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1.	Nilsson, Kerstin, et al. (författare) 54 forskare: Inte alla klarar höjd pensions-ålder 2017 Ingår i: Svenska Dagbladet, Stockholm. - 1101-2412. Tidskriftsartikel (populärvet., debatt m.m.)abstract Ett hållbart och acceptabelt pensionssystem måste utformas utifrån personliga förutsättningar och förhållanden i arbetslivet, så att fler klarar att arbeta i högre ålder. Att enbart genom ekonomiska åtgärder höja pensionsåldern är inte långsiktigt hållbart, skriver 54 forskare.DEBATT \| PENSIONForskning visar att cirka var fjärde har en diagnos eller skada orsakad av sitt arbete. Detta gör arbetsorsakad sjukdom och skada till ett betydelsefullt folkhälsoproblem. Att då enbart genom ekonomiska åtgärder höja pensionsåldern för samtliga (yrkes)grupper utifrån deras kronologiska ålder är inte långsiktigt hållbart när individers biologiska ålder är så olika bland annat till följd av arbetslivet. Detta är en demokratifråga. Forskning om äldre i arbetslivet och hållbart arbete visar att man då främst flyttar individer från pensionssystemet till sjukförsäkringssystemet och ökar klyftorna i samhället.Debatt Det här är en argumenterande text med syfte att påverka. Åsikterna som uttrycks är skribentens egna.Vi är 54 forskare som nu gemensamt har skrivit denna debattartikel. Anledningen är att vi är oroade över att cirka var fjärde blir sjuk av sitt arbete samtidigt som man i det förslag som ligger om att senarelägga ålderspensionen i princip utgår ifrån att arbetskraftsdeltagande enbart styrs av ekonomin. Vi vill trycka på betydelsen av åtgärder i arbetslivet för att komma tillrätta med ohälsan, det vill säga inte enbart ekonomiska restriktioner som tvingar folk som inte kan, vill och orkar att stanna kvar i arbetslivet till en högre kronologisk ålder.Pensionssystemet bygger på att vi ska arbeta en viss del av våra liv för att förtjäna möjligheter till pension. Vi bör dock inte enbart utgå ifrån antalet år sedan en person föddes, då korttidsutbildade generellt träder in på arbetsmarknaden tidigare än långtidsutbildade. De har alltså varit en del av arbetskraften från en yngre ålder. Människor med kortare utbildning har oftare ett arbete som innebär påfrestningar som kan inverka negativt på hälsotillståndet och som till och med kan påskynda det biologiska åldrandet. Dessutom lever korttidsutbildade generellt sett inte lika länge som långtidsutbildade, vilket delvis även avspeglar skilda livs- och arbetsvillkor.Den svenska sjukförsäkringsreformen 2008 avsåg att få tillbaka människor i arbete. Men studien fann att den faktiskt bidrog till att fler gick i tidig ålderspension av dem som var i åldern 55–64 år. Ökningen var störst bland korttidsutbildade. Mer än 5 procent fler gick i tidig ålderspension då det blev svårare att få sjukpenning och sjukersättning. Vi kan notera att det är vanligare att manliga chefer tar ut tidig ålderspension, jämfört med kvinnliga maskinskötare inom tillverkningsindustrin. I vissa yrken är det dessutom vanligare att människor, trots pension, både orkar och faktiskt ges möjlighet att arbeta vidare om de har en specialkompetens som efterfrågas. Om vi endast kombinerar ekonomiska morötter med piskor finns en stor risk att vi ökar klyftan mellan grupper som både kan och vill fortsätta att yrkesarbeta och personer som av olika skäl inte längre kan eller orkar.Ta nytta av den forskning som vi har tagit fram. Ett hållbart och acceptabelt pensionssystem måste utformas utifrån personliga förutsättningar och förhållanden i arbetslivet. Ett hållbart arbetsliv för allt fler i vår åldrande befolkning fordrar att vi samtidigt beaktar faktorer som relaterar till biologisk/kroppslig ålder, mental/kognitiv ålder samt social ålder/livsloppsfas och våra attityder som är kopplade till ålder. Vi måste ta större hänsyn till olika förutsättningar och varierande funktionsförmåga och utifrån detta anpassa de åtgärder som gör att arbetslivet blir möjligt och hållbart för allt fler även i högre ålder.”Morötter” är viktigare för en god arbetshälsa och hög produktivitet än en piska i form av oron för en dålig ekonomi.Forskning visar att pedagogik som bygger på ”morötter” oftast är betydligt bättre än ”piskor” för att nå framgångsrika och långsiktiga mål. ”Morötter” i samhället, för organisationer, företag och individer är därför viktiga för god arbetshälsa och fortsatt produktivitet och kan bidra till ett längre arbetsliv även för grupper som tidigare inte ens klarat av att arbeta fram till pensionsåldern. Genom forskning inom området har bland annat swage-modellen utarbetats. Detta är ett verktyg som visar på komplexiteten i ett hållbart arbetsliv och tillsammans med systematiskt arbetsmiljöarbete, handlingsplaner och åtgärder syftar till ett mer hållbart arbetsliv. Morötter är enligt forskningen i detta sammanhang åtgärder för en god fysisk och mental arbetsmiljö, avpassad arbetsbelastning, stödjande teknik, att man kan anpassa arbetstakten, alternativa arbetstidsmodeller vid behov. Det är viktigt att man känner sig trygg och förväntas och tillåts vara delaktig, att man blir sedd av chefen och arbetskamraterna. Att de egna arbetsuppgifterna upplevs som meningsfulla och behövda av andra skapar självförverkligande och tillfredsställelse i arbetet. Att man känner att ens arbetsuppgifter och man själv är viktig för organisationen och företaget. Att man trots högre ålder inkluderas i olika nysatsningar och får tillgång till kompetensutveckling och inte blir åsidosatt eller åldersdiskriminerad. Utvärderingar visar att de äldre medarbetarna som fick några av dessa anpassningar och möjligheter var mer effektiva, utvilade, stimulerade när de var på arbetet samtidigt som sjukfrånvaron minskade. Vilket i sin tur bidrar till ett längre arbetsliv för grupper som tidigare inte klarat av att arbeta fram till pensionsåldern. I organisationer som bygger på en deltagar- och lärandekultur rustas de anställda för att klara omställningar, nya arbetsuppgifter och vid behov även yrkesbyten.Med en åldrande befolkning där allt fler lever allt längre behöver vi arbeta till en högre ålder i framtiden för att pensionssystemet ska hålla. Men ”morötter” är viktigare för en god arbetshälsa och hög produktivitet än en piska i form av oron för en dålig ekonomi. Det kräver också att vi ändrar våra attityder och förhållningssätt till äldre på arbetsmarknaden, vilket vi bäst gör genom att organisationer och företag får incitament till och erbjuder mer individanpassade arbetsvillkor, särskilt för personer i högre ålder. Låt oss därför använda den framtagna kunskapen i praktiken för att göra arbetslivet friskt och hållbart för alla åldrar.
2.	Nilsson, Kerstin, et al. (författare) Vi är oroade över senare ålderspension 2017 Ingår i: Dagens Samhälle. - 1652-6511. Tidskriftsartikel (populärvet., debatt m.m.)abstract Var fjärde person blir i dag sjuk till följd av sitt arbete. Att höja pensionsåldern för alla yrkesgrupper, utan konkreta åtgärder för att minska ohälsan, är därför problematiskt och mycket oroande. Det är, enligt forskarna, inte långsiktigt samhällsekonomiskt lönsamt att utan andra åtgärder höja pensionsåldern för alla. Vi – 54 forskare – är mycket oroade över konsekvenserna av att, som föreslagits, senarelägga ålderspensionen.Förslaget utgår i princip från arbetskraftsdeltagande i princip enbart styrs av ekonomin, medan forskningen visar att det bara är en av flera faktorer som styr hur länge och hur mycket människor väljer att arbeta.Det här sättet att lösa problemet med en åldrande befolkning och ett sviktande pensionssystem är inte samhällsekonomiskt lönsamt på lång sikt, utan riskerar bara att flytta runt folk mellan olika ersättningssystem. Pensionssystemet bygger på att vi ska arbeta en viss del av våra liv för att tjäna in vår pension. Vi bör dock inte enbart utgå ifrån ålder eller antalet år sedan en person föddes då korttidsutbildade generellt träder in på arbetsmarknaden tidigare än långtidsutbildade. De med kortare utbildningstid har alltså varit en del av arbetskraften från en yngre ålder. Människor med kortare utbildning har också oftare ett arbete som innebär påfrestningar som kan inverka negativt på hälsotillståndet och som till och med kan påskynda det biologiska åldrandet. Dessutom lever korttidsutbildade generellt sett inte lika länge som långtidsutbildade, vilket delvis även avspeglar skilda livs- och arbetsvillkor.Ta nytta av den forskning som vi har tagit fram. Ekonomin är självklart viktigt för att vi ska vilja arbeta, men den är som sagt enbart en av flera faktorer med betydelse vårt arbetsliv.Hälsotillståndet, både det fysiska och det mentala, har en avgörande betydelse för hur länge och hur mycket vi orkar arbeta. Ett fysiskt och mentalt belastande arbete är en stark riskfaktor för en nedsatt hälsa i slutet av arbetslivet. Arbetstid, arbetstakt och möjlighet till återhämtning spelar en allt större roll ju äldre vi blir. Andra aspekter är arbetsinnehåll, hur meningsfulla och stimulerande arbetsuppgifterna är, balansen mellan arbete och familjesituation och fritidsaktiviteter. Organisationskultur, ledarskapet, stöd i arbetet och kompetens har stor betydelse för om vi ska kunna och vilja arbeta till en högre ålder. Vi måste ta större hänsyn till olika förutsättningar och varierande funktionsförmåga och utifrån detta anpassa de åtgärder som gör att arbetslivet blir möjligt och hållbart för allt fler även i högre ålder.Ett hållbart och acceptabelt pensionssystem måste därför utformas utifrån personliga förutsättningar och förhållanden i arbetslivet. Ett hållbart arbetsliv för allt fler i vår åldrande befolkning fordrar att vi samtidigt beaktar faktorer som relaterar till biologisk/kroppslig ålder, mental/kognitiv ålder samt social ålder/livsloppsfas samt de attityder som är kopplade till ålder.
