| 1. |
- Anderson, Johan, et al.
(författare)
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European approach to assess the fire performance of façades
- 2020
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Ingår i: Fire and Materials. - : John Wiley and Sons Ltd. - 0308-0501 .- 1099-1018.
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Tidskriftsartikel (refereegranskat)abstract
- Several attempts have been made in the past to develop a European harmonized testing and assessment method for façades before the European commission decided to publish a call for tender on the topic. A project consortium from five countries (Sweden, UK, France, Germany and Hungary) applied to the call for tender and was contracted to develop a European approach to assess the fire performance of façades. 24 sub-contractors and 14 stakeholder entities were part of the project. The objective of the European project was to address a request from the Standing Committee of Construction (SCC) to provide EC Member States regulators with a means to regulate the fire performance of façade systems based on a European approach agreed by SCC. The initial stages of this project were focused on establishing a register of the regulatory requirements in all Member States in relation to the fire performance of façade systems, and to identify those Member States who have regulatory requirements for the fire performance façade systems which go beyond the current EN 13501 (reaction to fire and fire resistance) classification systems and to collate the details of these additional requirements. After having confirmed the regulatory needs a testing and classification methodology based on BS 8414 and DIN 4102-20 was developed to address the identified key performance and classification characteristics. This paper is a short overview of results the two-year development work, which Final Report published by the European Commission in 2018. © 2020 The Authors. Fire and Materials published by John Wiley & Sons Ltd.
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| 2. |
- Boström, Mathias, 1973-
(författare)
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Fonografen som föreställning : Introduktionen av ljudinspelningar vid svenska minnesinstitutioner
- 2024
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- With the invention of the phonograph in 1877 came the possibility to mechanically capture, store and reproduce sound. This thesis deals with how sound recording technology was introduced in memory institutions in Sweden. The focus of the thesis is on the first phonogram format, wax cylinder recordings, and their life cycle in use. This study deals only with memory institutions primarily directed towards Swedish-speaking majority culture, whereas cylinder recordings of the cultural Others will be the subject of a separate publication.The aim of the thesis is to increase the knowledge and enhance the understanding of the archival use of the cylinder phonograph in discourse and practice, with a focus on music recordings. With inspiration taken from a model of knowledge production by Bruno Latour, the study encompasses technology transfer, collecting practices and repertory analysis, institutionalization and professionalization, institutional economics, public presentations, and research practices. The cylinder phonograph was used by ten Swedish memory institutions 1898-1948, primarily by institutions directed towards traditional culture (dialects, folklore, and folk music), and with professional ambitions to some degree. Equipment and knowledge were to a certain extent transferred through professional networks in Sweden, with Danish and German memory institutions as important foreign competence centres. In comparison with some of the neighbouring countries, the introduction of sound recording technology in Sweden was generally some years later and the collections smaller. This is due to that professional memory institutions were founded later in Sweden, and that the collectors and scholars were primarily interested in typical representations of music in notation, rather than the phonogram’s particular representation of a single performance. Sound recording technology was therefore not regarded as a threat in relation to collecting music by ear. It was instead seen as a complement that could also, as objective reference recordings, increase the value of collections made by ear. The use of recording technology did, in several cases, narrow down the collected repertory and the informants that were chosen, due to that quality of performance now became important in a new sense. Few scholars in Sweden asked for archival recordings for research, and the cylinder recordings were not used for public presentations and publications in the period when the technology was in active use. Thus, it is not surprising that the cylinder phonograph did not became an important method for memory institutions in Sweden.
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| 3. |
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| 4. |
- Fjell, Astrid, et al.
