| 1. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 2. |
- Ablikim, M., et al.
(författare)
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Measurement of the $D\to K^-\pi^+$ strong phase difference in $\psi(3770)\to D^0\overline{D}{}^0$
- 2014
-
Ingår i: PHYSICS LETTERS B. - : Elsevier BV. - 0370-2693. ; 734
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Tidskriftsartikel (refereegranskat)abstract
- We study $D^0\overline{D}{}^0$ pairs produced in $e^+e^-$ collisions at $\sqrt{s}=3.773$ GeV using a data sample of 2.92 fb$^{-1}$ collected with the BESIII detector. We measure the asymmetry $\mathcal{A}^{CP}_{K\pi}$ of the branching fractions of $D \to K^-\pi^+$ in $CP$-odd and $CP$-even eigenstates to be $(12.7\pm1.3\pm0.7)\times10^{-2}$. $\mathcal{A}^{CP}_{K\pi}$ can be used to extract the strong phase difference $\delta_{K\pi}$ between the doubly Cabibbo-suppressed process $\overline{D}{}^{0}\to K^-\pi^+$ and the Cabibbo-favored process $D^0\to K^- \pi^+$. Using world-average values of external parameters, we obtain $\cos\delta_{K\pi} = 1.02\pm0.11\pm0.06\pm0.01$. Here, the first and second uncertainties are statistical and systematic, respectively, while the third uncertainty arises from the external parameters. This is the most precise measurement of $\delta_{K\pi}$ to date.
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| 3. |
- Ablikim, M., et al.
(författare)
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Observation of e(+)e(-) -> gamma X(3872) at BESIII
- 2014
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 112:9, s. 092001-
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Tidskriftsartikel (refereegranskat)abstract
- With data samples collected with the BESIII detector operating at the BEPCII storage ring at center-of-mass energies from 4.009 to 4.420 GeV, the process e(+)e(-) -> gamma X(3872) is observed for the first time with a statistical significance of 6.3 sigma. The measured mass of the X(3872) is (3871.9 +/- 0.7(stat) +/- 0.2(syst)) MeV/c(2), in agreement with previous measurements. Measurements of the product of the cross section sigma[e(+)e(-) -> gamma X(3872)] and the branching fraction B [X(3872) -> pi(+)pi(-)J/psi] at center-of-mass energies 4.009, 4.229, 4.260, and 4.360 GeV are reported. Our measurements are consistent with expectations for the radiative transition process Y(4260) -> gamma X(3872).
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| 4. |
- Ablikim, M., et al.
(författare)
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Observation of e(+)e(-) -> pi(0)pi(0)h(c) and a Neutral Charmoniumlike Structure Z(c)(4020)(0)
- 2014
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 113:21, s. 212002-
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Tidskriftsartikel (refereegranskat)abstract
- Using data collected with the BESIII detector operating at the Beijing Electron Positron Collider at center-of-mass energies of root s = 4.23, 4.26, and 4.36 GeV, we observe e(+)e(-) -> pi(0)pi(0)h(c) for the first time. The Born cross sections are measured and found to be about half of those of e(+)e(-) -> pi(+)pi(-)h(c) within less than 2 sigma. In the pi(0)h(c) mass spectrum, a structure at 4.02 GeV/c(2) is found. It is most likely to be the neutral isospin partner of the Z(c)(4020)(+/-) observed in the process of e(+)e(-) -> pi(+)pi(-)h(c) being found. A fit to the pi(0)h(c) invariant mass spectrum, with the width of the Z(c)(4020)(0) fixed to that of its charged isospin partner and possible interferences with non-Z(c)(4020)(0) amplitudes neglected, gives a mass of (4023.9 +/- 2.2 +/- 3.8) MeV/c(2) for the Z(c)(4020)(0), where the first error is statistical and the second systematic.
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| 5. |
- Ablikim, M., et al.
(författare)
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Observation of $e^+e^− → γX$(3872) at BESIII
- 2014
-
Ingår i: PHYSICAL REVIEW LETTERS. - 1079-7114. ; 112:9
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Tidskriftsartikel (refereegranskat)abstract
- With data samples collected with the BESIII detector operating at the BEPCII storage ring at center-of-mass energies from 4.009 to 4.420 GeV, the process $e^{+} e^{-} \to \gamma X(3872)$ is observed for the first time with a statistical significance of $6.3\sigma$. The measured mass of the $X(3872)$ is ($3871.9\pm 0.7_{\rm stat.}\pm 0.2_{\rm sys.}$) MeV/$c^2$, in agreement with previous measurements. Measurements of the product of the cross section $\sigma[e^{+} e^{-} \to \gamma X(3872)]$ and the branching fraction $\mathcal{B}[X(3872) \to \pi^{+} \pi^{-} J/\psi]$ at center-of-mass energies 4.009, 4.229, 4.260, and 4.360 GeV are reported. Our measurements are consistent with expectations for the radiative transition process $Y(4260) \to \gamma X(3872)$.
