| 1. |
- Caffaro, Federica, et al.
(författare)
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Falls from Tractors in Older Age : Risky Behaviors in a Group of Swedish and Italian Farmers Over 65
- 2019
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Ingår i: Proceedings of the 20th Congress of the International Ergonomics Association (IEA 2018). : Aging, Gender and Work, Anthropometry, Ergonomics for Children and Educational Environments - Aging, Gender and Work, Anthropometry, Ergonomics for Children and Educational Environments. - Cham : Springer International Publishing. - 9783319960654 - 9783319960647 ; , s. 78-86, s. 78-86
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Konferensbidrag (refereegranskat)abstract
- The frequent mounting and dismounting the tractor required by many farming operations increases the risk of falls, particularly for older farmers. The present study explored the risk factors related to tractor ingress and egress in older farmers from two countries with a different tradition in terms of safety culture: Sweden and Italy. Eighteen male farmers aged 65 + (8 from Skåne region, southern Sweden, and 10 from Piedmont region, northwestern Italy) were observed while mounting and dismounting their most used tractor, to investigate the routine behaviors adopted and to identify possible sources of risk of fall. The presence of three critical behaviors was recorded: the maintenance of three-point contact with the machine when entering and exiting the cab; facing the cab and the use of the last step when exiting. Farmers were also interviewed about their health status, attitudes toward safety, and perceived risks while performing the task. The results showed that similar unsafe behaviors were adopted by most of both Swedish and Italian participants; in particular, none of the farmers got off the tractor by facing the cab. Older farmers from both countries referred to age and previous experience as the major protective factors against falls, without acknowledging that new risks can rise from the age-related changes in their motor skills. The results raised some considerations about the need to develop targeted elderly-centered solutions to support the correct mounting/dismounting behaviors, both in the design of the machines and in information campaigns and training courses, which may have a cross-cultural validity.
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| 2. |
- Grasso, Silvia, et al.
(författare)
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The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries
- 2017
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- The docking protein p140Cap negatively regulates tumour cell features. Its relevance on breast cancer patient survival, as well as its ability to counteract relevant cancer signalling pathways, are not fully understood. Here we report that in patients with ERBB2-amplified breast cancer, a p140Cap-positive status associates with a significantly lower probability of developing a distant event, and a clear difference in survival. p140Cap dampens ERBB2-positive tumour cell progression, impairing tumour onset and growth in the NeuT mouse model, and counteracting epithelial mesenchymal transition, resulting in decreased metastasis formation. One major mechanism is the ability of p140Cap to interfere with ERBB2-dependent activation of Rac GTPase-controlled circuitries. Our findings point to a specific role of p140Cap in curbing the aggressiveness of ERBB2-amplified breast cancers and suggest that, due to its ability to impinge on specific molecular pathways, p140Cap may represent a predictive biomarker of response to targeted anti-ERBB2 therapies.
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