| 1. |
|
|
| 2. |
- Andersson-Engels, Stefan, et al.
(författare)
-
Effects of Optical-constants On Time-gated Transillumination of Tissue and Tissue-like Media
- 1992
-
Ingår i: Journal of Photochemistry and Photobiology, B: Biology. - 1011-1344. ; 16:2, s. 155-167
-
Tidskriftsartikel (refereegranskat)abstract
- Light transillumination was used to study structures inside turbid media. Time-gated viewing was performed to suppress multiply-scattered light and thus improve spatial resolution. We demonstrate that, for the case of scattering-dominated attenuation (scattering coefficient much greater than the absorption coefficient), the detection of early transmitted light will be practically insensitive to variations in the absorption coefficient. This is an important observation for the development of time-gated optical mammography, since optical mammography using continuous-wave light is based on increased light absorption in the tumour region caused by the neovascularization surrounding a tumour. In order to detect tumours in time-gated viewing it is the scattering coefficient of the tumour that must be characteristic. The scattering coefficient is measured to be lower in the tumour region than in the surrounding breast tissue for one resected breast specimen.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Andersson-Engels, Stefan, et al.
(författare)
-
Laser Spectroscopy in Medical Diagnostics
- 1992
-
Ingår i: Photodynamic Therapy: Basic Principles and Clinical Applications. - 0824786807 ; , s. 387-424
-
Bokkapitel (refereegranskat)
|
|
| 6. |
- Andersson-Engels, Stefan, et al.
(författare)
-
Multispectral Tissue Characterization With Time-resolved Detection of Diffusely Scattered White-light
- 1993
-
Ingår i: Optics Letters. - 0146-9592. ; 18:20, s. 1697-1699
-
Tidskriftsartikel (refereegranskat)abstract
- A novel technique for the noninvasive measurement of tissue optical properties simultaneously at all visible and near-infrared wavelengths is presented. The technique is based on.the time-resolved detection of multicolor diffusely scattered light. Short pulses of white light are/produced by using self-phase modulation by focusing the light from a short-pulsed high-power laser into a cuvette filled with water. After spectral dispersion in a polychromator and temporal dispersion in a streak tube, a two-dimensional CCD camera was used as a detector, with one dimension used for time resolution and the other one for wavelength separation.
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
- Berg, Roger, et al.
(författare)
-
Time-resolved tranillumination imaging
- 1993
-
Ingår i: Medical Optical Tomography: Functional Imaging and Monitoring. ; , s. 397-424
-
Bokkapitel (refereegranskat)
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
- Svanberg, Katarina, et al.
(författare)
-
Photodynamic Therapy of Nonmelanoma Malignant-tumors of the Skin Using Topical Delta-amino Levulinic Acid Sensitization and Laser Irradiation
- 1994
-
Ingår i: British Journal of Dermatology. - : Oxford University Press (OUP). - 1365-2133 .- 0007-0963. ; 130:6, s. 743-751
-
Tidskriftsartikel (refereegranskat)abstract
- Eighty basal cell carcinomas (BCCs) in 21 patients, 10 lesions of Bowen's disease in three patients, and four lesions of cutaneous T-cell lymphoma in two patients, were treated with photodynamic laser therapy (PDT), using topical application of the haem precursor delta-amino levulinic acid (ALA). The diagnoses were confirmed histologically prior to treatment. Fifty-five of the BCCs were superficial lesions, and 25 were nodular. Of the 80 BCCs, 39 (49%) were located on the trunk, 36 (45%) on the head and neck region, four (15%) on the leg and one on the arm. The two principal locations of the 10 Bowen's disease lesions were the leg (50%) and the trunk (40%). The T-cell lymphoma lesions were located on the shoulder and on the arm. A water-in-oil based cream containing 20% ALA was applied to the lesions, with a margin of about 10-20 mm beyond the visible tumour border, 4-6 h before the laser procedure. During this period of time the highly fluorescent and photodynamically active substance protoporphyrin IX (Pp IX) is synthesized via the haem cycle. Laser-induced fluorescence (LIF) was used for real-time monitoring of the Pp IX distribution in the tumour and in the normal surrounding skin, before and after treatment in all patients. Before laser treatment the Pp-IX distribution demonstrated by LIF showed a demarcation between tumour and normal skin of about 15:1 for BCC and Bowen's disease, and 5:1 for T-cell lymphomas. Laser light from a pulsed frequency-doubled Nd:YAG laser pumping a dye laser with light emission at 630 nn was used for the therapy. The power density in the irradiation was kept below 110 mW/cm(2), in order to avoid hyperthermal effects. A total energy of 60 J/cm(2) was delivered for 10-20 min, depending on the tumour size. A complete response rate of 100% in superficial BCCs and 64% in nodular BCCs occurred after a single laser treatment, and a response rate of 100% was achieved after one additional. treatment in the nodular BCCs. in the Bowen's disease lesions a complete response of 90% was obtained with a single treatment. Two of the four T-cell lymphomas resolved completely. The follow-up time was between 6 and 14 months.
|
|
| 15. |
|
|
| 16. |
- Svanberg, Sune, et al.
(författare)
-
Applications of terawatt lasers
- 1994
-
Ingår i: LASER SPECTROSCOPY - XITH INTERNATIONAL CONFERENCE. - : AIP. - 1551-7616 .- 0094-243X. - 1563962624 ; :290, s. 264-269
-
Konferensbidrag (refereegranskat)
|
|