3.	Jöud, Anna, et al. (författare) The association between pain characteristics, pain catastrophizing and health care use – Baseline results from the SWEPAIN cohort 2017 Ingår i: Scandinavian Journal of Pain. - : Walter de Gruyter GmbH. - 1877-8860 .- 1877-8879. ; 16, s. 122-128 Tidskriftsartikel (refereegranskat)abstract Background and aim Pain is common and adds to the global burden of disease. However, individuals suffering from pain are a heterogeneous group in terms of pain spreading, intensity and duration. While pain influences overall health care consultation not everyone with pain consult health care. To be able to provide health care matching the patients’ needs increased knowledge about what factors determines the decision to consult health care is essential. The aim of this study was to explore the combined importance of pain spreading, intensity, duration and pain catastrophizing for consulting health care. Methods In this cross-sectional study we used population based survey data from southeast Sweden (SWEPAIN) including 7792 individuals’ aged 16–85 reporting pain. We used Modified Poisson regressions to analyse factors of importance related to the decision to consult health care. Results High and moderate pain intensity, as compared to low, increases the probability of consulting health care (High PR = 1.7 [95% CI 1.51–1.88], moderate PR = 1.2 [1.15–1.41]). Having widespread pain, as compared to localised pain, increased the probability of consulting health (PR = 1.2 [1.03–1.36). Pain duration was not associated with increased probability of consulting health care (PR = 1.0 CI0.88–1.07). However an interaction (p = 0.05) between pain duration and pain catastrophizing beliefs was seen indicating a combined importance of the two when consulting health care. Conclusion Our result suggests that pain intensity, pain spreading and pain catastrophizing independently influence the decision to consult health care while there is an interaction effect between pain duration and pain catastrophizing beliefs where the importance of pain catastrophizing believes differ with pain duration; the importance of pain catastrophizing believes differ with pain duration. Implications Treatment and rehabilitation strategies should incorporate this finding in order to meet the individual's needs focusing on the biopsychosocial model within health care focusing not only on actual pain reliefs but also on for example acceptance and behavioural changes.
4.	Thul, Peter J., et al. (författare) A subcellular map of the human proteome 2017 Ingår i: Science. - : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 356:6340 Tidskriftsartikel (refereegranskat)abstract Resolving the spatial distribution of the human proteome at a subcellular level can greatly increase our understanding of human biology and disease. Here we present a comprehensive image-based map of subcellular protein distribution, the Cell Atlas, built by integrating transcriptomics and antibody-based immunofluorescence microscopy with validation by mass spectrometry. Mapping the in situ localization of 12,003 human proteins at a single-cell level to 30 subcellular structures enabled the definition of the proteomes of 13 major organelles. Exploration of the proteomes revealed single-cell variations in abundance or spatial distribution and localization of about half of the proteins to multiple compartments. This subcellular map can be used to refine existing protein-protein interaction networks and provides an important resource to deconvolute the highly complex architecture of the human cell.
5.	Adam, Lucille, et al. (författare) Early Resistance of Non-virulent Mycobacterial Infection in C57BL/6 Mice Is Associated With Rapid Up-Regulation of Antimicrobial Cathelicidin Camp 2018 Ingår i: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 9 Tidskriftsartikel (refereegranskat)abstract Early clearance of tuberculosis is the successful eradication of inhaled bacteria before the development of an adaptive immune response. We previously showed, by utilizing a non-virulent mycobacteria infection model, that C57BL/6 mice are more efficient than BALB/c in their control of bacterial growth in the lungs during the first weeks of the infection. Here, we assessed early (within 1-3 days) innate immune events locally in the lungs to identify factors that may contribute to the control of non-virulent mycobacterial burden. We confirmed that C57BL/6 mice are more resistant to infection compared with BALB/c after intranasal inoculation with mycobacterium. Transcriptomic analyses revealed a remarkably silent signature in C57BL/6 mice despite effective control of bacterial growth. In contrast, BALB/c mice up-regulated genes associated with neutrophil and myeloid cell chemotaxis and migration. Flow cytometry analyses corroborated the transcriptomic analyses and demonstrated influx of both neutrophil and myeloid cell populations in BALB/c mice, while these did not increase in C57BL/6 mice. We further detected increased release of TNF-alpha from BALB/c lung cells but limited release from C57BL/6-derived cells. However, C57BL/6 mice showed a marked early up-regulation of the Camp gene, encoding the cathelicidin CRAMP peptide, post-mycobacterial exposure. CRAMP (LL-37 in human) expression in the lungs was confirmed using immunofluorescence staining. Altogether, these findings show that C57BL/6 mice can clear the mycobacterial infection early and that this early control is associated with high CRAMP expression in the lungs without concomitant influx of immune cells. The role of CRAMP/LL-37 during mycobacterial infection may be relevant for novel protective strategies, and warrants further studies of human cohorts.
6.	Albinsson, Malin, 1972-, et al. (författare) Kartläggning av särskilt stöd och tidiga insatser : Fallstudier av internationella utbildningssystem 2016 Rapport (övrigt vetenskapligt/konstnärligt)
7.	Arvidsson, Inger, et al. (författare) A follow-up study of burnout among Swedish school teachers 2017 Konferensbidrag (refereegranskat)
8.	Arvidsson, Inger, et al. (författare) Betydelsen av fysiska och psykosociala riskfaktorer för sjukdom/besvär i muskler och leder - En uppföljningsstudie av kvinnor inom vård och skola 2015 Rapport (övrigt vetenskapligt/konstnärligt)abstract Vi har upprättat en kohort med 1591 kvinnor från fem vanliga yrken: Operationssköterskor (Op), anestesisköterskor (Ane), undersköterskor på operation (Usk), biomedicinska analytiker som gör ultraljudsundersökningar (BMA) samt lärarinnor (Lär). Enkät har skickats ut vid baseline och i genomsnitt ca 28 månader därefter. Data från uppföljningen är inte analyserade ännu, varför rapporten enbart omfattar resultat från baseline. Fallen definierades baserat på kombinationen av frekvens och intensitet av rapporterade besvär. Samband mellan smärttillstånd och arbetsbelastning, individ- och livsstilsfaktorer analyserades med multivariat analys, backward proceedure. Samband påvisades för nacken med högt mekaniskt index, lågt fysiskt index, missnöje med datorarbetsplatsens utformning, höga krav, låg kontroll, höga känslomässiga krav, låga sensoriska krav samt låg ålder. axlarna med högt mekaniskt index, missnöjd med datorarbetsplatsens utformning, krav och lite egen tid för återhämtning. handleder/händer med högt mekaniskt index, höga krav, låg kontroll, hög ålder, högt BMI och inga/få hemmavarande barn. ländryggen med högt mekaniskt index, höga krav, låg kontroll, låga sensoriska krav, hög ålder, högt BMI och lite egen tid för återhämtning. fötterna med högt BMI, högt fysiskt index, hög ålder, höga krav, inga eller få hemmavarande barn samt låg kontroll. De ergonomiska problem som framkommit vid intervjuerna av operationspersonal har presenterats för studenter på Lunds tekniska högskola. Ett särskilt problem avsåg de statiska, obekväma och ansträngande arbetsställningarna som uppkom då operationssjuksköterskorna assisterade under operationer. Med hjälp av en operationhake höll de isär såret under operationen. Haken har ett grepp som tvingar Op till ett böjt och icke funktionellt handgrepp. Studenterna tog fram prototyp för en hållare till haken, som ger möjlighet till en mer ergonomisk handledsställning, samt att byta hand vid behov under operationen. Hållaren till haken utvärderas f n på två operationsavdelningar.
