| 1. |
- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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| 2. |
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| 3. |
- Yang, W., et al.
(författare)
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Immunogenic neoantigens derived from gene fusions stimulate T cell responses
- 2019
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Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 25:5
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Tidskriftsartikel (refereegranskat)abstract
- Anti-tumor immunity is driven by self versus non-self discrimination. Many immunotherapeutic approaches to cancer have taken advantage of tumor neoantigens derived from somatic mutations. Here, we demonstrate that gene fusions are a source of immunogenic neoantigens that can mediate responses to immunotherapy. We identified an exceptional responder with metastatic head and neck cancer who experienced a complete response to immune checkpoint inhibitor therapy, despite a low mutational load and minimal pre-treatment immune infiltration in the tumor. Using whole-genome sequencing and RNA sequencing, we identified a novel gene fusion and demonstrated that it produces a neoantigen that can specifically elicit a host cytotoxic T cell response. In a cohort of head and neck tumors with low mutation burden, minimal immune infiltration and prevalent gene fusions, we also identified gene fusion-derived neoantigens that generate cytotoxic T cell responses. Finally, analyzing additional datasets of fusion-positive cancers, including checkpoint-inhibitor-treated tumors, we found evidence of immune surveillance resulting in negative selective pressure against gene fusion-derived neoantigens. These findings highlight an important class of tumor-specific antigens and have implications for targeting gene fusion events in cancers that would otherwise be less poised for response to immunotherapy, including cancers with low mutational load and minimal immune infiltration.
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| 4. |
- Bouvier, Vera, et al.
(författare)
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Distribution, genesis and annual-origin of De Geer moraines in Sweden: insights revealed by LiDAR
- 2015
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Ingår i: GFF. - : Informa UK Limited. - 1103-5897 .- 2000-0863. ; 137:4, s. 319-333
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Tidskriftsartikel (refereegranskat)abstract
- Abstract: De Geer moraines (DGMs) were first identified in Sweden by Gerard De Geer in 1889 and have been mapped since then in many parts of Sweden. Using airborne Light Detection and Ranging (LiDAR) data, we have mapped DGMs over the entire country, and we show that they occur predominantly in two distinct areas: in south-central Sweden north of the Middle Swedish end-moraine zone and in northeast Sweden. DGM formation occurs predominantly where the local relief is low, the ice-margin retreat rate was high and the sedimentation rate low. Formation of DGMs occurred over short time spans of a few hundred years – between 11 500 and 11 000 cal years BP for the southern group and from 10 700 and 9900 cal years BP for the DGMs in the north. DGMs have been suggested to be made by a number of processes at subaquatic ice margins, including pushing during winter readvance, squeezing into subglacial crevasses, deformation during calving events and deposition as subaquatic fans. Therefore, we recognize DGMs to be equifinal landforms, made by several related mechanisms. However, we observe that the most common occurrence of DGMs in Sweden are as regularly spaced even ridges below the highest shoreline whose spacing closely corresponds to independently determined ice-margin retreat rates. We therefore suggest that where regular evenly spaced DGMs occur, their spacing likely represents the local ice-margin retreat rate, and that the majority of these ridges were made annually by winter advances.
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| 8. |
- See, V., et al.
(författare)
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The energy budget of stellar magnetic fields
- 2015
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 453:4, s. 4301-4310
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Tidskriftsartikel (refereegranskat)abstract
- Spectropolarimetric observations have been used to map stellar magnetic fields, many of which display strong bands of azimuthal fields that are toroidal. A number of explanations have been proposed to explain how such fields might be generated though none are definitive. In this paper, we examine the toroidal fields of a sample of 55 stars with magnetic maps, with masses in the range 0.1-1.5M(circle dot). We find that the energy contained in toroidal fields has a power-law dependence on the energy contained in poloidal fields. However the power index is not constant across our sample, with stars less and more massive than 0.5M(circle dot) having power indices of 0.72 +/- 0.08 and 1.25 +/- 0.06, respectively. There is some evidence that these two power laws correspond to stars in the saturated and unsaturated regimes of the rotation-activity relation. Additionally, our sample shows that strong toroidal fields must be generated axisymmetrically. The latitudes at which these bands appear depend on the stellar rotation period with fast rotators displaying higher latitude bands than slow rotators. The results in this paper present new constraints for future dynamo studies.
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| 9. |
- Vaugoyeau, Marie, et al.
(författare)
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Interspecific variation in the relationship between clutch size, laying date and intensity of urbanization in four species of hole-nesting birds
- 2016
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Ingår i: Ecology and Evolution. - : Wiley. - 2045-7758. ; 6:16, s. 5907-5920
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Tidskriftsartikel (refereegranskat)abstract
- The increase in size of human populations in urban and agricultural areas has resulted in considerable habitat conversion globally. Such anthropogenic areas have specific environmental characteristics, which influence the physiology, life history, and population dynamics of plants and animals. For example, the date of bud burst is advanced in urban compared to nearby natural areas. In some birds, breeding success is determined by synchrony between timing of breeding and peak food abundance. Pertinently, caterpillars are an important food source for the nestlings of many bird species, and their abundance is influenced by environmental factors such as temperature and date of bud burst. Higher temperatures and advanced date of bud burst in urban areas could advance peak caterpillar abundance and thus affect breeding phenology of birds. In order to test whether laying date advance and clutch sizes decrease with the intensity of urbanization, we analyzed the timing of breeding and clutch size in relation to intensity of urbanization as a measure of human impact in 199 nest box plots across Europe, North Africa, and the Middle East (i.e., the Western Palearctic) for four species of hole-nesters: blue tits (Cyanistes caeruleus), great tits (Parus major), collared flycatchers (Ficedula albicollis), and pied flycatchers (Ficedula hypoleuca). Meanwhile, we estimated the intensity of urbanization as the density of buildings surrounding study plots measured on orthophotographs. For the four study species, the intensity of urbanization was not correlated with laying date. Clutch size in blue and great tits does not seem affected by the intensity of urbanization, while in collared and pied flycatchers it decreased with increasing intensity of urbanization. This is the first large-scale study showing a species-specific major correlation between intensity of urbanization and the ecology of breeding. The underlying mechanisms for the relationships between life history and urbanization remain to be determined. We propose that effects of food abundance or quality, temperature, noise, pollution, or disturbance by humans may on their own or in combination affect laying date and/or clutch size.
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| 10. |
- Zarb, M., et al.
(författare)
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An international investigation into student concerns regarding transition into higher education
- 2018
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Ingår i: ITiCSE 2018 Proceedings of the 23rd Annual ACM Conference on Innovation and Technology in Computer Science Education. - New York, NY, USA : Association for Computing Machinery (ACM). - 9781450357074 ; , s. 344-345
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Konferensbidrag (refereegranskat)abstract
- The experience of transitioning into and starting higher education is a very individual one, with some applicants viewing the prospect of higher education as an unknown entity; for those who are first in their family or community to consider higher education, this can seem an "alien environment". These are just some of the issues that lead to applicants experiencing levels of concern when considering a transition into higher education. This international working group proposes to consider concerns across a wide range of participants: namely students who are in the process of transitioning into a higher education environment, and students who have recently completed this transition.
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