(författare)
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Factors associated with self-rated health in a Norwegian population of older people participating in a preventive home visit program : a cross-sectional study
- 2020
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Ingår i: BMC Geriatrics. - : Springer Science and Business Media LLC. - 1471-2318. ; 20:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Assessing self-rated health by preventive home visits of older people can provide information about the person's well-being, quality of life and risk of developing illness. The aim of this study was to examine associations between self-rated health and factors related to demographics, lifestyle, health conditions and medical diagnoses by older people participating in a preventive home visit program.METHODS: A cross-sectional study including 233 participants (age 75-79) from three municipalities of Western Norway was conducted. Data were collected through preventive home visits performed by six nurses, using a questionnaire including self-rated health assessment and questions and tests related to demographics (e.g. education and housing), lifestyle (e.g. social activities, alcohol and smoking), health conditions (e.g. sensory impairment, pain and limited by disease) and medical diagnoses. Descriptive and inferential statistics including linear block-wise regression model were applied.RESULTS: The block-wise regression model showed that the variables Limited by disease and Pain were negatively associated with self-rated health and Use internet was positively associated. The model had a R2 0.432. The variable that contributed to largest change in the model was Limited by disease (R2 Change; 0.297, p-value< 0.001).CONCLUSIONS: In the present study, being limited by disease and pain were strongly associated with poor self-rated health, indicating that these are important factors to assess during a preventive home visit. Also, digital competence (Use internet) was associated with a better self-rated health, suggesting that it could be useful to ask, inform and motivate for the use of digital tools that may compensate for or improve social support, social contact and access to health -related information.
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| 5. |
- Hermann, Monica, et al.
(författare)
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Polypharmacy and Potential Drug-Drug Interactions in Home-Dwelling Older People : A Cross-Sectional Study
- 2021
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Ingår i: Journal of Multidisciplinary Healthcare. - 1178-2390. ; 14, s. 589-597
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Tidskriftsartikel (refereegranskat)abstract
- Background: Risks associated with polypharmacy and drug-drug interactions represent a challenge in drug treatment, especially in older adults. The aim of the present study was to assess the use of prescription and non-prescription drugs and the frequency of potential drug-drug interactions in home-dwelling older individuals.Methods: A cross-sectional study design was applied. Data were collected during preventive home visits among individuals aged ≥75 in three separate communities of Western Norway. A questionnaire, which was filled out by the individual, their next-of-kin, and the nurse performing the home visit was used for the collection of demographic and clinical data (age, sex, medication use, diagnoses, need of assistance with drug administration). Potential drug-drug interactions were identified electronically by IBM Micromedex Drug Interaction Checking. Point prevalence of potential drug-drug interactions and polypharmacy (≥5 drugs) were calculated. Binary logistic regression analyses were performed to assess factors potentially associated with polypharmacy or potential drug-drug interactions.Results: Among the 233 individuals (mean age 78±3 years, 46% male) included in the study, 43% used ≥5 drugs, 3.4% ≥10 drugs, while 4.3% used no drugs. In 54% of the 197 individuals using two or more drugs, at least one potential drug-drug interaction was detected. Low-dose aspirin and simvastatin were most frequently involved in potential drug-drug interactions. In total, 25% of the individuals reported current use of drugs sold over the counter of which more than 95% were analgesic drugs. Potential drug-drug interactions involving ibuprofen were identified in nine of 11 (82%) individuals using over-the-counter ibuprofen.Conclusion: The study revealed a high prevalence of polypharmacy and potential drug-drug interactions with both prescription and non-prescription drugs in older home-dwelling individuals. Close monitoring of the patients at risk of drug-drug interactions, and increased awareness of the potential of over-the-counter drugs to cause drug-drug interactions, is needed.
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| 6. |
- Kanellis, Dimitris C., et al.
(författare)
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The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output
- 2021
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Ingår i: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 7:32
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Tidskriftsartikel (refereegranskat)abstract
- Eukaryotic initiation factor 4A-III (eIF4A3), a core helicase component of the exon junction complex, is essential for splicing, mRNA trafficking, and nonsense-mediated decay processes emerging as targets in cancer therapy. Here, we unravel eIF4A3's tumor-promoting function by demonstrating its role in ribosome biogenesis (RiBi) and p53 (de)regulation. Mechanistically, eIF4A3 resides in nucleoli within the small subunit processome and regulates rRNA processing via R-loop clearance. EIF4A3 depletion induces cell cycle arrest through impaired RiBi checkpoint-mediated p53 induction and reprogrammed translation of cell cycle regulators. Multilevel omics analysis following eIF4A3 depletion pinpoints pathways of cell death regulation and translation of alternative mouse double minute homolog 2 (MDM2) transcript isoforms that control p53. EIF4A3 expression and subnuclear localization among clinical cancer specimens correlate with the RiBi status rendering eIF4A3 an exploitable vulnerability in high-RiBi tumors. We propose a concept of eIF4A3's unexpected role in RiBi, with implications for cancer pathogenesis and treatment.
