| 1. |
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| 2. |
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| 3. |
- Dalton, A. S., et al.
(författare)
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An updated radiocarbon-based ice margin chronology for the last deglaciation of the North American Ice Sheet Complex
- 2020
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Ingår i: Quaternary Science Reviews. - : Elsevier BV. - 0277-3791. ; 234
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Tidskriftsartikel (refereegranskat)abstract
- The North American Ice Sheet Complex (NAISC; consisting of the Laurentide, Cordilleran and Innuitian ice sheets) was the largest ice mass to repeatedly grow and decay in the Northern Hemisphere during the Quaternary. Understanding its pattern of retreat following the Last Glacial Maximum is critical for studying many facets of the Late Quaternary, including ice sheet behaviour, the evolution of Holocene landscapes, sea level, atmospheric circulation, and the peopling of the Americas. Currently, the most up-to-date and authoritative margin chronology for the entire ice sheet complex is featured in two publications (Geological Survey of Canada Open File 1574 [Dyke et al., 2003]; 'Quaternary Glaciations - Extent and Chronology, Part II' [Dyke, 2004]). These often-cited datasets track ice margin recession in 36 time slices spanning 18 ka to 1 ka (all ages in uncalibrated radiocarbon years) using a combination of geomorphology, stratigraphy and radiocarbon dating. However, by virtue of being over 15 years old, the ice margin chronology requires updating to reflect new work and important revisions. This paper updates the aforementioned 36 ice margin maps to reflect new data from regional studies. We also update the original radiocarbon dataset from the 2003/2004 papers with 1541 new ages to reflect work up to and including 2018. A major revision is made to the 18 ka ice margin, where Banks and Eglinton islands (once considered to be glacial refugia) are now shown to be fully glaciated. Our updated 18 ka ice sheet increased in areal extent from 17.81 to 18.37 million km(2), which is an increase of 3.1% in spatial coverage of the NAISC at that time. Elsewhere, we also summarize, region-by-region, significant changes to the deglaciation sequence. This paper integrates new information provided by regional experts and radiocarbon data into the deglaciation sequence while maintaining consistency with the original ice margin positions of Dyke et al. (2003) and Dyke (2004) where new information is lacking; this is a pragmatic solution to satisfy the needs of a Quaternary research community that requires up-to-date knowledge of the pattern of ice margin recession of what was once the world's largest ice mass. The 36 updated isochrones are available in PDF and shapefile format, together with a spreadsheet of the expanded radiocarbon dataset (n = 5195 ages) and estimates of uncertainty for each interval. (C) 2020 Elsevier Ltd. All rights reserved.
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| 4. |
- Panico, B., et al.
(författare)
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Cosmic Rays Investigation by the PAMELA experiment
- 2020
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Ingår i: Journal of Physics. - : IOP Publishing.
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Konferensbidrag (refereegranskat)abstract
- PAMELA (Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics) is a satellite-borne experiment. It was launched on June 15th 2006 from the Baikonur space centre on board the Russian Resurs-DK1 satellite. For about 10 years PAMELA took data, giving a fundamental contribution to the cosmic ray physics. It made high-precision measurements of the charged component of the cosmic radiation challenging the standard model of the mechanisms of production, acceleration and propagation of cosmic rays in the galaxy and in the heliosphere. PAMELA gave results on different topics on a very wide range of energy. Moreover, the long PAMELA life gives the possibility to study the variation of the proton, electron and positron spectra during the last solar minimum. The time dependence of the cosmic-ray proton and helium nuclei from the solar minimum through the following period of solar maximum activity is currently being studied. Low energy particle spectra were accurately measured also for various solar events that occurred during the PAMELA mission. In this paper a review of main PAMELA results will be reported.
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| 5. |
- Panico, B., et al.
(författare)
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Time dependence of the proton and helium flux measured by PAMELA
- 2020
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Ingår i: Journal of Physics. - : IOP Publishing.
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Konferensbidrag (refereegranskat)abstract
- The energy spectra of galactic cosmic rays carry fundamental information regarding their origin and propagation, but, near Earth, cosmic rays are significantly affected by the solar magnetic field which changes over time. The time dependence of proton and electron spectra were measured from July 2006 to December 2009 by PAMELA experiment, that is a ballooon-borne experiment collecting data since 15 June 2006. These studies allowed to obtain a more complete description of the cosmic radiation, providing fundamental information about the transport and modulation of cosmic rays inside the heliosphere. The study of the time dependence of the cosmic-ray protons and helium nuclei from the unusual 23rd solar minimum through the following period of solar maximum activity is presented.
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| 6. |
- Lagou, Vasiliki, et al.
(författare)
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Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
- 2021
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association study meta-analyses in individuals of European descent without diabetes. Here we report sex dimorphism in allelic effects on fasting insulin at IRS1 and ZNF12 loci, the latter showing higher RNA expression in whole blood in women compared to men. We also observe sex-homogeneous effects on fasting glucose at seven novel loci. Fasting insulin in women shows stronger genetic correlations than in men with waist-to-hip ratio and anorexia nervosa. Furthermore, waist-to-hip ratio is causally related to insulin resistance in women, but not in men. These results position dissection of metabolic and glycemic health sex dimorphism as a steppingstone for understanding differences in genetic effects between women and men in related phenotypes.
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| 7. |
- Lewin, Harris A., et al.
(författare)
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The Earth BioGenome Project 2020 : Starting the clock
- 2022
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences (PNAS). - 0027-8424 .- 1091-6490. ; 119:4
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Ljungman, P., et al.
(författare)
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Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19; An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry
- 2023
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Ingår i: FRONTIERS IN IMMUNOLOGY. - : Frontiers Media SA. - 1664-3224. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- IntroductionCOVID-19 has been associated with high morbidity and mortality in allogeneic hematopoietic stem cell transplant (allo-HCT) recipients. MethodsThis study reports on 986 patients reported to the EBMT registry during the first 29 months of the pandemic. ResultsThe median age was 50.3 years (min - max; 1.0 - 80.7). The median time from most recent HCT to diagnosis of COVID-19 was 20 months (min - max; 0.0 - 383.9). The median time was 19.3 (0.0 - 287.6) months during 2020, 21.2 (0.1 - 324.5) months during 2021, and 19.7 (0.1 - 383.9) months during 2022 (p = NS). 145/986 (14.7%) patients died; 124 (12.6%) due to COVID-19 and 21 of other causes. Only 2/204 (1%) fully vaccinated patients died from COVID-19. There was a successive improvement in overall survival over time. In multivariate analysis, increasing age (p<.0001), worse performance status (p<.0001), contracting COVID-19 within the first 30 days (p<.0001) or 30 - 100 days after HCT (p=.003), ongoing immunosuppression (p=.004), pre-existing lung disease (p=.003), and recipient CMV seropositivity (p=.004) had negative impact on overall survival while patients contracting COVID-19 in 2020 (p<.0001) or 2021 (p=.027) had worse overall survival than patients with COVID-19 diagnosed in 2022. DiscussionAlthough the outcome of COVID-19 has improved, patients having risk factors were still at risk for severe COVID-19 including death.
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| 9. |
- Lundberg, T. R., et al.
(författare)
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The International Olympic Committee framework on fairness, inclusion and nondiscrimination on the basis of gender identity and sex variations does not protect fairness for female athletes
- 2024
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Ingår i: Scandinavian Journal of Medicine and Science in Sports. - : Wiley. - 0905-7188 .- 1600-0838. ; 34:3
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Tidskriftsartikel (refereegranskat)abstract
- The International Olympic Committee (IOC) recently published a framework on fairness, inclusion, and nondiscrimination on the basis of gender identity and sex variations. Although we appreciate the IOC's recognition of the role of sports science and medicine in policy development, we disagree with the assertion that the IOC framework is consistent with existing scientific and medical evidence and question its recommendations for implementation. Testosterone exposure during male development results in physical differences between male and female bodies; this process underpins male athletic advantage in muscle mass, strength and power, and endurance and aerobic capacity. The IOC's “no presumption of advantage” principle disregards this reality. Studies show that transgender women (male-born individuals who identify as women) with suppressed testosterone retain muscle mass, strength, and other physical advantages compared to females; male performance advantage cannot be eliminated with testosterone suppression. The IOC's concept of “meaningful competition” is flawed because fairness of category does not hinge on closely matched performances. The female category ensures fair competition for female athletes by excluding male advantages. Case-by-case testing for transgender women may lead to stigmatization and cannot be robustly managed in practice. We argue that eligibility criteria for female competition must consider male development rather than relying on current testosterone levels. Female athletes should be recognized as the key stakeholders in the consultation and decision-making processes. We urge the IOC to reevaluate the recommendations of their Framework to include a comprehensive understanding of the biological advantages of male development to ensure fairness and safety in female sports.
