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- Bråkenhielm, E, et al.
(författare)
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Lymphatics in the broken heart
- 2021
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Ingår i: The Journal of clinical investigation. - 1558-8238. ; 131:20
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Tidskriftsartikel (refereegranskat)
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3. |
- Brakenhielm, E, et al.
(författare)
-
Lymphatics in the broken heart
- 2021
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Ingår i: The Journal of clinical investigation. - 1558-8238. ; 131:20
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Tidskriftsartikel (refereegranskat)
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- Pang, JJ, et al.
(författare)
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Efficacy and tolerability of bevacizumab in patients with severe Covid-19
- 2021
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 814-
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Tidskriftsartikel (refereegranskat)abstract
- On the basis of Covid-19-induced pulmonary pathological and vascular changes, we hypothesize that the anti-vascular endothelial growth factor (VEGF) drug bevacizumab might be beneficial for treating Covid-19 patients. From Feb 15 to April 5, 2020, we conducted a single-arm trial (NCT04275414) and recruited 26 patients from 2-centers (China and Italy) with severe Covid-19, with respiratory rate ≥30 times/min, oxygen saturation ≤93% with ambient air, or partial arterial oxygen pressure to fraction of inspiration O2 ratio (PaO2/FiO2) >100 mmHg and ≤300 mmHg, and diffuse pneumonia confirmed by chest imaging. Followed up for 28 days. Among these, bevacizumab plus standard care markedly improves the PaO2/FiO2 ratios at days 1 and 7. By day 28, 24 (92%) patients show improvement in oxygen-support status, 17 (65%) patients are discharged, and none show worsen oxygen-support status nor die. Significant reduction of lesion areas/ratios are shown in chest computed tomography (CT) or X-ray within 7 days. Of 14 patients with fever, body temperature normalizes within 72 h in 13 (93%) patients. Relative to comparable controls, bevacizumab shows clinical efficacy by improving oxygenation and shortening oxygen-support duration. Our findings suggest bevacizumab plus standard care is highly beneficial for patients with severe Covid-19. Randomized controlled trial is warranted.
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