| 1. |
- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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| 2. |
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| 3. |
- Yang, W., et al.
(författare)
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Immunogenic neoantigens derived from gene fusions stimulate T cell responses
- 2019
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Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 25:5
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Tidskriftsartikel (refereegranskat)abstract
- Anti-tumor immunity is driven by self versus non-self discrimination. Many immunotherapeutic approaches to cancer have taken advantage of tumor neoantigens derived from somatic mutations. Here, we demonstrate that gene fusions are a source of immunogenic neoantigens that can mediate responses to immunotherapy. We identified an exceptional responder with metastatic head and neck cancer who experienced a complete response to immune checkpoint inhibitor therapy, despite a low mutational load and minimal pre-treatment immune infiltration in the tumor. Using whole-genome sequencing and RNA sequencing, we identified a novel gene fusion and demonstrated that it produces a neoantigen that can specifically elicit a host cytotoxic T cell response. In a cohort of head and neck tumors with low mutation burden, minimal immune infiltration and prevalent gene fusions, we also identified gene fusion-derived neoantigens that generate cytotoxic T cell responses. Finally, analyzing additional datasets of fusion-positive cancers, including checkpoint-inhibitor-treated tumors, we found evidence of immune surveillance resulting in negative selective pressure against gene fusion-derived neoantigens. These findings highlight an important class of tumor-specific antigens and have implications for targeting gene fusion events in cancers that would otherwise be less poised for response to immunotherapy, including cancers with low mutational load and minimal immune infiltration.
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| 4. |
- See, V., et al.
(författare)
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The energy budget of stellar magnetic fields
- 2015
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 453:4, s. 4301-4310
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Tidskriftsartikel (refereegranskat)abstract
- Spectropolarimetric observations have been used to map stellar magnetic fields, many of which display strong bands of azimuthal fields that are toroidal. A number of explanations have been proposed to explain how such fields might be generated though none are definitive. In this paper, we examine the toroidal fields of a sample of 55 stars with magnetic maps, with masses in the range 0.1-1.5M(circle dot). We find that the energy contained in toroidal fields has a power-law dependence on the energy contained in poloidal fields. However the power index is not constant across our sample, with stars less and more massive than 0.5M(circle dot) having power indices of 0.72 +/- 0.08 and 1.25 +/- 0.06, respectively. There is some evidence that these two power laws correspond to stars in the saturated and unsaturated regimes of the rotation-activity relation. Additionally, our sample shows that strong toroidal fields must be generated axisymmetrically. The latitudes at which these bands appear depend on the stellar rotation period with fast rotators displaying higher latitude bands than slow rotators. The results in this paper present new constraints for future dynamo studies.
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| 5. |
- Bouvier, J., et al.
(författare)
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The Gaia-ESO Survey: A lithium-rotation connection at 5 Myr?
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 590
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Tidskriftsartikel (refereegranskat)abstract
- Context. The evolution of lithium abundance in cool dwarfs provides a unique probe of nonstandard processes in stellar evolution. Aims. We investigate the lithium content of young low-mass stars in the 5 Myr old, star forming region NGC 2264 and its relationship with rotation. Methods. We combine lithium equivalent width measurements (EW(Li)) from the Gaia-ESO Survey with the determination of rotational periods from the CSI 2264 survey. We only consider bona fide nonaccreting cluster members to minimize the uncertainties on EW(Li). Results. We report the existence of a relationship between lithium content and rotation in NGC 2264 at an age of 5 Myr. The Li-rotation connection is seen over a restricted temperature range (Teff = 3800-4400 K), where fast rotators are Li-rich compared to slow rotators. This correlation is similar to, albeit of lower amplitude than, the Li-rotation connection previously reported for K dwarfs in the 125 Myr old Pleiades cluster. We investigate whether the nonstandard pre-main-sequence models developed so far to explain the Pleiades results, which are based on episodic accretion, pre-main-sequence, core-envelope decoupling, and/or radius inflation due to enhanced magnetic activity, can account for early development of the Li-rotation connection. While radius inflation appears to be the most promising possibility, each of these models has issues. We therefore also discuss external causes that might operate during the first few Myr of pre-main-sequence evolution, such as planet engulfment and/or steady disk accretion, as possible candidates for the common origin for Li excess and fast rotation in young low-mass pre-main-sequence stars. Conclusions. The emergence of a connection between lithium content and rotation rate at such an early age as 5 Myr suggests a complex link between accretion processes, early angular momentum evolution, and possibly planet formation, which likely impacts early stellar evolution and has yet to be fully deciphered.
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| 6. |
- Villebrun, F., et al.
(författare)
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Magnetic fields of intermediate-mass T Tauri stars : I. Magnetic detections and fundamental stellar parameters
- 2019
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 622
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Tidskriftsartikel (refereegranskat)abstract
- Context. The origin of the fossil magnetic fields detected in 5 to 10% of intermediate-mass main sequence stars is still highly debated.Aims. We want to bring observational constraints to a large population of intermediate-mass pre-main sequence (PMS) stars in order to test the theory that convective-dynamo fields generated during the PMS phases of stellar evolution can occasionally relax into fossil fields on the main sequence.Methods. Using distance estimations, photometric measurements, and spectropolarimetric data from HARPSpol and ESPaDOnS of 38 intermediate-mass PMS stars, we determined fundamental stellar parameters (T-eff, L and v sin i) and measured surface magnetic field characteristics (including detection limits for non-detections, and longitudinal fields and basic topologies for positive detections). Using PMS evolutionary models, we determined the mass, radius, and internal structure of these stars. We compared different PMS models to check that our determinations were not model-dependant. We then compared the magnetic characteristics of our sample accounting for their stellar parameters and internal structures.Results. We detect magnetic fields in about half of our sample. About 90% of the magnetic stars have outer convective envelopes larger than similar to 25% of the stellar radii, and heavier than similar to 2% of the stellar mass. Going to higher mass, we find that the magnetic incidence in intermediate-mass stars drops very quickly, within a timescale on the order of few times 0.1 Myr. Finally, we propose that intermediate-mass T Tauri stars with large convective envelopes, close to the fully convective limit, have complex fields and that their dipole component strengths may decrease as the sizes of their convective envelopes decrease, similar to lower-mass T Tauri stars.
