| 1. |
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| 2. |
- Schael, S, et al.
(författare)
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Precision electroweak measurements on the Z resonance
- 2006
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Ingår i: Physics Reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 427:5-6, s. 257-454
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Forskningsöversikt (refereegranskat)abstract
- We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLID experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, m(Z) and Gamma(Z), and its couplings to fermions, for example the p parameter and the effective electroweak mixing angle for leptons, are precisely measured: m(Z) = 91.1875 +/- 0.0021 GeV, Gamma(Z) = 2.4952 +/- 0.0023 GeV, rho(l) = 1.0050 +/- 0.0010, sin(2)theta(eff)(lept) = 0.23153 +/- 0.00016. The number of light neutrino species is determined to be 2.9840 +/- 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model (SM). At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its SM expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m(t) = 173(+10)(+13) GeV, and the mass of the W boson, m(W) = 80.363 +/- 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the SM. Using in addition the direct measurements of m(t) and m(W), the mass of the as yet unobserved SM Higgs boson is predicted with a relative uncertainty of about 50% and found to be less than 285 GeV at 95% confidence level. (c) 2006 Elsevier B.V. All rights reserved.
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| 3. |
- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 4. |
- Abel, I, et al.
(författare)
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Overview of the JET results with the ITER-like wall
- 2013
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:10, s. 104002-
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Tidskriftsartikel (refereegranskat)abstract
- Following the completion in May 2011 of the shutdown for the installation of the beryllium wall and the tungsten divertor, the first set of JET campaigns have addressed the investigation of the retention properties and the development of operational scenarios with the new plasma-facing materials. The large reduction in the carbon content (more than a factor ten) led to a much lower Z(eff) (1.2-1.4) during L- and H-mode plasmas, and radiation during the burn-through phase of the plasma initiation with the consequence that breakdown failures are almost absent. Gas balance experiments have shown that the fuel retention rate with the new wall is substantially reduced with respect to the C wall. The re-establishment of the baseline H-mode and hybrid scenarios compatible with the new wall has required an optimization of the control of metallic impurity sources and heat loads. Stable type-I ELMy H-mode regimes with H-98,H-y2 close to 1 and beta(N) similar to 1.6 have been achieved using gas injection. ELM frequency is a key factor for the control of the metallic impurity accumulation. Pedestal temperatures tend to be lower with the new wall, leading to reduced confinement, but nitrogen seeding restores high pedestal temperatures and confinement. Compared with the carbon wall, major disruptions with the new wall show a lower radiated power and a slower current quench. The higher heat loads on Be wall plasma-facing components due to lower radiation made the routine use of massive gas injection for disruption mitigation essential.
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| 8. |
- Mlecnik, B, et al.
(författare)
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Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study
- 2022
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 14:18
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: In this study, we evaluated the prognostic value of Immunoscore in patients with stage I–III colon cancer (CC) in the Asian population. These patients were originally included in an international study led by the Society for Immunotherapy of Cancer (SITC) on 2681 patients with AJCC/UICC-TNM stages I–III CC. METHODS: CD3+ and cytotoxic CD8+ T-lymphocyte densities were quantified in the tumor and invasive margin by digital pathology. The association of Immunoscore with prognosis was evaluated for time to recurrence (TTR), disease-free survival (DFS), and overall survival (OS). RESULTS: Immunoscore stratified Asian patients (n = 423) into different risk categories and was not impacted by age. Recurrence-free rates at 3 years were 78.5%, 85.2%, and 98.3% for a Low, Intermediate, and High Immunoscore, respectively (HR[Low-vs-High] = 7.26 (95% CI 1.75−30.19); p = 0.0064). A High Immunoscore showed a significant association with prolonged TTR, OS, and DFS (p < 0.05). In Cox multivariable analysis stratified by center, Immunoscore association with TTR was independent (HR[Low-vs-Int+High] = 2.22 (95% CI 1.10–4.55) p = 0.0269) of the patient’s gender, T-stage, N-stage, sidedness, and MSI status. A significant association of a High Immunoscore with prolonged TTR was also found among MSS (HR[Low-vs-Int+High] = 4.58 (95% CI 2.27−9.23); p ≤ 0.0001), stage II (HR[Low-vs-Int+High] = 2.72 (95% CI 1.35−5.51); p = 0.0052), low-risk stage-II (HR[Low-vs-Int+High] = 2.62 (95% CI 1.21−5.68); p = 0.0146), and high-risk stage II patients (HR[Low-vs-Int+High] = 3.11 (95% CI 1.39−6.91); p = 0.0055). CONCLUSION: A High Immunoscore is significantly associated with the prolonged survival of CC patients within the Asian population.