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| 10. |
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| 11. |
- Lewis, A.M., et al.
(författare)
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Templates of Expected Measurement Uncertainties for Neutron-Induced Capture and Charged-Particle Production Cross Section Observables
- 2023
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Ingår i: EPJ Nuclear Sciences & Technologies. - : EDP Sciences. - 2491-9292. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- This paper provides a template of expected uncertainties and correlations for measurements of neutron-induced capture and charged-particle production cross sections. Measurements performed in-beam include total absorption spectroscopy, total energy detection, γ-ray spectroscopy, and direct charged-particle detection. Offline measurements include activation analysis and accelerator mass spectrometry. The information needed for proper use of the datasets in resonance region and high energy region evaluations is described, and recommended uncertainties are provided when specific values are not available for a dataset.
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| 12. |
- Saunois, Marielle, et al.
(författare)
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The Global Methane Budget 2000–2017
- 2020
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Ingår i: Earth System Science Data. - : Copernicus GmbH. - 1866-3516 .- 1866-3508. ; 12:3, s. 1561-1623
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Tidskriftsartikel (refereegranskat)abstract
- Understanding and quantifying the global methane (CH4) budget is important for assessing realistic pathways to mitigate climate change. Atmospheric emissions and concentrations of CH4 continue to increase, making CH4 the second most important human-influenced greenhouse gas in terms of climate forcing, after carbon dioxide (CO2). The relative importance of CH4 compared to CO2 depends on its shorter atmospheric lifetime, stronger warming potential, and variations in atmospheric growth rate over the past decade, the causes of which are still debated. Two major challenges in reducing uncertainties in the atmospheric growth rate arise from the variety of geographically overlapping CH4 sources and from the destruction of CH4 by short-lived hydroxyl radicals (OH). To address these challenges, we have established a consortium of multidisciplinary scientists under the umbrella of the Global Carbon Project to synthesize and stimulate new research aimed at improving and regularly updating the global methane budget. Following Saunois et al. (2016), we present here the second version of the living review paper dedicated to the decadal methane budget, integrating results of top-down studies (atmospheric observations within an atmospheric inverse-modelling framework) and bottom-up estimates (including process-based models for estimating land surface emissions and atmospheric chemistry, inventories of anthropogenic emissions, and data-driven extrapolations).For the 2008–2017 decade, global methane emissions are estimated by atmospheric inversions (a top-down approach) to be 576 Tg CH4 yr−1 (range 550–594, corresponding to the minimum and maximum estimates of the model ensemble). Of this total, 359 Tg CH4 yr−1 or ∼ 60 % is attributed to anthropogenic sources, that is emissions caused by direct human activity (i.e. anthropogenic emissions; range 336–376 Tg CH4 yr−1 or 50 %–65 %). The mean annual total emission for the new decade (2008–2017) is 29 Tg CH4 yr−1 larger than our estimate for the previous decade (2000–2009), and 24 Tg CH4 yr−1 larger than the one reported in the previous budget for 2003–2012 (Saunois et al., 2016). Since 2012, global CH4 emissions have been tracking the warmest scenarios assessed by the Intergovernmental Panel on Climate Change. Bottom-up methods suggest almost 30 % larger global emissions (737 Tg CH4 yr−1, range 594–881) than top-down inversion methods. Indeed, bottom-up estimates for natural sources such as natural wetlands, other inland water systems, and geological sources are higher than top-down estimates. The atmospheric constraints on the top-down budget suggest that at least some of these bottom-up emissions are overestimated. The latitudinal distribution of atmospheric observation-based emissions indicates a predominance of tropical emissions (∼ 65 % of the global budget, < 30∘ N) compared to mid-latitudes (∼ 30 %, 30–60∘ N) and high northern latitudes (∼ 4 %, 60–90∘ N). The most important source of uncertainty in the methane budget is attributable to natural emissions, especially those from wetlands and other inland waters.Some of our global source estimates are smaller than those in previously published budgets (Saunois et al., 2016; Kirschke et al., 2013). In particular wetland emissions are about 35 Tg CH4 yr−1 lower due to improved partition wetlands and other inland waters. Emissions from geological sources and wild animals are also found to be smaller by 7 Tg CH4 yr−1 by 8 Tg CH4 yr−1, respectively. However, the overall discrepancy between bottom-up and top-down estimates has been reduced by only 5 % compared to Saunois et al. (2016), due to a higher estimate of emissions from inland waters, highlighting the need for more detailed research on emissions factors. Priorities for improving the methane budget include (i) a global, high-resolution map of water-saturated soils and inundated areas emitting methane based on a robust classification of different types of emitting habitats; (ii) further development of process-based models for inland-water emissions; (iii) intensification of methane observations at local scales (e.g., FLUXNET-CH4 measurements) and urban-scale monitoring to constrain bottom-up land surface models, and at regional scales (surface networks and satellites) to constrain atmospheric inversions; (iv) improvements of transport models and the representation of photochemical sinks in top-down inversions; and (v) development of a 3D variational inversion system using isotopic and/or co-emitted species such as ethane to improve source partitioning.The data presented here can be downloaded from https://doi.org/10.18160/GCP-CH4-2019 (Saunois et al., 2020) and from the Global Carbon Project.
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| 13. |
- Verbakel, J. Y., et al.
(författare)
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Validation of ultrasound strategies to assess tumor extension and to predict high-risk endometrial cancer in women from the prospective IETA (International Endometrial Tumor Analysis)-4 cohort
- 2020
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Ingår i: Ultrasound in Obstetrics and Gynecology. - : Wiley. - 0960-7692 .- 1469-0705. ; 55:1, s. 115-124
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To compare the performance of ultrasound measurements and subjective ultrasound assessment (SA) in detecting deep myometrial invasion (MI) and cervical stromal invasion (CSI) in women with endometrial cancer, overall and according to whether they had low- or high-grade disease separately, and to validate published measurement cut-offs and prediction models to identify MI, CSI and high-risk disease (Grade-3 endometrioid or non-endometrioid cancer and/or deep MI and/or CSI). Methods: The study comprised 1538 patients with endometrial cancer from the International Endometrial Tumor Analysis (IETA)-4 prospective multicenter study, who underwent standardized expert transvaginal ultrasound examination. SA and ultrasound measurements were used to predict deep MI and CSI. We assessed the diagnostic accuracy of the tumor/uterine anteroposterior (AP) diameter ratio for detecting deep MI and that of the distance from the lower margin of the tumor to the outer cervical os (Dist-OCO) for detecting CSI. We also validated two two-step strategies for the prediction of high-risk cancer; in the first step, biopsy-confirmed Grade-3 endometrioid or mucinous or non-endometrioid cancers were classified as high-risk cancer, while the second step encompassed the application of a mathematical model to classify the remaining tumors. The ‘subjective prediction model’ included biopsy grade (Grade 1 vs Grade 2) and subjective assessment of deep MI or CSI (presence or absence) as variables, while the ‘objective prediction model’ included biopsy grade (Grade 1 vs Grade 2) and minimal tumor-free margin. The predictive performance of the two two-step strategies was compared with that of simply classifying patients as high risk if either deep MI or CSI was suspected based on SA or if biopsy showed Grade-3 endometrioid or mucinous or non-endometrioid histotype (i.e. combining SA with biopsy grade). Histological assessment from hysterectomy was considered the reference standard. Results: In 1275 patients with measurable lesions, the sensitivity and specificity of SA for detecting deep MI was 70% and 80%, respectively, in patients with a Grade-1 or -2 endometrioid or mucinous tumor vs 76% and 64% in patients with a Grade-3 endometrioid or mucinous or a non-endometrioid tumor. The corresponding values for the detection of CSI were 51% and 94% vs 50% and 91%. Tumor AP diameter and tumor/uterine AP diameter ratio showed the best performance for predicting deep MI (area under the receiver–operating characteristics curve (AUC) of 0.76 and 0.77, respectively), and Dist-OCO had the best performance for predicting CSI (AUC, 0.72). The proportion of patients classified correctly as having high-risk cancer was 80% when simply combining SA with biopsy grade vs 80% and 74% when using the subjective and objective two-step strategies, respectively. The subjective and objective models had an AUC of 0.76 and 0.75, respectively, when applied to Grade-1 and -2 endometrioid tumors. Conclusions: In the hands of experienced ultrasound examiners, SA was superior to ultrasound measurements for the prediction of deep MI and CSI of endometrial cancer, especially in patients with a Grade-1 or -2 tumor. The mathematical models for the prediction of high-risk cancer performed as expected. The best strategies for predicting high-risk endometrial cancer were combining SA with biopsy grade and the subjective two-step strategy, both having an accuracy of 80%.