9.	Arvidsson, Inger, et al. (författare) Burnout among school teachers : quantitative and qualitative results from a follow-up study in southern Sweden 2019 Ingår i: BMC Public Health. - : BioMed Central. - 1471-2458. ; 19 Tidskriftsartikel (refereegranskat)abstract Background: Teachers are at high risk of stress-related disorders. This longitudinal study aimed to (a) identify which occupational, sociodemographic and life-style factors and self-efficacy at baseline that were of importance for burnout, (b) explore associations between changes in the studied factors versus changes in burnout, and (c) by interviews increase the understanding of perceived job demands among teachers.Methods: A cohort of 310 Swedish teachers in school-years 4–9 responded to a questionnaire of occupational, sociodemographic and life-style factors, self-efficacy and burnout, at baseline and at follow-up (mean 30 months later). A combined measure with four levels of burnout was crafted, based on exhaustion, cynicism and professional efficacy (Maslach Burnout Inventory-General Survey). Quantitative data were analysed with multiple ordinal regression, and qualitative data were analysed with content analysis of interview responses from a subgroup of the teachers (n = 81).Results: The occurrence of high burnout (level 2 and 3 combined) were similar at baseline and follow-up (14% vs. 15%). However, many teachers fluctuated between the levels of burnout (28% increased and 24% decreased). Burnout at baseline was of importance for change of work or being off duty at follow up. In the multi-exposure model, low self-efficacy [OR 0.42; CI 0.26–0.68] and high job demands [OR 1.97; CI 1.02–3.8] were the strongest explanatory variables. Low self-efficacy remained as the strongest explanatory factor after adjustment for burnout at baseline. Increased job demands during follow-up was associated with an increased level of burnout [OR 3.41; CI 1.73–6.69], whereas increased decision latitude was associated with a decreased level of burnout [OR 0.51; CI 0.30–0.87]. Two major categories of demands emerged in the qualitative analysis; i.e. too high workload and a sense of inadequacy.Conclusions: A substantial proportion of teachers showed signs of burnout at both occasions. Low self-efficacy and high job demands was of importance for burnout, and changes in burnout was further associated with changes in decision latitude. The results points to the need of actions on individual, organizational and a societal levels.
10.	Arvidsson, Inger, et al. (författare) Cross-sectional associations between occupational factors and musculoskeletal pain in women teachers, nurses and sonographers. 2016 Ingår i: BMC Musculoskeletal Disorders. - : Springer Science and Business Media LLC. - 1471-2474. ; 17:1 Tidskriftsartikel (refereegranskat)abstract It is usually assumed that musculoskeletal pain is associated with both the physical workload and the psychosocial work environment, as well as with personal and lifestyle factors. This study aims to ascertain the prevalence of musculoskeletal pain in women with varying or different occupational exposures, and to explore the associations between musculoskeletal pain and the occupational and personal factors.
11.	Berggren, Linda, et al. (författare) Nordic children's conceptualizations of healthy eating in relation to school lunch 2017 Ingår i: Health Education. - : Emerald Group Publishing Limited. - 0965-4283 .- 1758-714X. ; 117:2, s. 130-147 Tidskriftsartikel (refereegranskat)abstract Purpose: Pupils' perspective should be better taken into account when developing nutrition education at school. The purpose of this paper is to explore Nordic children's perspectives on the healthiness of meals in the context of school lunches.Design/methodology/approach: In total, 78 focus group discussions were conducted with 10-11-year-old girls and boys (n=457) from schools in Finland, Iceland, Norway and Sweden, which were participating in the Nordic school meal project ProMeal during the school year 2013-2014. A flexible discussion guide and stimulus material in the form of 14 photographs displaying different school lunch contexts were used. The discussions were analyzed using thematic analysis.Findings: These Nordic children seem to share the adult-set aim of healthy eating in the school context as a socio-cultural norm. Although healthy eating was constructed as a rational, normative and acceptable way to eat at school, unhealthy eating was emphasized as negotiably acceptable when eaten occasionally and under certain circumstances (e.g. at special occasions). Unhealthy eating also comprised emotionally laden descriptions such as enjoyment and disgust. Practical implications: Children's conceptualizations of healthy eating are connected to nutritional, socio-cultural, emotional and normative dimensions, which should be reflected also when developing nutrition education in school.Originality/value: The need for research exploring children's experiences of, and understandings about, school lunch motivated this unique multicenter study with a large number of participating children. In the focus groups a child-oriented, photo-elicitation method was used.
12.	Berggren, Linda, et al. (författare) Perspectives about health outcomes related to food among Nordic children 2016 Konferensbidrag (refereegranskat)abstract Perspectives about health outcomes related to food among Nordic childrenLinda Berggren* 1, Sanna Talvia2, Eldbjørg Fossgard3, Unnur Björk Arnfjörð4, Agneta Hörnell 1, Anna Ólafsdóttir 4,Ingibjörg Gunnarsdóttir 5, Hege Wergedahl 3, Hanna Lagström 6, Maria Waling1, Cecilia Olsson11Umeå University, Department of food and nutrition, Umeå, Sweden, 2Child and Youth Research institute, Turku, Finland,3Faculty of Education, Bergen University College, Bergren, Norway, 4School of Education, University of Iceland, 5TheNational University Hospital of Iceland , Unit for Nutrition Research, Reykjavik, Iceland, 6University of Turku, TurkuInstitute of Child and Youth Research, Turku, FinlandPreferred presentation type: Only PosterBackground and aims: Dietary intake in school has previously been studied but little is known about Nordic children’sperspectives on food healthiness in the school lunch context. This study aims to explore 10-year-old Nordic children’sperspectives on outcomes of healthy eating in the school lunch context.Methods: Seventy-two focus groups were conducted in Sweden, Finland, Norway and Iceland with a total of 423participants. A flexible topic guide and 14 preselected photos displaying different school lunch contexts were used asstimuli material. Interviews were transcribed and analyzed using thematic analysis.Results: Children reasoned that school lunch are and should be healthy since the food eaten at school has short andlong term outcomes related to cognitive and physical health. It was commonly expressed that food eaten in school affectsschool work and functioning in learning activities. It was also stated that food eaten in school can have negative andpositive effects on your mood, e.g. eating unhealthy food or an insufficient amount of food, puts you in a bad mood whichcan affect the rest of the school day. The discussions mainly relied on negative short term effects such as feeling ill andreduced stamina. Some food and food groups such as vegetables, milk and fish, were mentioned in a more positivesense highlighting the positive short- and long term outcomes on health. When describing the long-term outcomes ofeating, children mentioned that healthy eating helps to build muscles, grow and prevent diseases, such as cancer anddiabetes. Sugar and fat was frequently mentioned as being the cause of overweight and some other diseases.Conclusion: In general, Nordic children have an adequate understanding of established relations between food andhealth. Yet, we know that many pupils do not eat according to recommendations. This highlights the importance of takingthe complexity of food choice into consideration in nutritional education.Disclosure of Interest: None to declare
13.	Björk, Anne (författare) Aspects of Vitamin D : Prevalence of deficiency and impact on musculoskeletal parameters 2017 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract Vitamin D is central in calcium turnover, and adequate levels are important for skeletal health. It is not clear how large contributions from food and sunlight are in Swedish primary care patients, considering the low radiation of UVB in Sweden and fortification of some foods, and whether differences exist between patients of immigrant and Swedish origin. Increasing incidence of osteoporosis-related fractures is a major global health problem. Genetic variations in metabolising enzymes and in the Vitamin D receptor (VDR) have also been shown to be of importance to the overall effect of vitamin D. Polymorphic variation in the gene CYP2R1 encoding the 25-hydroxylase has previously been reported to correlate with circulating levels of 25(OH)D3. Results of association studies between genetic variants of the VDR and muscle strength, as well as falls have been contradictory.The purposes of this thesis were to examine possible differences in plasma-25(OH)D3 levels and intake of vitamin D between Swedish and immigrant female primary care patients, to estimate what foods contribute the most, and to identify contributors to vitamin D status (Paper I-II). Furthermore, the relationship between polymorphisms in the CYP2R1 gene and levels of 25(OH)D3 as well as other biochemical parameters (parathyroid hormone, calcium, phosphate and fibroblast growth factor 23) of skeletal homeostasis, bone mineral density and incidence of fractures was investigated (Paper III). Also, the association between genetic variations in the gene for the vitamin D receptor and measures of muscle strength, physical performance and falls (Paper IV), was investigated by using data from a Swedish multicenter study of elderly men (MrOS).Most important results: Vitamin D deficiency was common, with significant difference between Swedish born and immigrant patients (Paper I). Food intake of vitamin D is associated with circulating vitamin D, but the factors most strongly affecting vitamin D levels were reported sun holiday and origin (Paper II). CYP2R1 polymorphisms are associated with circulating levels of 25(OH)D3 and bone mineral density (Paper III). VDR genetic variants do not appear to have a direct effect on muscle strength or physical performance and incidence of falls in elderly Swedish men (Paper IV).