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| 7. |
- Zarb, M., et al.
(författare)
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An international investigation into student concerns regarding transition into higher education
- 2018
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Ingår i: ITiCSE 2018 Proceedings of the 23rd Annual ACM Conference on Innovation and Technology in Computer Science Education. - New York, NY, USA : Association for Computing Machinery (ACM). - 9781450357074 ; , s. 344-345
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Konferensbidrag (refereegranskat)abstract
- The experience of transitioning into and starting higher education is a very individual one, with some applicants viewing the prospect of higher education as an unknown entity; for those who are first in their family or community to consider higher education, this can seem an "alien environment". These are just some of the issues that lead to applicants experiencing levels of concern when considering a transition into higher education. This international working group proposes to consider concerns across a wide range of participants: namely students who are in the process of transitioning into a higher education environment, and students who have recently completed this transition.
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| 14. |
- Vaugoyeau, Marie, et al.
(författare)
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Interspecific variation in the relationship between clutch size, laying date and intensity of urbanization in four species of hole-nesting birds
- 2016
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Ingår i: Ecology and Evolution. - : Wiley. - 2045-7758. ; 6:16, s. 5907-5920
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Tidskriftsartikel (refereegranskat)abstract
- The increase in size of human populations in urban and agricultural areas has resulted in considerable habitat conversion globally. Such anthropogenic areas have specific environmental characteristics, which influence the physiology, life history, and population dynamics of plants and animals. For example, the date of bud burst is advanced in urban compared to nearby natural areas. In some birds, breeding success is determined by synchrony between timing of breeding and peak food abundance. Pertinently, caterpillars are an important food source for the nestlings of many bird species, and their abundance is influenced by environmental factors such as temperature and date of bud burst. Higher temperatures and advanced date of bud burst in urban areas could advance peak caterpillar abundance and thus affect breeding phenology of birds. In order to test whether laying date advance and clutch sizes decrease with the intensity of urbanization, we analyzed the timing of breeding and clutch size in relation to intensity of urbanization as a measure of human impact in 199 nest box plots across Europe, North Africa, and the Middle East (i.e., the Western Palearctic) for four species of hole-nesters: blue tits (Cyanistes caeruleus), great tits (Parus major), collared flycatchers (Ficedula albicollis), and pied flycatchers (Ficedula hypoleuca). Meanwhile, we estimated the intensity of urbanization as the density of buildings surrounding study plots measured on orthophotographs. For the four study species, the intensity of urbanization was not correlated with laying date. Clutch size in blue and great tits does not seem affected by the intensity of urbanization, while in collared and pied flycatchers it decreased with increasing intensity of urbanization. This is the first large-scale study showing a species-specific major correlation between intensity of urbanization and the ecology of breeding. The underlying mechanisms for the relationships between life history and urbanization remain to be determined. We propose that effects of food abundance or quality, temperature, noise, pollution, or disturbance by humans may on their own or in combination affect laying date and/or clutch size.
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| 15. |
- Wickerts, L, et al.
(författare)
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Monitoring respiration and oxygen saturation in patients during the first night after elective bariatric surgery: A cohort study
- 2017
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Ingår i: F1000Research. - : F1000 Research Ltd. - 2046-1402. ; 6, s. 735-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Obstructive sleep apnoea and obese hypoventilation is not uncommon in patients with obesity. Residuals effect from surgery/anaesthesia and opioid analgesics may worsen respiration during the first nights after bariatric surgery. The aim of this observational study was to monitor respiration on the first postoperative night following elective bariatric surgery. Methods: This observational study aimed to determine the incidence and severity of hypo/apnoea in low risk obsess patients undergoing elective bariatric surgery in general anesthaesia. Patients with known or suspected sleep respiratory disturbances was not included. ESS was scored prior to surgery. Oxygen desaturation was analyzed by continuous respiratory monitoring. Mean oxygen saturation (SpO2), nadir SPo2, apnoea/hypopnea index and oxygen desaturation index was assess by standard tools. Results: 45 patients were monitored with portable polygraphy equipment (Embletta, ResMed) during the first postoperative night at the general ward following elective laparoscopic bariatric surgery. The prop ESS was 0-5 in 22, 6-10 in 14 and 11-16 in 6 of the patients studied (missing data 3). Mean SpO2 was 93%; 10 patients had a mean SpO2 of less than 92% and 4 of less than 90%. The lowest mean SpO2 was 87%. There were 16 patients with a nadir SpO2 of less than 85%, lowest nadir SpO2 being 63%. An Apnoea Hypo/apnoea Index (AHI) > 5 was found in 2 patients only (AHI 10 and 6), and an Oxygen Desaturation index (ODI) > 5 was found in 3 patients (24, 10 and 6, respectively). 3 patients had more prolonged (> 30 seconds) apnoea with nadir SpO2 81%, 83% and 86%. ESS score and type of surgery did not impact on respiration/oxygenation during the observation period. Conclusions: A low mean SpO2 and episodes of desaturation were not uncommon during the first postoperative night following elective bariatric surgery in patients without history of night time breathing disturbance. AHI and/or ODI of more than 5 were only rarely seen. Night-time respiration monitoring provided seemingly sparse additional information. Further studies are need to assess risk factors and potential impact of the desaturation episodes that occurs during sleep.
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