| 1. |
- Alallaq, Sanaria, 1976-
(författare)
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Characterization of adventitious root formation in Populus species and Norway spruce
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Adventitious root (AR) formation is a form of post-embryonic development and is a key adaptive trait in plants. De novo adventitious root regeneration represents an elegant evolutionary innovation that allows many plant species to multiply through vegetative propagation; it is widely used in forestry and horticulture to multiply elite genotypes. However, several tree species with high economic and ecological value are difficult to root, and the genetic and molecular bases underlying AR regeneration remain largely elusive. Recently our laboratory showed that jasmonate (JA) and cytokinins (CK) act cooperatively to repress AR initiation (ARI) in Arabidopsishypocotyls, while auxin positively controls ARI by repressing this negative effect. With the recent availability of the reference genomes of Populus spp. and Norway spruce (Picea abies), the aim of this thesis is to explore the molecular and mechanistic foundations of AR formation in woody species and check whether or not there is conservation of the molecular mechanisms identified in Arabidopsis. First, physiological, molecular and hormonic approaches coupled with extensive anatomical analysis were combined to explore the role of light spectral quality in the control of ARI in P. abies de-rooted seedlings. We showed that constant red light (cRL) promotes ARI by reducing the content of the wound-induced phytohormones JA and JA-isoleucine and repressing the accumulation of the isopentyl-adenine-type cytokinins. These results suggest that the cooperative role of JA and CK signaling in the repression of ARI is evolutionarily conserved.Next we compared transcriptomic data from the cambium tissue of woody stem cuttings of the hybrid aspen T89, which is difficult-to-root, and from the hybrid poplar OP42, which is easy-to-root, under hydroponic conditions. The analyses revealed high transcriptional activity in OP42, with twice as many transcription factors differentially expressed in OP42 24 hours after cutting compared to T89. Although we did not observe significant differences in the expression of Auxin response factor (ARF) genes between the two genotypes, the production of transgenic plants downregulating or over-expressing ARF6, 8 or 17 confirmed that PtARF6 and PtARF8 positively and PtARF17 negatively regulate AR development in transgenic hybrid aspen T89. Interestingly, the expression of MYC2 orthologs as well as the expression of several genes involved in JA signaling increased more in T89 than in OP42, suggesting that JA could be a negative regulator of ARI in Populus spp. We also showed that overexpressing PtMYC2 led to a reduced number of ARs in hybrid aspen T89 cuttings. In addition, many genes encoding ROS scavenging proteins such as peroxidases or GSTs were significantly differentially expressed in OP42 24 h after cutting but not in T89, which is interesting since peroxidase activity has often been positively correlated with ARI. In parallel to this research, we characterized the rooting phenotype of clones from the Swedish Aspen (SwAsp) collection usingin vitro cuttings. We observed a significant variation in the rooting ability as well as different root system establishment between the clones. We analyzed the expression of some genes known to be involved in AR development in selected clones with contrasting AR phenotypes but could not identify any correlation between gene expression and rooting phenotype. A transcriptomic analysis of selected clones, with contrasting AR phenotypes, could be a useful tool in the identification of marker genes, which can be used for future selection of the best rooting clones of Populus or other economically important trees in breeding programs.
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| 2. |
- Alallaq, Sanaria, et al.
(författare)
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Red Light Controls Adventitious Root Regeneration by Modulating Hormone Homeostasis in Picea abies Seedlings
- 2020
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Ingår i: Frontiers in Plant Science. - : Frontiers Media S.A.. - 1664-462X. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Vegetative propagation relies on the capacity of plants to regeneratede novoadventitious roots (ARs), a quantitative trait controlled by the interaction of endogenous factors, such as hormones and environmental cues among which light plays a central role. However, the physiological and molecular components mediating light cues during AR initiation (ARI) remain largely elusive. Here, we explored the role of red light (RL) on ARI in de-rooted Norway spruce seedlings. We combined investigation of hormone metabolism and gene expression analysis to identify potential signaling pathways. We also performed extensive anatomical characterization to investigate ARI at the cellular level. We showed that in contrast to white light, red light promoted ARI likely by reducing jasmonate (JA) and JA-isoleucine biosynthesis and repressing the accumulation of isopentyl-adenine-type cytokinins. We demonstrated that exogenously applied JA and/or CK inhibit ARI in a dose-dependent manner and found that they possibly act in the same pathway. The negative effect of JA on ARI was confirmed at the histological level. We showed that JA represses the early events of ARI. In conclusion, RL promotes ARI by repressing the accumulation of the wound-induced phytohormones JA and CK.
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| 3. |
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| 4. |
- Artusi, Federico, 1992-, et al.
(författare)
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Embedding Values into Digital Artifacts : The Case of App Development in the Energy Sector The shift in focus from physical products to digital artifacts requires that designers understand and create new ways to embody values and experiences in the user experience.
- 2022
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Ingår i: Research technology management. - : Routledge. - 0895-6308 .- 1930-0166. ; 65:2, s. 18-28
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Tidskriftsartikel (refereegranskat)abstract
- The shift toward digital offerings poses challenges for companies that are adapting their development process from creating physical products to new digital artifacts. The ways in which companies design physical products and their interaction with customers is not effective in the digital domain. This article outlines how Sorgenia, a fast-growing utility company in Italy, conceptualized and designed the mobile app its consumers use to access its services. The classical dimensions of the user experience (aesthetic, emotional, and symbolic) need to be layered and coordinated throughout the customer’s interaction with the app to make the underlying values emerge progressively. In doing so, customers can be guided to comprehend a digital artifact fully, overcoming the interpretive barriers caused by the lack of physicality.
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| 5. |
- Aubry, Emilie, et al.