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| 6. |
- Ablikim, M., et al.
(författare)
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Observation of electromagnetic Dalitz decays J/\psi \to P e^+e^-
- 2014
-
Ingår i: PHYSICAL REVIEW D. - 2470-0010 .- 1550-7998 .- 1550-2368. ; 89:9
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Tidskriftsartikel (refereegranskat)abstract
- Based on a sample of (225.3\pm2.8)\times 10^{6} J/\psi events collected with the BESIII detector, the electromagnetic Dalitz decays of J/\psi \to P e^+e^-(P=\eta'/\eta/\pi^0) are studied. By reconstructing the pseudoscalar mesons in various decay modes, the decays J/\psi \to \eta' e^+e^-, J/\psi \to \eta e^+e^- and J/\psi \to \pi^0 e^+e^- are observed for the first time. The branching fractions are determined to be \mathcal{B}(J/\psi\to \eta' e^+e^-) = (5.81\pm0.16\pm0.31)\times10^{-5}, \mathcal{B}(J/\psi\to \eta e^+e^-) = (1.16\pm0.07\pm0.06)\times10^{-5}, and \mathcal{B}(J/\psi\to \pi^0 e^+e^-)=(7.56\pm1.32\pm0.50)\times10^{-7}, where the first errors are statistical and the second ones systematic.
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| 7. |
- Ablikim, M., et al.
(författare)
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Observation of the decay psi(3686) -> Lambda(Sigma)over-bar(+/-) pi(-/+) + c.c
- 2013
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 88:11, s. 112007-
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Tidskriftsartikel (refereegranskat)abstract
- Using a sample of 1:06 X 10(8) psi(3686) events collected with the BESIII detector, we present the first observation of the decays of psi(3686) -> Lambda(Sigma) over bar (+) pi(-) + c.c. and psi(3686) -> Lambda(Sigma) over bar (-) pi(+) + c.c. The branching fractions are measured to be B(psi(3686) -> Lambda(Sigma) over bar (+) pi(-) + c.c.) = (1.40 +/- 0.03 +/- 0.13) X 10(-4) and B(psi(3686) -> Lambda (Sigma) over bar (-) pi(+) + c.c.) = (1.54 +/- 0.04 +/- 0.13) X 10(-4) where the first errors are statistical and the second ones systematic.
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| 8. |
- Ablikim, M., et al.
(författare)
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Precision measurements of $B(D^+ \rightarrow \mu^+ \nu_{\mu})$, the pseudoscalar decay constant $f_{D^+}$, and the quark mixing matrix element $|V_{\rm cd}|$
- 2014
-
Ingår i: PHYSICAL REVIEW D. - 2470-0010 .- 1550-7998 .- 1550-2368. ; 89:5
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Tidskriftsartikel (refereegranskat)abstract
- We report a measurement of the branching fraction $B(D^+ \rightarrow \mu^+ \nu_{\mu}) = [3.71 \pm 0.19 (\rm stat) \pm 0.06 (\rm sys)]\times 10^{-4}$ based on 2.92 ${\rm fb^{-1}}$ of data accumulated at $\sqrt{s}=3.773$ GeV with the BESIII detector at the BEPCII collider. This measurement, in conjunction with the Cabibbo-Kobayashi-Maskawa matrix element $|V_{\rm cd}|$ determined from a global Standard Model fit, implies a value for the weak decay constant $f_{D^+}=(203.2 \pm 5.3 \pm 1.8)$ MeV. Additionally, using this branching fraction measurement together with a Lattice QCD prediction for $f_{D^+}$, we find $|V_{\rm cd}|=0.2210\pm 0.0058 \pm 0.0047$. In either case, these are the most precise results for these quantities to date.
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| 9. |
- Ablikim, M., et al.