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| 14. |
- Dulvy, Nicholas K., et al.
(författare)
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Overfishing drives over one-third of all sharks and rays toward a global extinction crisis
- 2021
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Ingår i: Current Biology. - : Cell Press. - 0960-9822 .- 1879-0445. ; 31:21, s. 4773-4787
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Tidskriftsartikel (refereegranskat)abstract
- The scale and drivers of marine biodiversity loss are being revealed by the International Union for Conservation of Nature (IUCN) Red List assessment process. We present the first global reassessment of 1,199 species in Class Chondrichthyes-sharks, rays, and chimeras. The first global assessment (in 2014) concluded that one-quarter (24%) of species were threatened. Now, 391 (32.6%) species are threatened with extinction. When this percentage of threat is applied to Data Deficient species, more than one-third (37.5%) of chondrichthyans are estimated to be threatened, with much of this change resulting from new information. Three species are Critically Endangered (Possibly Extinct), representing possibly the first globalmarine fish extinctions due to overfishing. Consequently, the chondrichthyan extinction rate is potentially 25 extinctions per million species years, comparable to that of terrestrial vertebrates. Overfishing is the universal threat affecting all 391 threatened species and is the sole threat for 67.3% of species and interacts with three other threats for the remaining third: loss and degradation of habitat (31.2% of threatened species), climate change (10.2%), and pollution (6.9%). Species are disproportionately threatened in tropical and subtropical coastal waters. Science-based limits on fishing, effective marine protected areas, and approaches that reduce or eliminate fishing mortality are urgently needed to minimize mortality of threatened species and ensure sustainable catch and trade of others. Immediate action is essential to prevent further extinctions and protect the potential for food security and ecosystem functions provided by this iconic lineage of predators.
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| 15. |
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| 16. |
- Mullier, G.A., et al.
(författare)
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Observation of the γγ→ττ Process in Pb+Pb Collisions and Constraints on the τ-Lepton Anomalous Magnetic Moment with the ATLAS Detector
- 2023
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Ingår i: Physical Review Letters. - : APS. - 1079-7114 .- 0031-9007. ; 131:15
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Tidskriftsartikel (refereegranskat)abstract
- This Letter reports the observation of τ-lepton-pair production in ultraperipheral lead-lead collisions Pb+Pb→Pb(γγ→ττ)Pb and constraints on the τ-lepton anomalous magnetic moment a_{τ}. The dataset corresponds to an integrated luminosity of 1.44 nb^{-1} of LHC Pb+Pb collisions at sqrt[s_{NN}]=5.02 TeV recorded by the ATLAS experiment in 2018. Selected events contain one muon from a τ-lepton decay, an electron or charged-particle track(s) from the other τ-lepton decay, little additional central-detector activity, and no forward neutrons. The γγ→ττ process is observed in Pb+Pb collisions with a significance exceeding 5 standard deviations and a signal strength of μ_{ττ}=1.03_{-0.05}^{+0.06} assuming the standard model value for a_{τ}. To measure a_{τ}, a template fit to the muon transverse-momentum distribution from τ-lepton candidates is performed, using a dimuon (γγ→μμ) control sample to constrain systematic uncertainties. The observed 95% confidence-level interval for a_{τ} is -0.057
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| 17. |
- Mullier, G.A., et al.
(författare)
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Strong Constraints on Jet Quenching in Centrality-Dependent p+Pb Collisions at 5.02 TeV from ATLAS
- 2023
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Ingår i: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 131:7
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Tidskriftsartikel (refereegranskat)abstract
- Jet quenching is the process of color-charged partons losing energy via interactions with quark-gluon plasma droplets created in heavy-ion collisions. The collective expansion of such droplets is well described by viscous hydrodynamics. Similar evidence of collectivity is consistently observed in smaller collision systems, including p p and p + Pb collisions. In contrast, while jet quenching is observed in Pb + Pb collisions, no evidence has been found in these small systems to date, raising fundamental questions about the nature of the system created in these collisions. The ATLAS experiment at the Large Hadron Collider has measured the yield of charged hadrons correlated with reconstructed jets in 0.36 nb - 1 of p + Pb and 3.6 pb - 1 of p p collisions at 5.02 TeV. The yields of charged hadrons with p T ch > 0.5 GeV near and opposite in azimuth to jets with p T jet > 30 or 60 GeV, and the ratios of these yields between p + Pb and p p collisions, I p Pb , are reported. The collision centrality of p + Pb events is categorized by the energy deposited by forward neutrons from the struck nucleus. The I p Pb values are consistent with unity within a few percent for hadrons with p T ch > 4 GeV at all centralities. These data provide new, strong constraints that preclude almost any parton energy loss in central p + Pb collisions. © 2023 CERN, for the ATLAS Collaboration.
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| 18. |
- Sherman, C. Samantha, et al.
(författare)
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Half a century of rising extinction risk of coral reef sharks and rays
- 2023
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Sharks and rays are key functional components of coral reef ecosystems, yet many populations of a few species exhibit signs of depletion and local extinctions. The question is whether these declines forewarn of a global extinction crisis. We use IUCN Red List to quantify the status, trajectory, and threats to all coral reef sharks and rays worldwide. Here, we show that nearly two-thirds (59%) of the 134 coral-reef associated shark and ray species are threatened with extinction. Alongside marine mammals, sharks and rays are among the most threatened groups found on coral reefs. Overfishing is the main cause of elevated extinction risk, compounded by climate change and habitat degradation. Risk is greatest for species that are larger-bodied (less resilient and higher trophic level), widely distributed across several national jurisdictions (subject to a patchwork of management), and in nations with greater fishing pressure and weaker governance. Population declines have occurred over more than half a century, with greatest declines prior to 2005. Immediate action through local protections, combined with broad-scale fisheries management and Marine Protected Areas, is required to avoid extinctions and the loss of critical ecosystem function condemning reefs to a loss of shark and ray biodiversity and ecosystem services, limiting livelihoods and food security. © 2023, The Author(s).
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| 19. |
- Aad, G., et al.
(författare)
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Luminosity determination in pp collisions at √s=13 TeV using the ATLAS detector at the LHC
- 2023
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Ingår i: European Physical Journal C. - : Institute for Ionics. - 1434-6044 .- 1434-6052. ; 83:10
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Tidskriftsartikel (refereegranskat)abstract
- The luminosity determination for the ATLAS detector at the LHC during Run 2 is presented, with pp collisions at a centre-of-mass energy s=13 TeV. The absolute luminosity scale is determined using van der Meer beam separation scans during dedicated running periods in each year, and extrapolated to the physics data-taking regime using complementary measurements from several luminosity-sensitive detectors. The total uncertainties in the integrated luminosity for each individual year of data-taking range from 0.9% to 1.1%, and are partially correlated between years. After standard data-quality selections, the full Run 2 pp data sample corresponds to an integrated luminosity of 140.1 ± 1.2 fb - 1 , i.e. an uncertainty of 0.83%. A dedicated sample of low-pileup data recorded in 2017–2018 for precision Standard Model physics measurements is analysed separately, and has an integrated luminosity of 338.1 ± 3.1 pb - 1 . © 2023, The Author(s).
