| 1. |
- Olofsson, Sarah, et al.
(författare)
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The Friend Locator : Supporting Visitors at Large-scale Events
- 2006
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Ingår i: Personal and Ubiquitous Computing. - : Springer London. - 1617-4909 .- 1617-4917. ; 10:2-3, s. 84-89
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Tidskriftsartikel (refereegranskat)abstract
- According to festival visitors, the best way to experience a music festival is to be together with friends. However, when at a crowded festival, visitors tend to lose each other especially when a lot of people are in motion. This paper reports upon findings made in an ethnographic field study that was carried out during Sweden's largest music event, the Hultsfred Rock Festival. The study was part of an international research and development project, called the Wireless Festival, which focuses on solutions for large-scale events. The aim of our study was to determine who the typical visitor to the festival was, identify what was important for festival visitors and finally to observe the visitors use of mobile phones. Our findings imply the festival visitors' need for a friend locator appliance. An early design solution for such appliance is discussed in relation to the findings made.
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| 2. |
- Rewers, Marian, et al.
(författare)
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The Environmental Determinants of Diabetes in the Young (TEDDY) Study
- 2008
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Ingår i: Annals of the New York Academy of Sciences. - : Wiley. - 0077-8923 .- 1749-6632. ; 1150, s. 1-13
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Tidskriftsartikel (refereegranskat)abstract
- The etiology of type 1 diabetes (T1D) remains unknown, but a growing body of evidence points to infectious agents and/or components of early childhood diet. The National Institutes of Health has established the TEDDY Study consortium of six clinical centers in the United States and Europe and a data coordinating center to identify environmental factors predisposing to, or protective against, islet autoimmunity and T1D. From 2004-2009, TEDDY will screen more than 360,000 newborns from both the general population and families already affected by T1D to identify an estimated 17,804 children with high-risk HLA-DR,DQ genotypes. Of those, 7,801 (788 first-degree relatives and 7,013 newborns with no family history of T1D) will be enrolled in prospective follow-up beginning before the age of 4.5 months. As of May 2008, TEDDY has screened more than 250,000 newborns and enrolled nearly 5,000 infants--approximately 70% of the final cohort. Participants are seen every 3 months up to 4 years of age, with subsequent visits every 6 months until the subject is 15 years of age. Blood samples are collected at each visit for detection of candidate infectious agents and nutritional biomarkers; monthly stool samples are collected for infectious agents. These samples are saved in a central repository. Primary endpoints include (1) appearance of one or more islet autoantibodies (to insulin, GAD65 or IA-2) confirmed at two consecutive visits; (2) development of T1D. By age 15, an estimated 800 children will develop islet autoimmunity and 400 will progress to T1D; 67 and 27 children have already reached these endpoints.
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| 3. |
- Westerlund, Jessica, 1977, et al.
(författare)
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Expression of Islet1 in thyroid development related to budding, migration, and fusion of primordia.
- 2008
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Ingår i: Developmental dynamics : an official publication of the American Association of Anatomists. - : Wiley. - 1058-8388. ; 237:12, s. 3820-9
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Tidskriftsartikel (refereegranskat)abstract
- The LIM homeodomain transcription factor Isl1 was investigated in mouse thyroid organogenesis. All progenitor cells of the midline thyroid diverticulum and lateral primordia (ultimobranchial bodies) expressed Isl1. This pattern persisted until the growing anlagen fused at embryonic day (E) 13.5. In Isl1 null mutants thyroid progenitors expressing Nkx2.1 and Pax8 were readily specified in the anterior endoderm but the size of the thyroid rudiment was reduced. In late development, only immature C-cells expressed Isl1. In the adult gland the number of Isl1+ cells was small compared with cells expressing calcitonin. Analysis of microarray profiles indicated a higher level of Isl1 expression in medullary thyroid carcinomas than in tumors derived from follicular cells. Together, these findings suggest that Isl1 may be a novel regulator of thyroid development before terminal differentiation of the endocrine cell types. Isl1 is an embryonic C-cell precursor marker that may be relevant also in cancer developed from the mature C-cell.
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