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- Bengtsson, Bo
(författare)
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Housing in game-theoretical perspective
- 1995
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Ingår i: Housing Studies. - Harlow : Longman. - 0267-3037 .- 1466-1810. ; 10, s. 229-243
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Tidskriftsartikel (refereegranskat)
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- Bengtsson, Bo
(författare)
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Social democratic Sweden: A story of success
- 1999
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Ingår i: The Co-operative Alternative in Europe: The Case of Housing. - : Aldershot: Ashgate. ; , s. 249-274
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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- Florén, Claes-Henrik, et al.
(författare)
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Bone mineral density in patients with Crohn's disease during long-term treatment with azathioprine
- 1998
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Ingår i: Journal of Internal Medicine. - 1365-2796. ; 243:2, s. 123-126
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To ascertain whether patients with Crohn's disease treated with azathioprine maintained bone mineral mass better than patients treated with steroids alone. DESIGN: Retrospective study. SETTING: University Hospital of Malmo, Sweden. SUBJECTS: A total of 59 patients with ileocolonic, ileocaecal or colonic Crohn's disease. METHODS: Bone mass was assessed by dual photon X-ray absorptiometry at the level of L2-L4. RESULTS: Patients treated with a high lifetime dose of steroids (> 5 g prednisolone) had significantly (P = 0.011) lower Z-score of L2-L4 (-0.87 +/- 1.11; 11 SD) than steroid-treated patients, who had received a low dose of prednisolone (< 5 g) (0.08 +/- 1.16 SD). Azathioprine did not negatively influence the steroid effect on bone mineral density. CONCLUSIONS: Azathioprine does not seem to affect bone mineral density by itself. However, by being steroid-saving, it seems to conserve bone mineral mass in patients with Crohn's disease.
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- Gundersen, Kjell Gunnar, et al.
(författare)
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Sensitivity and specificity of structural optic disc parameters in chronic glaucoma
- 1996
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Ingår i: Acta Ophthalmologica Scandinavica. - : Wiley. - 1395-3907. ; 74:2, s. 120-125
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Tidskriftsartikel (refereegranskat)abstract
- We studied different structural optic disc parameters and their ability to discriminate between normal and glaucoma eyes using computerized raster tomography. Two hundred and seventy-six eyes of 138 normal subjects and 146 eyes of 102 glaucoma patients were examined with a raster tomographic imaging system (The Glaucoma-Scope®, Ophthalmic Imaging Systems, Sacramento, CA). Glaucoma eyes were classified into four groups according to their perimetric mean deviation values. Minimum rim width within the 60° and 90° sectors across the vertical meridian, vertical and horizontal cup-disc ratio, rim and cup area were calculated for each optic disc. Receiver operating characteristics curves were set up for comparisons of the different parameters. Representing localised changes of the optic disc, minimum rim width 60° and 90° showed the best separating characteristics with sensitivity values of 91% at a feued specificity of 90%, followed by vertical cup-disc ratio. Global indices like cup and rim area and horizontal cup-disc ratio showed the poorest separation. These differences were particularly obvious in the group with mild to moderate glaucomatous visual field defects. Thus, global parameters were less likely to detect early focal glaucomatous optic nerve head changes, than parameters representing localised changes.
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- Janson, Per-Olof, 1940, et al.
(författare)
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Acromegaly and Cushing's syndrome due to ectopic production of GHRH and ACTH by a thymic carcinoid tumour: in vitro responses to GHRH and GHRP-6.
- 1998
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Ingår i: Clinical endocrinology. - 0300-0664. ; 48:2, s. 243-50
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Tidskriftsartikel (refereegranskat)abstract
- A 50-year-old male presented with diabetes mellitus and Cushing's syndrome associated with a large mediastinal mass. The levels of serum cortisol were high (1500-1800 nmol/l) without diurnal variation. Plasma ACTH levels (200-250 ng/l) and urinary excretion of cortisol were also increased. The levels of these hormones did not change in response to stimulation with corticotrophin releasing hormone (CRH) or suppression with high doses of dexamethasone. The patient had an elevated baseline GH level (7.3 mU/l), and the levels of immunoreactive GH-releasing hormone (GHRH) in eight plasma samples were markedly increased (600-1500 ng/l). Circulating levels of IGF-1, chromogranin A and neuropeptide Y (NPY) were also increased. Computer-assisted tomography and octreotide scintigraphy revealed a large mediastinal tumour and metastases in the left supraclavicular fossa. During treatment with octreotide, the baseline GH level was decreased (to 4.4 mU/l), while the GH pulse height was unchanged. Surgical removal of most of the tumour tissue resulted in a further decrease in the baseline serum GH level to a value (1.6 mU/l) about 20% of that before treatment, while the pulse height and mean GH were affected to a lesser extent. Postoperatively, circulating levels of cortisol and IGF-1 decreased, and the patient exhibited clinical improvement. Histological examination showed a neuroendocrine tumour with characteristics consistent with a foregut carcinoid of thymic origin. Immunoreactive GHRH, ACTH and NPY, but not immunoreactive GH, were detected in 80-90% of the tumour cells and the three peptides appeared to be co-localized. In primary culture, cells from this tumour displayed calcium influx in response to GHRH or GH releasing peptide-6 (GHRP-6), while there were not such responses by cells from another carcinoid not producing GHRH, ACTH or NPY. These results demonstrate a rare case of ectopic production of GHRH, ACTH and NPY, and indicate that the tumour cells were responsive to GHRH and GHRP-6 as well as octreotide.
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- Lindström, Kjell, et al.