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| 20. |
- Diaz, Ben P., et al.
(författare)
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Seasonal mixed layer depth shapes phytoplankton physiology, viral production, and accumulation in the North Atlantic
- 2021
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Seasonal shifts in phytoplankton accumulation and loss largely follow changes in mixed layer depth, but the impact of mixed layer depth on cell physiology remains unexplored. Here, we investigate the physiological state of phytoplankton populations associated with distinct bloom phases and mixing regimes in the North Atlantic. Stratification and deep mixing alter community physiology and viral production, effectively shaping accumulation rates. Communities in relatively deep, early-spring mixed layers are characterized by low levels of stress and high accumulation rates, while those in the recently shallowed mixed layers in late-spring have high levels of oxidative stress. Prolonged stratification into early autumn manifests in negative accumulation rates, along with pronounced signatures of compromised membranes, death-related protease activity, virus production, nutrient drawdown, and lipid markers indicative of nutrient stress. Positive accumulation renews during mixed layer deepening with transition into winter, concomitant with enhanced nutrient supply and lessened viral pressure. Phytoplankton are important primary producers. Here the authors investigate phytoplankton physiological changes associated with bloom phases and mixing regimes in the North Atlantic, finding that stratification and deep mixing shape accumulation rates by altering physiology and viral production.
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| 21. |
- Kisiel, Marta A., 1984-, et al.
(författare)
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Inflammatory bowel disease and asthma. Results from the RHINE study
- 2023
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Ingår i: Respiratory Medicine. - : Elsevier. - 0954-6111 .- 1532-3064. ; 216
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Tidskriftsartikel (refereegranskat)abstract
- Background: Asthma and inflammatory bowel disease (IBD) are common inflammatory diseases. The aim of this study was to investigate the associations of IBD with asthma and respiratory symptoms. Methods: This study is based on 13,499 participants from seven northern European countries that filled in a postal questionnaire on asthma, respiratory symptoms, IBD including ulcerative colitis and Crohn's disease and various lifestyle variables. Results: There were 195 participants with IBD. The prevalence of asthma (14.5 vs 8.1%, p = 0.001), different respiratory symptoms (range 11.9-36.8% vs range 6.0-18.6%, p < 0.005), non-infectious rhinitis (52.1 vs. 41.6%, p = 0.004) and chronic rhinosinusitis (11.6 vs 6.0%, p = 0.001) were higher in subjects with IBD than in those without IBD. In multivariable regression analysis, the association between IBD and asthma was statistically significant (OR 1.95 (95% CI 1.28-2.96)) after adjusting for confounders such as sex, BMI, smoking history, educational level and physical activity. There was a significant association between asthma and ulcerative colitis (adjusted OR 2.02 (95% CI 1.27-2.19)), and asthma but not Crohn's disease (adjusted OR 1.66 (95% CI 0.69-3.95)). A significant gender interaction was found with a significant association between IBD and asthma in women but not in men ((OR 2.72 (95% CI 1.67-4.46) vs OR 0.87 (95% CI 0.35-2.19), p = 0.038). Conclusions: Patients with IBD, particularly those with ulcerative colitis and female, have a higher prevalence of asthma and respiratory symptoms. Our findings indicate that it is important to consider respiratory symptoms and disorders when examining patients with manifest or suspected IBD.
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| 22. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 23. |
- Mullier, G.A., et al.
(författare)
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Constraints on Higgs boson production with large transverse momentum using H →b b ¯ decays in the ATLAS detector
- 2022
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Ingår i: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 105:9
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Tidskriftsartikel (refereegranskat)abstract
- This paper reports constraints on Higgs boson production with transverse momentum above 1 TeV. The analyzed data from proton-proton collisions at a center-of-mass energy of 13 TeV were recorded with the ATLAS detector at the Large Hadron Collider from 2015 to 2018 and correspond to an integrated luminosity of 136 fb-1. Higgs bosons decaying into bb¯ are reconstructed as single large-radius jets recoiling against a hadronic system and are identified by the experimental signature of two b-hadron decays. The experimental techniques are validated in the same kinematic regime using the Z→bb¯ process. The 95% confidence-level upper limit on the cross section for Higgs boson production with transverse momentum above 450 GeV is 115 fb, and above 1 TeV it is 9.6 fb. The Standard Model cross section predictions for a Higgs boson with a mass of 125 GeV in the same kinematic regions are 18.4 fb and 0.13 fb, respectively. © 2022 CERN.
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| 24. |
- Mullier, G.A., et al.
(författare)
-
Measurement of muon pairs produced via ?? scattering in nonultraperipheral Pb+Pb collisions at √???=5.02 TeV with the ATLAS detector
- 2023
-
Ingår i: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 107:5
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Tidskriftsartikel (refereegranskat)abstract
- Results of a measurement of dimuon photoproduction in nonultraperipheral Pb+Pb collisions at √???=5.02 TeV are presented. The measurement uses ATLAS data from the 2015 and 2018 Pb+Pb data-taking periods at the LHC with an integrated luminosity of 1.94nb−1. The ??→?+?− pairs are identified via selections on pair momentum asymmetry and acoplanarity. Differential cross sections for dimuon production are measured in different centrality, average muon momentum, and pair rapidity intervals as functions of acoplanarity and ?⊥, the transverse momentum kick of one muon relative to the other. Measurements are also made as a function of the rapidity separation of the muons and the angle of the muon pair relative to the second-order event plane to test whether magnetic fields generated in the quark-gluon plasma affect the measured muons. A prior observation of a centrality-dependent broadening of the acoplanarity distribution is confirmed. Furthermore, the improved precision of the measurement reveals a depletion in the number of pairs having small acoplanarity or ?⊥ values in more central collisions. The acoplanarity distributions in a given centrality interval are observed to vary with the mean ?T of the muons in the pair, but the ?⊥ distributions do not. Comparisons with recent theoretical predictions are made. The predicted trends associated with effects of magnetic fields on the dimuons are not observed.
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| 25. |
- Mullier, G.A., et al.
(författare)
-
Measurement of the c-jet mistagging efficiency in tt¯ events using pp collision data at √s=13 TeV collected with the ATLAS detector
- 2022
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 82:1
-
Tidskriftsartikel (refereegranskat)abstract
- A technique is presented to measure the efficiency with which c-jets are mistagged as b-jets (mistagging efficiency) using tt¯ events, where one of the W bosons decays into an electron or muon and a neutrino and the other decays into a quark–antiquark pair. The measurement utilises the relatively large and known W→ cs branching ratio, which allows a measurement to be made in an inclusive c-jet sample. The data sample used was collected by the ATLAS detector at s=13 TeV and corresponds to an integrated luminosity of 139 fb- 1. Events are reconstructed using a kinematic likelihood technique which selects the mapping between jets and tt¯ decay products that yields the highest likelihood value. The distribution of the b-tagging discriminant for jets from the hadronic W decays in data is compared with that in simulation to extract the mistagging efficiency as a function of jet transverse momentum. The total uncertainties are in the range 3–17%. The measurements generally agree with those in simulation but there are some differences in the region corresponding to the most stringent b-jet tagging requirement. © 2022, The Author(s).
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| 26. |
- Mullier, G.A., et al.