14.	Björk, Anna Bell, et al. (författare) Evolving techniques in text-based medical consultation : Physicians' long-term experiences at an Ask the doctor service 2017 Ingår i: International Journal of Medical Informatics. - : ELSEVIER IRELAND LTD. - 1386-5056 .- 1872-8243. ; 105, s. 83-88 Tidskriftsartikel (refereegranskat)abstract Introduction: Both the demands and the options for patients to communicate with health care providers utilizing eHealth solutions are increasing. Some patients, or relatives to patients, want to consult another health care provider than the regular one, merely in text.Objective: To improve text-based medical consultation by learning from long-term experiences.Materials and methods: Physicians with comprehensive experience of answering free-text medical inquiries at an official health portal in Sweden were interviewed. The interviews were analyzed using a grounded theory approach.Results: Over time, the interviewed physicians developed strategies on how to formulate the answer to a medical inquiry from a previously unknown inquirer. The answering physicians experienced their primary role as providers of medical information and as mediators between an inquirer and the regular health care provider. Many of the answering physicians experienced a personal development with improved communication skills, also in face-to-face meetings with patients.Conclusion: Text-based medical consultation is part of an expanding area in eHealth. The development of strategies, guidelines, ethical considerations as well as educational efforts are needed to optimize the skills of asynchronous text-based health consultation.
15.	Björk, Anders, et al. (författare) PI-Nordic - A strategic research and innovation agenda for process intensification and innovation in process industries 2015 Rapport (populärvet., debatt m.m.)abstract A continued and sustainable growth in the Process Industry sector remains essential for Sweden’s economy. The strategic research agenda PI-Nordic describes a vison and way forward for the development and implementation of Process Intensification (PI) as an essential element for promoting this development. The agenda covers the chemical, water, forest, food, drug and mining industries, the equipment manufacturers and suppliers, the build-up of knowledge and expertise in academia and research institutes, and the essential role of funding bodies.
16.	Björk, Anna, et al. (författare) Symptoms of Neurodevelopmental Problems in Adolescents With Severe Obesity (AMOS II) 2019 Konferensbidrag (refereegranskat)
17.	Björk, Anna, et al. (författare) Type 1 diabetes mellitus and associated risk factors in patients with or without CHD: a case-control study 2017 Ingår i: Cardiology in the Young. - : Cambridge University Press (CUP). - 1047-9511 .- 1467-1107. ; 27:9, s. 1670-1677 Tidskriftsartikel (refereegranskat)abstract Background: Approximately 1% of children are born with CHD, and 90-95% reach adulthood. Increased exposure to infections and stress-strain can contribute to an increased risk of developing type 1 diabetes mellitus. CHD may increase the risk of more serious infections, stress-strain, and increased risk of developing type 1 diabetes mellitus. Methods: We analysed the onset of and the risk of mortality and morbidity associated with concurrent CHD in patients with type 1 diabetes mellitus compared with patients with type 1 diabetes mellitus without CHD. The study combined data from the National Diabetes Register and the National Patient Register. Results: A total of 104 patients with CHD and type 1 diabetes mellitus were matched with 520 controls. Patients with CHD and type 1 diabetes mellitus had an earlier onset of diabetes (13.9 versus 17.4 years, p < 0.001), longer duration of diabetes (22.4 versus 18.1 years, p < 0.001), higher prevalence of retinopathy (64.0 versus 43.0%, p = 0.003), higher creatinine levels (83.5 versus 74.1 mu mol/L, p = 0.03), higher mortality (16 versus 5%, p = 0.002), and after onset of type 1 diabetes mellitus higher rates of co-morbidity (5.28 versus 3.18, p <= 0.01), heart failure (9 versus 2%, p = 0.02), and stroke (6 versus 2%, p = 0.048) compared with controls. Conclusions: From a nationwide register of patients with type 1 diabetes mellitus, the coexistence of CHD and type 1 diabetes mellitus was associated with an earlier onset, a higher frequency of microvascular complications, co-morbidity, and mortality.
18.	Björk Brämberg, Elisabeth, et al. (författare) Access to primary and specialized somatic health care for persons with severe mental illness: a qualitative study of perceived barriers and facilitators in Swedish health care 2018 Ingår i: BMC Family Practice. - : Springer Science and Business Media LLC. - 1471-2296. ; 19 Tidskriftsartikel (refereegranskat)abstract Background: Persons with severe mental illness (e.g. schizophrenia, bipolar disorder) have a high prevalence of somatic conditions compared to the general population. Mortality data in the Nordic countries reveal that these persons die 15-20 years earlier than the general population. Some factors explaining this high prevalence may be related to the individuals in question; others arise from the health care system's difficulty in offering somatic health care to these patient groups. The aim of the present study was therefore to explore the experiences and views of patients, relatives and clinicians regarding individual and organizational factors which facilitate or hinder access to somatic health care for persons with severe mental illness. Methods: Flexible qualitative design. Data was collected by means of semi-structured individual interviews with patients with severe mental illness, relatives and clinicians representing primary and specialized health care. In all, 50 participants participated. Results: The main barrier to accessing somatic care is the gap between the organization of the health care system and the patients' individual health care needs. This is observed at both individual and organizational level. The health care system seems unable to support patients with severe mental illness and their psychiatric-somatic comorbidity. The main facilitators are the links between severe mental illness patients and medical departments. These links take the form of functions (i.e. systems which ensure that patients receive regular reminders), or persons (i.e. professional contacts who facilitate patients' access the health care). Conclusions: Health care services for patients with severe mental illness need reorganization. Organizational structures and systems that facilitate cooperation between different departments must be put in place, along with training for health care professionals about somatic disease among psychiatric patients. The links between individual and organizational levels could be strengthened by introducing professional contacts, such as liaison physicians and case managers. This is also important to reduce stress and responsibility among relatives.
19.	Björk, Jonas, et al. (författare) An efficient sampling strategy for selection of biobank samples using risk scores 2017 Ingår i: Scandinavian Journal of Public Health. - : SAGE Publications. - 1403-4948 .- 1651-1905. ; 45:17_suppl, s. 41-44 Tidskriftsartikel (refereegranskat)abstract Aim: The aim of this study was to suggest a new sample-selection strategy based on risk scores in case-control studies with biobank data. Methods: An ongoing Swedish case-control study on fetal exposure to endocrine disruptors and overweight in early childhood was used as the empirical example. Cases were defined as children with a body mass index (BMI) ≥18 kg/m2 (n=545) at four years of age, and controls as children with a BMI of 1/217 kg/m2 (n=4472 available). The risk of being overweight was modelled using logistic regression based on available covariates from the health examination and prior to selecting samples from the biobank. A risk score was estimated for each child and categorised as low (0-5%), medium (6-13%) or high (≥14%) risk of being overweight. Results: The final risk-score model, with smoking during pregnancy (p=0.001), birth weight (p<0.001), BMI of both parents (p<0.001 for both), type of residence (p=0.04) and economic situation (p=0.12), yielded an area under the receiver operating characteristic curve of 67% (n=3945 with complete data). The case group (n=416) had the following risk-score profile: low (12%), medium (46%) and high risk (43%). Twice as many controls were selected from each risk group, with further matching on sex. Computer simulations showed that the proposed selection strategy with stratification on risk scores yielded consistent improvements in statistical precision. Conclusions: Using risk scores based on available survey or register data as a basis for sample selection may improve possibilities to study heterogeneity of exposure effects in biobank-based studies.
20.	Björk, Jennie, et al. (författare) Creating Better Innovation Measurement Practices 2017 Ingår i: Mit Sloan Management Review. - : Sloan Management Review Association. - 1532-9194. ; 59:1, s. 45-53 Tidskriftsartikel (refereegranskat)abstract For most companies, innovation is a top managerial priority. Many managers look at successful innovators such as Apple Inc. and Google Inc. with envy, wishing their companies could be half as innovative. To boost and benchmark innovation, managers often use quantitative performance indicators.1 Some of these indicators measure innovation as results or outcomes such as sales from new products. Others measure innovation as a process, using metrics such as the number of innovation projects in progress. And some track input measures such as the number of ideas generated, while still others focus on the innovation portfolio, by looking at factors such as the percentage of investments in breakthrough projects versus product line extensions.
