| 1. |
- Altstadt, S.G., et al.
(författare)
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B-13,B-14(n,gamma) via Coulomb Dissociation for Nucleosynthesis towards the r-Process
- 2014
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Ingår i: Nuclear Data Sheets. - : Elsevier BV. - 1095-9904 .- 0090-3752. ; 120, s. 197-200
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Konferensbidrag (refereegranskat)abstract
- Radioactive beams of 14,15B produced by fragmentation of a primary 40Ar beam were directed onto a Pb target to investigate the neutron breakup within the Coulomb field. The experiment was performed at the LAND/R3B setup. Preliminary results for the Coulomb dissociation cross sections as well as for the astrophysically interesting inverse reactions, 13,14B(n,γ), are presented.
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| 2. |
- Caesar, C., et al.
(författare)
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Beyond the neutron drip line: The unbound oxygen isotopes O-25 and O-26
- 2013
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Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993 .- 0556-2813. ; 88:3
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Tidskriftsartikel (refereegranskat)abstract
- The very neutron-rich oxygen isotopes O-25 and O-26 are investigated experimentally and theoretically. The unbound states are populated in an experiment performed at the R3B-LAND setup at GSI via proton-knockout reactions from F-26 and F-27 at relativistic energies around 442 and 414 MeV/nucleon, respectively. From the kinematically complete measurement of the decay into O-24 plus one or two neutrons, the O-25 ground-state energy and width are determined, and upper limits for the O-26 ground-state energy and lifetime are extracted. In addition, the results provide indications for an excited state in O-26 at around 4 MeV. The experimental findings are compared to theoretical shell-model calculations based on chiral two- and three-nucleon (3N) forces, including for the first time residual 3N forces, which are shown to be amplified as valence neutrons are added.
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| 3. |
- Craddock, Nick, et al.
(författare)
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Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
- 2010
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7289, s. 713-720
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Tidskriftsartikel (refereegranskat)abstract
- Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic susceptibility to common disease. To address this we undertook a large, direct genome-wide study of association between CNVs and eight common human diseases. Using a purpose-designed array we typed,19,000 individuals into distinct copy-number classes at 3,432 polymorphic CNVs, including an estimated similar to 50% of all common CNVs larger than 500 base pairs. We identified several biological artefacts that lead to false-positive associations, including systematic CNV differences between DNAs derived from blood and cell lines. Association testing and follow-up replication analyses confirmed three loci where CNVs were associated with disease-IRGM for Crohn's disease, HLA for Crohn's disease, rheumatoid arthritis and type 1 diabetes, and TSPAN8 for type 2 diabetes-although in each case the locus had previously been identified in single nucleotide polymorphism (SNP)-based studies, reflecting our observation that most common CNVs that are well-typed on our array are well tagged by SNPs and so have been indirectly explored through SNP studies. We conclude that common CNVs that can be typed on existing platforms are unlikely to contribute greatly to the genetic basis of common human diseases.
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| 4. |
- Uberseder, E., et al.
(författare)
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First Experimental Constraint on the Fe-59(n, gamma)Fe-60 Reaction Cross Section at Astrophysical Energies via the Coulomb Dissociation of Fe-60
- 2014
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 112:21
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Tidskriftsartikel (refereegranskat)abstract
- The radionuclide Fe-60 has been of great interest to the nuclear astrophysics community for over a decade. An initial discrepancy between the observed and modeled Galactic Fe-60/Al-26 ratio motivated numerous studies focused on the nucleosynthesis of these two isotopes, though the cross section of the primary astrophysical production reaction, Fe-59(n,gamma)Fe-60, has remained purely theoretical. The present work offers a first experimental constraint on the Fe-59(n,gamma)Fe-60 cross section at astrophysical energies, obtained indirectly via Coulomb dissociation, and demonstrates that the theoretical reaction rates used in present stellar models are not highly erroneous.
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| 5. |
- Chakraborty, S., et al.
(författare)
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Ground-state configuration of neutron-rich Aluminum isotopes through Coulomb breakup
- 2014
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Ingår i: EPJ Web of Conferences. - : EDP Sciences. - 2101-6275 .- 2100-014X. ; 66
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Konferensbidrag (refereegranskat)abstract
- Neutron-rich 34,35Al isotopes have been studied through Coulomb excitation using LAND-FRS setup at GSI, Darmstadt. The method of invariant mass analysis has been used to reconstruct the excitation energy of the nucleus prior to decay. Comparison of experimental CD cross-section with direct breakup model calculation with neutron in p3/2 orbital favours 34Al(g.s) - νp3/2 as ground state configuration of 35Al. But ground state configuration of 34Al is complicated as evident from γ-ray spectra of 33Al after Coulomb breakup of 34Al. © Owned by the authors, published by EDP Sciences, 2014.
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| 6. |
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| 7. |
- Rahaman, A., et al.
(författare)
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Study of ground state wave-function of the Neutron-rich 29,30Na isotopes through coulomb breakup
- 2014
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Ingår i: EPJ Web of Conferences. - : EDP Sciences. - 2101-6275 .- 2100-014X. ; 66
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Konferensbidrag (refereegranskat)abstract
- Coulomb breakup of unstable neutron rich nuclei 29,30Na around the 'island of inversion' has been studied at energy around 434 MeV/nucleon and 409 MeV/nucleon respectively. Four momentum vectors of fragments, decay neutron from excited projectile and γ-rays emitted from excited fragments after Coulomb breakup are measured in coincidence. For these nuclei, the low-lying dipole strength above one neutron threshold can be explained by direct breakup model. The analysis for Coulomb breakup of 29,30Na shows that large amount of the cross section yields the 28Na, 29Na core in ground state. The predominant ground-state configuration of 29,30Na is found to be 28Na(g.s) νs1/2 and 29Na(g.s) νs1/2,respectively. © Owned by the authors, published by EDP Sciences, 2014.
