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- Abbate, F, et al.
(författare)
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Prolonged force increase following a high-frequency burst is not due to a sustained elevation of [Ca2+]i
- 2002
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Ingår i: American journal of physiology. Cell physiology. - : American Physiological Society. - 0363-6143 .- 1522-1563. ; 283:1, s. C42-C47
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Tidskriftsartikel (refereegranskat)abstract
- A brief high-frequency burst of action potentials results in a sustained force increase in skeletal muscle. The present study investigates whether this force potentiation is the result of a sustained increase of the free myoplasmic [Ca2+] ([Ca2+]i). Single fibers from mouse flexor brevis muscles were stimulated with three impulses at 150 Hz (triplet) at the start of a 350-ms tetanus or in the middle of a 700-ms tetanus; the stimulation frequency of the rest of the tetanus ranged from 20 to 60 Hz. After the triplet, force was significantly ( P < 0.05) increased between 17 and 20% when the triplet was given at the start of the tetanus and between 5 and 18% when the triplet was given in the middle ( n = 7). However, during this potentiation, [Ca2+]iwas not consistently increased. Hence, the increased force following a high-frequency burst is likely due to changes in the myofibrillar properties.
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