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| 9. |
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| 10. |
- Mlecnik, B, et al.
(författare)
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Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer
- 2023
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 15:2
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Tidskriftsartikel (refereegranskat)abstract
- Background: The prognostic value of Immunoscore was evaluated in Stage II/III colon cancer (CC) patients, but it remains unclear in Stage I/II, and in early-stage subgroups at risk. An international Society for Immunotherapy of Cancer (SITC) study evaluated the pre-defined consensus Immunoscore in tumors from 1885 AJCC/UICC-TNM Stage I/II CC patients from Canada/USA (Cohort 1) and Europe/Asia (Cohort 2). METHODS: Digital-pathology is used to quantify the densities of CD3+ and CD8+ T-lymphocyte in the center of tumor (CT) and the invasive margin (IM). The time to recurrence (TTR) was the primary endpoint. Secondary endpoints were disease-free survival (DFS), overall survival (OS), prognosis in Stage I, Stage II, Stage II-high-risk, and microsatellite-stable (MSS) patients. RESULTS: High-Immunoscore presented with the lowest risk of recurrence in both cohorts. In Stage I/II, recurrence-free rates at 5 years were 78.4% (95%-CI, 74.4–82.6), 88.1% (95%-CI, 85.7–90.4), 93.4% (95%-CI, 91.1–95.8) in low, intermediate and high Immunoscore, respectively (HR (Hi vs. Lo) = 0.27 (95%-CI, 0.18–0.41); p < 0.0001). In Cox multivariable analysis, the association of Immunoscore to outcome was independent (TTR: HR (Hi vs. Lo) = 0.29, (95%-CI, 0.17–0.50); p < 0.0001) of the patient’s gender, T-stage, sidedness, and microsatellite instability-status (MSI). A significant association of Immunoscore with survival was found for Stage II, high-risk Stage II, T4N0 and MSS patients. The Immunoscore also showed significant association with TTR in Stage-I (HR (Hi vs. Lo) = 0.07 (95%-CI, 0.01–0.61); P = 0.016). The Immunoscore had the strongest (69.5%) contribution χ2 for influencing survival. Patients with a high Immunoscore had prolonged TTR in T4N0 tumors even for patients not receiving chemotherapy, and the Immunoscore remained the only significant parameter in multivariable analysis. CONCLUSION: In early CC, low Immunoscore reliably identifies patients at risk of relapse for whom a more intensive surveillance program or adjuvant treatment should be considered.
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| 13. |
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| 14. |
- Romanelli, F, et al.
(författare)
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Overview of the JET results
- 2011
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 51:9
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Tidskriftsartikel (refereegranskat)abstract
- Since the last IAEA Conference JET has been in operation for one year with a programmatic focus on the qualification of ITER operating scenarios, the consolidation of ITER design choices and preparation for plasma operation with the ITER-like wall presently being installed in JET. Good progress has been achieved, including stationary ELMy H-mode operation at 4.5 MA. The high confinement hybrid scenario has been extended to high triangularity, lower ρ*and to pulse lengths comparable to the resistive time. The steady-state scenario has also been extended to lower ρ*and ν*and optimized to simultaneously achieve, under stationary conditions, ITER-like values of all other relevant normalized parameters. A dedicated helium campaign has allowed key aspects of plasma control and H-mode operation for the ITER non-activated phase to be evaluated. Effective sawtooth control by fast ions has been demonstrated with3He minority ICRH, a scenario with negligible minority current drive. Edge localized mode (ELM) control studies using external n = 1 and n = 2 perturbation fields have found a resonance effect in ELM frequency for specific q95values. Complete ELM suppression has, however, not been observed, even with an edge Chirikov parameter larger than 1. Pellet ELM pacing has been demonstrated and the minimum pellet size needed to trigger an ELM has been estimated. For both natural and mitigated ELMs a broadening of the divertor ELM-wetted area with increasing ELM size has been found. In disruption studies with massive gas injection up to 50% of the thermal energy could be radiated before, and 20% during, the thermal quench. Halo currents could be reduced by 60% and, using argon/deuterium and neon/deuterium gas mixtures, runaway electron generation could be avoided. Most objectives of the ITER-like ICRH antenna have been demonstrated; matching with closely packed straps, ELM resilience, scattering matrix arc detection and operation at high power density (6.2 MW m-2) and antenna strap voltages (42 kV). Coupling measurements are in very good agreement with TOPICA modelling. © 2011 IAEA, Vienna.