21.	Björk, Jonas, et al. (författare) Predicting participation in the population-based Swedish cardiopulmonary bio-image study (SCAPIS) using register data 2017 Ingår i: Scandinavian Journal of Public Health. - : SAGE Publications. - 1403-4948 .- 1651-1905. ; 45, s. 45-49 Tidskriftsartikel (refereegranskat)abstract Aims: To illustrate the importance of access to register data on determinants and predictors of study participation to assess validity of population-based studies. In the present investigation, we use data on sociodemographic conditions and disease history among individuals invited to the Swedish cardiopulmonary bio-image study (SCAPIS) in order to establish a model that predicts study participation. Methods: The pilot study of SCAPIS was conducted within the city of Gothenburg, Sweden, in 2012, with 2243 invited individuals (50% participation rate). An anonymous data set for the total target population (n = 24,502) was made available by register authorities (Statistics Sweden and the National Board of Health and Welfare) and included indicators of invitation to and participation in SCAPIS along with register data on residential area, sociodemographic variables, and disease history. Propensity scores for participation were estimated using logistic regression. Results: Residential area, country of birth, civil status, education, occupational status, and disposable income were all associated with participation in multivariable models. Adding data on disease history only increased overall classification ability marginally. The associations with disease history were diverse with some disease groups negatively associated with participation whereas some others tended to increase participation. Conclusions: The present investigation stresses the importance of a careful consideration of selection effects in population-based studies. Access to detailed register data also for non-participants can in the statistical analysis be used to control for selection bias and enhance generalizability, thereby making the results more relevant for policy decisions.
22.	Björk, Marie, 1963-, et al. (författare) Tecken på teoretiskt tänkande om strukturer i bassystemet 2019 Ingår i: Forskning om undervisning och lärande. - 2000-9674 .- 2001-6131. ; 7:2, s. 26-49 Tidskriftsartikel (refereegranskat)abstract I den här artikeln beskrivs och diskuteras teoretiskt tänkande om strukturer i bassystemet hos elever som deltar i ett utforskande arbete med mätning av sträckor i olika baser. Data kommer från en studie med 44 elever i årskurs 4 där Davydovs matematiska program för en lärandeverksamhet användes för design av undervisningen. Film, elevuppgifter och transkriptioner har analyserats kvalitativt och kategoriserats. Analysen visar tecken på teoretiskt tänkande i form av handlingar, exempelvis frågor om, och beskrivningar av relationer mellan positionerna till vänster och höger om radixpunkten (tecknet som skiljer heltalsdel och bråkdel). Resultatet redovisas under tre kategorier: (a) basens funktion för det värde som siffrorna anger i talet, (b) positionsväxling och (c) entalet som ett av en kvantitet. Resultatet diskuteras i relation till tidigare forskning om elevers svårigheter med decimaltal.
23.	Björk, Sofia, 1979, et al. (författare) Inledning 2015 Ingår i: Feministiskt tänkande och sociologi. Teorier, begrepp och tillämpningar. - Lund : Studentlitteratur. - 9789144100852 ; , s. 21-38 Bokkapitel (övrigt vetenskapligt/konstnärligt)
24.	Brattström, Anna, et al. (författare) Boxing in and box breaking of attention : A process model of how measurement impact innovation 2016 Konferensbidrag (refereegranskat)
25.	Brattström, Anna, et al. (författare) Boxing in and box breaking of attention : A process model of innovation measurement 2016 Konferensbidrag (refereegranskat)
26.	Bylund, Anna, 1977-, et al. (författare) Multilingual becoming in reading: a picture storybook-reading-assemblage in early years education 2015. - 1 Ingår i: Early Years Second Language Education. - Abingdon och New York : Routledge. - 9780415705271 - 9781315889948 ; , s. 78-92 Bokkapitel (övrigt vetenskapligt/konstnärligt)
27.	Dellborg, Mikael, 1954, et al. (författare) High mortality and morbidity among adults with congenital heart disease and type 2 diabetes 2015 Ingår i: Scandinavian Cardiovascular Journal. - 1401-7431. ; 49:6, s. 344-350 Tidskriftsartikel (refereegranskat)abstract Objectives. With improving prognosis the prevalence of adult congenital heart disease (ACHD) is increasing. Patients with type 2 diabetes mellitus (T2DM) have a shorter life expectancy compared with the general population. We investigated, in a large national diabetes registry, the prevalence of ACHD in combination with T2DM to estimate the associated clinical risk, outcome and patient characteristics. Design. Data from the Swedish National Diabetes Register (NDR) were linked with the Swedish National Patient Register (NPR) and the Cause of Death Register. Results. 833 ACHD patients were matched with 5 controls each. ACHD patients had significantly lower body mass index or BMI, higher creatinine and were more sedentary as compared with patients with T2DM but without congenital heart disease. The overall mortality was 26.2% for ACHD patients as compared with 19.9% (P < 0.001) for the control group, and five-year mortality rates were 5.2 versus 3.4%, P = 0.014. Conclusions. Congenital heart disease and secondary risk factors for cardiovascular disease frequently coexist and the development of T2DM also in the ACHD population is not uncommon with an estimated prevalence of between 4 and 8%. Treatment of conventional cardiovascular risk factors in patients with congenital heart disease could be considered secondary prevention given the relatively high morbidity and high risk for mortality observed in patients with the combination of ACHD and T2DM. © 2015 Informa Healthcare.
28.	Dev, Apurba, et al. (författare) Electrokinetic effect for molecular recognition : A label-free approach for real-time biosensing 2016 Ingår i: Biosensors & bioelectronics. - : Elsevier. - 0956-5663 .- 1873-4235. ; 82, s. 55-63 Tidskriftsartikel (refereegranskat)abstract We present a simple and inexpensive method for label-free detection of biomolecules. The method monitors the changes in streaming current in a fused silica capillary as target biomolecules bind to immobilized receptors on the inner surface of the capillary. To validate the concept, we show detection and time response of different protein-ligand and protein-protein systems: biotin-avidin and biotin-streptavidin, barstar-dibarnase and Z domain-immunoglobulin G (IgG). We show that specific binding of these biomolecules can be reliably monitored using a very simple setup. Using sequential injections of various proteins at a diverse concentration range and as well as diluted human serum we further investigate the capacity of the proposed technique to perform specific target detection from a complex sample. We also investigate the time for the signal to reach equilibrium and its dependence on analyte concentration and demonstrate that the current setup can be used to detect biomolecules at a concentration as low as 100 pM without requiring any advanced device fabrication procedures. Finally, an analytical model based on diffusion theory has been presented to explain the dependence of the saturation time on the analyte concentration and capillary dimensions and how reducing length and inner diameter of the capillary is predicted to give faster detection and in practice also lower limit of detection.
29.	Fedchenko, Maria, 1988, et al. (författare) Cardiovascular risk factors in adults with coarctation of the aorta. 2019 Ingår i: Congenital heart disease. - : Computers, Materials and Continua (Tech Science Press). - 1747-0803 .- 1747-079X. ; 14:4, s. 549-558 Tidskriftsartikel (refereegranskat)abstract The aging patient with adult congenital heart disease (ACHD) faces the risk of developing atherosclerotic disease. Patients with coarctation of the aorta (CoA) are especially vulnerable because of an inherent high risk of developing hypertension. However, data on the prevalence of other cardiovascular risk factors are scarce. Therefore, this study aimed to describe the prevalence of traditional cardiovascular risk factors (diabetes, hypertension, hyperlipidemia, smoking, obesity, and sedentary lifestyle) in adult patients with CoA.Patients with CoA who were registered at the ACHD clinic in Gothenburg were asked to participate in a comprehensive cardiovascular risk assessment. This assessment included a glucose tolerance test, cholesterol profile, ambulatory blood pressure measurements, and a lifestyle questionnaire.A total of 72 patients participated. The median age was 43.5years and 58.3% were men. Sixty-six (91.7%) patients had ≥one cardiovascular risk factor and 40.3% had ≥three risk factors. Three (4.2%) patients were newly diagnosed with diabetes or impaired glucose tolerance. More than half of the patients had hyperlipidemia (n=42, 58.3%) and 35 patients (48.6%) were overweight or obese. Only three (4.2%) patients smoked regularly. Of the 60 patients who underwent 24-hour ambulatory blood pressure measurement, 33 (55.0%) were hypertensive. Of the 30 patients with known hypertension only 9 (30.0%) had well-controlled blood pressure on ambulatory blood pressure measurement.Cardiovascular risk factors among patients with CoA are prevalent. This may indicate a need for more aggressive screening strategies of traditional risk factors to minimize the risk of these patients also developing atherosclerotic disease.