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| 7. |
- Mak, Jonathan K. L., et al.
(författare)
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Development of an Electronic Frailty Index for Hospitalized Older Adults in Sweden
- 2022
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Ingår i: The journals of gerontology. Series A, Biological sciences and medical sciences. - : Oxford University Press. - 1079-5006 .- 1758-535X. ; 77:11, s. 2311-2319
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Tidskriftsartikel (refereegranskat)abstract
- Background Frailty assessment in the Swedish health system relies on the Clinical Frailty Scale (CFS), but it requires training, in-person evaluation, and is often missing in medical records. We aimed to develop an electronic frailty index (eFI) from routinely collected electronic health records (EHRs) and assess its association with adverse outcomes in hospitalized older adults. Methods EHRs were extracted for 18 225 patients with unplanned admissions between 1 March 2020 and 17 June 2021 from 9 geriatric clinics in Stockholm, Sweden. A 48-item eFI was constructed using diagnostic codes, functioning and other health indicators, and laboratory data. The CFS, Hospital Frailty Risk Score, and Charlson Comorbidity Index were used for comparative assessment of the eFI. We modeled in-hospital mortality and 30-day readmission using logistic regression; 30-day and 6-month mortality using Cox regression; and length of stay using linear regression. Results Thirteen thousand one hundred and eighty-eight patients were included in analyses (mean age 83.1 years). A 0.03 increment in the eFI was associated with higher risks of in-hospital (odds ratio: 1.65; 95% confidence interval: 1.54-1.78), 30-day (hazard ratio [HR]: 1.43; 1.38-1.48), and 6-month mortality (HR: 1.34; 1.31-1.37) adjusted for age and sex. Of the frailty and comorbidity measures, the eFI had the highest area under receiver operating characteristic curve for in-hospital mortality of 0.813. Higher eFI was associated with longer length of stay, but had a rather poor discrimination for 30-day readmission. Conclusions An EHR-based eFI has robust associations with adverse outcomes, suggesting that it can be used in risk stratification in hospitalized older adults.
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| 8. |
- Mak, Jonathan K. L., et al.
(författare)
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Two Years with COVID-19 : The Electronic Frailty Index Identifies High-Risk Patients in the Stockholm GeroCovid Study
- 2023
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Ingår i: Gerontology. - : S. Karger. - 0304-324X .- 1423-0003. ; 69:4, s. 396-405
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Frailty, a measure of biological aging, has been linked to worse COVID-19 outcomes. However, as the mortality differs across the COVID-19 waves, it is less clear whether a medical record-based electronic frailty index (eFI) that we have previously developed for older adults could be used for risk stratification in hospitalized COVID-19 patients. Objectives: The aim of the study was to examine the association of frailty with mortality, readmission, and length of stay in older COVID-19 patients and to compare the predictive accuracy of the eFI to other frailty and comorbidity measures. Methods: This was a retrospective cohort study using electronic health records (EHRs) from nine geriatric clinics in Stockholm, Sweden, comprising 3,980 COVID-19 patients (mean age 81.6 years) admitted between March 2020 and March 2022. Frailty was assessed using a 48-item eFI developed for Swedish geriatric patients, the Clinical Frailty Scale, and the Hospital Frailty Risk Score. Comorbidity was measured using the Charlson Comorbidity Index. We analyzed in-hospital mortality and 30-day readmission using logistic regression, 30-day and 6-month mortality using Cox regression, and the length of stay using linear regression. Predictive accuracy of the logistic regression and Cox models was evaluated by area under the receiver operating characteristic curve (AUC) and Harrell's C-statistic, respectively. Results: Across the study period, the in-hospital mortality rate decreased from 13.9% in the first wave to 3.6% in the latest (Omicron) wave. Controlling for age and sex, a 10% increment in the eFI was significantly associated with higher risks of in-hospital mortality (odds ratio = 2.95; 95% confidence interval = 2.42-3.62), 30-day mortality (hazard ratio [HR] = 2.39; 2.08-2.74), 6-month mortality (HR = 2.29; 2.04-2.56), and a longer length of stay (beta-coefficient = 2.00; 1.65-2.34) but not with 30-day readmission. The association between the eFI and in-hospital mortality remained robust across the waves, even after the vaccination rollout. Among all measures, the eFI had the best discrimination for in-hospital (AUC = 0.780), 30-day (Harrell's C = 0.733), and 6-month mortality (Harrell's C = 0.719). Conclusion: An eFI based on routinely collected EHRs can be applied in identifying high-risk older COVID-19 patients during the continuing pandemic.