(författare)
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A vacuolar hexose transport is required for xylem development in the inflorescence stem
- 2022
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Ingår i: Plant Physiology. - : Oxford University Press. - 0032-0889 .- 1532-2548. ; 188:2, s. 1229-1247
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Tidskriftsartikel (refereegranskat)abstract
- In Angiosperms, the development of the vascular system is controlled by a complex network of transcription factors. However, how nutrient availability in the vascular cells affects their development remains to be addressed. At the cellular level, cytosolic sugar availability is regulated mainly by sugar exchanges at the tonoplast through active and/or facilitated transport. In Arabidopsis (Arabidopsis thaliana), among the genes encoding tonoplastic transporters, SUGAR WILL EVENTUALLY BE EXPORTED TRANSPORTER 16 (SWEET16) and SWEET17 expression has been previously detected in the vascular system. Here, using a reverse genetics approach, we propose that sugar exchanges at the tonoplast, regulated by SWEET16, are important for xylem cell division as revealed in particular by the decreased number of xylem cells in the swt16 mutant and the accumulation of SWEET16 at the procambium-xylem boundary. In addition, we demonstrate that transport of hexoses mediated by SWEET16 and/or SWEET17 is required to sustain the formation of the xylem secondary cell wall. This result is in line with a defect in the xylem cell wall composition as measured by Fourier-transformed infrared spectroscopy in the swt16swt17 double mutant and by upregulation of several genes involved in secondary cell wall synthesis. Our work therefore supports a model in which xylem development partially depends on the exchange of hexoses at the tonoplast of xylem-forming cells.
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| 6. |
- Bannoud, Florencia, et al.
(författare)
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Adventitious Rooting in Populus Species : Update and Perspectives
- 2021
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Ingår i: Frontiers in Plant Science. - : Frontiers Media S.A.. - 1664-462X. ; 12
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Forskningsöversikt (refereegranskat)abstract
- Populus spp. are among the most economically important species worldwide. These trees are used not only for wood and fiber production, but also in the rehabilitation of degraded lands. Since they are clonally propagated, the ability of stem cuttings to form adventitious roots is a critical point for plant establishment and survival in the field, and consequently for the forest industry. Adventitious rooting in different Populus clones has been an agronomic trait targeted in breeding programs for many years, and many factors have been identified that affect this quantitative trait. A huge variation in the rooting capacity has been observed among the species in the Populus genus, and the responses to some of the factors affecting this trait have been shown to be genotype-dependent. This review analyses similarities and differences between results obtained from studies examining the role of internal and external factors affecting rooting of Populus species cuttings. Since rooting is the most important requirement for stand establishment in clonally propagated species, understanding the physiological and genetic mechanisms that promote this trait is essential for successful commercial deployment.
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| 7. |
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| 8. |
- Barausse, Enrico, et al.
(författare)
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Prospects for fundamental physics with LISA
- 2020
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Ingår i: General Relativity and Gravitation. - : SPRINGER/PLENUM PUBLISHERS. - 0001-7701 .- 1572-9532. ; 52:8
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In this paper, which is of programmatic rather than quantitative nature, we aim to further delineate and sharpen the future potential of the LISA mission in the area of fundamental physics. Given the very broad range of topics that might be relevant to LISA,we present here a sample of what we view as particularly promising fundamental physics directions. We organize these directions through a "science-first" approach that allows us to classify how LISA data can inform theoretical physics in a variety of areas. For each of these theoretical physics classes, we identify the sources that are currently expected to provide the principal contribution to our knowledge, and the areas that need further development. The classification presented here should not be thought of as cast in stone, but rather as a fluid framework that is amenable to change with the flow of new insights in theoretical physics.
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| 9. |
- Barbara, Jonathan, et al.
(författare)
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The Sacra Infermeria — a focus group evaluation of an augmented reality cultural heritage experience
- 2022
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Ingår i: New Review of Hypermedia and Multimedia. - : Taylor & Francis. - 1361-4568 .- 1740-7842. ; 28:3-4, s. 143-171
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Tidskriftsartikel (refereegranskat)abstract
- The digital representation of our past has long been an important tool in the interpretation of cultural heritage in museums. The recent rise in the use of Augmented Reality (AR) has seen various approaches to adding dynamic information to existent artefacts. The challenge is even greater when uncertainty further complexifies the represented history. This paper presents a critical analysis of an AR installation in the Sacra Infermeria museum in Valletta, Malta. After a description of the AR configuration of the installation, we present a thematic analysis carried out from a multidisciplinary focus group of 11 researchers in the field of Interactive Digital Narratives (IDN), from three perspectives: the technological implementation of the AR experience, the historical accuracy, gamification and the influence of social media-centred design, and the representation of the complexity arising from the uncertainty of history. In the light of the results of the multidisciplinary focus group, we provide a list of recommendations and heuristics at the end of the article.
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| 10. |
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| 11. |
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| 12. |
- Bellini, Catherine, 1962-
(författare)
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A synthetic auxin for cloning mature trees
- 2024
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Ingår i: Nature Biotechnology. - : Springer Nature. - 1087-0156 .- 1546-1696.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 13. |
- Bellini, Diego, et al.
(författare)
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A metamodel for competence assessment Co.SMO competences software management for organizations
- 2021
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Ingår i: European Journal of Training and Development. - : Emerald Group Publishing Limited. - 2046-9012 .- 2046-9020. ; 45:6/7, s. 603-616
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Tidskriftsartikel (refereegranskat)abstract
- Purpose This paper aims to propose an explorative metamodel of the key organizational competences management and presents a Web-based tool (Co.S.M.O. Competences Software Management for Organizations) for all-around assessment of the identified competences. Design/methodology/approach Building on the Great Eight Competencies Model- GEC, the European Qualifications Framework-EQF and focus group feedback, an online questionnaire was developed to manage the key organizational competences and to adapt the competence metamodel to the Italian context. Findings The competence metamodel described in this study and its newly designed tool (software with online questionnaire) could be used at the organizational level to improve productivity and efficiency by allowing an easy identification of key organizational competences and facilitating their acquisition and sharing. Research limitations/implications Currently, the metamodel is mainly theoretical and the software sustained only a partial validation. Practical implications The developed tool is a dynamic, easy to use and interactive Web-based software useful for managing the competences in both for-profit and not-for-profit organizations. Social implications European official documents invite companies and institutions to work together and share human capital: the European Qualifications Framework-EQF, at the base of this model, facilitates a common organizational language for human resources management. Originality/value Managerial competence literature indicates that a comprehensive model capturing a link between the EQF and a managerial competence model has not yet been considered in the literature.
