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- Saenger, A. K., et al.
(författare)
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Multicenter analytical evaluation of a high-sensitivity troponin T assay
- 2011
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Ingår i: Clinica Chimica Acta. - : Elsevier BV. - 0009-8981 .- 1873-3492. ; 412:9-10, s. 748-754
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Tidskriftsartikel (refereegranskat)abstract
- Background: High-sensitivity cardiac troponin assays are being introduced clinically for earlier diagnosis of acute myocardial infarction (AMI). We evaluated the analytical performance of a high-sensitivity cardiac troponin T assay (hscTnT. Roche Diagnostics) in a multicenter, international trial. Methods: Three US and 5 European sites evaluated hscTnT on the Modular (R) Analytics E170, cobas (R) 6000, Elecsys 2010, and cobas (R) e 411. Precision, accuracy, reportable range, an inter-laboratory comparison trial, and the 99th percentile of a reference population were assessed. Results: Total imprecision (CVs) were 4.6-36.8% between 3.4 and 10.3 ng/L hscTnT. Assay linearity was up to 10,000 ng/L and the limit of blank and detection were 3 and 5 ng/L, respectively. The 99th percentile reference limit was 14.2 ng/L (n = 533). No significant differences between specimen types, assay incubation time, or reagent lots existed. A substantial positive bias (76%) exists between the 4th generation and hscTnT assays at the low end of the measuring range (< 50 ng/L). hscTnT serum pool concentrations were within 2SD limits of the mean of means in the comparison trial, indicating comparable results across multiple platforms and laboratories. Conclusion: The Roche hscTnT assay conforms to guideline precision requirements and will likely identify additional patients with myocardial injury suspicious for AMI.
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| 2. |
- Bergstroem, Stig M., et al.
(författare)
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Lower Katian (Upper Ordovician) delta(13)C chemostratigraphy, global correlation and sea-level changes in Baltoscandia
- 2011
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Ingår i: GFF. - : Informa UK Limited. - 2000-0863 .- 1103-5897. ; 133:1-2, s. 31-47
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Tidskriftsartikel (refereegranskat)abstract
- A long-standing problem in the Ordovician stratigraphy of south-eastern Norway has been to the relations between the Mjosa Formation in the Lake Mjosa region and coeval strata in the Oslo region. The recent discovery of the globally distributed Guttenberg delta(13)C excursion (Guttenberg Isotopic Carbon Excursion) in the Mjosa region provided the impetus to search for this excellent chemostratigraphic marker in the classical Oslo region succession, where it was found in the Frognerkilen Formation. Another positive delta(13)C excursion, which we identify as the Kope excursion, was discovered in the Solvang Formation. The new data show that the lower Katian delta(13)C chemostratigraphy in the Oslo region is closely similar to that from south-eastern and southern Estonia. This permits detailed correlations across Baltoscandia, which are useful for recognising the Baltic stage boundaries in the Oslo region succession. Both the Lake Mjosa and Oslo regions study successions can be chemostratigraphically correlated with those in North America and eastern Asia. The newly established stratigraphic relations in the Oslo region are also used for a re-assessment of lower Katian local and eustatic sea-level changes.
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| 3. |
- Bergstroem, Stig M., et al.
(författare)
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The delta C-13 chemostratigraphy of the Upper Ordovician Mjosa Formation at Furuberget near Hamar, southeastern Norway: Baltic, Trans-Atlantic, and Chinese relations
- 2010
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Ingår i: Norsk Geologisk Tidsskrift. - 1502-5322. ; 90:1-2, s. 65-78
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Tidskriftsartikel (refereegranskat)abstract
- Whereas no studies have previously been carried out on the delta C-13 chemostratigraphy of the Sandbian-Katian (Upper Ordovician) succession anywhere in Norway, such investigations in Sweden and the East Baltic region have made the delta C-13 chemostratigraphy of that interval well known. 1 an attempt to document for the first time the presence of the globally distributed and stratigraphically important Guttenberg Carbon Isotope Excursion (GICE), 45 samples were collected at 2 m intervals through the Furnesfjorden and Galas members of the Mjosa Formation from two sections at Furuberget in the Nes-Hamar District 70 km north of the City of Oslo. Relatively high delta C-13 values, which are interpreted to represent the GICE, were obtained throughout the Galls Member. The presence of this delta C-13 excursion in the middle part of the Mjosa Formation, combined with biostratigraphic and other evidence, are used for detailed correlations of the Mjosa Formation with other successions in Baltoscandia, North America, and on the Yangtze Platform in southern China.
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