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| 9. |
- McNamee, Robert, et al.
(författare)
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Reduction of fire spalling of concrete with small doses of polypropylene fibres
- 2021
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Ingår i: Fire and Materials. - : John Wiley and Sons Ltd. - 0308-0501 .- 1099-1018. ; 45:7, s. 943-
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Tidskriftsartikel (refereegranskat)abstract
- The addition of polypropylene (PP) fibres has been shown to reduce the fire spalling propensity of concrete. When including this type of fibres in the concrete, the concrete mix becomes less robust, and small deviations in the constitutes change the workability and properties of the concrete. So, from a manufacturing perspective as small dosages as possible of PP fibres are desirable. Very few large-scale fire resistance tests of concrete loaded in compression exist showing the function of PP fibres at low dosages on concrete mixes sensitive to spalling if no fibres are added. In this paper, results from 26 fire tests are presented and analysed. The test results are from four different experimental campaigns, but all the mixes have in common that the water-to-cement ratio is 0.40. The results show that an amount of only 0.6 kg/m3 PP fibres has a significant effect on the spalling propensity and that even lower amounts reduce the spalling although they do not eliminate it entirely. During one of the fire tests on large slabs loaded in compression, unloaded small cubes of the same mixes were also included in the furnace. None of the small specimens spalled, whereas some of the corresponding large slabs spalled beyond the layer of reinforcement. This illustrates that tests on small, unloaded specimens are not relevant when assessing fire spalling of larger cross-sections loaded in compression.
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| 10. |
- Mohaine, Siyimane, et al.
(författare)
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Cross-comparison of screening tests for fire spalling of concrete
- 2021
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Ingår i: Fire and Materials. - : John Wiley and Sons Ltd. - 0308-0501 .- 1099-1018. ; 45:7, s. 929-
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Tidskriftsartikel (refereegranskat)abstract
- Concrete spalling is an important phenomenon to consider when evaluating the fire behavior of concrete, as this can sometimes have an impact on the structural capacity of the studied element. Spalling can be assessed experimentally using screening tests although it is influenced by the size, geometry, and boundary conditions of the tested element, among other factors. No standardized and systematic methods are yet available to assess concrete spalling sensitivity by testing. Plus, comparative results between screenings tests (small and medium scale) and full-scale tests to evaluate their representativity remain scarce in the literature. In this study, five different spalling tests—with different geometries and boundary conditions—that are used as screening tests were investigated. A concrete mix known to be sensitive to spalling was used to evaluate the representativity of two types of screening tests (material screening tests and intermediate-scale screening tests). The representativity of these test setups was evaluated by comparing the measured spalling depths to the spalling measured on a full-scale slab test using the same concrete mix. This comparative study confirmed that the presence of load and/or restraint was essential for a good representativity for a screening test but should always be implemented in large enough specimens.
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| 11. |
- Papadopoulos, Harris, et al.
(författare)
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Preface
- 2023
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Ingår i: Proceedings of Machine Learning Research. - : ML Research Press. ; , s. 1-4
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Konferensbidrag (refereegranskat)
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| 12. |
- Pimienta, Pierre, et al.