(författare)
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Search for eta(c)(2S)h(c) -> p(p)over-bar decays and measurements of the chi(cJ) -> p(p)over-bar branching fractions
- 2013
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 88:11, s. 112001-
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Tidskriftsartikel (refereegranskat)abstract
- Using a sample of 1.06 x 10(8)psi(3686) events collected with the BESIII detector at BEPCII, the decays eta(c)(2S) -> p (p) over bar and h(c) -> p (p) over bar are searched for, where eta(c)(2S) and h(c) are reconstructed in the decay chains psi(3686) -> gamma eta(c)(2S), eta(c)(2S) -> p (p) over bar and psi(3686) -> pi(0)h(c), h(c) -> p (p) over bar, respectively. No significant signals are observed. The upper limits of the product branching fractions are determined to be B(psi(3686) -> gamma eta(c)(2S)) x B(eta(c)(2S) -> p (p) over bar) < 1.4 x 10(-6) and B(psi(3686) -> pi(0)h(c)) x B(h(c) -> p<(p)over bar>) < 1.3 x 10(-7) at the 90% C.L.. The branching fractions for chi(cJ) -> p<(p)over bar> (J = 0, 1, 2) are also measured to be (24.5 +/- 0.8 +/- 1.3, 8.6 +/- 0.5 +/- 0.5, 8.4 +/- 0.5 +/- 0.5) x 10(-5), which are the world's most precise measurements.
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| 10. |
- Ablikim, M., et al.
(författare)
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Search for the weak decays J/psi -> D-s(()*()-) e(+)nu(e) + c.c.
- 2014
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 90:11, s. 112014-
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Tidskriftsartikel (refereegranskat)abstract
- Using a sample of 2.25 x 10(8) J/psi events collected with the BESIII detector at the BEPCII collider, we search for the J/psi semileptonic weak decay J/psi -> D-s(-) e(+)nu(e) +c.c. with a much higher sensitivity than previous searches. We also perform the first search for J/psi -> D-s(*-) e(+) nu(e) + c.c. No significant excess of a signal above background is observed in either channel. At the 90% confidence level, the upper limits are determined to be B(J/psi -> D-s(-) e(+) nu(e) + c.c.) < 1.3 x 10(-6) and B(J/psi -> D-s*(-) e(+) nu(e) + c.c.) < 1.8 x 10(-6), respectively. Both are consistent with Standard Model predictions.
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| 11. |
- Wang, Zhaoming, et al.
(författare)
-
Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
- 2014
-
Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:24, s. 6616-6633
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.
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| 12. |
- Ablikim, M., et al.
(författare)
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Amplitude analysis of the D+ -> K-S(0)pi + (0)(pi) Dalitz plot
- 2014
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 89:5, s. 052001-
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Tidskriftsartikel (refereegranskat)abstract
- We perform an analysis of the D+ -> K-S(0)pi + (0)(pi) Dalitz plot using a data set of 2.92 fb(-1) of e(+) e(-) collisions at the (3770) mass accumulated by the BESIII experiment, in which 166694 candidate events are selected with a background of 15.1%. The Dalitz plot is found to be well represented by a combination of six quasitwo- body decay channels [k(SP)(0)(+) (1450)(+,) ] plus a small nonresonant component. Using the fit fractions from this analysis, partial branching ratios are updated with higher precision than previous measurements.
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| 13. |
- Ablikim, M., et al.
(författare)
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Measurement of chi(cJ) decaying into eta ' K+K-
- 2014
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 89:7, s. 074030-
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Tidskriftsartikel (refereegranskat)abstract
- Using (106.41 +/- 0.86) x 10(6) Psi(3686) events collected with the BESIII detector at BEPCII, we study for the first time the decay chi(cJ) -> eta'K+K- (J = 1, 2), where eta' -> gamma rho(0) and eta' -> eta pi(+)pi(-). A partial wave analysis in the covariant tensor amplitude formalism is performed for the decay chi(c1) -> eta'K+K-. Intermediate processes chi(c1) -> eta'f(2)'(1525) chi(c1) -> K-0*(1430)K-+/-(-/+) (K-0*(1430)(+/-) -> eta'K-+/-) are observed with statistical significances larger than 5 sigma, and their branching fractions are measured.
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| 14. |
- Ablikim, M., et al.
(författare)
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Measurement of the branching fraction for psi(3686) -> omega K+K-
- 2014
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 89:11, s. 112006-
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Tidskriftsartikel (refereegranskat)abstract
- With 1.06 x 10(8) psi(3686) events collected with the BESIII detector, the branching fraction of psi(3686) -> omega K+K- is measured to be (1.54 +/- 0.04 +/- 0.11) x 10(-4). This is the most precise result to date, due to the largest psi(3686) sample, improved signal reconstruction efficiency, good simulation of the detector performance, and a more accurate knowledge of the continuum contribution. Using the branching fraction of J/psi -> omega K+K-, the ratio B(psi(3868) -> K+K-)/B(J/psi -> K+K-) is determined to be (18.4 +/- 3.7)%. This constitutes a significantly improved test of the 12% rule, with the uncertainty now dominated by the J/psi branching fraction.
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| 15. |
- Ablikim, M., et al.
