| 1. |
- Sarwar, Nadeem, et al.
(författare)
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Interleukin-6 receptor pathways in coronary heart disease : a collaborative meta-analysis of 82 studies
- 2012
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Ingår i: The Lancet. - New York, NY, USA : Elsevier. - 0140-6736 .- 1474-547X. ; 379:9822, s. 1205-1213
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Tidskriftsartikel (refereegranskat)abstract
- Background: Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling. Methods: In a collaborative meta-analysis, we studied Asp358Ala (rs2228145) in IL6R in relation to a panel of conventional risk factors and inflammation biomarkers in 125 222 participants. We also compared the frequency of Asp358Ala in 51 441 patients with coronary heart disease and in 136 226 controls. To gain insight into possible mechanisms, we assessed Asp358Ala in relation to localised gene expression and to postlipopolysaccharide stimulation of interleukin 6. Findings: The minor allele frequency of Asp358Ala was 39%. Asp358Ala was not associated with lipid concentrations, blood pressure, adiposity, dysglycaemia, or smoking (p value for association per minor allele >= 0.04 for each). By contrast, for every copy of 358Ala inherited, mean concentration of IL6R increased by 34.3% (95% CI 30.4-38.2) and of interleukin 6 by 14.6% (10.7-18.4), and mean concentration of C-reactive protein was reduced by 7.5% (5.9-9.1) and of fibrinogen by 1.0% (0.7-1.3). For every copy of 358Ala inherited, risk of coronary heart disease was reduced by 3.4% (1.8-5.0). Asp358Ala was not related to IL6R mRNA levels or interleukin-6 production in monocytes. Interpretation: Large-scale human genetic and biomarker data are consistent with a causal association between IL6R-related pathways and coronary heart disease.
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| 2. |
- Laverty, David M., et al.
(författare)
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OpenPMU technology platform for Synchrophasor research applications
- 2012
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Ingår i: Power and Energy Society General Meeting, 2012 IEEE. - : IEEE conference proceedings. - 9781467327275 ; , s. 6345398-
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Konferensbidrag (refereegranskat)abstract
- OpenPMU, the Open Source Phasor Measurement Unit, is a platform for the development of Synchrophasor measurement technology in an open source manner. The OpenPMU design modularizes the key components of a Phasor Measurement Unit (PMU) into three subsystems; measurement, phase estimation and telecoms. The advantage to the researcher is that the interfaces between each subsystem are open and human readable, allowing for rapid integration of new work into an existing framework. This allows for new work to be prototyped rapidly and tested in an online environment.This paper introduces the OpenPMU technology platform. The subsystem modules and the methods of exchanging data are described. Present work on the platform is discussed and an open invitation to join the development process is extended to all.
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| 3. |
- Laverty, David M., et al.
(författare)
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The OpenPMU Platform for Open-Source Phasor Measurements
- 2013
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Ingår i: IEEE Transactions on Instrumentation and Measurement. - 0018-9456 .- 1557-9662. ; 62:4, s. 701-709
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Tidskriftsartikel (refereegranskat)abstract
- OpenPMU is an open platform for the development of phasor measurement unit (PMU) technology. A need has been identified for an open-source alternative to commercial PMU devices tailored to the needs of the university researcher and for enabling the development of new synchrophasor instruments from this foundation. OpenPMU achieves this through open-source hardware design specifications and software source code, allowing duplicates of the OpenPMU to be fabricated under open-source licenses. This paper presents the OpenPMU device based on the Labview development environment. The device is performance tested according to the IEEE C37.118.1 standard. Compatibility with the IEEE C37.118.2 messaging format is achieved through middleware which is readily adaptable to other PMU projects or applications. Improvements have been made to the original design to increase its flexibility. A new modularized architecture for the OpenPMU is presented using an open messaging format which the authors propose is adopted as a platform for PMU research.
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