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| 4. |
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| 5. |
- Adams, D, et al.
(författare)
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A large Streamer Chamber muon tracking detector in a high-flux fixed-target application
- 1999
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Ingår i: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT. - : ELSEVIER SCIENCE BV. - 0168-9002. ; 435:3, s. 354-374
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Arrays of limited streamer tubes of the Iarocci type were deployed in our experiment at CERN as part of a forward muon detector system with provisions for the beam to pass through the center of each panel in the array. A total of 16 4 m x 4 m panels were
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| 6. |
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| 7. |
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| 8. |
- Adams, D, et al.
(författare)
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The polarized double cell target of the SMC
- 1999
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Ingår i: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT. - : ELSEVIER SCIENCE BV. - 0168-9002. ; 437:1, s. 23-67
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The polarized target of the Spin Muon Collaboration at CERN was used for deep inelastic muon scattering experiments during 1993-1996 with a polarized muon beam to investigate the spin structure of the nucleon. Most of the experiments were carried out with
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| 9. |
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| 10. |
- Adeva, B, et al.
(författare)
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Large enhancement of deuteron polarization with frequency modulated microwaves
- 1996
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Ingår i: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT. - : ELSEVIER SCIENCE BV. - 0168-9002. ; 372:3, s. 339-343
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We report a large enhancement of 1.7 in deuteron polarization up to values of 0.6 due to frequency modulation of the polarizing microwaves in a two liter polarized target using the method of dynamic nuclear polarization. This target was used during a deep
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| 11. |
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| 12. |
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| 13. |
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| 14. |
- Berglund, P., et al.
(författare)
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Altering the specificity of subtilisin B. lentus by combining site-directed mutagenesis and chemical modification
- 1996
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Ingår i: Bioorganic & Medicinal Chemistry Letters. - 0960-894X .- 1464-3405. ; 6:21, s. 2507-2512
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Tidskriftsartikel (refereegranskat)abstract
- The thiol side chain of the M222C mutant of the subtilisin from Bacillus lentus (SBL) has been chemically modified by methyl-, aminoethyl-, and sulfonatoethylthiosulfonate reagents. Introduction of charged residues into the active site of the enzyme reduced the catalytic efficiency with Suc-AAPF-pNA as the substrate, but resulted in better binding of sterically demanding boronic acid inhibitors.
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| 15. |
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| 16. |
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| 17. |
- Dulya, C, et al.
(författare)
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A line-shape analysis for spin-1 NMR signals
- 1997
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Ingår i: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT. - : ELSEVIER SCIENCE BV. - 0168-9002. ; 398:2-3, s. 109-125
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- An analytic model of the deuteron absorption function has been developed and is compared to experimental NMR signals of deuterated butanol obtained at the SMC experiment in order to determine the deuteron polarization. The absorption function model includ
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| 18. |
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| 19. |
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| 20. |
- ZHOU, XZ, et al.
(författare)
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Generation of cytotoxic and humoral immune responses by nonreplicative recombinant Semliki Forest virus
- 1995
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 92:7, s. 3009-3013
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Tidskriftsartikel (refereegranskat)abstract
- The Semliki Forest virus (SFV) expression system can be used to package recombinant RNA into infectious suicide particles. Such RNA encodes only the SFV replicase and the heterologous protein but no structural proteins of SFV, and it is thus deficient in productive replication. We demonstrate here that infection of C57BL/6 (H-2b) and BALB/c (H-2d) mice with recombinant SFV expressing the nucleoprotein (NP) of influenza virus (SFV-NP) resulted in efficient priming of influenza virus-specific CD8+ cytotoxic T-cell (CTL) responses. The generated CTLs lysed both homologous (A/PR/8/34) and heterologous (A/HK/68) influenza virus-infected, or peptide-coated, target cells to a similar degree as CTLs induced by wild-type influenza virus in a major histocompatibility complex class I-restricted fashion. As few as 100 infectious units of virus induced a strong CTL response. Induction of CTL by SFV-NP could also be achieved in CD4 gene-targeted mice, demonstrating the independence of the primary CTL response of CD4+ helper T cells. One immunization generated a CTL response that peaked after 1 week, and an additional booster injection generated a CTL memory, which was still detectable after 40 days. SFV-NP immunizations also generated high-titered IgG humoral responses that remained significant after several months. These results demonstrate that the recombinant SFV suicide system is highly efficient in antigen presentation and suggest that it may have a potential as a recombinant vaccine.
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| 21. |
- Adeva, B, et al.
(författare)
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Measurement of proton and nitrogen polarization in ammonia and a test of equal spin temperature
- 1998
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Ingår i: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT. - : ELSEVIER SCIENCE BV. - 0168-9002. ; 419:1, s. 60-82
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The 1996 data taking of the SMC experiment used polarized protons to measure the spin-dependent structure function g(1) of the proton. Three liters of solid granular ammonia were irradiated at the Bonn electron linac in order to create the paramagnetic ra
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| 22. |
- Adeva, B, et al.