(författare)
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Observation of eta' -> pi(+) pi(-) pi(+) pi(-) and eta' -> pi(+) pi(-) pi(0) pi(0)
- 2014
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 112:25, s. 251801-
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Tidskriftsartikel (refereegranskat)abstract
- Using a sample of 1.3 x 10(9) J/psi events collected with the BESIII detector, we report the first observation of eta' -> pi(+) pi(-) pi(+) pi(-) and eta' -> pi(+) pi(-) pi(0) pi(0). The measured branching fractions are B(eta' -> pi(+) pi(-) pi(+) pi(-)) = [8.53 +/- 0.69(stat.) +/- 0.64(syst.)] x 10(-5) and B(eta' -> pi(+) pi(-) pi(0) pi(0)) = [1.82 +/- 0.35(stat.) +/- 0.18(syst.)] x 10(-4), which are consistent with theoretical predictions based on a combination of chiral perturbation theory and vector-meson dominance.
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| 16. |
- Ablikim, M., et al.
(författare)
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Observation of J/psi -> p(p)over-bara(0)(980) at BESIII
- 2014
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 90:5, s. 052009-
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Tidskriftsartikel (refereegranskat)abstract
- Using 2.25 x 10(8) J/psi events collected with the BESIII detector at the BEPCII storage rings, we observe for the first time the process J/psi -> p (p) over bara(0)(980) -> pi(0)eta with a significance of 6.5 sigma (3.2 sigma including systematic uncertainties). The product branching fraction of J/psi -> p (p) over bara(0)(980) -> p (p) over bara(0)pi(0)eta is measured to be (6.8 +/- 1.2 +/- 1.3) x 10(-5), where the first error is statistical and the second is systematic. This measurement provides information on the a(0) production near threshold coupling to p (p) over bar and improves the understanding of the dynamics of J/psi decays to four-body processes.
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| 17. |
- Ablikim, M., et al.
(författare)
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Precision measurement of the mass of the tau lepton
- 2014
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 90:1
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Tidskriftsartikel (refereegranskat)abstract
- An energy scan near the tau pair production threshold has been performed using the BESIII detector. About 24 pb(-1) of data, distributed over four scan points, were collected. This analysis is based on t pair decays to ee, e mu, eh, h, hh, e.,. and p. final states, where h denotes a charged p or K. The mass of the t lepton is measured from a maximum likelihood fit to the t pair production cross- section data to be m(tau) = 1776.91 +/- 0.12_0.10 - 0.13 _ MeV/c(2), which is currently the most precise value in a single measurement.
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| 18. |
- Ablikim, M., et al.
(författare)
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Search for C-parity violation in J/psi -> gamma gamma and gamma phi
- 2014
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 90:9, s. 092002-
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Tidskriftsartikel (refereegranskat)abstract
- Using 1.06 x 10(8) psi(3686) events recorded in e(+)e(-) collisions at root s = 3.686 GeV with the BESIII at the BEPCII collider, we present searches for C-parity violation in J/psi -> gamma gamma and gamma phi decays via psi(3686) -> J/psi pi(+)pi(-). No significant signals are observed in either channel. Upper limits on the branching fractions are set to be B(J/psi -> gamma gamma) < 2.7 x 10(-7) and B(J/psi -> gamma phi) < 1.4 x 10(-6) at the 90% confidence level. The former is one order of magnitude more stringent than the previous upper limit, and the latter represents the first limit on this decay channel.
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| 19. |
- Ablikim, M., et al.
(författare)
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Search for the radiative transitions Psi(3770) -> gamma eta(c) and gamma eta(c) (2S)
- 2014
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 89:11, s. 112005-
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Tidskriftsartikel (refereegranskat)abstract
- By using a 2.92 fb-1 data sample taken at pffisffiffi 3.773 GeV with the BESIII detector operating at the BEPCII collider, we search for the radiative transitions.d3770c and cd2S through the hadronic decays cdcd2S. K0 SK p. No significant excess of signal events above background is observed. We set upper limits at a 90% confidence level for the product branching fractions to be Bdd3770cxBd.c. K0 SK k p < 1.6x10-5 and Bd.d3770cd2SxBd.cd2S. K0 SK p<5.6x10-6. Combining our result with world-average values of Bd.cd.cd2S. K0 SK p, we find the branching fractions Bd.d3770c< 6.8 x 10-4 and Bd.d3770cd2S< 2.0 x 10-3 at a 90% confidence level.
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| 20. |
- Ablikim, M., et al.