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| 17. |
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| 18. |
- Al Mamun, Md Abdullah, 1982, et al.
(författare)
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Correlations of software code metrics : An empirical study
- 2017
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Ingår i: IWSM Mensura '17. - New York, NY, USA : Association for Computing Machinery (ACM). - 9781450348539 ; , s. 255-266
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Konferensbidrag (refereegranskat)abstract
- Background: The increasing up-trend of software size brings about challenges related to release planning and maintainability. Foreseeing the growth of software metrics can assist in taking proactive decisions regarding different areas where software metrics play vital roles. For example, source code metrics are used to automatically calculate technical debt related to code quality which may indicate how maintainable a software is. Thus, predicting such metrics can give us an indication of technical debt in the future releases of software. Objective: Estimation or prediction of software metrics can be performed more meaningfully if the relationships between different domains of metrics and relationships between the metrics and different domains are well understood. To understand such relationships, this empirical study has collected 25 metrics classified into four domains from 9572 software revisions of 20 open source projects from 8 well-known companies. Results: We found software size related metrics are most correlated among themselves and with metrics from other domains. Complexity and documentation related metrics are more correlated with size metrics than themselves. Metrics in the duplications domain are observed to be more correlated to themselves on a domain-level. However, a metric to domain level relationship exploration reveals that metrics with most strong correlations are in fact connected to size metrics. The Overall correlation ranking of duplication metrics are least among all domains and metrics. Contribution: Knowledge earned from this research will help to understand inherent relationships between metrics and domains. This knowledge together with metric-level relationships will allow building better predictive models for software code metrics. © 2017 Association for Computing Machinery.
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| 19. |
- Al Mamun, Md Abdullah, 1982, et al.
(författare)
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Effects of measurements on correlations of software code metrics
- 2019
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Ingår i: Empirical Software Engineering. - : Springer Science and Business Media LLC. - 1382-3256 .- 1573-7616. ; 24:4, s. 2764-2818
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Tidskriftsartikel (refereegranskat)abstract
- ContextSoftware metrics play a significant role in many areas in the life-cycle of software including forecasting defects and foretelling stories regarding maintenance, cost, etc. through predictive analysis. Many studies have found code metrics correlated to each other at such a high level that such correlated code metrics are considered redundant, which implies it is enough to keep track of a single metric from a list of highly correlated metrics.ObjectiveSoftware is developed incrementally over a period. Traditionally, code metrics are measured cumulatively as cumulative sum or running sum. When a code metric is measured based on the values from individual revisions or commits without consolidating values from past revisions, indicating the natural development of software, this study identifies such a type of measure as organic. Density and average are two other ways of measuring metrics. This empirical study focuses on whether measurement types influence correlations of code metrics.MethodTo investigate the objective, this empirical study has collected 24 code metrics classified into four categories, according to the measurement types of the metrics, from 11,874 software revisions (i.e., commits) of 21 open source projects from eight well-known organizations. Kendall's tau-B is used for computing correlations. To determine whether there is a significant difference between cumulative and organic metrics, Mann-Whitney U test, Wilcoxon signed rank test, and paired-samples sign test are performed.ResultsThe cumulative metrics are found to be highly correlated to each other with an average coefficient of 0.79. For corresponding organic metrics, it is 0.49. When individual correlation coefficients between these two measure types are compared, correlations between organic metrics are found to be significantly lower (with p <0.01) than cumulative metrics. Our results indicate that the cumulative nature of metrics makes them highly correlated, implying cumulative measurement is a major source of collinearity between cumulative metrics. Another interesting observation is that correlations between metrics from different categories are weak.ConclusionsResults of this study reveal that measurement types may have a significant impact on the correlations of code metrics and that transforming metrics into a different type can give us metrics with low collinearity. These findings provide us a simple understanding how feature transformation to a different measurement type can produce new non-collinear input features for predictive models.
