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Sequential Multicom...
Sequential Multicomponent Strategy for the Diastereoselective Synthesis of Densely Functionalized Spirooxindole-Fused Thiazolidines
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- Rainoldi, Giulia (författare)
- Univ Milan, Dipartimento Chim, Via Golgi 19, I-20133 Milan, Italy.
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- Begnini, Fabio (författare)
- Uppsala universitet,Organisk kemi
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- de Munnik, Mariska (författare)
- Vrije Univ Amsterdam, Dept Chem & Pharmaceut Sci, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands.;Vrije Univ Amsterdam, AIMMS, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands.
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- Lo Presti, Leonardo (författare)
- Univ Milan, Dipartimento Chim, Via Golgi 19, I-20133 Milan, Italy.
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- Vande Velde, Christophe M. L. (författare)
- Univ Antwerp, Fac Appl Engn, Adv Reactor Technol, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.
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- Orru, Romano (författare)
- Vrije Univ Amsterdam, Dept Chem & Pharmaceut Sci, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands.;Vrije Univ Amsterdam, AIMMS, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands.
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- Lesma, Giordano (författare)
- Univ Milan, Dipartimento Chim, Via Golgi 19, I-20133 Milan, Italy.
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- Ruijter, Eelco (författare)
- Vrije Univ Amsterdam, Dept Chem & Pharmaceut Sci, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands.;Vrije Univ Amsterdam, AIMMS, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands.
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- Silvani, Alessandra (författare)
- Univ Milan, Dipartimento Chim, Via Golgi 19, I-20133 Milan, Italy.
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Univ Milan, Dipartimento Chim, Via Golgi 19, I-20133 Milan, Italy Organisk kemi (creator_code:org_t)
- 2018-01-25
- 2018
- Engelska.
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Ingår i: ACS COMBINATORIAL SCIENCE. - : AMER CHEMICAL SOC. - 2156-8952 .- 2156-8944. ; 20:2, s. 98-105
- Relaterad länk:
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https://research.vu....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We developed two Ugi-type three-component reactions of spirooxindole-fused 3-thiazolines, isocyanides, and either carboxylic acids or trimethylsilyl azide, to give highly functionalized spirooxindole-fused thiazolidines. Two diverse libraries were generated using practical and robust procedures affording the products in typically good yields. The obtained thiazolidines proved to be suitable substrates for further transformations. Notably, both the Ugi-Joullie and the azido-Ugi reactions resulted highly diastereoselective, affording predominantly the trans-configured products, as confirmed by X-ray crystallographic analysis.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Nyckelord
- thiazolidine
- spirooxindole
- multicomponent reactions
- Asinger reaction
- Ugi-Joullie reaction
- azido-Ugi reaction
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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