| 1. |
- Berglund, Eva Caroline, et al.
(författare)
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A Study Protocol for Validation and Implementation of Whole-Genome and -Transcriptome Sequencing as a Comprehensive Precision Diagnostic Test in Acute Leukemias
- 2022
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Ingår i: Frontiers in Medicine. - Lausanne, Switzerland : Frontiers Media SA. - 2296-858X. ; 9, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- Background: Whole-genome sequencing (WGS) and whole-transcriptome sequencing (WTS), with the ability to provide comprehensive genomic information, have become the focal point of research interest as novel techniques that can support precision diagnostics in routine clinical care of patients with various cancer types, including hematological malignancies. This national multi-center study, led by Genomic Medicine Sweden, aims to evaluate whether combined application of WGS and WTS (WGTS) is technically feasible and can be implemented as an efficient diagnostic tool in patients with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). In addition to clinical impact assessment, a health-economic evaluation of such strategy will be performed. Methods and Analysis: The study comprises four phases (i.e., retrospective, prospective, real-time validation, and follow-up) including approximately 700 adult and pediatric Swedish AML and ALL patients. Results of WGS for tumor (90×) and normal/germline (30×) samples as well as WTS for tumors only will be compared to current standard of care diagnostics. Primary study endpoints are diagnostic efficiency and improved diagnostic yield. Secondary endpoints are technical and clinical feasibility for routine implementation, clinical utility, and health-economic impact. Discussion: Data from this national multi-center study will be used to evaluate clinical performance of the integrated WGTS diagnostic workflow compared with standard of care. The study will also elucidate clinical and health-economic impacts of a combined WGTS strategy when implemented in routine clinical care. Clinical Trial Registration: [https://doi.org/10.1186/ISRCTN66987142], identifier [ISRCTN66987142].
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| 3. |
- Berglund, Erik, et al.
(författare)
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Effects of apixaban compared with warfarin as gain in event-free time : a novel assessment of the results of the ARISTOTLE trial
- 2020
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Ingår i: European Journal of Preventive Cardiology. - : Oxford University Press (OUP). - 2047-4873 .- 2047-4881. ; 27:12, s. 1311-1319
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: A novel approach to determine the effect of a treatment is to calculate the delay of event, which estimates the gain of event-free time. The aim of this study was to estimate gains in event-free time for stroke or systemic embolism, death, bleeding events, and the composite of these events, in patients with atrial fibrillation randomized to either warfarin or apixaban in the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial (ARISTOTLE).DESIGN: The ARISTOTLE study was a randomized double-blind trial comparing apixaban with warfarin.METHODS: Laplace regression was used to estimate the delay in time to the outcomes between the apixaban and the warfarin group in 6, 12, 18 and 22 months of follow-up.RESULTS: The gain in event-free time for apixaban versus warfarin was 181 (95% confidence interval 76 to 287) days for stroke or systemic embolism and 55 (-4 to 114) days for death after 22 months of follow-up. The corresponding gains in event-free times for major and intracranial bleeding were 206 (130 to 281) and 392 (249 to 535) days, respectively. The overall gain for the composite of all these events was a gain of 116 (60 to 171) days.CONCLUSIONS: In patients with atrial fibrillation, 22 months of treatment with apixaban, as compared with warfarin, provided gains of approximately 6 months in event-free time for stroke or systemic embolism, 7 months for major bleeding and 13 months for intracranial bleeding.
