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Prediction of treat...
Prediction of treatment-response to inhaled corticosteroids by mannitol-challenge test in COPD. A proof of concept
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Leuppi, JD (author)
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Tandjung, R (author)
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Anderson, SD (author)
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Stolz, D (author)
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Brutsche, MH (author)
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Bingisser, R (author)
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Perruchoud, AP (author)
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Surber, C (author)
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Knoblauch, A (author)
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- Andersson, Morgan (author)
- Lund University,Lunds universitet,Öron-, näs- och halssjukdomar, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Otorhinolaryngology (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Greiff, Lennart (author)
- Lund University,Lunds universitet,Öron-, näs- och halssjukdomar, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Otorhinolaryngology (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Chan, HK (author)
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Tamm, M (author)
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(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- English.
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In: Pulmonary Pharmacology & Therapeutics. - : Elsevier BV. - 1522-9629 .- 1094-5539. ; 18:2, s. 83-88
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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Abstract
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- Background: There are no predictors known that can identify COPD patients who will respond to treatment with ICS. Method: We investigated 30 patients (median age 65 (range 44-83, 12 females) with mild to moderately severe COPD. All patients had post bronchodilator FEV1/forced vital capacity ratio of less than 70% and a reversibility of less than 12% and 200 ml from baseline. We wanted to determine if airway responsiveness (AHR) to histamine and mannitol could predict who would respond to a 3-month course of ICS. Results: At baseline, all patients had AHR to histamine, but only 7 (23%) patients to mannitol. After 3 months of treatment with ICS, there was no significant change in spirometry or the quality of life when analysing all individuals together. However, FEV1 % predicted improved from 67% (IQR12) to 79% (IQR16) in mannitol positive patients; whereas it was unchanged in the mannitol negative patients. The difference in the mean change of FEV1% predicted between the two groups was 12 (IQR13.5) and this was highly significant (p=0.001). The improvement in quality of life (SGRQ 30 (IQR10.5) to 21 (IQR12; p=0.01) was only significant in the patients positive to mannitol. Conclusion: We propose that AHR to mannitol could predict ICS-responsiveness in mild to moderately severe COPD patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
Keyword
- mannitol challenge
- prediction of steroid response
- COPD
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Leuppi, JD
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Tandjung, R
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Anderson, SD
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Stolz, D
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Brutsche, MH
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Bingisser, R
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show more...
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Perruchoud, AP
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Surber, C
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Knoblauch, A
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Andersson, Morga ...
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Greiff, Lennart
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Chan, HK
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Tamm, M
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Otorhinolaryngol ...
- Articles in the publication
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Pulmonary Pharma ...
- By the university
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Lund University