(författare)
-
Measurement of the energy asymmetry in tt¯ j production at 13 TeV with the ATLAS experiment and interpretation in the SMEFT framework
- 2022
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 82:4
-
Tidskriftsartikel (refereegranskat)abstract
- A measurement of the energy asymmetry in jet-associated top-quark pair production is presented using 139fb-1 of data collected by the ATLAS detector at the Large Hadron Collider during pp collisions at s=13TeV. The observable measures the different probability of top and antitop quarks to have the higher energy as a function of the jet scattering angle with respect to the beam axis. The energy asymmetry is measured in the semileptonic tt¯ decay channel, and the hadronically decaying top quark must have transverse momentum above 350GeV. The results are corrected for detector effects to particle level in three bins of the scattering angle of the associated jet. The measurement agrees with the SM prediction at next-to-leading-order accuracy in quantum chromodynamics in all three bins. In the bin with the largest expected asymmetry, where the jet is emitted perpendicular to the beam, the energy asymmetry is measured to be - 0.043 ± 0.020 , in agreement with the SM prediction of - 0.037 ± 0.003. Interpreting this result in the framework of the Standard Model effective field theory (SMEFT), it is shown that the energy asymmetry is sensitive to the top-quark chirality in four-quark operators and is therefore a valuable new observable in global SMEFT fits. © 2022, The Author(s).
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| 27. |
- Mullier, G.A., et al.
(författare)
-
Measurement of the energy response of the ATLAS calorimeter to charged pions from W±→ τ±(→ π±ντ) ντ events in Run 2 data
- 2022
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 82:3
-
Tidskriftsartikel (refereegranskat)abstract
- The energy response of the ATLAS calorimeter is measured for single charged pions with transverse momentum in the range 10 < pT< 300 GeV. The measurement is performed using 139 fb - 1 of LHC proton–proton collision data at s=13 TeV taken in Run 2 by the ATLAS detector. Charged pions originating from τ-lepton decays are used to provide a sample of high-pT isolated particles, where the composition is known, to test an energy regime that has not previously been probed by in situ single-particle measurements. The calorimeter response to single-pions is observed to be overestimated by ∼ 2 % across a large part of the pT spectrum in the central region and underestimated by ∼ 4 % in the endcaps in the ATLAS simulation. The uncertainties in the measurements are ≲ 1 % for 15 < pT< 185 GeV in the central region. To investigate the source of the discrepancies, the width of the distribution of the ratio of calorimeter energy to track momentum, the energies per layer and response in the hadronic calorimeter are also compared between data and simulation. © 2022, The Author(s).
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| 28. |
- Mullier, G.A., et al.
(författare)
-
Measurements of azimuthal anisotropies of jet production in Pb+ Pb collisions at sNN =5.02 TeV with the ATLAS detector
- 2022
-
Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 105:6
-
Tidskriftsartikel (refereegranskat)abstract
- The azimuthal variation of jet yields in heavy-ion collisions provides information about the path-length dependence of the energy loss experienced by partons passing through the hot, dense nuclear matter known as the quark-gluon plasma. This paper presents the azimuthal anisotropy coefficients v2, v3, and v4 measured for jets in Pb+Pb collisions at sNN=5.02 TeV using the ATLAS detector at the LHC. The measurement uses data collected in 2015 and 2018, corresponding to an integrated luminosity of 2.2 nb-1. The vn values are measured as a function of the transverse momentum of the jets between 71 and 398 GeV and the event centrality. A nonzero value of v2 is observed in all but the most central collisions. The value of v2 is largest for jets with lower transverse momentum, with values up to 0.05 in mid-central collisions. A smaller, nonzero value of v3 of approximately 0.01 is measured with no significant dependence on jet pT or centrality, suggesting that fluctuations in the initial state play a small but distinct role in jet energy loss. No significant deviation of v4 from zero is observed in the measured kinematic region. © 2022 CERN. for the ATLAS Collaboration. Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.
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| 29. |
- Mullier, G.A., et al.
(författare)
-
Operation and performance of the ATLAS semiconductor tracker in LHC Run 2
- 2022
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Ingår i: Journal of Instrumentation. - : IOP Publishing Ltd. - 1748-0221. ; 17:1
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Tidskriftsartikel (refereegranskat)abstract
- The semiconductor tracker (SCT) is one of the tracking systems for charged particles in the ATLAS detector. It consists of 4088 silicon strip sensor modules. During Run 2 (2015-2018) the Large Hadron Collider delivered an integrated luminosity of 156 fb−1 to the ATLAS experiment at a centre-of-mass proton-proton collision energy of 13 TeV. The instantaneous luminosity and pile-up conditions were far in excess of those assumed in the original design of the SCT detector. Due to improvements to the data acquisition system, the SCT operated stably throughout Run 2. It was available for 99.9% of the integrated luminosity and achieved a data-quality efficiency of 99.85%. Detailed studies have been made of the leakage current in SCT modules and the evolution of the full depletion voltage, which are used to study the impact of radiation damage to the modules. © 2022 CERNüäβ
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| 30. |
- Mullier, G.A., et al.
(författare)
-
Search for flavour-changing neutral-current interactions of a top quark and a gluon in pp collisions at √s=13 TeV with the ATLAS detector
- 2022
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 82:4
-
Tidskriftsartikel (refereegranskat)abstract
- A search is presented for the production of a single top quark via left-handed flavour-changing neutral-current (FCNC) interactions of a top quark, a gluon and an up or charm quark. Two production processes are considered: u+ g→ t and c+ g→ t. The analysis is based on proton–proton collision data taken at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC. The data set corresponds to an integrated luminosity of 139 fb- 1. Events with exactly one electron or muon, exactly one b-tagged jet and missing transverse momentum are selected, resembling the decay products of a singly produced top quark. Neural networks based on kinematic variables differentiate between events from the two signal processes and events from background processes. The measured data are consistent with the background-only hypothesis, and limits are set on the production cross-sections of the signal processes: σ(u+g→t)×B(t→Wb)×B(W→ℓν)<3.0pb and σ(c+g→t)×B(t→Wb)×B(W→ℓν)<4.7pb at the 95% confidence level, with B(W→ ℓν) = 0.325 being the sum of branching ratios of all three leptonic decay modes of the W boson. Based on the framework of an effective field theory, the cross-section limits are translated into limits on the strengths of the tug and tcg couplings occurring in the theory: |CuGut|/Λ2<0.057TeV- 2 and |CuGct|/Λ2<0.14TeV- 2. These bounds correspond to limits on the branching ratios of FCNC-induced top-quark decays: B(t→ u+ g) < 0.61 × 10 - 4 and B(t→ c+ g) < 3.7 × 10 - 4. © 2022, The Author(s).
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| 31. |
- Mullier, G.A., et al.
(författare)
-
Search for Heavy Neutral Leptons in Decays of W Bosons Using a Dilepton Displaced Vertex in sqrt[s]=13 TeV pp Collisions with the ATLAS Detector
- 2023
-
Ingår i: Physical Review Letters. - : American Physical Society (APS). - 1079-7114 .- 0031-9007. ; 131:6
-
Tidskriftsartikel (refereegranskat)abstract
- A search for a long-lived, heavy neutral lepton (N) in 139 fb^{-1} of sqrt[s]=13 TeV pp collision data collected by the ATLAS detector at the Large Hadron Collider is reported. The N is produced via W→Nμ or W→Ne and decays into two charged leptons and a neutrino, forming a displaced vertex. The N mass is used to discriminate between signal and background. No signal is observed, and limits are set on the squared mixing parameters of the N with the left-handed neutrino states for the N mass range 3 GeV
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| 32. |
- Mullier, G.A., et al.
(författare)
-
Search for Higgs boson decays into a pair of pseudoscalar particles in the bbμμ final state with the ATLAS detector in pp collisions at s =13 TeV
- 2022
-
Ingår i: Physical Review D. - 2470-0010 .- 2470-0029. ; 105:1
-
Tidskriftsartikel (refereegranskat)abstract
- This paper presents a search for decays of the Higgs boson with a mass of 125 GeV into a pair of new pseudoscalar particles, H→aa, where one a-boson decays into a b-quark pair and the other into a muon pair. The search uses 139 fb-1 of proton-proton collision data at a center-of-mass energy of s=13 TeV recorded between 2015 and 2018 by the ATLAS experiment at the LHC. A narrow dimuon resonance is searched for in the invariant mass spectrum between 16 GeV and 62 GeV. The largest excess of events above the Standard Model backgrounds is observed at a dimuon invariant mass of 52 GeV and corresponds to a local (global) significance of 3.3σ (1.7σ). Upper limits at 95% confidence level are placed on the branching ratio of the Higgs boson to the bbμμ final state, B(H→aa→bbμμ), and are in the range 0.2-4.0×10-4, depending on the signal mass hypothesis. © 2022 CERN.