30.	Feministiskt tänkande och sociologi: teorier, begrepp och tillämpningar 2015 Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)
31.	Flejmer, Anna M. (författare) Radiation burden from modern radiation therapy techniques including proton therapy for breast cancer treatment - clinical implications 2016 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract The purpose of this thesis was to study the clinical implications of modern radiotherapy techniques for breast cancer treatment. This was investigated in several individual studies.Study I investigated the implications of using the analytical anisotropic algorithm (AAA) from the perspective of clinical recommendations for breast cancer radiotherapy. Pencil beam convolution plans of 40 breast cancer patients were recalculated with AAA. The latter plans had a significantly worse coverage of the planning target volume (PTV) with the 93% isodose, higher maximum dose in hotspots, higher volumes of the ipsilateral lung receiving doses below 25 Gy and smaller volumes with doses above 25 Gy. AAA also predicted lower doses to the heart.Study II investigated the implications of using the irregular surface compensator (ISC), an electronic compensation algorithm, in comparison to three‐dimensional conformal radiotherapy (3D‐CRT) for breast cancer treatment. Ten breast cancer patients were planned with both techniques. The ISC technique led to better coverage of the clinical target volume of the tumour bed (CTV‐T) and PTV in almost all patients with significant improvement in homogeneity.Study III investigated the feasibility of using scanning pencil beam proton therapy for regional and loco‐regional breast cancer with comparison of ISC photon planning. Ten patients were included in the study, all with dose heterogeneity in the target and/or hotspots in the normal tissues outside the PTV. The proton plans showed comparable or better CTV‐T and PTV coverage, with large reductions in the mean doses to the heart and the ipsilateral lung.Study IV investigated the added value of enhanced inspiration gating (EIG) for proton therapy. Twenty patients were planned on CT datasets acquired during EIG and freebreathing (FB) using photon 3D‐CRT and scanning proton therapy. Proton spot scanning has a high potential to reduce the irradiation of organs‐at‐risk for most patients, beyond what could be achieved with EIG and photon therapy, especially in terms of mean doses to the heart and the left anterior descending artery.Study V investigated the impact of physiological breathing motion during proton radiotherapy for breast cancer. Twelve thoracic patients were planned on CT datasets during breath‐hold at inhalation phase and breath‐hold at exhalation phase. Between inhalation and exhalation phase there were very small differences in dose delivered to the target and cardiovascular structures, with very small clinical implication.The results of these studies showed the potential of various radiotherapy techniques to improve the quality of life for breast cancer patients by limiting the dose burden for normal tissues.
32.	Frishammar, Johan, et al. (författare) Auditing Innovation Capability in the new Innovation Landscape 2016 Konferensbidrag (refereegranskat)
33.	Frishammar, Johan, et al. (författare) Opportunities and challenges in the new innovation landscape : Implications for innovation auditing and innovation management 2019 Ingår i: European Management Journal. - : Elsevier BV. - 0263-2373 .- 1873-5681. ; 37:2, s. 151-164 Tidskriftsartikel (refereegranskat)abstract Innovation auditing is a well-established practice used by managers to identify strengths and weaknesses in innovation. Existing audit frameworks fall short, however, because they neglect three major trends that currently transform the innovation landscape. These trends are as follows: 1) a shift from closed to more open models of innovation ("openness"), 2) a shift from providing physical products to industrial product services ("servitization"), and 3) a shift from an analog to a highly digitalized world ("digitalization"). This article identifies new innovation practices, opportunities, and challenges that arise for manufacturing firms along these trends. The article proposes a revised innovation audit framework, which acknowledges these trends and supports innovation management in increasingly dynamic and competitive environments. (C) 2018 Elsevier Ltd. All rights reserved.
34.	Grimby-Ekman, Anna, 1967, et al. (författare) Comorbidities, intensity, frequency and duration of pain, daily functioning and health care seeking in local, regional, and widespread pain-a descriptive population-based survey (SwePain) 2015 Ingår i: Bmc Musculoskeletal Disorders. - : Springer Science and Business Media LLC. - 1471-2474. ; 16 Tidskriftsartikel (refereegranskat)abstract Background: The clinical knowledge of factors related to the spread of pain on the body has increased and understanding these factors is essential for effective pain treatment. This population-based study examines local (LP), regional (RP), and widespread pain (WSP) on the body regarding comorbidities, pain aspects, and impact of pain and elucidates how the spread of pain varies over time. Material and methods: A postal questionnaire that addressed pain aspects (intensity, frequency, duration and anatomical spreading on a body manikin), comorbidities and implications of pain (i.e., work situation, physical activity, consumption of health care and experience of hospitality and treatment of health care) was sent to 9000 adults living in southeastern Sweden. Of these, 4774 (53 %) completed and returned the questionnaire. After 9 weeks, a follow-up questionnaire was sent to the 2983 participants who reported pain in the first questionnaire (i.e. 62 % of 4774 subjects). Of these, 1940 completed and returned the questionnaire (i.e. 65 % of 2983 subjects). The follow-up questionnaire included the same items as the first questionnaire. Results: This study found differences in intensity, frequency and duration of pain, comorbidities, aspects of daily functioning and health care seeking in three pain categories based on spreading of pain: LP, RP and WSP. Compared to the participants with RP and LP, the participants with WSP had lower education and worse overall health, including more frequent heart disease and hypertension. In addition, participants with WSP had more intense, frequent, and long-standing pain, required more medical consultations, and experienced more impact on work. The participants with RP constituted an intermediate group regarding frequency and intensity of pain, and impact on work. The participants with LP were the least affected group regarding these factors. A substantial transition to RP had occurred by the 9-week follow-up. Conclusions: This study shows an association between increased spread of pain and prevalence of heart disease, hypertension, more severe pain characteristics (i.e., intensity, frequency and duration), problems with common daily activities and increased health care seeking. The WSP group was the most affected group and the LP group was the least affected group. Regarding these factors, RP was an obvious intermediate group. The transitions between the pain categories warrant research that broadly investigates factors that increase and decrease pain.
35.	Hultman, Martin, 1976, et al. (författare) The far right and climate change denial: Denouncing environmental challenges via anti-establishment rhetoric, marketing of doubts, industrial/breadwinner masculinities enactments and ethno-nationalism 2019 Ingår i: The far right and the environment: Politics, discourse and communication. - : Routledge. - 9781351104036 ; , s. 121-135 Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract Most obvious and explicitly illustrated by the politics of the Trump administration in the US, but also evident in Europe, far-right nationalism have merged with climate change denialism. This merge is just starting to get scholarly attention, despite this research may provide new and important knowledge of resistance towards effective climate politics as well as of broader political issues such as democracy, human rights and diversity. Sweden has high credentials in both environmental politics as well as in welcoming refugees, but these values and politic has of lately been heavily challenged by the neo-fascist party Sweden Democrats. This chapter deals with the environmental communication in this political landscape from 2013 and onwards with a specific focus on climate change denialism of Sweden Democrats (SD). Since two consecutive elections, SD are firmly placed in an unneglectable swing role that Swedish governments both of liberal-conservative and social democratic-green shapes have needed to consider. In this chapter we focus empirically on the period 2013–2017 and follow the arguments from and work by SD politicians. The chapter discuss how and in what way far-right and climate change denialist groups have merged with focus on anti-establishment rhetoric, marketing of doubts, industrial/breadwinner masculinities and nationalism.
36.	Hällgren, Camilla, Docent, 1973-, et al. (författare) Digital Competence at the intersection of social values and identity : In policy, practice and theory? 2019 Ingår i: Fjärde nationella konferensen i pedagogiskt arbete. Tema: Pedagogiskt arbete i en global tid. Den 19:e – 20:e augusti år 2019 i Umeå.. Konferensbidrag (refereegranskat)abstract In Swedish and European policies, education is identified as one key agent for advancing opportunities of digitalization and delivering digital transformations. In Sweden the National Digitalization Strategy for the School System was presented 2017. Later, the Swedish national curricula were revised with stronger writings about digital competence and put into effect on the 1st of July 2018. Digital competence is said to apply to all students and staff members from preschool to adult education. In short, these revisions propose, abilities to programming as central, but also abilities to solve problems, to use of digital technology creatively while turning ideas into action, work with digital texts, media and tools, understand and use digital systems and services, to critically approach media and information as well as understand the impact of digitalization on society and individuals. Digitalization policies are indeed comprehensive, yet, we argue there are still important matters calling for attention. For instance, what does competence mean in relation to digitalization? What does digital competence mean in relation to social values in the curricula? And, what does adequate digital competence mean in relation to actual, everyday practices in schools and more widely? This presentation reports early results of an ongoing critical discourse analysis of the intersection of digital competence and social values, in policy and practice. It is argued that there is a discursive gap that needs to be bridged by ethical considerations. It is suggested that if the government’s digital agenda is to be truly in human service, bring about a bright future and a sustainable digital transformation of Sweden, components of social values, what it is to exist as a human; that is what technology does to the human condition, need to be included and equally relevant to other components of digital competences.