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| 14. |
- Bellini, Daniele, et al.
(författare)
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Allylic and Allenylic Dearomatization of Indoles promoted by Graphene Oxide via Covalent Grafting Activation Mode
- 2020
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Ingår i: Chemistry - A European Journal. - : Wiley. - 1521-3765 .- 0947-6539. ; 26:46, s. 10427-10432
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Tidskriftsartikel (refereegranskat)abstract
- The site‐selective allylative and allenylative dearomatization of indoles with alcohols is performed under carbocatalytic regime in the presence of graphene oxide (GO, 10 wt% loading) as the promoter. Metal‐free conditions, absence of stoichiometric additive, environmentally friendly conditions (H2O/CH3CN, 55 °C, 6 h), broad substrate scope (33 examples, yield up to 92%) and excellent site‐ and stereoselectivity characterize the present methodology. Moreover, a covalent activation model exerted by GO functionalities was corroborated by spectroscopic, experimental and computational evidences. Recovering and regeneration of the GO catalyst via simple acidic treatment was also documented.
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| 15. |
- Bellini, Emanuele, et al.
(författare)
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Resilience learning through self adaptation in digital twins of human-cyber-physical systems
- 2021
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Ingår i: Proceedings of the 2021 IEEE International Conference on Cyber Security and Resilience (CSR). - : IEEE. - 9781665402859 - 9781665402866 ; , s. 168-173
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Konferensbidrag (refereegranskat)abstract
- Human-Cyber-Physical-Systems (HPCS), such as critical infrastructures in modern society, are subject to several systemic threats due to their complex interconnections and interdependencies. Management of systemic threats requires a paradigm shift from static risk assessment to holistic resilience modeling and evaluation using intelligent, data-driven and run-time approaches. In fact, the complexity and criticality of HCPS requires timely decisions considering many parameters and implications, which in turn require the adoption of advanced monitoring frameworks and evaluation tools. In order to tackle such challenge, we introduce those new paradigms in a framework named RESILTRON, envisioning Digital Twins (DT) to support decision making and improve resilience in HCPS under systemic stress. In order to represent possibly complex and heterogeneous HCPS, together with their environment and stressors, we leverage on multi-simulation approaches, combining multiple formalisms, data-driven approaches and Artificial Intelligence (AI) modelling paradigms, through a structured, modular and compositional framework. DT are used to provide an adaptive abstract representation of the system in terms of multi-layered spatially-embedded dynamic networks, and to apply self-adaptation to time-warped What-If analyses, in order to find the best sequence of decisions to ensure resilience under uncertainty and continuous HPCS evolution.
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| 16. |
- Bellini, Elena, et al.
(författare)
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Sensory Design in the Birth Environment: Learning from Existing Case Studies
- 2023
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Ingår i: Buildings. - : MDPI AG. - 2075-5309. ; 13:3
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Tidskriftsartikel (refereegranskat)abstract
- Studies have shown how built environments for hospitals can influence psychological and physiological conditions and status for childbearing women. Sensory attributes of birth spaces can enhance comfort, feelings of wellbeing, and, to some extent, clinical outcomes. Recently, some case studies of multisensory rooms for the birth environment have been developed based on, e.g., Snoezelen room examples. The aim of this research is to develop an overview of how sensory aspects for birth environments are designed, used, and tested in current and recent studies. Case studies were selected according to sensory aspect significance, observing space factors, and relationship with the experience and comfort of users (women, partners, midwives). All case studies were analysed to collect information about the design and validation process. The collected data were organised in categories and compared for the selected case studies. Main findings were summarised in tables with the aim of underlining how sensory design processes and projects can positively influence comfort for birthing. Conclusions about how to bring forward the issue of sensory design so that it can be used and applied to support childbearing women is discussed.
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| 17. |
- Bellini, Tommaso, et al.
(författare)
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Clinical Course, Laboratory Findings, and Prognosis of SARS-CoV-2 Infection in Infants up to 90 Days of Age: A Single-Center Experience and a Proposal for a Management Pathway
- 2024
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Ingår i: Healthcare. - 2227-9032. ; 12:5, s. 1-14
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To provide a comprehensive description of the clinical features, biochemical characteristics, and outcomes of infants up to 90 days old with COVID-19. Moreover, to assess the severity of the disease and propose an effective management pathway. Methods: Retrospective single-center study spanning three years. Patient data includes age, sex, symptoms, comorbidities, blood and urine test results, cultures, admission, length of stay, therapies, intensive care unit admission, and mortality. Results: A total of 274 patients were enrolled in the study, comprising 55% males. Among them, 60 patients (22%) were under the age of 29 days, while 214 (78%) fell within the 29 to 90 days age range. The overall incidence of SARS-CoV-2 infections was 0.28 per 10,000 Pediatric Emergency Department admissions. Blood inflammatory markers showed no significant abnormalities, and there were no recorded instances of positive blood cultures. Less than 1% of infants showed urinary tract infections with positive urine cultures, and 1.5% of patients had a concurrent RSV infection. Hospitalization rates were 83% for neonates and 67% for infants, with a median length of stay (LOS) of 48 h for both age groups. None of the patients required admission to the Pediatric or Neonatal Intensive Care Unit, and only one required High Flow Nasal Cannula (HFNC). No secondary serious bacterial infections were observed, and all hospitalized patients were discharged without short-term sequelae. No deaths were reported. Discussion and Conclusions: Infants with COVID-19 generally exhibit milder or asymptomatic forms of the disease, making home management a viable option in most cases. Blood tests, indicative of a mild inflammatory response, are recommended primarily for children showing symptoms of illness. Hospitalization precautions for infants without apparent illness or comorbidities are deemed unnecessary. Given the evolving nature of experiences with COVID-19 in infants, maintaining a high level of clinical suspicion remains imperative.
