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Träfflista för sökning "WFRF:(Blackwell K. T.) srt2:(2000-2004)"

Sökning: WFRF:(Blackwell K. T.) > (2000-2004)

  • Resultat 1-9 av 9
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  • Yang, K. H., et al. (författare)
  • The role of protein kinase C in the biochemical pathways of classical conditioning
  • 2001
  • Ingår i: Neurocomputing. - 0925-2312 .- 1872-8286. ; 38, s. 79-85
  • Tidskriftsartikel (refereegranskat)abstract
    • Evidence suggests that protein kinase C (PKC) is required for long term memory storage such as classical conditioning. Stimulation of parallel fibers (PF) and climbing fibers (CF) of the cerebellum leads to production of the second messengers diacylglycerol, arachidonic acid, and calcium which are activators of PKC. A model is developed that describes the cascade of biochemical reactions in response to PF and CF stimulation and leading to PKC activation. Model simulations are used to evaluate the temporal specificity of PKC activation and the sensitivity of PKC activation to the interstimulus interval (ISI) of classical conditioning. Simulations at different ISI show that if PF stimulation precedes CF stimulation, PKC activation is elevated.
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  • Hellgren Kotaleski, Jeanette, et al. (författare)
  • Sensitivity to interstimulus interval due to calcium interactions in the Purkinje cell spines
  • 2002
  • Ingår i: Neurocomputing. - 0925-2312 .- 1872-8286. ; 44, s. 13-18
  • Tidskriftsartikel (refereegranskat)abstract
    • Pairing specific LTD (PSD) is produced by paired parallel fiber (PF) and climbing fiber (CF) stimulation and requires Ca2+ elevation. CF or PF activation cause Ca2+ increase through voltage dependent channels and IP3 induced Ca2+ release, respectively. We developed a model of Ca2+ dynamics in Purkinje cell spines to investigate why paired PF-CF activation is necessary for PSD. Simulations show a supralinear increase of the Ca2+ signal if the CF input occurs in a restricted time interval following the PF input. Ca2- buffers significantly contribute to this phenomenon. This mechanism may be involved in the requirement of temporal specificity in classical conditioning.
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  • Hellgren Kotaleski, Jeanette, et al. (författare)
  • Subcellular interactions between parallel fibre and climbing fibre signals in Purkinje cells predict sensitivity of classical conditioning to interstimulus interval
  • 2002
  • Ingår i: Integrative Physiological & Behavioral Science. - 1053-881X .- 2168-7846. ; 37:4, s. 265-292
  • Tidskriftsartikel (refereegranskat)abstract
    • Classical conditioning of the nictitating membrane response requires a specific temporal interval between conditioned stimulus and unconditioned stimulus, and produces an increase in Protein Kinase C (PKC) activation in Purkinje cells. To evaluate whether biochemical interactions within the Purkinje cell may explain the temporal sensitivity, a model of PKC activation by Ca2+, diacylglycerol (DAG), and arachidonic acid (AA) is developed. Ca2+ elevation is due to CF stimulation and IP3 induced Ca2+ release (IICR). DAG and IP3 result from PF stimulation, while AA results from phospholipase A2 (PLA(2)). Simulations predict increased PKC activation when PF stimulation precedes CF stimulation by 0.1 to 3 s. The sensitivity of IICR to the temporal relation between PF and CF stimulation, together with the buffering system of Purkinje cells, significantly contribute to the temporal sensitivity.
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  • Resultat 1-9 av 9

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