37.	Hällgren, Camilla, 1973-, et al. (författare) Digital Competences at the Intersection of Value Issues and Social Relations? 2019 Konferensbidrag (refereegranskat)abstract When the Swedish commission for digitalisation launched their first report; A digital agenda in human service - a bright future can be ours, in 2014, a major part was dedicated to teaching, learning and the educational system. Then, in June 2017 a national strategy for sustainable digital transformation in Sweden followed, aiming for Sweden to become a leading country in advancing the opportunities of digitalisation. To deliver this aim, a modernisation of the education system was identified as one key measure. In the same year the National Digitalisation Strategy for the School System was presented and the Swedish national curricula were revised with stronger writings about digital competence and put into effect in 1st of July 2018. In short, these revisions propose abilities to programming as central, but also abilities to solve problems, translate ideas into action by creative use of digital technology, work with digital texts, media and tools, understand and use digital systems and services, to critically and responsibly relate to media and information as well as understand the impact of digitalisation on individuals and society. Moreover, digital competence is said to apply to all students and staff members from preschool to adult education. The strategies on digitalisation are comprehensive - but there are still important matters that call for attention. For instance, what does digital competence mean, and more specific, what does it mean in relation to value issues in curricula and more widely? What does adequate digital competence mean in relation actual, everyday practices where technology, social values and matters of identity intersect – both outside and within formal school contexts, like the K-12 school, youth recreation centers and higher education?In this paper, the intersection of digital competence and social values in education is explored by critical discourse analysis. Ideas of governing through policy are conceptualised from critical and post-structural perspectives. A first analysis of the most recent policy documents on digitalization, produced by the Swedish government is presented. One initial and tentative result is the overwhelming absence of ethical matters. In neither of the policies the use of IT, and the competences therefore required is related to value issues and social relations mediated by technology. Ethics, rather, seems to concern questions of netiquette and behavior (such as avoiding bullying) and legal issues of copyright, cheating and fraud. One other tentative result is the gap between policies of digital competence and the policies of social values inscribed as fundamentals in the curricula and more widely. We suggest that this discursive gap is a dilemma. This is not, however, to argue that current framings of digital competence are inadequate, but to suggest that if the government’s digital agenda shall be a true human service, bring a bright future and a sustainable digital transformation of Sweden, the ethical component needs to be upgraded. Value issues, social relations, what it is to exist as a human; what technology does to the human condition, need to be included and equally relevant to other components of digital competences.
38.	Jarnehammar, Anna, et al. (författare) En uppdaterad byggvarudeklaration 2016 Rapport (övrigt vetenskapligt/konstnärligt)abstract Systemet för Byggvarudeklarationen har idag en omfattande användning och är i jämförelse med andra länder ett unikt system för miljöinformation. Systemet har i dagsläget fler än 10 000 deklarerade byggvaror. Det är accepterat av både leverantörer och användare av byggvaror som ett överenskommet format för att lämna miljöinformation. Informationen används för att dokumentera och göra miljöanpassade materialval vid nyproduktion, drift och ändring av byggnader. Innehållet i deklarationerna garanteras av den enskilde byggvaruleverantören. I föreliggande projekt har Byggvarudeklarationen uppdaterats i enlighet med förändrad lagstiftning, nya marknadskrav samt anpassats för att informationen ska kunna hanteras digitalt genom förädlingskedjan inom samhällsbyggnadssektorn. Lagstiftning som har legat till grund för uppdateringen är: - Byggproduktförordningen och kraven på prestandadeklaration -REACH, CLP och RoHS - Direktivet om offentlig upphandling När det gäller marknadskraven är det främst de olika miljöcertifieringssystem (Miljöbyggnad, BREEAM, LEED) för byggnader som idag tillämpas i Sverige som har varit utgångspunkten för förändringarna. Det digitala formatet har utvecklats med fokus på att göra Byggvarudeklarationerna spårbara genom unika dokumentidentiteter dvs att enskilda artiklar har en koppling till en unik byggvarudeklaration. XML-schema även utvecklats utifrån det överenskomna innehållet så att all miljöinformation kan överföras digitalt. Vidare har en applikation och en databas utvecklats som ska användas av den som vill upprätta en digital byggvarudeklaration. Den nya byggvarudeklarationen innehåller följande 11 avsnitt: 1. Grunddata 2. Hållbarhetsarbete 3. Innehållsdeklaration 4. Råvaror 5. Miljöpåverkan 6. Distribution 7. Byggskede 8. Bruksskede 9. Rivning 10. Avfallshantering 11. Innemiljö
39.	Johansson, Sara, et al. (författare) The consequences of managerial controls for digital innovation projects 2018 Konferensbidrag (refereegranskat)
40.	Karlsson, Anna, et al. (författare) Establish and Manage a network for continuous innovation : - Invoking organizational pressure 2015 Konferensbidrag (refereegranskat)abstract Social networks and relationships between actors have been identified as important both in terms of increasing our understanding of innovation and for organizations’ to realize innovation outcomes. While previous studies have informed us how knowledge creation in informal network structures can be influenced and managed by subtle management techniques, we know little of how companies intentionally can create and utilize networks for continuous innovation. The aim of this paper is to explore how a network for continuous innovation can be established and managed. A longitudinal case study have been performed using data covering the establishment and subsequent management of a network for supporting continuous innovation, spanning the product management and R&D department of a large multinational company. The results argue for the importance of the creation of a support structure as one layer within the network in order to uphold the development and evolvement of the network over time through support with competence development and influence the network through different kinds of subtle management techniques. Moreover, the paper argues for the importance of invoking organizational pressure for innovation outcome.
41.	Karlsson, Anna, et al. (författare) Establishing and managing a network for continuous innovation : Invoking organizational pressure 2017 Ingår i: Creativity and Innovation Management. - : John Wiley & Sons. - 0963-1690 .- 1467-8691. ; 26:2, s. 128-141 Tidskriftsartikel (refereegranskat)abstract Social networks in organizations have been identified as important both in terms of increasing our understanding of innovation and for organizations to realize innovation outcomes. While previous studies have informed us of the importance of networks for innovation, we know little of how companies intentionally can design and utilize networks to achieve continuous innovation. The aim of this paper is to explore how a network for continuous innovation can be established and managed. A longitudinal case study has been performed using data covering the establishment and subsequent management of a network for supporting continuous innovation, spanning the product management and R&D department of a large multinational company. The results reveal the potential to use intra-organizational networks to invoke organizational pressure conducive for making innovation happen. This pressure is induced by autonomy and self-organizing in the network and consists of reciprocal expectations and demands between the top (management) and the bottom (employees involved in the network) of the organizational hierarchy. Implications for theory and practice are discussed
42.	Karlsson, Anna, 1983-, et al. (författare) The role of attention for radical innovation : Identifying moves that matter 2018 Konferensbidrag (refereegranskat)abstract Although the human problem of managing attention has been identified as a central problem in the management of innovation, limited research has considered how attention is handled by different actors in the various phases of the innovation process. Moreover, more attention and commitment may be needed for radical ideas to succeed, making this type of innovations particularly interesting to study. This study aims to contribute to the literature addressing the development of radical innovations in established companies by focusing on the role of attention for this type of innovations. Based on an in-depth longitudinal case study, this paper provides an account of how attention was handled in such a setting. Interview data was collected from individuals involved in the project at two different points in time – adjacent to the formal start of the development project and close to the launch. Results reveal three attentional streams (‘Providing input & motivation’, ‘Propelling the idea forward’ and ‘Protecting the idea & individuals’) involving different actors during the innovation process. Along with the finding that managers engage in diverting behavior, and their rationales for doing so, this contributes to theory. Lastly, two of the attentional streams identified highlight an organizational-level paradox connected to radical innovation. A paradox that leaves managers in an ambiguous position.