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| 18. |
- Bellini, Tommaso, et al.
(författare)
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Ten new paediatric emergency medicine commandments
- 2024
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Ingår i: Acta Pædiatrica. - 1651-2227. ; 113:1, s. 22-24
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Forskningsöversikt (refereegranskat)abstract
- AIM: We suggest the top ten tips that any clinician working in a pediatric emergency department should always keep in mind.METHODS: A literature review was conducted using, as a starting point, the previously published Ten Commandments for Emergency Medicine, Pediatric Emergency Medicine, and Perinatal Medicine.RESULTS AND CONCLUSION: A standard curriculum for pediatric emergency physicians is lacking. These ten commandments should be considered as advice for physicians who practice this profession every day and not as unbreakable rules established from above.
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| 19. |
- Brunoni, Federica, et al.
(författare)
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Conifers exhibit a characteristic inactivation of auxin to maintain tissue homeostasis
- 2020
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Ingår i: New Phytologist. - : John Wiley & Sons. - 0028-646X .- 1469-8137. ; 226:6, s. 1753-1765
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Tidskriftsartikel (refereegranskat)abstract
- Dynamic regulation of the concentration of the natural auxin (IAA) is essential to coordinate most of the physiological and developmental processes and responses to environmental changes. Oxidation of IAA is a major pathway to control auxin concentrations in angiosperms and, along with IAA conjugation, to respond to perturbation of IAA homeostasis. However, these regulatory mechanisms remain poorly investigated in conifers. To reduce this knowledge gap, we investigated the different contributions of the IAA inactivation pathways in conifers. MS-based quantification of IAA metabolites under steady-state conditions and after perturbation was investigated to evaluate IAA homeostasis in conifers. Putative Picea abies GH3 genes (PaGH3) were identified based on a comprehensive phylogenetic analysis including angiosperms and basal land plants. Auxin-inducible PaGH3 genes were identified by expression analysis and their IAA-conjugating activity was explored. Compared to Arabidopsis, oxidative and conjugative pathways differentially contribute to reduce IAA concentrations in conifers. We demonstrated that the oxidation pathway plays a marginal role in controlling IAA homeostasis in spruce. By contrast, an excess of IAA rapidly activates GH3-mediated irreversible conjugation pathways. Taken together, these data indicate that a diversification of IAA inactivation mechanisms evolved specifically in conifers.
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| 20. |
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| 21. |
- Chardon, Fabien, et al.
(författare)
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Natural variation in the long-distance transport of nutrients and photoassimilates in response to N availability
- 2022
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Ingår i: Journal of plant physiology (Print). - : Elsevier. - 0176-1617 .- 1618-1328. ; 273
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Tidskriftsartikel (refereegranskat)abstract
- Phloem and xylem tissues are necessary for the allocation of nutrients and photoassimilates. However, how the long-distance transport of carbon (C) and nitrogen (N) is coordinated with the central metabolism is largely unknown. To better understand how the genetic and environmental factors influence C and N transport, we analysed the metabolite profiles of phloem exudates and xylem saps of five Arabidopsis thaliana accessions grown in low or non-limiting N supply. We observed that xylem saps were composed of 46 or 56% carbohydrates, 27 or 45% amino acids, and 5 or 13% organic acids in low or non-limiting N supply, respectively. In contrast, phloem exudates were composed of 76 or 86% carbohydrates, 7 or 18% amino acids, and 5 or 6% organic acids. Variation in N supply impacted amino acid, organic acid and sugar contents. When comparing low N and non-limiting N, the most striking differences were variations of glutamine, aspartate, and succinate abundance in the xylem saps and citrate and fumarate abundance in phloem exudates. In addition, we observed a substantial variation of metabolite content between genotypes, particularly under high N. The content of several organic acids, such as malate, citrate, fumarate, and succinate was affected by the genotype alone or by the interaction between genotype and N supply. This study confirmed that the response of the transport of nutrients in the phloem and the xylem to N availability is associated with the regulation of the central metabolism and could be an adaptive trait.
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| 22. |
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| 23. |
- Dell'Era, C, et al.
(författare)
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Designing an Omni-Experience to Save Retailing : Lessons from an Italian Book Retailer
- 2020
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Ingår i: Research Technology Management. - : Taylor & Francis (Routledge): SSH Titles. - 0895-6308 .- 1930-0166. ; 63:3, s. 24-32
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Tidskriftsartikel (refereegranskat)abstract
- Overview: Online-based retailers have made competing in the physical retail industry increasingly challenging. Building strong experiences to differentiate from the online-based players is key to survival. Brands can leverage different forms of engagement, such as sensorial or cognitive ones, to support their customer experience. "Read, Eat, Dream" (RED), a new concept by LaFeltrinelli, the major Italian bookseller, is an example of how to create an "omni-experience" by leveraging customers' lifestyles. This article outlines how LaFeltrinelli conceptualized and implemented the RED concept and presents four key design elements central to creating an omni-experience. By creating an omni-experience, retailers can transform from fulfillment centers to spaces where customers can engage, which in turn increases the length of their visit and occasions for purchase. An omni-experience also establishes the retail store as a reference point for some customers' specific activities.
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| 24. |
- Dob, Asma, et al.