(författare)
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Recommendation of RILEM TC 256-SPF on fire spalling assessment during standardised fire resistance tests : complementary guidance and requirements
- 2024
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Ingår i: Materials and Structures/Materiaux et Constructions. - : Springer Science and Business Media B.V.. - 1359-5997 .- 1871-6873. ; 57:1
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Tidskriftsartikel (refereegranskat)abstract
- The recommendation is based on the co-authors’ work organized by the RILEM TC 256-SPF “Spalling of concrete due to fire: testing and modelling”. It aims to provide useful information, guidance and best practices in fire spalling assessment to laboratories that perform large-scale tests based on fire resistance test standards. It provides guidance on the spalling observation techniques during testing, as well as post-test spalling quantification/assessment methods. This document is intended to be used in conjunction with the fire resistance test standards, e.g. EN 1363-1 and ISO 834-1.
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| 13. |
- Pimienta, Pierre, et al.
(författare)
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Recommendation of RILEM TC 256-SPF on the method of testing concrete spalling due to fire : material screening test
- 2023
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Ingår i: Materials and Structures/Materiaux et Constructions. - : Springer Science and Business Media B.V.. - 1359-5997 .- 1871-6873. ; 56:9
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Tidskriftsartikel (refereegranskat)abstract
- The recommendation is based on the co-authors’ work organized by the RILEM TC 256-SPF “Spalling of concrete due to fire: testing and modelling”. The Committee has defined two types of screening tests for characterization of concrete propensity to fire spalling: Material screening tests and Product screening tests. Definitions of both types of tests are given in the paper. The following recommendations apply to Material screening tests. The material screening tests described in these recommendations are a set of minimum requirements to test concrete spalling propensity (for example, the minimal specimen size). This document covers the aspects of concrete characterization, specimen geometries, storage conditions, test methods and measured parameters.
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| 14. |
-
Preface
- 2022
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Proceedings (redaktörskap) (övrigt vetenskapligt/konstnärligt)
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| 15. |
- Rizoska, Biljana, et al.
(författare)
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Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice
- 2024
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Ingår i: Molecular and Cellular Neuroscience. - : Elsevier. - 1044-7431 .- 1095-9327. ; 130
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Tidskriftsartikel (refereegranskat)abstract
- Amyloid beta (Aβ) peptides, which aggregate to form neocortical plaques in Alzheimer's disease, exist in states that range from soluble monomers and oligomers/protofibrils to insoluble fibrillar amyloid. The present study evaluated the effects of mAb158, a mouse monoclonal antibody version of lecanemab that preferentially binds to soluble Aβ protofibrils, in aged transgenic mice (Tg2576) with Aβ pathology. Female Tg2576 mice (12 months old) received weekly intraperitoneal mAb158 (35 mg/kg) or vehicle for 4 weeks or for 18 weeks, with or without a subsequent 12-week off-treatment period. Aβ protofibril levels were significantly lower in mAb158-treated animals at both 4 and 18 weeks, while longer treatment duration (18 weeks) was required to observe significantly lower Aβ42 levels in insoluble brain fractions and lower Aβ plaque load. Following the off-treatment period, comparison of the vehicle- and mAb158-treated mice demonstrated that the Aβ protofibril levels, insoluble Aβ42 levels and Aβ plaque load remained significantly lower in mAb158-treated animals, as compared with age-matched controls. However, there was a significant increase of brain accumulation of both the Aβ protofibril levels, insoluble Aβ42 levels and Aβ plaque load after treatment cessation. Thus, repeated mAb158 treatment of aged Tg2576 mice first reduced Aβ protofibril levels within 4 weeks of treatment, which then was followed by a reduction of amyloid plaque pathology within 18 weeks of treatment. These effects were maintained 12 weeks after the final dose, indicating that mAb158 had a disease-modifying effect on the Aβ pathology in this mouse model. In addition, brain accumulation of both Aβ protofibril levels and amyloid pathology progressed after discontinuation of the treatment which supports the importance of continued treatment with mAb158 to maintain the effects on Aβ pathology.
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| 16. |
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| 17. |
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| 18. |
- Rudman, Ann, et al.