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| 20. |
- Al Mamun, Md Abdullah, 1982, et al.
(författare)
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Engineering the Hardware/Software Interface for Robotic Platforms – A Comparison of Applied Model Checking with Prolog and Alloy
- 2013
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Ingår i: Proceedings of the 4th International Workshop on Domain-Specific Languages and models for ROBotic systems.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Robotic platforms serve different use cases ranging from experiments for prototyping assistive applications up to embedded systems for realizing cyber-physical systems in various domains. We are using 1:10 scale miniature vehicles as a robotic platform to conduct research in the domain of self-driving cars and collaborative vehicle fleets. Thus, experiments with different sensors like e.g. ultra-sonic, infrared, and rotary encoders need to be prepared and realized using our vehicle platform. For each setup, we need to configure the hardware/software interface board to handle all sensors and actors. Therefore, we need to find a specific configuration setting for each pin of the interface board that can handle our current hardware setup but which is also flexible enough to support further sensors or actors for future use cases. In this paper, we show how to model the domain of the configuration space for a hardware/software interface board to enable model checking for solving the tasks of finding any, all, and the best possible pin configuration. We present results from a formal experiment applying the declarative languages Alloy and Prolog to guide the process of engineering the hardware/software interface for robotic platforms on the example of a configuration complexity up to ten pins resulting in a configuration space greater than 14.5 million possibilities. Our results show that our domain model in Alloy performs better compared to Prolog to find feasible solutions for larger configurations with an average time of 0.58s. To find the best solution, our model for Prolog performs better taking only 1.38s for the largest desired configuration; however, this important use case is currently not covered by the existing tools for the hardware used as an example in this article.
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| 21. |
- Al Mamun, Md Abdullah, 1982, et al.
(författare)
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Evolution of technical debt: An exploratory study
- 2019
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Ingår i: CEUR Workshop Proceedings. - : CEUR-WS. - 1613-0073. ; 2476, s. 87-102, s. 87-102
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Konferensbidrag (refereegranskat)abstract
- Context: Technical debt is known to impact maintainability of software. As source code files grow in size, maintainability becomes more challenging. Therefore, it is expected that the density of technical debt in larger files would be reduced for the sake of maintainability. Objective: This exploratory study investigates whether a newly introduced metric ‘technical debt density trend’ helps to better understand and explain the evolution of technical debt. The ‘technical debt density trend’ metric is the slope of the line of two successive ‘technical debt density’ measures corresponding to the ‘lines of code’ values of two consecutive revisions of a source code file. Method: This study has used 11,822 commits or revisions of 4,013 Java source files from 21 open source projects. For the technical debt measure, SonarQube tool is used with 138 code smells. Results: This study finds that ‘technical debt density trend’ metric has interesting characteristics that make it particularly attractive to understand the pattern of accrual and repayment of technical debt by breaking down a technical debt measure into multiple components, e.g., ‘technical debt density’ can be broken down into two components showing mean density corresponding to revisions that accrue technical debt and mean density corresponding to revisions that repay technical debt. The use of ‘technical debt density trend’ metric helps us understand the evolution of technical debt with greater insights.
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| 22. |
- Al Mamun, Md Abdullah, 1982, et al.
(författare)
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Explicating, Understanding and Managing Technical Debt from Self-Driving Miniature Car Projects
- 2014
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Ingår i: Proceedings of the 30th IEEE International Conference on Software Maintenance and Evolution (ICSME). - Los Alamitos, CA : IEEE. - 9781479967919
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Konferensbidrag (refereegranskat)abstract
- Technical debt refers to various weaknesses in the design or implementation of a system resulting from trade-offs during software development usually for a quick release. Accumulating such debt over time without reducing it can seriously hamper the reusability and maintainability of the software. The aim of this study is to understand the state of the technical debt in the development of self-driving miniature cars so that proper actions can be planned to reduce the debt to have more reusable and maintainable software. A case study on a selected feature from two self-driving miniature car development projects is performed to assess the technical debt. Additionally, an interview study is conducted involving the developers to relate the findings of the case study with the possible root causes. The result of the study indicates that "the lack of knowledge" is not the primary reason for the accumulation of technical debt from the selected code smells. The root causes are rather in factors like time pressure followed by issues related to software/hardware integration and incomplete refactoring as well as reuse of legacy, third party, or open source code.