(författare)
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Jasmonate inhibits adventitious root initiation through repression of CKX1 and activation of RAP2.6L transcription factor in Arabidopsis
- 2021
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Ingår i: Journal of Experimental Botany. - : Oxford University Press. - 0022-0957 .- 1460-2431. ; 72:20, s. 7107-7118
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Tidskriftsartikel (refereegranskat)abstract
- Adventitious rooting is a de novo organogenesis process that enables plants to propagate clonally and cope with environmental stresses. Adventitious root initiation (ARI) is controlled by interconnected transcriptional and hormonal networks, but there is little knowledge of the genetic and molecular programs orchestrating these networks. Thus, we have applied genome-wide transcriptome profiling to elucidate the transcriptional reprogramming events preceding ARI. These reprogramming events are associated with the down-regulation of cytokinin (CK) signaling and response genes, which could be triggers for ARI. Interestingly, we found that CK free base (iP, tZ, cZ, and DHZ) content declined during ARI, due to down-regulation of de novo CK biosynthesis and up-regulation of CK inactivation pathways. We also found that MYC2-dependent jasmonate (JA) signaling inhibits ARI by down-regulating the expression of the CYTOKININ OXIDASE/DEHYDROGENASE1 (CKX1) gene. We also demonstrated that JA and CK synergistically activate expression of the transcription factor RELATED to APETALA2.6 LIKE (RAP2.6L), and constitutive expression of this transcription factor strongly inhibits ARI. Collectively, our findings reveal that previously unknown genetic interactions between JA and CK play key roles in ARI.
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| 25. |
- Eijsbouts, C., et al.
(författare)
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Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders
- 2021
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 53:11, s. 1543-1552
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Tidskriftsartikel (refereegranskat)abstract
- Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1, CADM2, PHF2/FAM120A, DOCK9, CKAP2/TPTE2P3 and BAG6. The first four are associated with mood and anxiety disorders, expressed in the nervous system, or both. Mirroring this, we also found strong genome-wide correlation between the risk of IBS and anxiety, neuroticism and depression (rg > 0.5). Additional analyses suggested this arises due to shared pathogenic pathways rather than, for example, anxiety causing abdominal symptoms. Implicated mechanisms require further exploration to help understand the altered brain–gut interactions underlying IBS. © 2021, The Author(s).
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| 26. |
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| 27. |
- Flammini, Francesco, Senior Lecturer, 1978-, et al.
(författare)
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Security of human machine systems
- 2023
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Ingår i: Handbook of Human-Machine Systems. - : wiley. - 9781119863663 - 9781119863632 ; , s. 419-430
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- In this chapter, we provide an overview of cyber-physical security applied to human machine systems (HMS), including a basic taxonomy, reference models, historical background and state-of-the-art. We discuss the most relevant technical contributions in the field of secure HMS by highlighting current trends, challenges, opportunities, and future directions. In particular, we will explore security paradigms integrating human-related factors, with a focus on data privacy, the Internet of Things, and computer security. Secure HMS are even more relevant in the context of future trustworthy autonomous systems, which will be required to detect and counteract evolving threats through intelligent behaviors based on learning and adaptation.
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| 28. |
- Flammini, Francesco, Senior Lecturer, 1978-, et al.
(författare)
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Towards Trustworthy Autonomous Systems : Taxonomies and Future Perspectives
- 2024
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Ingår i: IEEE Transactions on Emerging Topics in Computing. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 2168-6750. ; 12:2, s. 601-614
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Tidskriftsartikel (refereegranskat)abstract
- The class of Trustworthy Autonomous Systems (TAS) includes cyber-physical systems leveraging on self-x technologies that make them capable to learn, adapt to changes, and reason under uncertainties in possibly critical applications and evolving environments. In the last decade, there has been a growing interest in enabling artificial intelligence technologies, such as advanced machine learning, new threats, such as adversarial attacks, and certification challenges, due to the lack of sufficient explainability. However, in order to be trustworthy, those systems also need to be dependable, secure, and resilient according to well-established taxonomies, methodologies, and tools. Therefore, several aspects need to be addressed for TAS, ranging from proper taxonomic classification to the identification of research opportunities and challenges. Given such a context, in this paper address relevant taxonomies and research perspectives in the field of TAS. We start from basic definitions and move towards future perspectives, regulations, and emerging technologies supporting development and operation of TAS.
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| 29. |
- Frödin, Kerstin, 1971-
(musiker, creator_code:cre_t)
-
Chantbook for Lipparella : by Walter Zimmermann
- 2022
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Konstnärligt arbeteabstract
- Lipparella omfattande samarbete med tonsättaren Walter Zimmermann har lett till porträttkonserter på Goethe Institutet och Fylkingen i Stockholm samt en CD inspelning på det tyska skivboladet World Edition. Zimmermann, som länge hört till de mest egensinniga komponisterna i Tyskland, har komponerat två nya verk för Lipparella med texter av Inger Christensen och Gunnar Ekelöf. Båda diktarnas inspelade röster ingår också i verken. Ensemblen har även studerat in redan befintlig musik av Zimmermann, delvis i nya versioner för ensemblens besättning. Här finns bland annat soloverk för alla i ensemblen, och fyra sånger med vardera ett instrument.
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| 30. |
- Frödin, Kerstin, 1971-
(musiker, creator_code:cre_t)
-
Hidden voices : by Lipparella
- 2021
-
Konstnärligt arbete (refereegranskat)abstract
- Album by the ensemble Lipparella.Lipparella performs music byChrichan Larson - Czarne Latawce (2013) Madeleine Isaksson - Hemligheten (2013)Christer Lindwall - What is the word (2018-19Lipparella: Louise Agnani - viola da gamba Mikael Bellini - counter tenorKerstin Frödin - recordersAnna Lindal - violin Peter Söderberg - theorbo Tracks:Czarne Latawce: I. 01:12Czarne Latawce: II. 01:01Czarne Latawce: III. 00:48Czarne Latawce: IV. 04:13Czarne Latawce: V. 03:21Czarne Latawce: VI. 00:40Czarne Latawce: VII. 03:29Czarne Latawce: VIII. 01:47Hemligheten: I. 03:23Hemligheten: II. 00:48Hemligheten: III. 03:13Hemligheten: IV. 04:16Hemligheten: V. 01:57Hemligheten: VI. 01:55Hemligheten: VII. 04:05What Is the Word 22:10
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| 31. |
- Kidwai, Maria, et al.