(författare)
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A model for quality assessment in primary health care using the tracer condition technique with insulin treated diabetes as one of the tracers
- 1997
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Ingår i: Scandinavian Journal of Primary Health Care. - : Informa Healthcare. - 0281-3432 .- 1502-7724. ; 15:2, s. 92-96
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Tidskriftsartikel (refereegranskat)abstract
- Objective-To find a method for quality assessment in primary health care and to apply this method on a defined disease.Design-General practitioners and hospital doctors worked out a programme for evaluating the quality of outpatient care of patients with insulin treated diabetes as one of five tracers. An expert committee comprising experienced general practitioners and hospital doctors compared two health centres with one outpatient medical department Data were collected during a defined period combined with a one-year retrospective view, official statistics on medical care, and a questionnaire completed by the patients.Setting-Two primary health care centres and one outpatient medical department in southwestern Sweden.Patients-243 insulin treated diabetic patients attending the hospital and 87 insulin treated patients attending the health centres.Main results-There were no difficulties for the expert panel to agree on which indicators were to be studied. The expert panel concluded that there was no difference between the quality of the two levels of care studied.Conclusions-Medical audit was a useful method for evaluating medical quality. Co-operation between hospital doctors and general practitioners was of great value for evaluation of the quality of primary health care.
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- Ranefall, Petter, et al.
(författare)
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A new method for segmentation of colour images applied to immunohistochemically stained cell nuclei
- 1997
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Ingår i: Analytical Cellular Pathology. - : IOS PRESS. - 0921-8912 .- 1878-3651. ; 15:3, s. 145-156
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Tidskriftsartikel (refereegranskat)abstract
- A new method for segmenting images of immunohistochemically stained cell nuclei is presented. The aim is to distinguish between cell nuclei with a positive staining reaction and other cell nuclei, and to make it possible to quantify the reaction. First, a
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- Thurfjell, Lennart, et al.
(författare)
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A Boundary Approach for Fast Neighborhood Operations on Three-Dimensional Binary Data
- 1995
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Ingår i: Graphical Models and Image Processing. - : ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS. - 1077-3169 .- 1090-2481. ; 57:1, s. 13-19
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents algorithms for fast erosion, dilation, and connected component labeling of three-dimensional binary data, The algorithms are based on a boundary representation of the data where the only voxels stored are those that belong to an object
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- Zhu, J, et al.
(författare)
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Peripheral nerve myelin modulates the effect of antidepressants on major histocompatibility complex expression on macrophages in experimental allergic neuritis
- 1995
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Ingår i: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - : SAGE Publications. - 0394-6320 .- 2058-7384. ; 8:3, s. 185-198
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The effect of bovine peripheral nerve myelin (BPM) used for induction of experimental allergic neuritis (EAN) in Lewis rats, on antidepressants' modulation of interferon-gamma (IFN-γ)-induced major histocompatibility complex (MHC) class I and II antigen expression on peritoneal macrophages in EAN rats was studied. Antidepressants with different profiles concerning inhibition of the neuronal reuptake of the monoamines serotonin (5-HT) and noradrenalin (NA), respectively, in concentrations of 10−4 to 10−8 M were used. At the concentration of 1.0 U/ml IFN-γ, most antidepressants significantly enhanced both MHC class I and class II expression, except maprotiline, a selective NA reuptake inhibiting antidepressant that suppressed MHC class I expression. Zimeldine, a selective 5-HT reuptake inhibitor did not affect MHC class II expression. BPM in general had an enhancing effect on modulation of both MHC class I and class II expression by antidepressants. By itself BPM enhanced MHC class I expression, but did not affect class II expression at IFN-γ 1.0 U/ml. The modulating effect of BPM on regulation of MHC expression by antidepressants could be the result of contaminating T cells and release of IFN-γ into cultures. The modulatory effect of antidepressants on MHC expression may to some extent be exerted by the action on 5-HT and/or NA regulation, but also by direct effects of antidepressants on macrophages. They probably play a role in zimeldine-induced Guillain-Barré syndrome in some patients and in the suppression of clinical signs of EAN in Lewis rats reported for some antidepressants.
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- Ögren, Mats, et al.
(författare)
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Prognosis in elderly men with screening-detected abdominal aortic aneurysm
- 1996
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Ingår i: European Journal of Vascular and Endovascular Surgery. - 1532-2165. ; 11:1, s. 42-47
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To study the natural course of screening-detected symptomless abdominal aortic aneurysm (AAA) in elderly men. SETTING: Malmo, a city in southern Sweden with 230,000 inhabitants and a single referral hospital. MATERIALS: 423 seventy-four-year-old men, randomly selected from the population and belonging to the prospective population study "Men born in 1914", were invited. 343 underwent AAA screening, whereas 80 declined or had moved. CHIEF OUTCOME MEASURES: Five year all cause mortality in relation to participation in and findings at ultrasound screening for AAA. MAIN RESULTS: An abdominal aortic aneurysm was present in 38 (11%) out of 340 men who underwent screening and who had a native aorta. During 5 years of follow-up, one third (13/38) of these men died; 7 from myocardial infarction and 3 from stroke. The mortality rate in men with AAA was 80.2/1000 person years; twice as high as it was in men without AAA (39.4/1000 person years; p = 0.018). Six men underwent AAA surgery. None of them died from aneurysm rupture. However, aneurysm surgery did not reduce the total mortality rate in these men. The highest mortality rate, 91.9/1000 person years, was found in the men who did not participate in the screening. CONCLUSIONS: It is our conclusion that screening for early detection and intervention is of questionable value from a public health perspective.
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