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| 4. |
- Berglund, Lars, 1964-
(författare)
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Arde Fillis / Isti sunt : a contrafactum by Gustav Düben based on a madrigal by Stefano Landi, and previously attributed to Giacomo Carissimi
- 2020
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Ingår i: Contrafacta. Modes of Music Re-textualization in the Late Sixteenth and Seventeenth Century. - Krakow : Musica Iagellonica. - 9788370992392 ; , s. 187-208
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Bokkapitel (refereegranskat)abstract
- A Düben collection manuscript with the shelf number Vmhs 11:2 contains a com-position ascribed to Giacomo Carissimi, with the text incipit Isti sunt triumphatores. The attribution to Carissimi has been regarded as uncertain, but it is still included in several work catalogues. This article shows that the attribution is certainly false. The piece is a re-texted version of a madrigal composed by Stefano Landi, included in his first collection of madrigals, printed in Venice 1619. The title of the original madrigal is “Arde Filli d’un viso”. The text is a poem by Matteo Piacentini published first in Vicenza in 1600, and then again in Venice in 1611, but in Landi’s madrigal the text is modified, or likely misread; the title of the original poem is “Arde Fillide in viso”.The Vmhs 11:2 manuscript in Uppsala contains a complete set of partbooks of two madrigals for five voices, the one by Stefano Landi, and Galeazzo Sabbatini’s “Io amo che tanto basta”. They were prepared by the young Gustav Düben in the early 1650s, perhaps originally intended for instrumental performance. At a later moment, prob-ably after 1663, Düben started to prepare a contrafactum of Landi’s madrigal, using a Latin liturgical text, Isti sunt triumphatores. The text appears to have been borrowed from a printed collection of motets by Gasparo Casati, in that case most likely from the Antwerp reprint published by Marie and Madeleine Phalèse. Liturgically, the text is associated with the Feasts of Apostles, and the contrafactum could possibly have been intended for such a service in the German Church in Stockholm, where Gustav Düben was the organist. It was most likely at this point that Düben misattributed the piece to Carissimi, perhaps associating the manuscript with the time when an en-semble of Italian singers visited the Swedish court between 1652 and 1654, bringing with them a large number of works by Carissimi.The contrafactum is not completed. Only the first thirty-seven bars of the canto primo part have text underlay, and eleven bars of the alto. Since the Latin text was very dif-ferent than the Italian madrigal text, both regarding meter and content, the re-texting involved a number of challenges. In the preserved part, a number of modifications have been made to the music, which is typical of re-texting practices. The melismatic passage opening the madrigal has been set syllabically in the contrafactum, thus annihi-lating the word painting in the original. Notes have been split in two to accommodate the text, or on the contrary joined in melismas. The attempt at a re-texting does not seem very successful, and it is possible that Düben abandoned the task for this reason, even though such an assumption must remain tentative.
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| 8. |
- Berglund, Lars, 1964-
(författare)
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Kaspar Förster Jun. (1616–1673): Sacrae cantiones 1, 2, & 3 vocuum
- 2021
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Bok (refereegranskat)abstract
- A critical edition of 12 concertato motets for 1 to 3 voices by Kaspar Förster jnr (1616-1673). Förster was born in Danzig (Gdansk) and studied in Rome for Giacomo Carissimi in the 1630s. From c. 1637-1652 he was a singer at the Polish court, and from 1652-1667 Hofkapellmeister in Denmark. He died in Oliwa 1673. Förster's music is Italianate in style, with smooth vocal melodies and a sectionalized motet style with a variation of styles and textures. His music is highly expressive, with a harmonic language where he develops the Roman tradition in new direction. He was an important mediator of the new Italian musical style in Northern Europe.
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| 11. |
- Berglund, Lars, 1964-
(författare)
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Mourning a dead Queen. The music at the funeral of Ulrika Eleonora the Elderin Stockholm (1693)
- 2020
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Ingår i: Contrafacta. Modes of Music Re-textualization in the Late Sixteenth and Seventeenth Century. - Krakow : Musica Iagellonica. - 9788370992392 ; , s. 247-263
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Bokkapitel (refereegranskat)abstract
- Ulrika Eleonora the Elder, Queen of Sweden from 1680, died in July 1693. She was buried in the Royal funeral church, Riddarholmskyrkan, on November 28 of the same year. The Queen’s funeral was designed to be one of the most magnificent ceremonies of state in Sweden during the Baroque era. The decorations for the ceremony were created by the Royal court architect, Nicodemus Tessin the Younger (1654–1728). For the Queen’s coffin he built a castrum doloris with a huge black pyramid, covered with emblems and inscriptions painted in a golden colour, which were illuminated by lamps inside the construction. Little or nothing has been known about the music played dur-ing this ceremony. According to the official printed account two musical works were performed. In this article I am able to show that the works referred to consisted of one composition by the French court violinist Pierre Verdier, Kristus är mitt liv, and one by the Flemish composer Daniel Danielis, Aspice e caelis, with a new text in Swedish. This can be shown by means of source and watermark studies and by analysing the texts. The biblical verse on which Verdier’s piece is based (Phil. 1:21: “[for to me,] to live is Christ and to die is gain”), was the Queen’s motto and the text for the funeral sermon. Moreover, Danielis’ Aspice e caelis was originally composed for the funeral of princess Eleonora of Güstrow-Mecklenburg, who was a cousin to Ulrika Eleonora’s husband, the King. That piece has been re-texted with an undoubtedly tailor-made Swedish text, which closely follows the varied rhythm and stress patterns of Danielis’ recitative setting, at the same time mirroring the import and affect of the original text, but not the exact wording. Both works are marked by a sad, plaintive affect appropriate for such an occasion. Both are scored for gamba consort, which at this time was associated with tears and sorrow. In both works we find instances of symbolic, rhetorical personi-fication: in Verdier’s composition the duet between bass and soprano can be associated with the Queen’s tender relation to Christ. In Danielis’ motet the solo soprano voice represents the female gender of the person being buried. Apart from these two works, also a choral arrangement by Christian Ritter, Einen guten Kampf, can be associated with the funeral.The recycling of music for the funeral is not a coincidence, but should be understood as a representation of dynastic continuity. In a similar way, the visual decorations of the funeral were re-used at later royal funerals. There are also indications that Verdier’s Kristus är mitt liv was used again at the funeral of Ulrika Eleonora’s husband King Charles XI in 1697.