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| 33. |
- Mullier, G.A., et al.
(författare)
-
Search for Higgs bosons decaying into new spin-0 or spin-1 particles in four-lepton final states with the ATLAS detector with 139 fb−1 of pp collision data at √s = 13 TeV
- 2022
-
Ingår i: Journal of High Energy Physics. - : SPRINGER. - 1029-8479 .- 1126-6708. ; 2022:3
-
Tidskriftsartikel (refereegranskat)abstract
- Searches are conducted for new spin-0 or spin-1 bosons using events where a Higgs boson with mass 125 GeV decays into four leptons (ℓ = e, μ). This decay is presumed to occur via an intermediate state which contains two on-shell, promptly decaying bosons: H → XX/ZX → 4ℓ, where the new boson X has a mass between 1 and 60 GeV. The search uses pp collision data collected with the ATLAS detector at the LHC with an integrated luminosity of 139 fb−1 at a centre-of-mass energy s = 13 TeV. The data are found to be consistent with Standard Model expectations. Limits are set on fiducial cross sections and on the branching ratio of the Higgs boson to decay into XX/ZX, improving those from previous publications by a factor between two and four. Limits are also set on mixing parameters relevant in extensions of the Standard Model containing a dark sector where X is interpreted to be a dark boson. [Figure not available: see fulltext.] © 2022, The Author(s).
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| 34. |
- Mullier, G.A., et al.
(författare)
-
Search for Lepton-Flavor Violation in Z -Boson Decays with τ Leptons with the ATLAS Detector
- 2021
-
Ingår i: Physical Review Letters. - : American Physical Society (APS). - 0031-9007 .- 1079-7114. ; 127:27
-
Tidskriftsartikel (refereegranskat)abstract
- A search for lepton-flavor-violating Z→eτ and Z→μτ decays with pp collision data recorded by the ATLAS detector at the LHC is presented. This analysis uses 139 fb-1 of Run 2 pp collisions at s=13 TeV and is combined with the results of a similar ATLAS search in the final state in which the τ lepton decays hadronically, using the same data set as well as Run 1 data. The addition of leptonically decaying τ leptons significantly improves the sensitivity reach for Z→ℓτ decays. The Z→ℓτ branching fractions are constrained in this analysis to B(Z→eτ)
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| 35. |
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| 36. |
- Aad, G., et al.
(författare)
-
Combination of inclusive top-quark pair production cross-section measurements using ATLAS and CMS data at √s=7 and 8 TeV
- 2023
-
Ingår i: Journal of High Energy Physics (JHEP). - : Springer Nature. - 1126-6708 .- 1029-8479. ; 2023:7
-
Tidskriftsartikel (refereegranskat)abstract
- A combination of measurements of the inclusive top-quark pair production cross-section performed by ATLAS and CMS in proton–proton collisions at centre-of-mass energies of 7 and 8 TeV at the LHC is presented. The cross-sections are obtained using top-quark pair decays with an opposite-charge electron–muon pair in the final state and with data corresponding to an integrated luminosity of about 5 fb−1 at √s = 7 TeV and about 20 fb−1 at √s = 8 TeV for each experiment. The combined cross-sections are determined to be 178.5 ± 4.7 pb at √s = 7 TeV and pb at √s = 8 TeV with a correlation of 0.41, using a reference top-quark mass value of 172.5 GeV. The ratio of the combined cross-sections is determined to be R8/7 = 1.363 ± 0.032. The combined measured cross-sections and their ratio agree well with theory calculations using several parton distribution function (PDF) sets. The values of the top-quark pole mass (with the strong coupling fixed at 0.118) and the strong coupling (with the top-quark pole mass fixed at 172.5 GeV) are extracted from the combined results by fitting a next-to-next-to-leading-order plus next-to-next-to-leading-log QCD prediction to the measurements. Using a version of the NNPDF3.1 PDF set containing no top-quark measurements, the results obtained are = GeV and αs(mZ)=.
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| 37. |
- Aad, G., et al.
(författare)
-
Measurement of the H→ γγ and H→ ZZ∗→ 4 ℓ cross-sections in pp collisions at √s=13.6 TeV with the ATLAS detector
- 2024
-
Ingår i: European Physical Journal C. - : Institute for Ionics. - 1434-6044 .- 1434-6052. ; 84:1
-
Tidskriftsartikel (refereegranskat)abstract
- The inclusive Higgs boson production cross-section is measured in the di-photon and the ZZ∗→ 4 ℓ decay channels using 31.4 and 29.0 fb - 1 of pp collision data respectively, collected with the ATLAS detector at a centre-of-mass energy of s=13.6 TeV . To reduce the model dependence, the measurement in each channel is restricted to a particle-level phase space that closely matches the channel’s detector-level kinematic selection, and it is corrected for detector effects. These measured fiducial cross-sections are σfid,γγ= 76-13+14 fb, and σfid,4ℓ= 2.80±0.74 fb, in agreement with the corresponding Standard Model predictions of 67.6 ± 3.7 fb and 3.67 ± 0.19 fb. Assuming Standard Model acceptances and branching fractions for the two channels, the fiducial measurements are extrapolated to the full phase space yielding total cross-sections of σ(pp→H)=67-11+12 pb and 46 ± 12 pb at 13.6 TeV from the di-photon and ZZ∗→ 4 ℓ measurements respectively. The two measurements are combined into a total cross-section measurement of σ(pp→ H) = 58.2 ± 8.7 pb, to be compared with the Standard Model prediction of σ(pp→ H) SM= 59.9 ± 2.6 pb.
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| 38. |
- Andrean, Stefio Y., 1991-, et al.
(författare)
-
Measurements of differential cross-sections in top-quark pair events with a high transverse momentum top quark and limits on beyond the Standard Model contributions to top-quark pair production with the ATLAS detector at √s=13 TeV
- 2022
-
Ingår i: Journal of High Energy Physics (JHEP). - : Springer Nature. - 1126-6708 .- 1029-8479. ; :6
-
Tidskriftsartikel (refereegranskat)abstract
- Cross-section measurements of top-quark pair production where the hadronically decaying top quark has transverse momentum greater than 355 GeV and the other top quark decays into ℓνb are presented using 139 fb−1 of data collected by the ATLAS experiment during proton-proton collisions at the LHC. The fiducial cross-section at √s = 13 TeV is measured to be σ = 1.267 ± 0.005 ± 0.053 pb, where the uncertainties reflect the limited number of data events and the systematic uncertainties, giving a total uncertainty of 4.2%. The cross-section is measured differentially as a function of variables characterising the tt¯ system and additional radiation in the events. The results are compared with various Monte Carlo generators, including comparisons where the generators are reweighted to match a parton-level calculation at next-to-next-to-leading order. The reweighting improves the agreement between data and theory. The measured distribution of the top-quark transverse momentum is used to search for new physics in the context of the effective field theory framework. No significant deviation from the Standard Model is observed and limits are set on the Wilson coefficients of the dimension-six operators OtG and O(8)tq, where the limits on the latter are the most stringent to date.
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| 39. |
- Andrean, Stefio Y., 1991-, et al.
