework to develop intelligent, distributed, resilient, collaborative and cooperative systems, promoting the fusion of computational entities and physical devices. Agent technology plays a crucial role to develop this kind of systems by offering a decentralized, distributed, modular, robust and reconfigurable control structure. This paper describes the implementation of a summer school aiming to enhance the participants’ knowledge in the field of multi-agent systems applied to industrial environments, being able to gain the necessary theoretical and practical skills to develop real industrial agent based applications. This is accomplished in an international framework where individual knowledge and experiences are shared in a complementary level.
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| 6. |
- Neves, Pedro, et al.
(författare)
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Layout validation and re-configuration in Plug&Produce systems
- 2016
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Ingår i: Assembly Automation. - : EMERALD GROUP PUBLISHING LTD. - 0144-5154 .- 1758-4078. ; 36:4, s. 412-428
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Tidskriftsartikel (refereegranskat)abstract
- Purpose - This paper aims to provide a method and decision support tool to enhance swift reconfiguration of Plug&Produce (P&P) systems in the presence of continuously changing production orders. Design/methodology/approach - The paper reviews different production scenarios and system design and configuration methods and more particularly specifies the need of decision support tools for P&P systems that integrate configuration and planning activities. This problem is then addressed by proposing a method that helps reduce the solution space of the reconfiguration problem and allows the timely selection of the most promising reconfiguration alternative. Findings - The proposed method was found to be helpful in reducing the reconfiguration alternatives that need to be considered and in selecting the most promising one for different orders. The advantages and limitations of this method are identified, and an illustrative test case of the approach is presented, corroborating the method applicability in the absence of large queues in the system. Originality/value - This paper addresses a less explored domain within the P&P systems research field, which is the system reconfiguration. It proposed a method to support system validation and reconfiguration jointly with an illustrative test case. This represents an original contribution to the P&P research field, and it can have impact in improving agility and decreasing the complexity of reconfiguration activities to cope with constantly changing production orders.
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| 7. |
- Ribeiro, Luis, et al.
(författare)
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Collaborative routing of products using a self-organizing mechatronic agent framework : A simulation study
- 2015
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Ingår i: Computers in industry (Print). - : Elsevier. - 0166-3615 .- 1872-6194. ; 68, s. 27-39
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Tidskriftsartikel (refereegranskat)abstract
- Scheduling is a fundamental activity in modern shop floors. It is also known to be a highly complex problem which has motivated several sub-formulations and the subsequent models. Traditional approaches, typically enumerative or heuristic, struggle to contain the computation complexity and often present solutions for restricted cases that feature unrealistic assumptions in respect to the system size, flow of products and the system logistics/behaviour. The multiagent-based architecture presented in this paper is aligned with a set of emerging architectures that seek to explore more heterarchical decision and control models to circumvent the limitations of the traditional approaches. The main distinguishing factor of the proposed architecture is that it directly addresses (re)routing/local scheduling of products in plug and produce systems. It does not make any assumptions on the alignment of the orders and, instead, it dynamically handles the potential rescheduling of the orders already on the system based on the available resources, and their state, in a time efficient way. The architecture was tested under a simulation environment, that is geometrically accurate and that supports plug and produce in runtime, to characterize its performance under dynamic conditions.
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| 8. |
- Ribeiro, Luis, et al.
(författare)
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Industrial Agents for the Fast Deployment of Evolvable Assembly Systems
- 2015. - 1st ed.