43.	Larsson, Britt, et al. (författare) Pain Sensitivity and its Relation to Spreading on the Body, Intensity, Frequency, and Duration of Pain A Cross-Sectional Population-based Study (SwePain) 2017 Ingår i: The Clinical Journal of Pain. - : LIPPINCOTT WILLIAMS & WILKINS. - 0749-8047 .- 1536-5409. ; 33:7, s. 579-587 Tidskriftsartikel (refereegranskat)abstract Objectives:Individuals with chronic pain often report increased pain sensitivity compared with pain-free individuals; hence, it is crucial to determine whether and how different pain characteristics influence or interact with pain sensitivity. An alternative to experimental pain sensitivity testing is the self-reported pain sensitivity questionnaire (PSQ), which captures pain sensitivity in various body areas.This study compares PSQ in individuals with and without pain and clarifies how pain sensitivity relates to spreading of pain on the body, and to intensity, frequency, duration of pain and to age and sex.Materials and Methods:A total of 5905 individuals with pain and 572 individuals without pain from the general population in southeastern Sweden completed and returned a postal questionnaire.Results:The mean PSQ score was 3.9 (95% confidence interval [CI], 3.88-3.98) in individuals with pain and 3.5 (95% CI, 3.38-3.64) in pain-free individuals. Hence, PSQ was the highest among individuals with pain, with a difference of 0.4 (95% CI, 0.30-0.56). There was a considerable variation in the PSQ values (mean=3.5; SD=1.54) among pain-free individuals. Pain sensitivity was positively related to spreading, intensity, and frequency of pain, with a correlation coefficient of 0.3. PSQ was higher in widespread pain, 4.5 (95% CI, 4.27-4.69) in women and 4.3 (95% CI, 3.94-4.71) in men, than in local pain, 3.7 (95% CI, 3.61-3.91) in women and 3.8 (95% CI, 3.66-3.95) in men. The score for women with regional pain was between local and widespread pain at 4.0 (95% CI, 3.95-4.11) and that for men with regional pain was 3.8 (95% CI, 3.69-3.87), which is equal to that of local pain.Discussion:The positive association between pain sensitivity and spreading of pain on the body provides some evidence that the extent of spreading may be related to the degree of pain sensitivity. Before clinical use of PSQ, psychometric development and further research are needed.
44.	Larsson, Britt, 1953-, et al. (författare) Predictors of chronic pain intensity, spread and sensitivity in the general population: A two-year follow-up study from the swepain cohort 2019 Ingår i: Journal of Rehabilitation Medicine. - Uppsala, Sweden : Medical Journals Sweden AB. - 1650-1977 .- 1651-2081. ; 51:3, s. 183-192 Tidskriftsartikel (refereegranskat)abstract © 2019 Foundation of Rehabilitation Information. Objective: To determine whether the intensity, spread and sensitivity of chronic pain can be predicted using demographic features, socioeconomic conditions and comorbidities. Design: A longitudinal study design was employed. Data was collected at baseline and at 2-year followup. Setting: General population in south-eastern Sweden. Subjects: A representative stratified random sample of 34,000 individuals, between 18 and 85 years of age, selected from a sampling frame of 404,661 individuals based on the Swedish Total Population Register. Methods: Eligible individuals were sent postal surveys in 2013 and 2015. The 2 surveys included the same questions about basic demographic data, comorbidities, and chronic pain intensity, spread and sensitivity. Results: Several socio-demographic features and comorbidities at baseline were significant predictors of characteristics of pain (intensity, spread and sensitivity) at the 2-year follow-up. When characteristics of pain at baseline were included in the regression analyses they were relatively strong significant predictors of characteristics of pain after 2 years. After this adjustment there were fewer socio-demographic and comorbidity predictors; the effect estimates for those significant predictors had decreased. Conclusion: Clinical assessment should focus on several characteristics of pain and include a broad medical screening to capture the overall burden of pain in adults from a longitudinal perspective.
45.	Lundberg, Emma, et al. (författare) The Cell Atlas : Creation of an image-based atlas of the subcellular distribution of the human proteome. 2016 Ingår i: Molecular Biology of the Cell. - : The American Society for Cell Biology - ASCB. - 1059-1524 .- 1939-4586. ; 27 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
46.	Magnusson, Mats, et al. (författare) Measuring front-end innovation 2016 Konferensbidrag (refereegranskat)
47.	Mahdessian, Diana, et al. (författare) Profiling the human cytoplasmic proteome. 2016 Ingår i: Molecular Biology of the Cell. - : AMER SOC CELL BIOLOGY. - 1059-1524 .- 1939-4586. ; 27 Tidskriftsartikel (refereegranskat)
48.	Martín-Bylund, Anna (författare) Towards a minor bilingualism : Exploring variations of language and literacy in early childhood education 2017 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract The aim of this compilation thesis is to explore variations in bilingualism with the help of everyday specific situations at a Spanish-Swedish early childhood institution in Sweden, and by means of a ‘material-semiotic theorizing’. This means that material and semiotic elements are treated equally and entwined. Through studying a bilingual preschool practice, theory and politics as three interwoven practices, the thesis produces knowledge on language and literacy as socially and materially divergent, transformative occurrences. The research process is a commitment with Deleuzio-Guattarian philosophy, theory and politics, and is defined as a becoming in and of the three practices (education, theory, politics). Ethical and methodological undertakings are described as results of the interaction of these practices. Processes of data production include a yearlong fieldwork with all year groups (1-5) at a bilingual preschool in Sweden with a Spanish-Swedish language policy. The materials of data (approx. 59 hours of video-recordings and additional field-notes of everyday activities) are extended and developed upon in interaction with theoretical concepts and political concerns in terms of an analytical process that ‘puts theory to work’. The results are phrased as three temporal suggestions: 1) Bilingualism is a plural, collectively produced, both transitory and specific phenomenon 2) Bilingualism emerges with different, simultaneous dimensions of language and literacy (language as both code and material intensities) 3) Bilingualism is shared and public but also private and inconclusive. The thesis also shows the interconnectedness and continuity between different constructions of bilingualism (i.e. separate – flexible, public - private) as well as the productivity of the unknown and of what is labelled as (il)literate expertise. The impact that these suggestions may have in working with bilingualism in early childhood education is discussed. At the same time the discussion inspires to thinking towards a minor bilingualism also in more general terms.
49.	Martin, Myriam, et al. (författare) Factor H uptake regulates intracellular C3 activation during apoptosis and decreases the inflammatory potential of nucleosomes. 2016 Ingår i: Cell Death and Differentiation. - : Springer Science and Business Media LLC. - 1350-9047 .- 1476-5403. ; 23, s. 903-911 Tidskriftsartikel (refereegranskat)abstract Factor H (FH) binds apoptotic cells to limit the inflammatory potential of complement. Here we report that FH is actively internalized by apoptotic cells to enhance cathepsin L-mediated cleavage of endogenously expressed C3, which results in increased surface opsonization with iC3b. In addition, internalized FH forms complexes with nucleosomes, facilitates their phagocytosis by monocytes and induces an anti-inflammatory biased cytokine profile. A similar cytokine response was noted for apoptotic cells coated with FH, confirming that FH diminishes the immunogenic and inflammatory potential of autoantigens. These findings were supported by in vivo observations from CFH(-/-) MRL-lpr mice, which exhibited higher levels of circulating nucleosomes and necrotic cells than their CFH(+/+) littermates. This unconventional function of FH broadens the established view of apoptotic cell clearance and appears particularly important considering the strong associations with genetic FH alterations and diseases such as systemic lupus erythematosus and age-related macular degeneration.Cell Death and Differentiation advance online publication, 15 January 2016; doi:10.1038/cdd.2015.164.
50.	Martin, Myriam, et al. (författare) Plasma C4d as marker for lupus nephritis in systemic lupus erythematosus 2017 Ingår i: Arthritis Research and Therapy. - : Springer Science and Business Media LLC. - 1478-6354 .- 1478-6362. ; 19:1 Tidskriftsartikel (refereegranskat)abstract Background: In the present study, we sought to evaluate the complement activation product C4d as a marker for lupus nephritis in systemic lupus erythematosus (SLE). Methods: C4d levels were determined by enzyme-linked immunosorbent assay in plasma samples of patients with established SLE using a novel approach based on detection of a short linear cleavage neoepitope. Cross-sectional associations were studied in 98 patients with SLE with samples taken at lower or higher respective disease activity. Temporal associations were investigated in 69 patients with SLE who were followed longitudinally for up to 5 years. Plasma samples from 77 healthy donors were included as controls. Results: C4d levels were negligible in healthy control subjects and significantly increased in patients with SLE in the cross-sectional study (p < 0.0001). C4d levels discriminated between higher and lower disease activity according to ROC curve analysis (p < 0.001), exhibiting a positive predictive value of 68%. At higher disease activity, C4d levels correlated with the modified Systemic Lupus Erythematosus Disease Activity Index (p = 0.011) and predominantly with lupus nephritis (p = 0.003), exhibiting a sensitivity of 79% to identify patients with nephritis. High C4d levels together with the presence of anti-dsDNA autoantibodies preceded and thus predicted future lupus nephritis in the longitudinal study (OR 5.4, 95% CI 1.4-21.3). When we considered only patients with renal involvement (19 of 69) during the longitudinal study, we found that high C4d levels alone could forecast recurrence of future lupus nephritis (OR 3.3, 95% CI 1.2-9.6). Conclusions: C4d appears to be a valuable marker for use in monitoring of patients with SLE, particularly for lupus nephritis. Importantly, C4d levels can predict impending flares of lupus nephritis and may thus be useful for informing treatment.

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