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| 12. |
- Berglund, Lars, 1964-
(författare)
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Northern Travellers in Southern Soundscapes : Swedish Musical Tourists in the 17th and 18th Centuries
- 2020
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Ingår i: Turismo Musicale: Storia, Geografia, Didattica. - Bologna : Pàtron editore. - 9788855534970 ; , s. 23-31
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Bokkapitel (refereegranskat)abstract
- Many Swedish noblemen made educational journeys in Europe in the early modern period. These journeys were motivated by notions of nation building, while at the same time they served the social ambitions of the families. I focus on two such journeys: Carl Lilliecrona, travelling around 1640 and Jean Lefebure and Bengt Ferrner around 1760. The examples suggest a shift: whereas Lilliecrona’s journey could be described as an anthropological experience in a musical terra incognita, more than a century later, Lefebure and Ferrner followed a more predetermined course, aiming to conform with now standardized cosmopolitan patterns of taste.
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| 13. |
- Berglund, Lars, 1964-, et al.
(författare)
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Prelude to an abdication: Italian music and musicians at the Swedish court of Queen Christina, 1652–1654
- 2024
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Ingår i: Svensk tidskrift för musikforskning. - 0081-9816 .- 2002-021X. ; 106
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Tidskriftsartikel (refereegranskat)abstract
- From November 1652 until June 1654, an ensemble of Italian singers and musicians resided at the court of Queen Christina of Sweden, first in Stockholm and thereafter in Uppsala. They performed both secular music at her chambers and sacred music in the church, and also staged theatrical plays at the royal castle. This article presents new information about the recruitment process and the incentives behind it, and a reconstruction of the repertoire of the ensemble and the performance contexts for that repertoire. The ensemble was not an opera troupe, as has repeteadly been asserted in the literature. Instead they were arguably primarily recruited to perform sacred music in a Catholic tradition. The headquarters of the Jesuit Society in Rome was even directly involved in the recruitment of the singers. Thus, the recruitment process went hand in hand with Christina’s plans to abdicate, convert to Catholicism and move to Rome, and must be interpreted as part of that process.
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| 15. |
- Bergström, Göran, 1964, et al.
(författare)
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Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population
- 2021
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Ingår i: Circulation. - Philadelphia : American Heart Association. - 0009-7322 .- 1524-4539. ; 144:12, s. 916-929
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Tidskriftsartikel (refereegranskat)abstract
- Background: Early detection of coronary atherosclerosis using coronary computed tomography angiography (CCTA), in addition to coronary artery calcification (CAC) scoring, may help inform prevention strategies. We used CCTA to determine the prevalence, severity, and characteristics of coronary atherosclerosis and its association with CAC scores in a general population.Methods: We recruited 30 154 randomly invited individuals age 50 to 64 years to SCAPIS (the Swedish Cardiopulmonary Bioimage Study). The study includes individuals without known coronary heart disease (ie, no previous myocardial infarctions or cardiac procedures) and with high-quality results from CCTA and CAC imaging performed using dedicated dual-source CT scanners. Noncontrast images were scored for CAC. CCTA images were visually read and scored for coronary atherosclerosis per segment (defined as no atherosclerosis, 1% to 49% stenosis, or ≥50% stenosis). External validity of prevalence estimates was evaluated using inverse probability for participation weighting and Swedish register data.Results: In total, 25 182 individuals without known coronary heart disease were included (50.6% women). Any CCTA-detected atherosclerosis was found in 42.1%; any significant stenosis (≥50%) in 5.2%; left main, proximal left anterior descending artery, or 3-vessel disease in 1.9%; and any noncalcified plaques in 8.3% of this population. Onset of atherosclerosis was delayed on average by 10 years in women. Atherosclerosis was more prevalent in older individuals and predominantly found in the proximal left anterior descending artery. Prevalence of CCTA-detected atherosclerosis increased with increasing CAC scores. Among those with a CAC score >400, all had atherosclerosis and 45.7% had significant stenosis. In those with 0 CAC, 5.5% had atherosclerosis and 0.4% had significant stenosis. In participants with 0 CAC and intermediate 10-year risk of atherosclerotic cardiovascular disease according to the pooled cohort equation, 9.2% had CCTA-verified atherosclerosis. Prevalence estimates had excellent external validity and changed marginally when adjusted to the age-matched Swedish background population.Conclusions: Using CCTA in a large, random sample of the general population without established disease, we showed that silent coronary atherosclerosis is common in this population. High CAC scores convey a significant probability of substantial stenosis, and 0 CAC does not exclude atherosclerosis, particularly in those at higher baseline risk.
