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Träfflista för sökning "WFRF:(Berglund Lars 1964 ) srt2:(2010-2014)"

Sökning: WFRF:(Berglund Lars 1964 ) > (2010-2014)

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  • Dahlgren, Angelica, et al. (författare)
  • Do Alcohol-dependent individuals with DRD2 A1 allele have an increased risk of relapse? A pilot study
  • 2011
  • Ingår i: Alcohol and Alcoholism. - : Oxford University Press (OUP). - 0735-0414 .- 1464-3502. ; 46:5, s. 509-513
  • Tidskriftsartikel (refereegranskat)abstract
    • Aims: The TaqIA polymorphism of the dopamine D2 receptor (DRD2) gene has been extensively studied in relation to alcoholism, and the TaqI A1 allele appears to be over-represented in alcohol-dependent individuals. In a recent study, this allele has also been associated with a highly increased mortality rate in alcohol-dependent individuals. In the present study, we investigated whether the TaqI A1 allele of the DRD2 gene region was associated with a higher relapse rate in alcohol-dependent individuals. Methods: Adult women (n = 10) and men (n = 40) with a diagnosis of alcohol-dependence were recruited from two Swedish 12-step treatment units for alcoholism. Subjects were genotyped for the TaqIA polymorphism. On average, 11/2 year after the end of the treatment program, subjects were re-interviewed by using the alcohol-related items from the Addiction Severity Index follow-up version. Results: Thirty-three (66%) subjects self-reported relapse and 17 (34%) abstinence during the follow-up period. Thirty-sex percent (18/50) were carriers of the A1 allele of the DRD2 gene region, and 64% (32/50) were non-carriers. Among the carriers of the A1 allele, 89% (16/18) reported relapse in contrast to 53% (17/32) in the non-carriers (P = 0.01; odds ratio = 7.1). Conclusion: The present study is, to our knowledge, the first report of an association between the TaqI A1 allele and a substantially increased relapse rate. It should be emphasized that the number of subjects is relatively small, and this investigation should therefore be considered as a pilot study. © The Author 2011. Published by Oxford University Press on behalf of the Medical Council on Alcohol. All rights reserved.
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  • Ylva, Berglund, et al. (författare)
  • Framsynt efterord
  • 2013
  • Ingår i: Mellanrum. Fem års seminarier om social hållbarhet och stadsutveckling i Göteborg.
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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