| 1. |
- Holst, J., et al.
(författare)
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Antithrombotic effect of recombinant truncated tissue factor pathway inhibitor (TFPI1-161) in experimental venous thrombosis : A comparison with low molecular weight heparin
- 1994
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Ingår i: Thrombosis and Haemostasis. - 0340-6245. ; 71:2, s. 214-219
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Tidskriftsartikel (refereegranskat)abstract
- The aim was to investigate whether a truncated recombinant Tissue Factor Pathway Inhibitor (TFPI1-161) which lacked the third Kunitz-type domain and the basic c-terminal region, had an antithrombotic effect comparable to LMWH in a randomised double-dummy study. The experimental thrombosis was induced in jugular veins, in a total of 40 rabbits by a combination of destruction of the endothelium and restricted blood flow. Group 1: placebo, gr 2- LMWH 60 anti-FXa IU/kg, gr 3-5: 0.1, 1.0 and 10.0 mg/kg TFPI1-161. TFPI1-161 reduced the thrombus weights in all treated groups, significantly in doses of 1.0 and 10.0 mg/kg compared to placebo. The frequency of thrombosis and occlusive thrombosis were also significantly reduced in those doses. The antithrombotic properties of TFPI1-161 (1.0-10.0 mg/ kg) measured as thrombus weight, frequency of thrombosis and frequency of occlusive thrombosis was equivalent to the antithrombotic properties of LMWH. In the anti-FXa, APTT and PT-assays TFPI1-161 displayed a dose dependent increase of activity. Recombinant-TFPI1-161 did not influence the anti-FIIa-assay. No haemorrhagic side effects were noted.
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| 2. |
- Kvarnsjo, L., et al.
(författare)
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A method of measuring eddy current impedances in giant magnetostrictive materials
- 1990
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Ingår i: IEEE transactions on magnetics. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9464 .- 1941-0069. ; 26, s. 2574-2576
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Tidskriftsartikel (refereegranskat)abstract
- A method of calculating eddy-current impedances for giant magnetostrictive materials during dynamic magnetization is suggested. The method is based on solving the power-balance equation for each time step of the recorded data. The experimentally obtained impedances can be used for accurately modeling the magnetostrictive process
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| 3. |
- Kvarnsjo, L., et al.
(författare)
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Application of a stress-dependent magnetic Preisach hysteresis model on a simulation model for Terfenol-D
- 1992
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Ingår i: IEEE transactions on magnetics. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9464 .- 1941-0069. ; 28, s. 2623-2625
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Tidskriftsartikel (refereegranskat)abstract
- A previously reported simulation model for the highly magnetorestrictive material. Terfenol-D has been extended by implementation of the recently developed stress-dependent magnetic Preisach hysteresis model. The model is based on static measurements of material characteristics combined with equations for the dynamic mechanical and magnetic behavior of the material. As a test of the model the authors have simulated the behavior of a Terfenol-D rod for different load conditions. The results show that the model is able to describe the influence of nonlinearities, eddy currents, and hysteresis on the magnetomechanical transduction process of magnetorestrictive materials
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| 4. |
- Lundgren, A., et al.
(författare)
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A magnetostrictive electric generator
- 1993
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Ingår i: IEEE transactions on magnetics. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9464 .- 1941-0069. ; 29, s. 3150-3152
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Tidskriftsartikel (refereegranskat)abstract
- An electric generator based on the magnetostrictive effect is presented. Longitudinal oscillations of a Terfenol-D rod give rise to a varying flux which induces a current in a coil wound around the rod. A small prototype of such a device is discussed, and both calculations and experiments are performed. The problem of eddy current losses is addressed
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| 5. |
- Tiberg, H., et al.
(författare)
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A method of computing electro-mechanical transfer functions for magnetostrictive functional units
- 1992
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Ingår i: IEEE transactions on magnetics. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9464 .- 1941-0069. ; 28, s. 2808-2810
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Tidskriftsartikel (refereegranskat)abstract
- Transfer functions of a magnetostrictive functional unit are presented. The functional unit consists of a Terfenol-D rod with a magnetizing coil and a closed magnetic circuit. The rod is modeled by a previously presented simulation model for Terfenol-D rods. In a mathematical formulation of the electromechanical coupling the quality of the magnetic circuit is taken into account when computing transfer functions of the functional unit. Numerical results are presented
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