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| 23. |
- Al Mamun, Md Abdullah, 1982, et al.
(författare)
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Improving Code Smell Predictions in Continuous Integration by Differentiating Organic from Cumulative Measures
- 2019
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Ingår i: The Fifth International Conference on Advances and Trends in Software Engineering. - 2519-8394. - 9781510883741 ; , s. 62-71
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Konferensbidrag (refereegranskat)abstract
- Continuous integration and deployment are enablers of quick innovation cycles of software and systems through incremental releases of a product within short periods of time. If software qualities can be predicted for the next release, quality managers can plan ahead with resource allocation for concerning issues. Cumulative metrics are observed to have much higher correlation coefficients compared to non-cumulative metrics. Given the difference in correlation coefficients of cumulative and noncumulative metrics, this study investigates the difference between metrics of these two categories concerning the correctness of predicting code smell which is internal software quality. This study considers 12 metrics from each measurement category, and 35 code smells collected from 36,217 software revisions (commits) of 242 open source Java projects. We build 8,190 predictive models and evaluate them to determine how measurement categories of predictors and targets affect model accuracies predicting code smells. To further validate our approach, we compared our results with Principal Component Analysis (PCA), a statistical procedure for dimensionality reduction. Results of the study show that within the context of continuous integration, non-cumulative metrics as predictors build better predictive models with respect to model accuracy compared to cumulative metrics. When the results are compared with models built from extracted PCA components, we found better results using our approach.
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| 24. |
- Al Mamun, Md Abdullah, 1982, et al.
(författare)
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MDE-based Sensor Management and Verification for a Self-Driving Miniature Vehicle
- 2013
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Ingår i: 13th ACM Workshop on Domain-Specific Modeling, DSM 2013; Indianapolis, IN; United States. - New York, NY, USA : Association for Computing Machinery (ACM). - 9781450326001
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Konferensbidrag (refereegranskat)abstract
- Innovations for today’s vehicle functions are mainly driven by software. They realize comfort systems like automated parking but also safety systems where sensors are continuously monitoring the vehicle's surroundings to brake autonomously for avoiding collisions with cars, pedestrians, or bicyclists. In simulation environments, various traffic situations with alternative sensor setups are imitated before testing them on prototypical cars. In this paper, we are presenting an MDE approach for managing different sensor setups in a cyber-physical system development environment to leverage automated model verification, support system testing, and enable code generation. For example, the models are used as the single point of truth to configure and generate sensor setups for system validations in a 3D simulation environment. After their validation, a considered sensor configuration is transformed into a constraint-satisfaction model to be solved by the logical programming language Prolog. Based on this transformation, the conformance to the embedded system specification is formally verified and possible pin assignments, for how to connect the required sensors are calculated. The approach was validated during the development of a self- driving miniature vehicle using an STM32F4-based embedded system running the real-time operating system ChibiOS as the software/hardware interface to the sensors and actors.
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| 25. |
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| 26. |
- Berger, Christian, 1980, et al.
(författare)
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COTS-Architecture with a Real-Time OS for a Self-Driving Miniature Vehicle
- 2013
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Ingår i: Proceedings of Workshop ASCoMS (Architecting Safety in Collaborative Mobile Systems) of the 32nd International Conference on Computer Safety, Reliability and Security. ; , s. 411-422
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Konferensbidrag (refereegranskat)abstract
- The international competition 2007 DARPA Urban Challenge significantly fostered the research and development on intelligent vehicles. Recent prototypes from Google for instance are able to drive fully autonomously through the San Francisco bay area for more than 450,000km. Even if self-driving vehicles are not yet available for purchase for customers, technology spin-offs are increasingly finding their ways into today's vehicles as pedestrian collision warning system, automated parking, or adaptive cruise control with temporary lane following. Thus, the upcoming generation of software and computer engineers needs to be accordingly educated to be already familiar with the concepts and pitfalls of these complex systems. In this article, we describe the architecture of a self-driving miniature vehicle based solely on commercial-off-the-shelf (COTS) components for the hardware and the real-time operating system ChibiOS/RT for the software/hardware interface.