(författare)
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Sjuksköterskor i frontlinjen av COVID-19 pandemin : vilka blev konsekvenserna? Teknisk rapport om enkät och datainsamling
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport summerar datainsamlingen som genomfördes av SCB (Statistiska centralbyrån) i projektet ”Sjuksköterskor i frontlinjen av COVID-19 pandemin: Vilka blev konsekvenserna?”. Projektet är finansierat av AFA försäkring (Diarienr 200311). I kapitel 1 beskrivs bakgrund till LUST (Longitudinell Undersökning om Sjuksköterskors Tillvaro) studien. I kapitel 2 beskrivs studien utifrån design, rekrytering och datainsamling. I kapitel 3 redovisas översikt över innehållet i enkäten som skickades ut studiedeltagarna. Projektet bedrivs på Högskolan Dalarna och inom ramen för Petter Gustavssons forskargrupp vid Karolinska Institutet.Sjuksköterskor har varit i frontlinjen av COVID-19-pandemin och de stressorer som de utsatts för i sitt arbete inom hälso- och sjukvården kan orsaka hälsoproblem. I föreliggande projekt har en nationell kartläggning av sjuksköterskors arbetssituation och hälsa under COVID-19 pandemin gjorts. Undersökningen är gjord utifrån de tre sjuksköterskekohorter som följts inom ramen för LUST-studien sedan 2002 (Gustavsson et al., 2013; Rudman, Hörberg, et al., 2020; Rudman et al., 2010). I LUST-studien har närmare 4500 sjuksköterskestudenter följts med uppföljande enkäter från deras utbildningstid 11 till 15 år efter examen. En uppföljande enkätundersökning genomfördes i september 2021 till januari 2022 vilket motsvarar 15 till 19 år efter examen. En speciellt anpassad enkät med relevans och aktualitet för arbetet under pandemin hade utvecklats gemensamt med forskare som har expertis gällande sjuksköterskor i olika verksamheter som belastats under COVID-19 pandemin. Enkäterna besvarades när pandemin pågått i ungefär ett år och nio månader.I samarbete med SCB har datainsamlingen genomförts som en postenkät med påminnelser och med möjlighet att besvara frågorna online. Svarsfrekvensen för enkätstudien blev 57% för hela undersökningen (för samtliga kohorter), vilket bedöms vara en hög svarsfrekvens med tanke på hur belastad sjuksköterskekåren har varit under COVID-19 pandemin.
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| 19. |
- Rudman, Ann, et al.
(författare)
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The use of the evidence-based practice process by experienced registered nurses to inform and transform clinical practice during the COVID-19 pandemic : A longitudinal national cohort study
- 2024
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Ingår i: Worldviews on Evidence-Based Nursing. - : John Wiley and Sons Inc. - 1545-102X .- 1741-6787. ; 21:1, s. 14-22
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Tidskriftsartikel (refereegranskat)abstract
- Background: During the COVID-19 pandemic, many registered nurses (RNs) worked on the frontline caring for severely ill patients. They did so with limited knowledge of how to treat and prevent the disease. This extreme situation puts pressure on RNs to find evidence on which to base the care of their patients. Aims: To examine: (1) the extent to which evidence-based practice (EBP) process was applied by Swedish RN cohorts 15–19 years after graduation during the pandemic, (2) whether there was any change to their EBP process from pre-pandemic to late pandemic, (3) the relationship between RNs' use of the EBP process and the duration of exposure to work situations severely affected by the COVID-19 pandemic, and (4) whether level of education, position and care setting were associated with the extent of RNs' EBP process. Methods: In 2021, the level of EBP activities was investigated among 2237 RNs 15–19 years after graduation. The scale used to measure EBP consisted of six items of the EBP process. Unpaired t-tests or one-way analysis of variance (ANOVA) were used in the analysis. Results: RNs used the EBP process to a moderate extent to inform and transform their clinical practice. There was a minor but significant decrease in practicing the EBP process from pre-pandemic to late in the pandemic. RNs who were most affected by the pandemic scored higher on the scale than less-affected colleagues. RNs in nonclinical positions reported more EBP activities, as did RNs in management positions. RNs working in outpatient settings reported more EBP activities than their colleagues in hospitals. Linking Evidence to Action: It is imperative that RNs hone their skills in EBP if they are to be prepared for future healthcare crises. Healthcare providers have a duty to facilitate the development of EBP and, in this regard, RNs in clinical positions in hospitals need particular support. © 2023 The Authors. Worldviews on Evidence-based Nursing published by Wiley Periodicals LLC on behalf of Sigma Theta Tau International.