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Ingår i: Industrial Agents. - Amsterdam, Netherlands : Elsevier. - 9780128003411 ; , s. 301-321, s. 301-322
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Bokkapitel (refereegranskat)abstract
- The current manufacturing scenario is characterized by high market unpredictability. Agility is therefore a central challenge for modern companies that need to understand and be proactive towards their product offer in respect to “what is offered, when it is offered, where, how and by whom” (Brown & Bessant 2003).The “what” and the “when” are particularly relevant to the research in emerging paradigms as they account for variety, customization and volume; and timing, speed and seasonality (Brown & Bessant 2003).In this scenario, several design approaches and models have been proposed in the last decade to enable re-configurability and subsequently enhance the companies’ ability to adjust their offer in nature and time.From a paradigmatic point of view research has concentrated on the organizational structure of the shop-floor and the associated controls aspects. Concepts like Reconfigurable Manufacturing Systems (RMS) (Koren & Shpitalni 2010) and Fractal Factories (FF) (Montreuil 1999) support the physical construction of production systems by regulating their layout and making a few assumptions on their logical organization. On the other hand, concepts like Bionic Manufacturing Systems (BMS)(Ueda 1992), Holonic Manufacturing Systems (HMS)(Van Brussel et al. 1998), Evolvable Assembly Systems (Ribeiro et al. 2010) essentially provide the theoretical guidelines for the logical/computational organization of the system (see (Tharumarajah 1996) for a comparison between BMS, HMS and FF and (Setchi & Lagos 2004) for the rationale supporting the shift from Dedicated Lines to Flexible Manufacturing System and finally RMS).While these paradigms provide the conceptual framework and the main design guidelines their actual interpretation and implementation has led to a wider set of architectures (Monostori, Váncza & Kumara 2006; Leitão 2009; Parunak 2000; Pěchouček & Mařík 2008).These architectures align the high-level principles with the technological offer and limitations while seeking to address the re-configurability requirements of (Mehrabi, Ulsoy & Koren 2000; Rösiö & Säfsten 2013):module mobility – modules are easy and quick to move and install;“diagnosability” – it is quick to identify the sources of quality and reliability problems;“integrability” – modules are easy to integrate into the rest of the system.“convertibility” – it is easy and quick to switch between existing products and it is easy to adapt the system to future products;scalability – it is easy to enlarge and downsize the production system;“automatibility” – a dynamic level of automation is enabled;modularity – all system elements are designed to be modular;customization – the capability and flexibility of the production system is designed according to the products to be produced in the system.Instant deployment, as addressed in the present chapter directly addresses mobility, “integrability”, “convertibility”, scalability and customization. Mechatronic modularity is a prerequisite and is enforced by the proposed architecture and the considered modular design. “Diagnosability” was not specifically tackled.In this context, the chapter analyses the agent-based architecture related with the Instantly Deployable Evolvable Assembly System (IDEAS) project that is inspired by the Evolvable Assembly System (EAS) paradigm (Ribeiro et al. 2010) as a mechanism to enable fast deployment of mechatronic modules. EAS advocates the use of process-oriented modules and envisions the production system as a collection of processes and the associated interacting agents.The architecture and the related test cases are used to draw the main lessons learned in respect to technological and conceptual implications.In this context, the remainder of this text is organized as follows: section 1.1 discusses the main deployment challenges, section 1.2 details the reference architecture and associated concepts, section 1.3 presents the principal implementation decisions, section 1.4 features the main lessons learned, sections 1.5 discusses the benefits of the proposed approach and finally section 1.6 reflects on the main conclusions.
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| 9. |
- Ribeiro, Luis, et al.
(författare)
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Summer School on intelligent agents in automation : Experience and reflections from the second edition
- 2017
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Ingår i: Industrial Informatics (INDIN), 2017 IEEE 15th International Conference on. - : IEEE. - 9781538608388 - 9781538608371 ; , s. 544-549
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Konferensbidrag (refereegranskat)abstract
- Several research agendas worldwide are targeting the development of Industrial Cyber-physical Systems as the next generation of intelligent embedded devices with improved interaction capabilities. These devices, and their potential uses, are though to deliver a radical increase in system sustainability, reconfigurability and flexibility which is perceived to be the root of the so called 4th Industrial Revolution. However such technical systems, at the envisioned revolutionary scale, do not exist just yet and require a convergent and multidisciplinary research and development efforts. The academia curricula are also, albeit slowly, adjusting to the emerging education requirements. The Summer School on Intelligent Agents in Automation is a joint effort from several researchers in core areas of the 4th Industrial Revolution landscape to close the gap and promote advanced education in this context. This paper describes the implementation of the 2nd edition of the event as well as the experience and reflections resultant from it.
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| 10. |
- Sanchez, M. Luz, et al.