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| 8. |
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| 9. |
- Aksyutina, Y., et al.
(författare)
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Momentum profile analysis in one-neutron knockout from Borromean nuclei
- 2013
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 718:4-5, s. 1309-1313
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Tidskriftsartikel (refereegranskat)abstract
- One-neutron knockout reactions from Borromean nuclei are analyzed using a profile function analysis technique. The profile function, which is derived as the square root of the variance of the measured fragment + neutron momenta as a function of their relative energy, is shown to be very sensitive to the angular momentum of the knocked out neutron. Three cases are studied here: He-7, where the profile function analysis shows a presence of (s(1/2))(2) component in the He-8 ground-state wave-function, Li-10, where the presence of a 11(2)% d-wave contribution to the relative energy spectrum above 1.5 MeV is found and, finally, the presence of a major s contribution around 0.5 MeV relative energy in the Be-13 case and that the observed decay to the Be-12 2(+) state originates in a d state in Be-13.
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| 10. |
- Aksyutina, Y., et al.
(författare)
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Structure of the unbound nucleus Be-13: One-neutron knockout reaction data from Be-14 analyzed in a holistic approach
- 2013
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Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 87:6
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Tidskriftsartikel (refereegranskat)abstract
- At the ALADIN-LAND setup at GSI the unbound nucleus Be-13 has been produced in one-neutron knockout reactions from a 304 MeV/nucleon relativistic beam of Be-14 ions impinging on a liquid hydrogen target. An analysis of the data including all available information about Be-13, and in particular recent data from a similar experiment performed at RIKEN, has been performed. A consistent description is reached. It is found that the excitation spectrum is dominated by s-waves at low energy, which solves problems from previous seemingly contradictory interpretations. A possible interference between two s-states in Be-13 is also discussed. The results indicate that the ground-state wave function of Be-14 is dominated by valence neutrons in the s-shell contributing with 60-75% of the total neutron knockout cross section.
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| 11. |
- Aksyutina, Y., et al.
(författare)
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Study of the Be14 continuum: Identification and structure of its second 2+ state
- 2013
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 111:24, s. article nr. 242501-
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Tidskriftsartikel (refereegranskat)abstract
- The coupling between bound quantum states and those in the continuum is of high theoretical interest. Experimental studies of bound drip-line nuclei provide ideal testing grounds for such investigations since they, due to the feeble binding energy of their valence particles, are easy to excite into the continuum. In this Letter, continuum states in the heaviest particle-stable Be isotope, Be14, are studied by employing the method of inelastic proton scattering in inverse kinematics. New continuum states are found at excitation energies E*=3.54(16) MeV and E*=5.25(19) MeV. The structure of the earlier known 21+ state at 1.54(13) MeV was confirmed with a predominantly (0d5/2)2 configuration while there is very clear evidence that the 22+ state has a predominant (1s1/2, 0d 5/2) structure with a preferential three-body decay mechanism. The region at about 7 MeV excitation shows distinct features of sequential neutron decay via intermediate states in Be13. This demonstrates that the increasing availability of energetic beams of exotic nuclei opens up new vistas for experiments leading towards a new understanding of the interplay between bound and continuum states. © 2013 American Physical Society.
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| 12. |
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| 13. |
- Everard, A., et al.
(författare)
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Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status
- 2014
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 5:5648
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is associated with a cluster of metabolic disorders, low-grade inflammation and altered gut microbiota. Whether host metabolism is controlled by intestinal innate immune system and the gut microbiota is unknown. Here we report that inducible intestinal epithelial cell-specific deletion of MyD88 partially protects against diet-induced obesity, diabetes and inflammation. This is associated with increased energy expenditure, an improved glucose homeostasis, reduced hepatic steatosis, fat mass and inflammation. Protection is transferred following gut microbiota transplantation to germ-free recipients. We also demonstrate that intestinal epithelial MyD88 deletion increases anti-inflammatory endocannabinoids, restores antimicrobial peptides production and increases intestinal regulatory T cells during diet-induced obesity. Targeting MyD88 after the onset of obesity reduces fat mass and inflammation. Our work thus identifies intestinal epithelial MyD88 as a sensor changing host metabolism according to the nutritional status and we show that targeting intestinal epithelial MyD88 constitutes a putative therapeutic target for obesity and related disorders.
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| 14. |
- Roeder, M., et al.
(författare)
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Efficiency determination of resistive plate chambers for fast quasi-monoenergetic neutrons
- 2014
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Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 50:7
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Tidskriftsartikel (refereegranskat)abstract
- Composite detectors made of stainless-steel converters and multigap resistive plate chambers have been irradiated with quasi-monoenergetic neutrons with a peak energy of 175 MeV. The neutron detection efficiency has been determined using two different methods. The data are in agreement with the output of Monte Carlo simulations. The simulations are then extended to study the response of a hypothetical array made of these detectors to energetic neutrons from a radioactive ion beam experiment.
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