(författare)
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Next-to-leading order QCD analysis of the spin structure function g(1) - art. no. 112002
- 1998
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Ingår i: PHYSICAL REVIEW D. - : AMERICAN PHYSICAL SOC. - 0556-2821. ; 5811:11, s. 2002-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We present a next-to-leading order QCD analysis of the presently available data on the spin structure function g(1) including the final data from the Spin Muon Collaboration. We present results for the first moments of the proton, deuteron, and neutron st
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| 29. |
- Berglund, A, et al.
(författare)
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Ornamentation predicts reproductive success in female pipefish
- 1997
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Ingår i: BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY. - : SPRINGER VERLAG. - 0340-5443. ; 40:3, s. 145-150
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In the sex-role reversed pipefish Syngnathus typhle females compete for access to males and males are choosy. Females develop a temporary ornament when competing over mates with other females and when performing nuptial dances with males. This ornament is
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| 30. |
- Berglund, B. E., et al.
(författare)
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Holocene forest dynamics and climate changes in the Abisko area, northern Sweden : the Sonesson model of vegetation history reconsidered and confirmed
- 1996
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Ingår i: Ecological Bulletins. - 0346-6868. ; 1996:1, s. 15-30
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Tidskriftsartikel (refereegranskat)abstract
- A new palaeoecological and palaeoclimatic project in the subalpine Abisko area, N Scandes, founded upon the pollen zone system defined by Sonesson is described. This model of vegetation history has been confirmed, although the chronology is partly revised. Sonesson's pollen diagrams are combined with new results from a lake sediment sequence at the tree-limit, which include sedimentologic, mineral magnetic, oxygen isotope and plant macrofossil studies. Since the deglaciation at c9000-8500 14C yr BP the vegetation of the Abisko area has generally been dominated by a subalpine birch Betula woodland tundra. The cliamte has generally been subarctic-oceanic since the deglaciation except for the period c.5500-3500 BP when temperate-continental conditions prevailed. This climatic development differs from the situation in the central Scandes.
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| 31. |
- Berglund, B, et al.
(författare)
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Sources and effects of low-frequency noise
- 1996
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Ingår i: The Journal of the Acoustical Society of America. - : Acoustical Society of America (ASA). - 0001-4966. ; 99:5, s. 2985-3002
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Tidskriftsartikel (refereegranskat)
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| 32. |
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| 33. |
- Berglund, Johan, et al.
(författare)
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Transition Metal Ions in Atmospheric Waters. 4.1 Metal Ion Catalyzed Autoxidation of Dissolved Sulfur Dioxide
- 1997
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Ingår i: Transport and Chemical Transformation of Pollutants in the Troposphere, Vol.2 : Heterogeneous and Liquid Phase Processes. Laboratory Studies Related to Aerosols and Clouds - Heterogeneous and Liquid Phase Processes. Laboratory Studies Related to Aerosols and Clouds. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 3540607927 ; , s. 97-104
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Bokkapitel (refereegranskat)abstract
- The overall kinetics for manganese(II/III) catalyzed autoxidation of dissolved sulfur dioxide has been studied by UV-vis spectrophotometry. A free-radical mechanism has been proposed, and the rate constant for one of the key reactions between manganese(II) and peroxomonosulfate has been determined by pulse radiolysis. Previous literature on manganese catalyzed autoxidation of SO2(aq) has been thoroughly discussed and explanations of some of the earlier discrepancies is offered. The oxidation of SO2(aq) by complexes of Pt(IV), Au(III) and Tl(III) has also been investigated. These two-electron oxidants oxidize SO2(aq) only in stoichiometric amounts and show no catalytic activity. The mechanistic differences observed between one- and two-electron oxidants are fruitful in order to explain the lack of catalytic activity of some atmospherically important metal ions like Ni(II).
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| 35. |
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| 36. |
- Berglund, P., et al.
(författare)
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Alcohols as enantioselective inhibitors in a lipase catalysed esterification of a chiral acyl donor
- 1995
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Ingår i: Biotechnology Letters. - 0141-5492. ; 17:1, s. 55-60
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Tidskriftsartikel (refereegranskat)abstract
- Increased reaction rates and increased enantioselectivities were observed with decreased concentrations of n-alkanols when resolving 2-methyldecanoic acid by esterification catalysed by immobilised lipase from Candida rugosa at controlled water activities in cyclohexane. The enantioselectivity was found to be independent of the water activity in the reaction medium at the n-heptanol concentrations investigated. However, when n-decanol was used as the acyl acceptor, not only the alcohol concentration but also the water activity in the reaction medium, influenced the enantioselectivity. The results obtained showed that the low enantioselectivity seen at a high alcohol concentration could be explained by the alcohol influencing the apparent V(max)(S) and V(max)(R) differently.