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| 16. |
- Boström, Mathias, 1973-
(författare)
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Fonografen som föreställning : Introduktionen av ljudinspelningar vid svenska minnesinstitutioner
- 2024
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- With the invention of the phonograph in 1877 came the possibility to mechanically capture, store and reproduce sound. This thesis deals with how sound recording technology was introduced in memory institutions in Sweden. The focus of the thesis is on the first phonogram format, wax cylinder recordings, and their life cycle in use. This study deals only with memory institutions primarily directed towards Swedish-speaking majority culture, whereas cylinder recordings of the cultural Others will be the subject of a separate publication.The aim of the thesis is to increase the knowledge and enhance the understanding of the archival use of the cylinder phonograph in discourse and practice, with a focus on music recordings. With inspiration taken from a model of knowledge production by Bruno Latour, the study encompasses technology transfer, collecting practices and repertory analysis, institutionalization and professionalization, institutional economics, public presentations, and research practices. The cylinder phonograph was used by ten Swedish memory institutions 1898-1948, primarily by institutions directed towards traditional culture (dialects, folklore, and folk music), and with professional ambitions to some degree. Equipment and knowledge were to a certain extent transferred through professional networks in Sweden, with Danish and German memory institutions as important foreign competence centres. In comparison with some of the neighbouring countries, the introduction of sound recording technology in Sweden was generally some years later and the collections smaller. This is due to that professional memory institutions were founded later in Sweden, and that the collectors and scholars were primarily interested in typical representations of music in notation, rather than the phonogram’s particular representation of a single performance. Sound recording technology was therefore not regarded as a threat in relation to collecting music by ear. It was instead seen as a complement that could also, as objective reference recordings, increase the value of collections made by ear. The use of recording technology did, in several cases, narrow down the collected repertory and the informants that were chosen, due to that quality of performance now became important in a new sense. Few scholars in Sweden asked for archival recordings for research, and the cylinder recordings were not used for public presentations and publications in the period when the technology was in active use. Thus, it is not surprising that the cylinder phonograph did not became an important method for memory institutions in Sweden.
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| 18. |
- Sundh, Josefin, 1972-, et al.
(författare)
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Beta-blockeRs tO patieNts with CHronIc Obstructive puLmonary diseasE (BRONCHIOLE) - Study protocol from a randomized controlled trial
- 2020
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Ingår i: Trials. - : BioMed Central (BMC). - 1745-6215. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Observational studies indicate that beta-blockers are associated with a reduced risk of exacerbation and mortality in patients with chronic obstructive pulmonary disease (COPD) even without overt cardiovascular disease, but data from randomized controlled trials (RCT) are lacking. The aim of this RCT is to investigate whether beta-blocker therapy in patients with COPD without diagnosed cardiovascular disease is associated with a decreased 1-year risk of the composite endpoint of death, exacerbations, or cardiovascular events.Methods: The Beta-blockeRs tO patieNts with CHronIc Obstructive puLmonary diseasE (BRONCHIOLE) study is an open-label, multicentre, prospective RCT. A total of 1700 patients with COPD will be randomly assigned to either standard COPD care and metoprolol at a target dose of 100 mg per day or to standard COPD care only. The primary endpoint is a composite of death, COPD exacerbations, and cardiovascular events. Major exclusion criteria are ischemic heart disease, left-sided heart failure, cerebrovascular disease, critical limb ischemia, and atrial fibrillation/flutter. Study visits are an inclusion visit, a metoprolol titration visit at 1 month, follow-up by telephone at 6 months, and a final study visit after 1 year. Outcome data are obtained from medical history and record review during study visits, as well as from national registries.Discussion: BRONCHIOLE is a pragmatic randomized trial addressing the potential of beta-blockers in patients with COPD. The trial is expected to provide relevant clinical data on the efficacy of this treatment on patient-related outcomes in patients with COPD.
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