(författare)
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Search for the rare decays J/y -> D-s(-) rho(+) and J/psi -> <(D)over bar(0)<(K)over bar*(0)
- 2014
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 89:7, s. 071101-
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Tidskriftsartikel (refereegranskat)abstract
- A search for the rare decays of J/psi -> D-S(-) rho(+) + c.c. and J/psi -> <(D)over bar(0)<(K)over bar*(0) + c.c. is performed with a data sample of 225.3-million J/psi events collected with the Beijing Spectrometer III detector. No evident signal is observed. Upper limits on the branching fractions are determined to be beta(J/psi -> D-S(-)rho(+) + c.c.) < 1.3 x 10(-5) and beta(J/psi -> <(D)over bar(0)<(K)over bar*(0) + c.c.) < 2.5 x 10(-6) at the 90% confidence level.
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| 21. |
- Ablikim, M., et al.
(författare)
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Study of e(+)e(-) -> p(p)over-bar in the vicinity of psi(3770)
- 2014
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 735, s. 101-107
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Tidskriftsartikel (refereegranskat)abstract
- Using 2917 pb(-1) of data accumulated at 3.773 GeV, 44.5 pb(-1) of data accumulated at 3.65 GeV and data accumulated during a psi(3770) line-shape scan with the BESIII detector, the reaction e(+)e(-) -> p (p) over bar is studied considering a possible interference between resonant and continuum amplitudes. The cross section of e(+)e(-) -> psi(3770) -> p (p) over bar, sigma(e(+)e(-)-> psi(3770) -> p (p) over bar), is found to have two solutions, determined to be (0.059(-0.020)(+0.070) +/- 0.012) pb with the phase angle phi = (255.8(-26.6)(+39.0) +/- 4.8). (< 0.166 pb at the 90% confidence level), or sigma(e(+)e(-) -> psi(3770) -> p<(p)over bar>) = (2.57(-0.13)(+0.12) +/- 0.12) pb with phi = (266.9(-6.3)(+6.1) +/- 0.9)degrees both of which agree with a destructive interference. Using the obtained cross section of psi(3770) -> p (p) over bar, the cross section of p (p) over bar -> psi(3770), which is useful information for the future PANDA experiment, is estimated to be either (9.8(-3.9)(+11.8)) nb (< 27.5 nb at 90% C.L.) or (425.6(-43.7)(+42.9)) nb. (C) 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license.
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| 22. |
- Ablikim, M., et al.
(författare)
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Study of e(+)e(-) -> p(p)over-bar pi(0) in the vicinity of the psi(3770)
- 2014
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 90:3, s. 032007-
-
Tidskriftsartikel (refereegranskat)abstract
- The process e(+)e(-) -> p (p) over bar pi(0) has been studied by analyzing data collected at root s = 3.773 GeV, root s = 3.650 GeV, and during a psi(3770) line shape scan with the BESIII detector at the BEPCII collider. The Born cross section of p (p) over bar pi(0) in the vicinity of the psi(3770) is measured, and the Born cross section of psi(3770) -> p (p) over bar pi(0) is extracted considering interference between resonant and continuum production amplitudes. Two solutions with the same probability and a significance of 1.5 sigma are found. The solutions for the Born cross section of psi(3770) -> p (p) over bar pi(0) are 33.8 +/- 1.8 +/- 2.1 pb and 0.06(-0.04-0.01)(+0.10+0.01) pb (< 0.22 pb at a 90% confidence level). Using the estimated cross section and a constant decay amplitude approximation, the cross section sigma(p<(p)over bar> -> psi(3770)pi(0)) is calculated for the kinematic situation of the planned (p) over bar ANDA experiment. The maximum cross section corresponding to the two solutions is expected to be less than 0.79 nb at 90% confidence level and 122 +/- 10 nb at a center-of-mass energy of 5.26 GeV.
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| 23. |
- Aad, G., et al.
(författare)
-
- 2013
-
Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :3
-
Tidskriftsartikel (refereegranskat)
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| 24. |
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| 25. |
- Deng, Min, et al.
(författare)
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Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis
- 2013
-
Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 45:6, s. 697-
-
Tidskriftsartikel (refereegranskat)abstract
- To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, P-combined = 2.92 x 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, P-combined = 2.35 x 10(-9), OR = 1.52). These two loci explain 12.48% of the overall variance in disease risk in the Han Chinese population. We found no association evidence for the previously reported loci in the Han Chinese population, suggesting genetic heterogeneity of disease susceptibility for ALS between ancestry groups. Our study identifies two new susceptibility loci and suggests new pathogenic mechanisms of ALS.
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| 26. |
- Du, Wenhui, et al.
