| 1. |
- Bonduelle, M., et al.
(författare)
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Medical follow-up study of 5-year-old ICSI children
- 2004
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Ingår i: Reprod Biomed Online. ; 9:1, s. 91-101
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Tidskriftsartikel (refereegranskat)abstract
- Children born after intracytoplasmic sperm injection (ICSI) are still a matter of concern. The purposes of the present study were to investigate the physical outcome in 5-year-old children born after ICSI and compare them with children born after spontaneous conception. Three hundred singleton children from Belgium, Sweden and the USA, born after ICSI, were matched by maternal age, child age and gender. In one centre, matching was also performed for maternal education. The main end-point was growth. Secondary end-points were general health, e.g. common diseases, chronic illnesses, surgical interventions and physical/neurological examinations. Standard deviation scores assessed growth. Growth assessed as stature at follow-up was similar in the two groups, despite a higher rate of preterm birth and low birth weight in the ICSI children. Common diseases and chronic illnesses occurred at similar rates in both groups. More ICSI children underwent surgical interventions and required other therapy e. g. physiotherapy and dietary therapy. Physical/neurological examinations revealed few abnormalities in either group. In conclusion, infertility treatment by ICSI does not adversely affect growth during childhood. The children's general health seems satisfactory.
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| 2. |
- Tjus, Tomas, 1954, et al.
(författare)
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Psychological follow-up of 5 year old ICSI children
- 2004
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Ingår i: Human Reproduction. ; :12, s. 2791-2797
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Tidskriftsartikel (refereegranskat)abstract
- The developmental outcome of children born after ICSI are still a matter of concern. The purpose of the present study was to investigate psychological outcomes for 5-year-old children born after ICSI and compare these with outcomes for children born after spontaneous conception (SC). Three hundred singleton children born after ICSI in Belgium Sweden and USA were matched by maternal age, child age, and gender. Outcome measures included WPPSI-R, Peabody Developmental Motor Scales, Parenting Stress Index and Child Behaviour Checklist. Regarding cognitive development, no significant differences were found on WPPSI-R verbal and performance subscales between ICSI and SC children. However, some differences were noted on subtests of the Performance Scale. ICSI children more often obtained a score below 1 SD of the mean of the subtests. Significant differences by site (Belgium, Sweden and New York) were found on subtests related to parenting stress, child behaviour problems and motor development. These findings can probably be explained by other variables other than conception mode e.g. cultural differences and selection bias. Although the finding that a higher proportion of ICSI children obtained scores below the cut-off on some visual-spatial subscale of the WPPSI-R warrants further investigation, ICSI does not appear to affect the psychological well-being or cognitive development at age 5.
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