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| 27. |
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| 28. |
- Cochius-den Otter, S, et al.
(författare)
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The CoDiNOS trial protocol: an international randomised controlled trial of intravenous sildenafil versus inhaled nitric oxide for the treatment of pulmonary hypertension in neonates with congenital diaphragmatic hernia
- 2019
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Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 9:11, s. e032122-
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Tidskriftsartikel (refereegranskat)abstract
- Congenital diaphragmatic hernia (CDH) is a developmental defect of the diaphragm that impairs normal lung development, causing pulmonary hypertension (PH). PH in CDH newborns is the main determinant for morbidity and mortality. Different therapies are still mainly based on ‘trial and error’. Inhaled nitric oxide (iNO) is often the drug of first choice. However, iNO does not seem to improve mortality. Intravenous sildenafil has reduced mortality in newborns with PH without CDH, but prospective data in CDH patients are lacking.Methods and analysisIn an open label, multicentre, international randomised controlled trial in Europe, Canada and Australia, 330 newborns with CDH and PH are recruited over a 4-year period (2018–2022). Patients are randomised for intravenous sildenafil or iNO. Sildenafil is given in a loading dose of 0.4 mg/kg in 3 hours; followed by continuous infusion of 1.6 mg/kg/day, iNO is dosed at 20 ppm. Primary outcome is absence of PH on day 14 without pulmonary vasodilator therapy and/or absence of death within the first 28 days of life. Secondary outcome measures include clinical and echocardiographic markers of PH in the first year of life. We hypothesise that sildenafil gives a 25% reduction in the primary outcome from 68% to 48% on day 14, for which a sample size of 330 patients is needed. An intention-to-treat analysis will be performed. A p-value (two-sided) <0.05 is considered significant in all analyses.Ethics and disseminationEthics approval has been granted by the ethics committee in Rotterdam (MEC-2017-324) and the central Committee on Research Involving Human Subjects (NL60229.078.17) in the Netherlands. The principles of the Declaration of Helsinki, the Medical Research Involving Human Subjects Act and the national rules and regulations on personal data protection will be used. Parental informed consent will be obtained.Trial registration numberNTR6982; Pre-results.
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| 33. |
- Ständer, Sonja, et al.
(författare)
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IFSI-Guideline on Chronic Prurigo including Prurigo nodularis.
- 2020
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Ingår i: ITCH. - : Ovid Technologies (Wolters Kluwer Health). - 2380-5048. ; 5:4, s. 1-13
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Forskningsöversikt (refereegranskat)abstract
- Chronic prurigo (CPG) is a highly burdensome pruritic disease characterized by chronic itch, a prolonged scratching behavior and the development of localized or generalized hyperkeratotic pruriginous lesions. Neuronal sensitization and the development of an itch-scratch cycle contribute to the augmentation of pruritus and the chronicity of the disease. We provide here the first international guideline for a rational diagnostic and therapeutic approach for CPG. Recommendations are based on available evidence and expert opinion. The diagnosis of CPG is made clinically. A detailed medical history together with laboratory and radiological examinations are advised in order to determine the severity of CPG, identify the underlying origin of the itch and assist in the elaboration of a treatment plan. Therapeutically, it is advised to adopt a multimodal approach, including general strategies to control itch, treatment of the underlying pruritic conditions, and of the pruriginous lesions. Topical (corticosteroids, calcineurin inhibitors, capsaicin) and systemic antipruritic agents (eg, gabapentinoids, immunosuppressants, and opioid modulators) as well as physical treatment modalities (phototherapy, cryotherapy) should be employed in a step-wise approach. Psychosomatic or psychological interventions may be recommended in CPG patients with signs of psychiatric/psychological comorbidities.
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| 34. |
- Aad, G., et al.
(författare)
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- 2012
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swepub:Mat__t (refereegranskat)
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