(författare)
-
New fast curing isotropic conductive adhesive for electronic packaging application
- 2010
-
Ingår i: Proceedings - 2010 11th International Conference on Electronic Packaging Technology and High Density Packaging, ICEPT-HDP 2010; Xi'an; 16 August 2010 through 19 August 2010. - 9781424481422 ; :Article number 5582446, s. 199-201
-
Konferensbidrag (refereegranskat)abstract
- With the rapid development of technologies on high density assembly and packaging in electronic industry, isotropic conductive adhesive (ICA) has been paid more and more attention as a potential substitute of solder, due to its advantages of low processing temperature, simple processing conditions and good manufacturability. However, the curing time of most traditional ICA is more than half an hour. The process duration of ICA is 2 or 3 times longer than that of solder. Thus, low efficiencies of energy using and product manufacturing has been one of factors which limits widely application of ICA. Generally, the curing speed of ICA depends on types and amount of curing agent as well as curing temperature. In our previous experiments, the effects of curing temperature and amount of curing agent have been investigated. So, the present work attempts to choose a new kind of curing agent to shorten process duration of ICA. By using new curing agent, the curing duration of ICA could be shortened in 5 minutes with a high curing rate compared with the previous version. In addition, the basic performance including bulk resistivity and viscosity are also investigated in this work. Finally, we present some discussions about the further optimization of performance, for example regarding the ways of achieving better electrical conductivity with lower filler content and improvement of viscosity etc. © 2010 IEEE.
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| 27. |
- Speliotes, Elizabeth K., et al.
(författare)
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- 2010
-
Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948
-
Tidskriftsartikel (refereegranskat)abstract
- Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
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| 28. |
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| 29. |
- Yan, G., et al.
(författare)
-
Silencing RhoA inhibits migration and invasion through Wnt/β-catenin pathway and growth through cell cycle regulation in human tongue cancer
- 2014
-
Ingår i: Acta Biochimica et Biophysica Sinica. - : China Science Publishing & Media Ltd.. - 1672-9145 .- 1745-7270. ; 46:8, s. 682-690
-
Tidskriftsartikel (refereegranskat)abstract
- Ras homolog gene family member A (RhoA) has been identified as a critical regulator of tumor aggressive behavior. In this study, we assessed the role of RhoA in the mechanisms underlying growth, migration, and invasion of squamous cell carcinoma of tongue (TSCC). Stable RhoA knockdown of TSCC cell lines SCC-4 and CAL27 were achieved using Lentiviral transfection. The effects of RhoA depletion on cell migration, invasion, and cell proliferation were determined. The possible underlying mechanism of RhoA depletion on TSCC cell line was also evaluated by determining the expression of Galectin-3 (Gal-3), β-catenin, and matrix metalloproteinase-9 (MMP-9) in vivo. Meanwhile, the underlying mechanism of TSCC growth was studied by analysis of cyclin D1/2, p21 CIP1/WAF1, and p27Kip1 protein levels. Immunohistochemical assessments were performed to further prove the alteration of Gal-3 and β-catenin expression. We found that, in mice injected with human TSCC cells in the tongue, RhoA levels were higher in primary tumors and metastasized lymph nodes compared with those in the normal tissues. Silencing of RhoA significantly reduced the tumor growth, decreased the levels of Gal-3, β-catenin, MMP-9, and cyclin D1/2, and increased the levels of p21 CIP1/WAF1 and p27Kip1. In vitro, RhoA knockdown also led to inhibition of cell migration, invasion, and proliferation. Our data suggest that RhoA plays a significant role in TSCC progression by regulating cell migration and invasion through Wnt/β-catenin signaling pathway and cell proliferation through cell cycle regulation, respectively. RhoA might be a novel therapeutic target of TSCC. © 2014 The Author .
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| 30. |
- Araghi, Marzieh Hosseini, et al.