(författare)
-
Probing the CP nature of the top–Higgs Yukawa coupling in tt¯H??¯? and tH events with H→bb¯?→??¯ decays using the ATLAS detector at the LHC
- 2024
-
Ingår i: Physics Letters B. - : Elsevier B.V.. - 0370-2693 .- 1873-2445. ; 849
-
Tidskriftsartikel (refereegranskat)abstract
- The CP properties of the coupling between the Higgs boson and the top quark are investigated using 139 fb−1 of proton–proton collision data recorded by the ATLAS experiment at the LHC at a centre-of-mass energy of s√=13?=13 TeV. The CP structure of the top quark–Higgs boson Yukawa coupling is probed in events with a Higgs boson decaying into a pair of b-quarks and produced in association with either a pair of top quarks, tt¯H??¯?, or a single top quark, tH. Events containing one or two electrons or muons are used for the measurement. Multivariate techniques are used to select regions enriched in tt¯H??¯? and tH events, where dedicated CP-sensitive observables are exploited. In an extension of the Standard Model (SM) with a CP-odd admixture in the top–Higgs Yukawa coupling, the mixing angle between CP-even and CP-odd couplings is measured to be α=11∘+52∘−73∘?=11−73∘∘+52∘, compatible with the SM prediction corresponding to α=0?=0.
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| 40. |
- Andrean, Stefio Y., 1991-, et al.
(författare)
-
Search for heavy particles in the b-tagged dijet mass distribution with additional b-tagged jets in proton-proton collisions at √s=13 TeV with the ATLAS experiment
- 2022
-
Ingår i: Physical Review D. - : American Physical Society (APS). - 2470-0010 .- 2470-0029. ; 105:1
-
Tidskriftsartikel (refereegranskat)abstract
- A search optimized for new heavy particles decaying to two b-quarks and produced in association with additional b-quarks is reported. The sensitivity is improved by b-tagging at least one lower-pT jet in addition to the two highest-pT jets. The data used in this search correspond to an integrated luminosity of 103 fb−1 collected with a dedicated trijet trigger during the 2017 and 2018 √s=13 TeV proton-proton collision runs with the ATLAS detector at the LHC. The search looks for resonant peaks in the b-tagged dijet invariant mass spectrum over a smoothly falling background. The background is estimated with an innovative data-driven method based on orthonormal functions. The observed b-tagged dijet invariant mass spectrum is compatible with the background-only hypothesis. Upper limits at 95% confidence level on a heavy vector-boson production cross section times branching ratio to a pair of b-quarks are derived.
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| 41. |
- Andrean, Stefio Y., 1991-, et al.
(författare)
-
Search for single production of a vectorlike T quark decaying into a Higgs boson and top quark with fully hadronic final states using the ATLAS detector
- 2022
-
Ingår i: Physical Review D. - : American Physical Society (APS). - 2470-0010 .- 2470-0029. ; 105:9
-
Tidskriftsartikel (refereegranskat)abstract
- A search is made for a vectorlike T quark decaying into a Higgs boson and a top quark in 13 TeV proton-proton collisions using the ATLAS detector at the Large Hadron Collider with a data sample corresponding to an integrated luminosity of 139 fb−1. The Higgs-boson and top-quark candidates are identified in the all-hadronic decay mode, where H → bb¯ and t → bW → bqq¯′ are reconstructed as large-radius jets. The candidate Higgs boson, top quark, and associated B hadrons are identified using tagging algorithms. No significant excess is observed above the background, so limits are set on the production cross section of a singlet T quark at 95% confidence level, depending on the mass mT and coupling κT of the vectorlike T quark to Standard Model particles. In the considered mass range between 1.0 and 2.3 TeV, the upper limiton the allowed coupling values increases with mT from a minimum value of 0.35 for 1.07 < mT < 1.4 TeV to 1.6 for mT=2.3 TeV.
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| 42. |
- Backman, Filip, 1991-, et al.
(författare)
-
Studies of the muon momentum calibration and performance of the ATLAS detector with pp collisions at √s=13 TeV
- 2023
-
Ingår i: European Physical Journal C. - : SPRINGER. - 1434-6044 .- 1434-6052. ; 83:8
-
Tidskriftsartikel (refereegranskat)abstract
- ATLAS detector based on the pp collisions data sample produced at ?−−√ = 13 TeV at the LHC during Run 2 and corresponding to an integrated luminosity of 139 fb-1. An innovative approach is used to correct for potential charge-dependent momentum biases related to the knowledge of the detector geometry, using the ?→?+?− resonance. The muon momentum scale and resolution are measured using samples of ?/?→?+?− and ?→?+?− events. A calibration procedure is defined and applied to simulated data to match the performance measured in real data. The calibration is validated using an independent sample of Υ→?+?− events. At the Z (?/?) peak, the momentum scale is measured with an uncertainty at the 0.05% (0.1%) level, and the resolution is measured with an uncertainty at the 1.5% (2%) level. The charge-dependent bias is removed with a dedicated in situ correction for momenta up to 450 GeV with a precision better than 0.03 TeV-1.
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| 43. |
- Capote, R., et al.
(författare)
-
Unrecognized Sources of Uncertainties (USU) in Experimental Nuclear Data
- 2020
-
Ingår i: Nuclear Data Sheets. - : Elsevier BV. - 0090-3752 .- 1095-9904. ; 163, s. 191-227
-
Tidskriftsartikel (refereegranskat)abstract
- Evaluated nuclear data uncertainties reported in the literature or archived in data libraries are often perceived as unrealistic, most often because they are thought to be too small. The impact of this issue in applied nuclear science has been discussed widely in recent years. Commonly suggested causes are: poor estimates of specific error components, neglect of uncertainty correlations, and overlooked known error sources. However, instances have been reported where very careful, objective assessments of all known error sources have been made with realistic error magnitudes and correlations provided, yet the resulting evaluated uncertainties still appear to be inconsistent with observed scatter of predicted mean values. These discrepancies might be attributed to significant unrecognized sources of uncertainty (USU) that limit the accuracy to which these physical quantities can be determined.The objective of our work has been to develop qualitative and quantitative procedures for revealing and including USU estimates in nuclear data evaluations involving experimental input data. This paper identifies several specific clues that can be explored by evaluators in identifying the existence of USU. It then describes numerical procedures we have introduced to generate quantitative estimates of USU magnitudes. Key requirements for these procedures to be viable are that sufficient numbers of data points be available, for statistical reasons, and that additional supporting information about the measurements be provided by the experimenters. Several realistic examples are described here to illustrate these procedures and demonstrate their outcomes and limitations. Our work strongly supports the view that USU is an important issue in nuclear data evaluation, with significant consequences for applications, and that this topic warrants further investigation by the nuclear science community.
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| 44. |
- Engstrom, G., et al.
(författare)
-
Cardiovagal Function Measured by the Deep Breathing Test: Relationships With Coronary Atherosclerosis
- 2022
-
Ingår i: Journal of the American Heart Association. - : Ovid Technologies (Wolters Kluwer Health). - 2047-9980. ; 11:7
-
Tidskriftsartikel (refereegranskat)abstract
- Background The cardiovagal function can be assessed by quantification of respiratory sinus arrhythmia (RSA) during a deep breathing test. However, population studies of RSA and coronary atherosclerosis are lacking. This population-based study examined the relationship between RSA during deep breathing and coronary atherosclerosis, assessed by coronary artery calcium score (CACS). Methods and Results SCAPIS (Swedish Cardiopulmonary Bioimage Study) randomly invited men and women aged 50 to 64 years from the general population. CACS was obtained from computed tomography scanning, and deep breathing tests were performed in 4654 individuals. Expiration-inspiration differences (E-Is) of heart rates were calculated, and reduced RSA was defined as E-I in the lowest decile of the population. The relationship between reduced RSA and CACS (CACS >= 100 or CACS >= 300) was calculated using multivariable-adjusted logistic regression. The proportion of CACS >= 100 was 24% in the lowest decile of E-I and 12% in individuals with E-I above the lowest decile (P<0.001), and the proportion of CACS >= 300 was 12% and 4.8%, respectively (P<0.001). The adjusted odds ratio (OR) for CACS >= 100 was 1.42 (95% CI, 1.10-1.84) and the adjusted OR for CACS >= 300 was 1.62 (95% CI, 1.15-2.28), when comparing the lowest E-I decile with deciles 2 to 10. Adjusted ORs per 1 SD lower E-I were 1.17 (P=0.001) for CACS >= 100 and 1.28 (P=0.001) for CACS >= 300. Conclusions Low RSA during deep breathing is associated with increased coronary atherosclerosis as assessed by CACS, independently of traditional cardiovascular risk factors. Cardiovagal dysfunction could be a prevalent and modifiable risk factor for coronary atherosclerosis in the general population.
