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The XBI BioLab for life science experiments at the European XFEL

Han, Huijong (författare)
European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld, Germany; Univ Oulu, Bioctr Oulu, Aapistie 7, Oulu 90220, Finland; Univ Oulu, Fac Biochem & Mol Med, Aapistie 7, Oulu 90220, Finland
Round, Ekaterina (författare)
European Mol Biol Lab, Notkestr 85, D-22607 Hamburg, Germany
Schubert, Robin (författare)
European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld, Germany; Univ Hamburg, DESY, Lab Struct Biol Infect & Inflammat, Inst Biochem & Mol Biol, Bldg 22a, Notkestr 85, D-22603 Hamburg, Germany; Hamburg Ctr Ultrafast Imaging CUI, Luruper Chaussee 149, D-22761 Hamburg, Germany
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Gül, Yasmin (författare)
European Mol Biol Lab, Notkestr 85, D-22607 Hamburg, Germany
Makroczyová, Jana (författare)
European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld, Germany; Slovak Acad Sci, Inst Mol Biol, Dubravska Cesta 21, Bratislava 84551, Slovakia
Meza, Domingo (författare)
Arizona State Univ, Biodesign Ctr Appl Struct Discovery, Tempe, AZ USA; Arizona State Univ, Sch Mol Sci, Tempe, AZ USA
Heuser, Philipp (författare)
European Mol Biol Lab, Notkestr 85, D-22607 Hamburg, Germany
Aepfelbacher, Martin (författare)
Univ Med Ctr Hamburg Eppendorf, Inst Med Microbiol Virol & Hyg, Martinistr 52, D-20246 Hamburg, Germany
Barák, Imrich (författare)
Slovak Acad Sci, Inst Mol Biol, Dubravska Cesta 21, Bratislava 84551, Slovakia
Betzel, Christian (författare)
Univ Hamburg, DESY, Lab Struct Biol Infect & Inflammat, Inst Biochem & Mol Biol, Bldg 22a, Notkestr 85, D-22603 Hamburg, Germany; Hamburg Ctr Ultrafast Imaging CUI, Luruper Chaussee 149, D-22761 Hamburg, Germany
Fromme, Petra (författare)
Arizona State Univ, Biodesign Ctr Appl Struct Discovery, Tempe, AZ USA; Arizona State Univ, Sch Mol Sci, Tempe, AZ USA
Kursula, Inari (författare)
Univ Oulu, Bioctr Oulu, Aapistie 7, Oulu 90220, Finland; Univ Oulu, Fac Biochem & Mol Med, Aapistie 7, Oulu 90220, Finland; Univ Bergen, Dept Biomed, Jonas Lies Vei 91, N-5009 Bergen, Norway
Nissen, Poul (författare)
Aarhus Univ, Dept Mol Biol & Genet, Nordic EMBL Partnership Mol Med, DANDRITE, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark
Tereschenko, Elena (författare)
Russian Acad Sci, Inst Crystallog, 59 Leninsky Prospekt, Moscow 117333, Russia
Schulz, Joachim (författare)
European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld, Germany
Uetrecht, Charlotte (författare)
European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld, Germany; Leibniz Inst Expt Virol, Heinrich Pette Inst, Martinistr 52, D-20251 Hamburg, Germany
Ulicný, Jozef (författare)
Safarik Univ, Fac Sci, Inst Phys, Dept Biophys, Jesenna 5, Kosice 04154, Slovakia
Wilmanns, Matthias (författare)
European Mol Biol Lab, Notkestr 85, D-22607 Hamburg, Germany
Hajdu, Janos (författare)
Uppsala universitet,Molekylär biofysik,Acad Sci Czech Republ, Inst Phys, European Extreme Light Infrastruct, Za Radnici 835, Dolni Brezany 25241, Czech Republic
Lamzin, Victor S. (författare)
European Mol Biol Lab, Notkestr 85, D-22607 Hamburg, Germany
Lorenzen, Kristina (författare)
European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld, Germany
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 (creator_code:org_t)
2021
2021
Engelska.
Ingår i: Journal of applied crystallography. - 0021-8898 .- 1600-5767. ; 54, s. 7-21
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The science of X-ray free-electron lasers (XFELs) critically depends on the performance of the X-ray laser and on the quality of the samples placed into the X-ray beam. The stability of biological samples is limited and key biomolecular transformations occur on short timescales. Experiments in biology require a support laboratory in the immediate vicinity of the beamlines. The XBI BioLab of the European XFEL (XBI denotes XFEL Biology Infrastructure) is an integrated user facility connected to the beamlines for supporting a wide range of biological experiments. The laboratory was financed and built by a collaboration between the European XFEL and the XBI User Consortium, whose members come from Finland, Germany, the Slovak Republic, Sweden and the USA, with observers from Denmark and the Russian Federation. Arranged around a central wet laboratory, the XBI BioLab provides facilities for sample preparation and scoring, laboratories for growing prokaryotic and eukaryotic cells, a Bio Safety Level 2 laboratory, sample purification and characterization facilities, a crystallization laboratory, an anaerobic laboratory, an aerosol laboratory, a vacuum laboratory for injector tests, and laboratories for optical microscopy, atomic force microscopy and electron microscopy. Here, an overview of the XBI facility is given and some of the results of the first user experiments are highlighted.

Ämnesord

NATURVETENSKAP  -- Fysik -- Annan fysik (hsv//swe)
NATURAL SCIENCES  -- Physical Sciences -- Other Physics Topics (hsv//eng)

Nyckelord

free-electron lasers (XFELs)
European XFEL (EuXFEL)
XBI Laboratory
serial femtosecond crystallography (SFX)
single-particle imaging (SPI)
coherent diffractive imaging (CDI)
time-resolved experiments
structural biology
sample preparation and characterization

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art (ämneskategori)

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