(författare)
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Species-specific transcriptional reprogramming during adventitious root initiation
- 2023
-
Ingår i: Trends in Plant Science. - : Elsevier. - 1360-1385 .- 1878-4372. ; 28:2, s. 128-130
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Tidskriftsartikel (refereegranskat)abstract
- Adventitious roots or shoot-borne roots transdifferentiate from cells close to vascular tissues after cell reprogramming, which is associated with increased transcriptional activity. Recently, Garg et al. provided a genome-wide landscape of transcriptional signatures during the early stages of adventitious root initiation in rice and showed that conserved transcription factors acquire species-specific function.
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| 32. |
- Lakehal, Abdellah, et al.
(författare)
-
ETHYLENE RESPONSE FACTOR 115 integrates jasmonate and cytokinin signaling machineries to repress adventitious rooting in Arabidopsis
- 2020
-
Ingår i: New Phytologist. - : Wiley-Blackwell Publishing Inc.. - 0028-646X .- 1469-8137. ; 228, s. 1611-1626
-
Tidskriftsartikel (refereegranskat)abstract
- Adventitious root initiation (ARI) is ade novoorganogenesis program and a key adaptive trait in plants. Several hormones regulate ARI but the underlying genetic architecture that integrates the hormonal crosstalk governing this process remains largely elusive. In this study, we use genetics, genome editing, transcriptomics, hormone profiling and cell biological approaches to demonstrate a crucial role played by the APETALA2/ETHYLENE RESPONSE FACTOR 115 transcription factor. We demonstrate that ERF115 functions as a repressor of ARI by activating the cytokinin (CK) signaling machinery. We also demonstrate thatERF115is transcriptionally activated by jasmonate (JA), an oxylipin-derived phytohormone, which represses ARI in NINJA-dependent and independent manners. Our data indicate that NINJA-dependent JA signaling in pericycle cells blocks early events of ARI. Altogether, our results reveal a previously unreported molecular network involving cooperative crosstalk between JA and CK machineries that represses ARI.
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| 33. |
- Lakehal, Abdellah, et al.
(författare)
-
Multiple Roles of Jasmonates in Shaping Rhizotaxis : Emerging Integrators
- 2020
-
Ingår i: Jasmonate in Plant Biology. - New York, NY : Humana Press. - 9781071601419 - 9781071601440 - 9781071601426 ; , s. 3-22
-
Bokkapitel (refereegranskat)abstract
- The root system and its architecture enormously contribute to plant survival and adaptation to the environment. Depending on the intrinsic genetic information and the surrounding rhizosphere, plants develop a highly plastic root system, which is a critical determinant for survival. Plant root system, which includes primary root (PR), lateral roots (LR) and adventitious roots (AR), is shaped by tightly controlled developmental programs. Phytohormones are the main signaling components that orchestrate and coordinate the genetic information and the external stimuli to shape the root system patterning or rhizotaxis. Besides their role in plant stress responses and defense against herbivory and pathogen attacks, jasmonic acid and its derivatives, including the receptor-active conjugate jasmonoyl-L-isoleucine (JA-Ile), emerge as potential regulators of rhizotaxis. In this chapter, we summarize and discuss the recent progress achieved during the recent years to understand the JA-mediated genetic and molecular networks guiding PR, LR, and AR initiation. We highlight the role of JAs as critical integrators in shaping rhizotaxis.
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| 34. |
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| 35. |
- Neuman, Nicklas, 1987-, et al.
(författare)
-
Food-related experiences and behavioral responses among people affected by chemosensory dysfunctions following COVID-19 : A scoping review
- 2023
-
Ingår i: Research in Nursing & Health. - : John Wiley & Sons. - 0160-6891 .- 1098-240X. ; 46:4, s. 385-399
-
Tidskriftsartikel (refereegranskat)abstract
- A category of symptoms that became characteristic early in the first wave of the coronavirus disease 2019 (COVID-19) pandemic was chemosensory dysfunctions (alterations ofsmell and taste). Such symptoms substantially affect food and eating – cornerstones for both nutrition-related health outcomes and for quality of life. Based on this, this scoping review aimed to map out existing scientific literature on food-related experiences and related behavioral responses among people affected by chemosensory dysfunctions following COVID-19. A librarian-supported search of PsycInfo, PubMed, and Scopus for publications written in English (2020 to April 26, 2022) was conducted. Two authors searched for and screened publications and three others extracted and collated data. These are reported following the Preferred Reporting Items of Systematic reviews and Meta-Analyses extension for Scoping Reviews. Of 1169 hits, 9 publications were included in the review. The results are thematized as “Psychological and social aspects” and “Nutritional aspects,” each with the subsections “Experiences” and “Behavioral responses.” A great variety of food-related problems, nutritional and mental health effects, and implications for social life are identified. People affected by chemosensory dysfunctions following COVID-19 suffer, as evident both in stories from qualitative studies and in measurements of quality of life. The results impact all professions who are and may come to be involved in treating these patients, such as nurses, physicians, dietitians, and psychologists. With more knowledge about the dysfunctions’ manifestation, duration, and impact on everyday life, multiprofessional teams need to collaborate in supporting patients medically, psychosocially, and nutritionally.
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| 36. |
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| 37. |
- Pengel, L. H.M., et al.