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| 37. |
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| 38. |
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| 39. |
- Byberg, L, et al.
(författare)
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Plasminogen activator inhibitor-1 activity is independently related to both insulin sensitivity and serum triglycerides in 70-year-old men.
- 1998
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Ingår i: Arteriosclerosis, Thrombosis and Vascular Biology. - : Ovid Technologies (Wolters Kluwer Health). - 1079-5642 .- 1524-4636. ; 18:2, s. 258-64
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Tidskriftsartikel (refereegranskat)abstract
- Increased levels of plasminogen activator inhibitor-1 (PAI-1) have been discussed as a part of the insulin resistance syndrome. However, it is not clear whether the relationship between PAI-1 and insulin resistance is independent of or mediated by increased triglycerides levels. The aim of this study was to investigate whether PAI-1 activity is associated with insulin sensitivity independently of serum triglycerides (sTG) and of other potential confounders. Seventy-year-old men (n=871), participating in a cohort study undergoing extensive metabolic investigations, had blood samples taken for determination of PAI-1 activity. Insulin sensitivity was determined by the euglycemic hyperinsulinemic clamp. In multivariate correlation and regression analyses, insulin sensitivity was a statistically significant determinant of PAI-1 activity (partial r=-.12; P<.001), independent of sTG, body mass index, waist-hip ratio, and other potential confounders. The levels of sTG were also independently related to PAI-1 activity (partial r=.18; P<.001). The relationships between PAI-1 and insulin sensitivity and sTG were independent of fasting glucose levels. Aggregation of risk factors of the insulin resistance syndrome was associated with increased activity of PAI-1 in men with normal glucose tolerance. We conclude that PAI-1 activity is related to insulin sensitivity and sTG, independently of each other and of other potential confounders, and that increased levels of PAI-1 should be regarded as a component of the insulin resistance syndrome.
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| 40. |
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| 41. |
- Bydén, M., et al.
(författare)
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Phase equilibria in two aqueous chiral surfactant systems
- 1997
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Ingår i: Progress in Colloid and Polymer Science. - 0340-255X .- 1437-8027. ; 105, s. 360-364
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Tidskriftsartikel (refereegranskat)abstract
- In this study, we present the binary phase diagrams of the pure (R)- and the racemic aqueous sodium-2-methyldecanoate surfactant systems. The latter is a 1:1 mixture of the pure (S)- and pure (R)-form. The systems were investigated using crossed polaroids, polarizing optical microscope and 2HNMR splittings. Both systems form a micellar phase, followed by a hexagonal, some intermediate phase and a large cubic phase. At even higher concentrations, the 2HNMR studies showed larger quadrupolar splittings up to 1200 Hz, due to a lamellar phase. The intermediate phase was in both cases very narrow, and extended up to > 23°C in the racemic system and up to 30°C in the pure (R)-system. The similarity between these two binary phase diagrams indicates that the change in molecular packing is so small that it does not drastically affect the phase behavior. The Krafft temperature in the micellar phase in both systems is 1°C, which is very low compared to that of unsubstituted alkanoates with the same chain length.
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| 42. |
- DeSantis, G., et al.
(författare)
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Site-directed mutagenesis combined with chemical modification as a strategy for altering the specificity of the S1 and S1' pockets of subtilisin Bacillus lentus
- 1998
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Ingår i: Biochemistry. - : American Chemical Society (ACS). - 0006-2960 .- 1520-4995. ; 37:17, s. 5968-5973
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Tidskriftsartikel (refereegranskat)abstract
- By combining site-directed mutagenesis with chemical modification, we have altered the S1 and S1 pocket specificity of subtilisin Bacillus lentus (SBL) through the incorporation. of unnatural amino acid moieties, in the following manner: WT → Cys(mutant) + H3CSO2SR → Cys-SR, where R may be infinitely variable. A paradigm between extent of activity changes and surface exposure of the modified residue has emerged. Modification of M222C, a buffed residue in the S1' pocket of SBL, caused dramatic changes in k(cat)/K(M), of an up to 122-fold decrease, while modification of S166C, which is located at the bottom of the S1 pocket and is partially surface exposed, effected more modest activity changes. Introduction of a positive charge at S166C does not alter k(cat)/K(M), whereas the introduction of a negative charge results in lowered activity, possibly due to electrostatic interference with oxyanion stabilization. Activity is virtually unaltered upon modification of S156C, which is located toward the bottom of the S1 pocket and surface exposed and whose side chain is solvated. An unexpected structure-activity relationship was revealed for S166C-SR enzymes in that the pattern of activity changes observed with increasing steric size of R was not monotonic. Molecular modeling analysis was used to analyze this unprecedented structure-activity relationship and revealed that the position of the β- carbon of Cys166 modulates binding of the P1 residue of the AAPF product inhibitor.
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