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| 45. |
- Jungen, SH, et al.
(författare)
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Spatial distribution of CD3- and CD8-positive lymphocytes as pretest for POLE wild-type in molecular subgroups of endometrial carcinoma
- 2023
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Ingår i: Frontiers in medicine. - : Frontiers Media SA. - 2296-858X. ; 10, s. 1110529-
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Tidskriftsartikel (refereegranskat)abstract
- Over the years, the molecular classification of endometrial carcinoma has evolved significantly. Both POLEmut and MMRdef cases share tumor biological similarities like high tumor mutational burden and induce strong lymphatic reactions. While therefore use case scenarios for pretesting with tumor-infiltrating lymphocytes to replace molecular analysis did not show promising results, such testing may be warranted in cases where an inverse prediction, such as that of POLEwt, is being considered. For that reason we used a spatial digital pathology method to quantitatively examine CD3+ and CD8+ immune infiltrates in comparison to conventional histopathological parameters, prognostics and as potential pretest before molecular analysis.MethodsWe applied a four-color multiplex immunofluorescence assay for pan-cytokeratin, CD3, CD8, and DAPI on 252 endometrial carcinomas as testing and compared it to further 213 cases as validation cohort from a similar multiplexing assay. We quantitatively assessed immune infiltrates in microscopic distances within the carcinoma, in a close distance of 50 microns, and in more distant areas.ResultsRegarding prognostics, high CD3+ and CD8+ densities in intra-tumoral and close subregions pointed toward a favorable outcome. However, TCGA subtyping outperforms prognostication of CD3 and CD8 based parameters. Different CD3+ and CD8+ densities were significantly associated with the TCGA subgroups, but not consistently for histopathological parameter. In the testing cohort, intra-tumoral densities of less than 50 intra-tumoral CD8+ cells/mm2 were the most suitable parameter to assume a POLEwt, irrespective of an MMRdef, NSMP or p53abn background. An application to the validation cohort corroborates these findings with an overall sensitivity of 95.5%.DiscussionMolecular confirmation of POLEmut cases remains the gold standard. Even if CD3+ and CD8+ cell densities appeared less prognostic than TCGA, low intra-tumoral CD8+ values predict a POLE wild-type at substantial percentage rates, but not vice versa. This inverse correlation might be useful to increase pretest probabilities in consecutive POLE testing. Molecular subtyping is currently not conducted in one-third of cases deemed low-risk based on conventional clinical and histopathological parameters. However, this percentage could potentially be increased to two-thirds by excluding sequencing of predicted POLE wild-type cases, which could be determined through precise quantification of intra-tumoral CD8+ cells.
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| 46. |
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| 47. |
- Mullier, G.A., et al.
(författare)
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A search for an unexpected asymmetry in the production of e+μ− and e−μ+ pairs in proton–proton collisions recorded by the ATLAS detector at √s = 13 TeV
- 2022
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 830
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Tidskriftsartikel (refereegranskat)abstract
- This search, a type not previously performed at ATLAS, uses a comparison of the production cross sections for e+μ− and e−μ+ pairs to constrain physics processes beyond the Standard Model. It uses 139fb−1 of proton–proton collision data recorded at √s=13 TeV at the LHC. Targeting sources of new physics which prefer final states containing e+μ− to e−μ+, the search contains two broad signal regions which are used to provide model-independent constraints on the ratio of cross sections at the 2% level. The search also has two special selections targeting supersymmetric models and leptoquark signatures. Observations using one of these selections are able to exclude, at 95% confidence level, singly produced smuons with masses up to 640 GeV in a model in which the only other light sparticle is a neutralino when the R-parity-violating coupling λ231′ is close to unity. Observations using the other selection exclude scalar leptoquarks with masses below 1880 GeV when geu1R=gμc1R=1, at 95% confidence level. The limit on the coupling reduces to geu1R=gμc1R=0.46 for a mass of 1420 GeV.
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| 48. |
- Mullier, G.A., et al.
(författare)
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AtlFast3 : The Next Generation of Fast Simulation in ATLAS
- 2022
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Ingår i: Computing and Software for Big Science. - : Springer Science and Business Media LLC. - 2510-2044 .- 2510-2036. ; 6:1
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Tidskriftsartikel (refereegranskat)abstract
- The ATLAS experiment at the Large Hadron Collider has a broad physics programme ranging from precision measurements to direct searches for new particles and new interactions, requiring ever larger and ever more accurate datasets of simulated Monte Carlo events. Detector simulation with GEANT4 is accurate but requires significant CPU resources. Over the past decade, ATLAS has developed and utilized tools that replace the most CPU-intensive component of the simulation—the calorimeter shower simulation—with faster simulation methods. Here, AtlFast3, the next generation of high-accuracy fast simulation in ATLAS, is introduced. AtlFast3 combines parameterized approaches with machine-learning techniques and is deployed to meet current and future computing challenges, and simulation needs of the ATLAS experiment. With highly accurate performance and significantly improved modelling of substructure within jets, AtlFast3 can simulate large numbers of events for a wide range of physics processes.
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| 49. |
- Mullier, G.A., et al.
(författare)
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Constraints on spin-0 dark matter mediators and invisible Higgs decays using ATLAS 13 TeV pp collision data with two top quarks and missing transverse momentum in the final state
- 2023
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Ingår i: European Physical Journal C. - : Institute for Ionics. - 1434-6044 .- 1434-6052. ; 83:6
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a statistical combination of searches targeting final states with two top quarks and invisible particles, characterised by the presence of zero, one or two leptons, at least one jet originating from a b-quark and missing transverse momentum. The analyses are searches for phenomena beyond the Standard Model consistent with the direct production of dark matter in pp collisions at the LHC, using 139 fb−1 of data collected with the ATLAS detector at a centre-of-mass energy of 13 TeV. The results are interpreted in terms of simplified dark matter models with a spin-0 scalar or pseudoscalar mediator particle. In addition, the results are interpreted in terms of upper limits on the Higgs boson invisible branching ratio, where the Higgs boson is produced according to the Standard Model in association with a pair of top quarks. For scalar (pseudoscalar) dark matter models, with all couplings set to unity, the statistical combination extends the mass range excluded by the best of the individual channels by 50 (25) GeV, excluding mediator masses up to 370 GeV. In addition, the statistical combination improves the expected coupling exclusion reach by 14% (24%), assuming a scalar (pseudoscalar) mediator mass of 10 GeV. An upper limit on the Higgs boson invisible branching ratio of 0.38 () is observed (expected) at 95% confidence level.
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| 50. |
- Mullier, G.A., et al.
(författare)
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Cross-section measurements for the production of a Z boson in association with high-transverse-momentum jets in pp collisions at √s = 13 TeV with the ATLAS detector
- 2023
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Ingår i: Journal of High Energy Physics (JHEP). - : Springer Science and Business Media Deutschland GmbH. - 1126-6708 .- 1029-8479. ; 2023:6
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Tidskriftsartikel (refereegranskat)abstract
- Cross-section measurements for a Z boson produced in association with high-transverse-momentum jets (pT ≥ 100 GeV) and decaying into a charged-lepton pair (e+e−, μ+μ−) are presented. The measurements are performed using proton–proton collisions at √s = 13 TeV corresponding to an integrated luminosity of 139 fb−1 collected by the ATLAS experiment at the LHC. Measurements of angular correlations between the Z boson and the closest jet are performed in events with at least one jet with pT ≥ 500 GeV. Event topologies of particular interest are the collinear emission of a Z boson in dijet events and a boosted Z boson recoiling against a jet. Fiducial cross sections are compared with state-of-the-art theoretical predictions. The data are found to agree with next-to-next-to-leading-order predictions by NNLOᴊᴇᴛ and with the next-to-leading-order multi-leg generators MADGRAPH5_AMC@NLO and SHERPA.
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