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| 2. |
- Kainu, T, et al.
(författare)
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Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus
- 2000
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Ingår i: Proceedings of the National Academy of Sciences. - 1091-6490. ; 97:17, s. 9603-9608
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Tidskriftsartikel (refereegranskat)abstract
- A significant proportion of familial breast cancers cannot be explained by mutations in the BRCA1 or BRCA2 genes. We applied a strategy to identify predisposition loci for breast cancer by using mathematical models to identify early somatic genetic deletions in tumor tissues followed by targeted linkage analysis. Comparative genomic hybridization was used to study 61 breast tumors from 37 breast cancer families with no identified BRCA1 or BRCA2 mutations. Branching and phylogenetic tree models predicted that loss of 13q was one of the earliest genetic events in hereditary cancers. In a Swedish family with five breast cancer cases, all analyzed tumors showed distinct 13q deletions, with the minimal region of loss at 13q21-q22. Genotyping revealed segregation of a shared 13q21 germ-line haplotype in the family. Targeted linkage analysis was carried out in a set of 77 Finnish, Icelandic, and Swedish breast cancer families with no detected BRCA1 and BRCA2 mutations. A maximum parametric two-point logarithm of odds score of 2.76 was obtained for a marker at 13q21 (D13S1308, theta = 0.10). The multipoint logarithm of odds score under heterogeneity was 3.46. The results were further evaluated by simulation to assess the probability of obtaining significant evidence in favor of linkage by chance as well as to take into account the possible influence of the BRCA2 locus, located at a recombination fraction of 0.25 from the new locus. The simulation substantiated the evidence of linkage at D13S1308 (P < 0.0017). The results warrant studies of this putative breast cancer predisposition locus in other populations.
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| 3. |
- Ohlsson, B. J., et al.
(författare)
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Size-, shape-, and position-controlled GaAs nano-whiskers
- 2001
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Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 79:20, s. 3335-3337
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Tidskriftsartikel (refereegranskat)abstract
- We have developed a technique for the synthesis of size-selected, GaAs, epitaxial nano-whiskers, grown on a crystalline substrate. As catalysts, we used size-selected gold aerosol particles, which enabled us to fully vary the surface coverage independently of the whisker diameter. The whiskers were rod shaped, with a uniform diameter between 10 and 50 nm, correlated to the size of the catalytic seed. Furthermore, by the use of nano-manipulation of the aerosol particles by means of atomic force microscopy, we can nucleate individual nano-whiskers in a controlled manner at specific positions on a substrate with accuracy on the nm level.
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| 4. |
- Tsegaye, T., et al.
(författare)
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Complementarity and quantum erasure with entangled-photon states
- 2000
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Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - 1050-2947 .- 1094-1622. ; 62:3, s. art. no.-32106
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Tidskriftsartikel (refereegranskat)abstract
- A quantum-erasure experiment was performed on superposition states of two photons in either of two spatiotemporal modes. Symmetrical tapping of energy from the two-mode state creates a four-mode entangled state. A direct measurement of one photon in two of the modes reveals the path of the second one, thereby eliminating the possibility of observing interference between the two remaining modes. It is shown that a unitary rotation of one of the two-mode states erases the path information; as a consequence, the visibility of the other two-mode state can be resurrected.
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| 5. |
- Tsegaye, T., et al.
(författare)
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Experimental demonstration of three mutually orthogonal polarization states of entangled photons
- 2000
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 85:24, s. 5013-5017
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Tidskriftsartikel (refereegranskat)abstract
- Linearly polarized classical light can be expressed in a vertical and a horizontal component. Geometrically rotating vertically polarized light by 90 degrees will convert it to the orthogonal horizontal polarization. We have experimentally generated a two-photon state of light which evolves into an orthogonal state upon geometrical rotation by 60 degrees. Rotating this state by an additional 60 degrees will yield a state which is mutually orthogonal to the first two states. Generalizing this procedure, one can generate N + 1 mutually orthogonal N-photon states that cyclicly evolve from one to another upon a geometric rotation by 180/(N + 1) degrees.
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| 6. |
- Barnes, W. L., et al.
(författare)
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Solid-state single photon sources : light collection strategies
- 2002
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Ingår i: European Physical Journal D. - : Springer Science and Business Media LLC. - 1434-6060 .- 1434-6079. ; 18:2, s. 197-210
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Tidskriftsartikel (refereegranskat)abstract
- We examine the problem of efficiently collecting the photons produced by solid-state single photon sources. The extent of the problem is first established with the aid of simple physical concepts. Several approaches to improving the collection efficiency are then examined and are broadly categorized into two types. First are those based on cavity quantum dynamics, in which the pathways by which the source may emit a photon are restricted, thus channeling emission into one desired mode. Second are those where we try to reshape the free space modes into a target mode in an optimal way, by means of refraction, without fundamentally altering the way in which the source emits. Respectively, we examine a variety of microcavities and solid immersion lenses. Whilst we find that the micropillar microcavities offer the highest collection efficiency (similar to70%), choosing this approach may not always be appropriate due to other constraints. Details of the different approaches, their merits and drawbacks are discussed in detail.
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