(författare)
-
Effectiveness of Lifestyle Interventions on Obstructive Sleep Apnea (OSA) : Systematic Review and Meta-Analysis
- 2013
-
Ingår i: Sleep. - : Oxford University Press. - 0161-8105 .- 1550-9109. ; 36:10, s. 1553-1562
-
Forskningsöversikt (refereegranskat)abstract
- Background: Obstructive sleep apnea (OSA) is a common sleep disorder associated with several adverse health outcomes. Given the close association between OSA and obesity, lifestyle and dietary interventions are commonly recommended to patients, but the evidence for their impact on OSA has not been systematically examined. Objectives: To conduct a systematic review and meta-analysis to assess the impact of weight loss through diet and physical activity on measures of OSA: apnea-hypopnea index (AHI) and oxygen desaturation index of 4% (ODI4). Methods: A systematic search was performed to identify publications using Medline (1948-2011 week 40), EMBASE (from 1988-2011 week 40), and CINAHL (from 1982-2011 week 40). The inverse variance method was used to weight studies and the random effects model was used to analyze data. Results: Seven randomized controlled trials (519 participants) showed that weight reduction programs were associated with a decrease in AHI (-6.04 events/h [95% confidence interval -11.18, -0.90]) with substantial heterogeneity between studies (I-2 = 86%). Nine uncontrolled before-after studies (250 participants) showed a significant decrease in AHI (-12.26 events/h [95% confidence interval -18.51, -6.02]). Four uncontrolled before-after studies (97 participants) with ODI4 as outcome also showed a significant decrease in ODI4 (-18.91 episodes/h [95% confidence interval -23.40, -14.43]). Conclusions: Published evidence suggests that weight loss through lifestyle and dietary interventions results in improvements in obstructive sleep apnea parameters, but is insufficient to normalize them. The changes in obstructive sleep apnea parameters could, however, be clinically relevant in some patients by reducing obstructive sleep apnea severity. These promising preliminary results need confirmation through larger randomized studies including more intensive weight loss approaches.
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| 31. |
- Chen, Yun, 1966, et al.
(författare)
-
Characterization of VCAM-1-Binding Peptide-Functionalized Quantum Dots for Molecular Imaging of Inflamed Endothelium
- 2013
-
Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 8:12
-
Tidskriftsartikel (refereegranskat)abstract
- Inflammation-induced activation of endothelium constitutes one of the earliest changes during atherogenesis. New imaging techniques that allow detecting activated endothelial cells can improve the identification of persons at high cardiovascular risk in early stages. Quantum dots (QDs) have attractive optical properties such as bright fluorescence and high photostability, and have been increasingly studied and developed for bio-imaging and bio-targeting applications. We report here the development of vascular cell adhesion molecule-1 binding peptide (VCAM-1 binding peptide) functionalized QDs (VQDs) from amino QDs. It was found that the QD fluorescence signal in tumor necrosis factor alpha (TNF-alpha) treated endothelial cells in vitro was significantly higher when these cells were labeled with VQDs than amino QDs. The VQD labeling of TNF-alpha-treated endothelial cells was VCAM-1 specific since pre-incubation with recombinant VCAM-1 blocked cells' uptake of VQDs. Our ex vivo and in vivo experiments showed that in the inflamed endothelium, QD fluorescence signal from VQDs was also much stronger than that of amino QDs. Moreover, we observed that the QD fluorescence peak was significantly blue-shifted after VQDs interacted with aortic endothelial cells in vivo and in vitro. A similar blue-shift was observed after VQDs were incubated with recombinant VCAM-1 in tube. We anticipate that the specific interaction between VQDs and VCAM-1 and the blue-shift of the QD fluorescence peak can be very useful for VCAM-1 detection in vivo.
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| 32. |
- Chen, Zhihui, et al.
(författare)
-
Exciton Polariton Contribution to the Stokes Shift in Colloidal Quantum Dots
- 2011
-
Ingår i: The Journal of Physical Chemistry C. - : American Chemical Society (ACS). - 1932-7447 .- 1932-7455. ; 115:13, s. 5286-5293
-
Tidskriftsartikel (refereegranskat)abstract
- We study the exciton polariton contribution to the Stokes shift in colloidal quantum dots (QDs). By detailed quantum mechanical description of light-matter interaction and temporal analysis of incident electromagnetic field across the QD using the finite-difference time-domain method, we have shown that the optical excitation of an exciton in the QD and its coupling with the excitation radiation (i.e., exciton polariton) induce strong variations in the dielectric constant of the QD which contribute significantly to the Stokes shift and cause modifications 50 in the absorption spectrum that agrees well with experiments.
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| 33. |
- Chen, Zhi-Hui, et al.
(författare)
-
Comb-shaped photonic crystal structure for efficient broadband light diffraction and funnelling in solar cells
- 2012
-
Ingår i: Solar Energy Materials and Solar Cells. - : Elsevier BV. - 0927-0248 .- 1879-3398. ; 99, s. 316-320
-
Tidskriftsartikel (refereegranskat)abstract
- We present a comb-shaped photonic-crystal (PhC) rods-lattice structure of broadband light diffraction and funnelling for solar cell applications. It is shown that the photonic band of this PhC structure is very dispersive over a broad bandwidth so that light will be efficiently diffracted in the wavelength region of solar radiation. The PhC structure also creates resonance modes leading to further diffraction and funnelling of light so that the light propagates in many pathways in the whole PhC lattice region, which will greatly facilitate light-matter interaction when light-absorbing elements are embedded in the PhC structure. The proposed structure is also valid for photodetection applications.