(författare)
-
Equity, Diversity and Inclusion (EDI) in Organ Transplantation : An ESOT Survey About EDI Within ESOT as an Organization and its Educational Activities, and Transplantation Research and Science
- 2023
-
Ingår i: Transplant International. - 0934-0874. ; 36
-
Tidskriftsartikel (refereegranskat)abstract
- The European Society of Organ Transplantation (ESOT) strives to promote equity, diversity, and inclusion (EDI) across all its activities. We surveyed the transplant community’s experiences and perspectives regarding EDI within ESOT as an organization and its educational activities, and research in general. A total of 299 respondents completed the questionnaire. About half agreed that ESOT’s Executive Committee, Council, and Sections/Committees are diverse and inclusive (51%) and that ESOT promotes EDI in its live and digital educational activities (54%). Forty percent of respondents agreed that scientific and clinical trials in the field of transplantation are diverse and inclusive. Despite the wide distribution of the survey, most of the respondents self-identified as White and were either physician or surgeon. However, the results contribute a unique insight into the experiences and perspectives of the transplantation community regarding EDI. Whilst ESOT is committed to the principles of EDI, perceptions and the high number of proposals show the apparent need to prioritize efforts to embed EDI across ESOT and transplantation science. These data should constitute a starting point for change and provide guidance for future efforts to promote EDI within the transplantation community.
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| 38. |
- Potapov, Anton M., et al.
(författare)
-
Global fine-resolution data on springtail abundance and community structure
- 2024
-
Ingår i: Scientific Data. - : Nature Publishing Group. - 2052-4463. ; 11:1
-
Tidskriftsartikel (refereegranskat)abstract
- Springtails (Collembola) inhabit soils from the Arctic to the Antarctic and comprise an estimated ~32% of all terrestrial arthropods on Earth. Here, we present a global, spatially-explicit database on springtail communities that includes 249,912 occurrences from 44,999 samples and 2,990 sites. These data are mainly raw sample-level records at the species level collected predominantly from private archives of the authors that were quality-controlled and taxonomically-standardised. Despite covering all continents, most of the sample-level data come from the European continent (82.5% of all samples) and represent four habitats: woodlands (57.4%), grasslands (14.0%), agrosystems (13.7%) and scrublands (9.0%). We included sampling by soil layers, and across seasons and years, representing temporal and spatial within-site variation in springtail communities. We also provided data use and sharing guidelines and R code to facilitate the use of the database by other researchers. This data paper describes a static version of the database at the publication date, but the database will be further expanded to include underrepresented regions and linked with trait data.
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| 39. |
- Potapov, Anton M., et al.
(författare)
-
Globally invariant metabolism but density-diversity mismatch in springtails
- 2023
-
Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
-
Tidskriftsartikel (refereegranskat)abstract
- Soil life supports the functioning and biodiversity of terrestrial ecosystems. Springtails (Collembola) are among the most abundant soil arthropods regulating soil fertility and flow of energy through above- and belowground food webs. However, the global distribution of springtail diversity and density, and how these relate to energy fluxes remains unknown. Here, using a global dataset representing 2470 sites, we estimate the total soil springtail biomass at 27.5 megatons carbon, which is threefold higher than wild terrestrial vertebrates, and record peak densities up to 2 million individuals per square meter in the tundra. Despite a 20-fold biomass difference between the tundra and the tropics, springtail energy use (community metabolism) remains similar across the latitudinal gradient, owing to the changes in temperature with latitude. Neither springtail density nor community metabolism is predicted by local species richness, which is high in the tropics, but comparably high in some temperate forests and even tundra. Changes in springtail activity may emerge from latitudinal gradients in temperature, predation and resource limitation in soil communities. Contrasting relationships of biomass, diversity and activity of springtail communities with temperature suggest that climate warming will alter fundamental soil biodiversity metrics in different directions, potentially restructuring terrestrial food webs and affecting soil functioning.
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| 40. |
- Ranjan, Alok, et al.
(författare)
-
Molecular basis of differential adventitious rooting competence in poplar genotypes
- 2022
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Ingår i: Journal of Experimental Botany. - : Oxford University Press. - 0022-0957 .- 1460-2431. ; 73:12, s. 4046-4064
-
Tidskriftsartikel (refereegranskat)abstract
- Recalcitrant adventitious root (AR) development is a major hurdle in propagating commercially important woody plants. Although significant progress has been made to identify genes involved in subsequent steps of AR development, the molecular basis of differences in apparent recalcitrance to form AR between easy-to-root and difficult-to-root genotypes remains unknown. To address this, we generated cambium tissue-specific transcriptomic data from stem cuttings of hybrid aspen, T89 (difficult-to-root) and hybrid poplar OP42 (easy-to-root), and used transgenic approaches to verify the role of several transcription factors in the control of adventitious rooting. Increased peroxidase activity was positively correlated with better rooting. We found differentially expressed genes encoding reactive oxygen species scavenging proteins to be enriched in OP42 compared with T89. A greater number of differentially expressed transcription factors in cambium cells of OP42 compared with T89 was revealed by a more intense transcriptional reprograming in the former. PtMYC2, a potential negative regulator, was less expressed in OP42 compared with T89. Using transgenic approaches, we demonstrated that PttARF17.1 and PttMYC2.1 negatively regulate adventitious rooting. Our results provide insights into the molecular basis of genotypic differences in AR and implicate differential expression of the master regulator MYC2 as a critical player in this process.
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| 41. |
- Robberto, Massimo, et al.