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| 20. |
- Sjöström, Johan, et al.
(författare)
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Large scale exposure of fires to facade - Initial testing of proposed European method
- 2021
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This report describes a series of tests of the new proposed method for assessing the performance of façades when exposed to flashover fires. The tests consider the large fire exposure and consists of the 8.5 meter high incombustible walls placed in a 90° angle towards each other. The report assesses reproducibility and the effect of moisture content, stick size, wind and depth of the combustion chamber.The data from the report will be publicly available at the project website for further use and scrutiny. https://www.ri.se/en/what-we-do/projects/finalisation-of-the-european-approach-to-assess-the-fire-performance-of-facades
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| 21. |
- Vestin, Erika, et al.
(författare)
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Herpes simplex viral infection doubles the risk of dementia in a contemporary cohort of older adults : a prospective study
- 2024
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Ingår i: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 97:4, s. 1841-1850
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Tidskriftsartikel (refereegranskat)abstract
- Background: Evidence indicates that herpes simplex virus (HSV) participates in the pathogenesis of Alzheimer’s disease (AD).Objective: We investigated AD and dementia risks according to the presence of herpesvirus antibodies in relation to anti-herpesvirus treatment and potential APOE ε4 carriership interaction.Methods: This study was conducted with 1002 dementia-free 70-year-olds living in Sweden in 2001–2005 who were followed for 15 years. Serum samples were analyzed to detect anti-HSV and anti-HSV-1 immunoglobulin (Ig) G, anti-cytomegalovirus (CMV) IgG, anti-HSV IgM, and anti-HSV and anti-CMV IgG levels. Diagnoses and drug prescriptions were collected from medical records. Cox proportional-hazards regression models were applied.Results: Cumulative AD and all-cause dementia incidences were 4% and 7%, respectively. Eighty-two percent of participants were anti-HSV IgG carriers, of whom 6% received anti-herpesvirus treatment. Anti-HSV IgG was associated with a more than doubled dementia risk (fully adjusted hazard ratio = 2.26, p = 0.031). No significant association was found with AD, but the hazard ratio was of the same magnitude as for dementia. Anti-HSV IgM and anti-CMV IgG prevalence, anti-herpesvirus treatment, and anti-HSV and -CMV IgG levels were not associated with AD or dementia, nor were interactions between anti-HSV IgG and APOE ε4 or anti-CMV IgG. Similar results were obtained for HSV-1.Conclusions: HSV (but not CMV) infection may be indicative of doubled dementia risk. The low AD incidence in this cohort may have impaired the statistical power to detect associations with AD.
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| 22. |
- Vestin, Erika, et al.
(författare)
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Herpes Simplex Viral Infection Doubles the Risk of Dementia in a Contemporary Cohort of Older Adults : A Prospective Study
- 2024
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Ingår i: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 97:4, s. 1841-1850
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Tidskriftsartikel (refereegranskat)abstract
- Background: Evidence indicates that herpes simplex virus (HSV) participates in the pathogenesis of Alzheimer's disease (AD). Objective: We investigated AD and dementia risks according to the presence of herpesvirus antibodies in relation to antiherpesvirus treatment and potential APOE epsilon 4 carriership interaction. Methods: This studywas conducted with 1002 dementia-free 70-year-olds living in Sweden in 2001-2005 who were followed for 15 years. Serum samples were analyzed to detect anti-HSV and anti-HSV-1 immunoglobulin (Ig) G, anti-cytomegalovirus (CMV) IgG, anti-HSV IgM, and anti-HSV and anti-CMV IgG levels. Diagnoses and drug prescriptions were collected from medical records. Cox proportional-hazards regression models were applied. Results: CumulativeADand all-cause dementia incidences were 4% and 7%, respectively. Eighty-two percent of participants were anti-HSV IgG carriers, of whom 6% received anti-herpesvirus treatment. Anti-HSV IgG was associated with a more than doubled dementia risk (fully adjusted hazard ratio = 2.26, p = 0.031). No significant association was found with AD, but the hazard ratio was of the same magnitude as for dementia. Anti-HSV IgM and anti-CMV IgG prevalence, anti-herpesvirus treatment, and anti-HSV and -CMV IgG levels were not associated with AD or dementia, nor were interactions between anti-HSV IgG and APOE epsilon 4 or anti-CMV IgG. Similar results were obtained for HSV-1. Conclusions: HSV (but not CMV) infection may be indicative of doubled dementia risk. The low AD incidence in this cohort may have impaired the statistical power to detect associations with AD.