(författare)
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A new QM/MM method oriented to the study of ionic liquids
- 2015
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Ingår i: Journal of Computational Chemistry. - : Wiley. - 0192-8651 .- 1096-987X. ; 36:25, s. 1893-1901
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Tidskriftsartikel (refereegranskat)abstract
- The interest on room temperature ionic liquids has grown in the last decades because of their use as all-purpose solvent and their low environmental impact. In the present work, a new theoretical procedure is developed to study pure ionic liquids within the framework of the quantum mechanics/molecular mechanics method. Each type of ion (cation or anion) is considered as an independent entity quantum mechanically described that follows a differentiated path in the liquid. The method permits, through an iterative procedure, the full coupling between the polarized charge distribution of the ions and the liquid structure around them. The procedure has been tested with 1-ethyl-3-methylimidazolium tetrafluoroborate. It was found that, similar to non-polar liquids and as a consequence of the low value of the reaction field, the cation and anion charge distributions are hardly polarized by the rest of molecules in the liquid. Their structure is characterized by an alternance between anion and cation shells as evidenced by the coincidence of the first maximum of the anion-anion and cation-cation radial distribution functions with the first minimum of the anion-cation. Some degree of stacking between the cations is also found.
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| 11. |
- Santos, Tiago, et al.
(författare)
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A system reconfiguration architecture for hybrid automation systems based in agents and programmable logic controllers
- 2016
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Ingår i: 2016 IEEE 14TH INTERNATIONAL CONFERENCE ON INDUSTRIAL INFORMATICS (INDIN). - : IEEE. - 9781509028702 ; , s. 98-103
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Konferensbidrag (refereegranskat)abstract
- As web related technologies continue to find their way into production related activities, their true potential can only be explored with a shop floor that is cyber-physically agile. This means the ability to quickly reconfigure a production system during production changeovers while significantly reducing setup times and non value-adding activities keeping the overall performance of the control system. Currently, system reconfiguration in mainly supported by reprogramming. However, reprogramming of large complex systems is often a time consuming and risky activity since it has a non negligible potential for introducing errors which normally result in long debugging times. In this context, this paper details an agent-based system architecture that enables quick system reconfiguration and minimizes the reprogramming effort. For this purpose a production system is abstracted as a multiagent system that dynamically interacts with a native, programmable-logic-controller-based control system and is able to re-parametrize it. The focus on re-parametrization means that the native system can still operate in the absence of the agent system which improves the overall robustness of the solution, using readily available equipment and enables its integration with legacy systems.
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| 12. |
- van Leeuwen, F., et al.
(författare)
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Gaia Data Release 1 : Open cluster astrometry: Performance, limitations, and future prospects
- 2017
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 601
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Tidskriftsartikel (refereegranskat)abstract
- Context. The first Gaia Data Release contains the Tycho-Gaia Astrometric Solution (TGAS). This is a subset of about 2 million stars for which, besides the position and photometry, the proper motion and parallax are calculated using Hipparcos and Tycho-2 positions in 1991.25 as prior information. Aims. We investigate the scientific potential and limitations of the TGAS component by means of the astrometric data for open clusters. Methods. Mean cluster parallax and proper motion values are derived taking into account the error correlations within the astrometric solutions for individual stars, an estimate of the internal velocity dispersion in the cluster, and, where relevant, the effects of the depth of the cluster along the line of sight. Internal consistency of the TGAS data is assessed. Results. Values given for standard uncertainties are still inaccurate and may lead to unrealistic unit-weight standard deviations of least squares solutions for cluster parameters. Reconstructed mean cluster parallax and proper motion values are generally in very good agreement with earlier Hipparcos-based determination, although the Gaia mean parallax for the Pleiades is a significant exception. We have no current explanation for that discrepancy. Most clusters are observed to extend to nearly 15 pc from the cluster centre, and it will be up to future Gaia releases to establish whether those potential cluster-member stars are still dynamically bound to the clusters. Conclusions. The Gaia DR1 provides the means to examine open clusters far beyond their more easily visible cores, and can provide membership assessments based on proper motions and parallaxes. A combined HR diagram shows the same features as observed before using the Hipparcos data, with clearly increased luminosities for older A and F dwarfs.
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