(författare)
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HST Survey of the Orion Nebula Cluster in the H2O 1.4 μm Absorption Band. I. A Census of Substellar and Planetary-mass Objects
- 2020
-
Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 896:1
-
Tidskriftsartikel (refereegranskat)abstract
- In order to obtain a complete census of the stellar and substellar population, down to a few MJup in the ∼1 Myr old Orion Nebula Cluster, we used the infrared channel of the Wide Field Camera 3 of the Hubble Space Telescope with the F139M and F130N filters. These bandpasses correspond to the 1.4 μm H2O absorption feature and an adjacent line-free continuum region. Out of 4504 detected sources, 3352 (about 75%) appear fainter than m 130 = 14 (Vega mag) in the F130N filter, a brightness corresponding to the hydrogen-burning limit mass (M ≃ 0.072 M⊙) at ∼1 Myr. Of these, however, only 742 sources have a negative F130M-F139N color index, indicative of the presence of H2O vapor in absorption, and can therefore be classified as bona fide M and L dwarfs, with effective temperatures T ≲ 2850 K at an assumed 1 Myr cluster age. On our color-magnitude diagram (CMD), this population of sources with H2O absorption appears clearly distinct from the larger background population of highly reddened stars and galaxies with positive F130M-F139N color index and can be traced down to the sensitivity limit of our survey, m 130 ≃ 21.5, corresponding to a 1 Myr old ≃3 MJup planetary-mass object under about 2 mag of visual extinction. Theoretical models of the BT-Settl family predicting substellar isochrones of 1, 2, and 3 Myr down to ∼1 MJup fail to reproduce the observed H2O color index at M ≲ 20 MJup. We perform a Bayesian analysis to determine extinction, mass, and effective temperature of each substellar member of our sample, together with its membership probability.
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| 42. |
- Sibrecht, Greta, et al.
(författare)
-
Cooling strategies during neonatal transport for hypoxic-ischaemic encephalopathy
- 2023
-
Ingår i: Acta Paediatrica, International Journal of Paediatrics. - : Wiley. - 0803-5253. ; 112:4, s. 587-602
-
Forskningsöversikt (refereegranskat)abstract
- Aim: We reviewed the literature on cooling methods during transport of newborn infants with hypoxic-ischaemic encephalopathy (HIE) born in a non-tertiary centre and transferred to a neonatal intensive care unit for therapeutic hypothermia. Methods: The electronic databases CENTRAL, MEDLINE, Embase, CINAHL, and Scopus were searched from inception up to 8 March 2022 for studies comparing cooling versus no cooling, active versus passive cooling, and servo-controlled versus non-servo-controlled cooling. Odds ratio and confidence of interval were calculated for dichotomous outcomes and mean difference and confidence interval for continuous outcomes. Results: The final analysis included 14 studies, 1 randomised and 13 non-randomised, involving 1098 newborn infants. Compared with the other cooling methods, servo-controlled active cooling was more likely to maintain body temperature within the target range of 33°C–34°C on arrival at a neonatal intensive care unit: odds ratio 13.58, 95% confidence interval 4.32–42.66, risk difference 0.33, 95% confidence interval 0.19–0.46; 224 participants; three studies; I2 0%. The certainty of evidence was low. Only five studies reported mortality rates. Conclusion: Servo-controlled active cooling may be the preferred method during transport of newborn infants with HIE. A future area of focus should be long-term neurodevelopmental outcomes after servo-controlled active cooling.
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| 43. |
- Trunschke, Annette, et al.
(författare)
-
Towards Experimental Handbooks in Catalysis
- 2020
-
Ingår i: Topics in Catalysis. - : Springer Science and Business Media LLC. - 1572-9028 .- 1022-5528. ; 63:19-20, s. 1683-1699
-
Tidskriftsartikel (refereegranskat)abstract
- The “Seven Pillars” of oxidation catalysis proposed by Robert K. Grasselli represent an early example of phenomenological descriptors in the field of heterogeneous catalysis. Major advances in the theoretical description of catalytic reactions have been achieved in recent years and new catalysts are predicted today by using computational methods. To tackle the immense complexity of high-performance systems in reactions where selectivity is a major issue, analysis of scientific data by artificial intelligence and data science provides new opportunities for achieving improved understanding. Modern data analytics require data of highest quality and sufficient diversity. Existing data, however, frequently do not comply with these constraints. Therefore, new concepts of data generation and management are needed. Herein we present a basic approach in defining best practice procedures of measuring consistent data sets in heterogeneous catalysis using “handbooks”. Selective oxidation of short-chain alkanes over mixed metal oxide catalysts was selected as an example.
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| 44. |
- Zeng, Yinwei, et al.
(författare)
-
Chemical induction of hypocotyl rooting reveals extensive conservation of auxin signalling controlling lateral and adventitious root formation
- 2023
-
Ingår i: New Phytologist. - : New Phytologist Foundation. - 0028-646X .- 1469-8137. ; 240:5, s. 1883-1899
-
Tidskriftsartikel (refereegranskat)abstract
- Upon exposure to light, etiolated Arabidopsis seedlings form adventitious roots (AR) along the hypocotyl. While processes underlying lateral root formation are studied intensively, comparatively little is known about the molecular processes involved in the initiation of hypocotyl AR. AR and LR formation were studied using a small molecule named Hypocotyl Specific Adventitious Root INducer (HYSPARIN) that strongly induces AR but not LR formation. HYSPARIN does not trigger rapid DR5-reporter activation, DII-Venus degradation or Ca2+ signalling. Transcriptome analysis, auxin signalling reporter lines and mutants show that HYSPARIN AR induction involves nuclear TIR1/AFB and plasma membrane TMK auxin signalling, as well as multiple downstream LR development genes (SHY2/IAA3, PUCHI, MAKR4 and GATA23). Comparison of the AR and LR induction transcriptome identified SAURs, AGC kinases and OFP transcription factors as specifically upregulated by HYSPARIN. Members of the SAUR19 subfamily, OFP4 and AGC2 suppress HYS-induced AR formation. While SAUR19 and OFP subfamily members also mildly modulate LR formation, AGC2 regulates only AR induction. Analysis of HYSPARIN-induced AR formation uncovers an evolutionary conservation of auxin signalling controlling LR and AR induction in Arabidopsis seedlings and identifies SAUR19, OFP4 and AGC2 kinase as novel regulators of AR formation.
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| 45. |
- Niemi, MEK, et al.
(författare)
-
- 2021
-
swepub:Mat__t
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| 46. |
- Kanai, M, et al.
(författare)
-
- 2023
-
swepub:Mat__t
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