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| 23. |
- Weick, Linn, 1991, et al.
(författare)
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Patient experience of implant loss after immediate breast reconstruction : An interpretative phenomenological analysis
- 2023
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Ingår i: Health Care for Women International. - : Taylor & Francis Group. - 0739-9332 .- 1096-4665. ; 44:1, s. 61-79
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Tidskriftsartikel (refereegranskat)abstract
- Immediate breast reconstruction (IBR) is an integral part of modern breast cancer treatment. Our aim was to investigate patient experience with implant loss after IBR by using interpretative phenomenological analysis (IPA). We conducted semi-structured interviews with eight informants. We analyzed data according to the IPA flexible seven-stage process and four main themes were developed: immediate breast reconstruction as the indisputable choice, a difficult experience, an altered body: redefining normality, and trying to cope. The experience of implant loss appears to affect women for many years and might overshadow some of the benefits of IBR.
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| 24. |
- Werner, Hugo, et al.
(författare)
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Evaluating Different Approaches to Calibrating Conformal Predictive Systems
- 2020
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Ingår i: Proceedings of the 9th Symposium on Conformal and Probabilistic Prediction and Applications, COPA 2020. - : ML Research Press. ; , s. 134-150
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Konferensbidrag (refereegranskat)abstract
- Conformal predictive systems (CPSs) provide probability distributions for real-valued labels of test examples, rather than point predictions (as output by regular regression models) or confidence intervals (as output by conformal regressors). The performance of a CPS is dependent on both the underlying model and the way in which the quality of its predictions is estimated; a stronger underlying model and a better quality estimation can significantly improve the performance. Recent studies have shown that conformal regressors that use random forests as the underlying model may benefit from using out-of-bag predictions for the calibration, rather than setting aside a separate calibration set, allowing for more data to be used for training and thereby improving the performance of the underlying model. These studies have furthermore shown that the quality of the individual predictions can be effectively estimated using the variance of the predictions or by k-nearest-neighbor models trained on the prediction errors. It is here investigated whether these methods are also effective in the context of split conformal predictive systems. Results from a large empirical study are presented, using 33 publicly available datasets. The results show that by using either variance or the k-nearest-neighbor method for estimating prediction quality, a significant increase in performance, as measured by the continuous ranked probability score, can be obtained compared to omitting the quality estimation. The results furthermore show that the use of out-of-bag examples for calibration is competitive with the most effective way of splitting training data into a proper training set and a calibration set, without requiring tuning of the calibration set size.
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| 25. |
- Werner, Hugo, et al.
(författare)
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Evaluation of Updating Strategies for Conformal Predictive Systems in the Presence of Extreme Events
- 2021
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Ingår i: Proceedings of the 10th Symposium on Conformal and Probabilistic Prediction and Applications, COPA 2021. - : ML Research Press. ; , s. 229-242
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Konferensbidrag (refereegranskat)abstract
- Six different strategies for updating split conformal predictive systems in an online (streaming) setting are evaluated. The updating strategies vary in the extent and frequency of retraining as well as in how training data is split into proper training and calibration sets. An empirical evaluation is presented, considering passenger booking data from a ferry company, which stretches over a number of years. The passenger volumes have changed drastically during 2020 due to COVID-19 and part of the evaluation is focusing on which updating strategies work best under such circumstances. Some strategies are observed to outperform others with respect to continuous ranked probability score and validity, highlighting the potential value of choosing a proper strategy.
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| 26. |
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