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| 34. |
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| 35. |
- Chen, Zhihui, 1984-
(författare)
-
Light manipulation in micro and nano photonic materials and structures
- 2012
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Light manipulation is an important method to enhance the light-matter interactions in micro and nano photonic materials and structures by generating usefulelectric field components and increasing time and pathways of light propagationthrough the micro and nano materials and structures. For example, quantum wellinfrared photodetector (QWIP) cannot absorb normal incident radiation so thatthe generation of an electric field component which is parallel to the original incident direction is a necessity for the function of QWIP. Furthermore, the increaseof time and pathways of light propagation in the light-absorbing quantum wellregion will increase the chance of absorbing the photons.The thesis presents the theoretical studies of light manipulation and light-matter interaction in micro and nano photonic materials and structures, aiming atimproving the performance of optical communication devices, photonic integrateddevices and photovoltaic devices.To design efficient micro and nano photonic devices, it is essential to knowthe time evolution of the electromagnetic (EM) field. Two-dimensional and three-dimensional finite-difference time-domain (FDTD) methods have been adopted inthe thesis to numerically solve the Maxwell equations in micro and nano photonicmaterials and structures.Light manipulation in micro and nano material and structures studied in thisthesis includes: (1) light transport in the photonic crystal (PhC) waveguide, (2)light diffraction by the micro-scale dielectric PhC and metallic PhC structures(gratings); and (3) exciton-polaritons of semiconductor quantum dots, (4) surfaceplasmon polaritons at semiconductor-metallic material interface for subwavelengthlight control. All these aspects are found to be useful in optical devices of multiplebeam splitter, quantum well/dot infrared photodetectors, and solar cells.
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| 36. |
- Chen, Zhihui, et al.
(författare)
-
Multiple beam splitting to free space from a V groove in a photonic crystal waveguide
- 2011
-
Ingår i: Applied physics. B, Lasers and optics (Print). - : Springer Science and Business Media LLC. - 0946-2171 .- 1432-0649. ; 102:4, s. 857-861
-
Tidskriftsartikel (refereegranskat)abstract
- We present multiple-beam splitting to free space from a V groove in a two-dimensional photonic crystal waveguide (PCW) with a few additional dielectric rods at the exit of the PCW. Numerical study shows that 'one-beam-in to two-beams-out' (one-to-two, also denoted as Y-shaped), one-to-three, and one-to-five beam splittings can be easily realized over a wide bandwidth, and the split beams have remarkable properties such as symmetric energy distributions and high directional transmissions. Off-axis directional emission can also be achieved by simple displacements of the additional rods at the exit of the PCW.
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| 37. |
- Chen, Zhihui, et al.
(författare)
-
Time-resolved photocurrents in quantum well/dot infrared photodetectors with different optical coupling structures
- 2012
-
Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 100:4, s. 043502-
-
Tidskriftsartikel (refereegranskat)abstract
- Temporal developments of photocurrents excited by an infrared radiation pulse in quantum well/dot infrared photodetectors with different optical coupling structures have been theoretically studied. It is shown that the light diffraction in a conventional reflective grating structure is a near-field effect containing severe crosstalk from neighboring pixels. A concave reflector not only eliminates the crosstalk but also strongly diffracts and focuses the incident electric field into deep active layers, which significantly increases the photocurrents in the photodetectors.
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| 38. |
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| 39. |
- Fan, Lijun, et al.
(författare)
-
Statistical downscaling of summer temperature extremes in northern China
- 2013
-
Ingår i: Advances in Atmospheric Sciences. - : Springer Science and Business Media LLC. - 0256-1530 .- 1861-9533. ; 30:4, s. 1085-1095
-
Tidskriftsartikel (refereegranskat)abstract
- Two approaches of statistical downscaling were applied to indices of temperature extremes based on percentiles of daily maximum and minimum temperature observations at Beijing station in summer during 1960-2008. One was to downscale daily maximum and minimum temperatures by using EOF analysis and stepwise linear regression at first, then to calculate the indices of extremes; the other was to directly downscale the percentile-based indices by using seasonal large-scale temperature and geo-potential height records. The cross-validation results showed that the latter approach has a better performance than the former. Then, the latter approach was applied to 48 meteorological stations in northern China. The cross-validation results for all 48 stations showed close correlation between the percentile-based indices and the seasonal large-scale variables. Finally, future scenarios of indices of temperature extremes in northern China were projected by applying the statistical downscaling to Hadley Centre Coupled Model Version 3 (HadCM3) simulations under the Representative Concentration Pathways 4.5 (RCP 4.5) scenario of the Fifth Coupled Model Inter-comparison Project (CMIP5). The results showed that the 90th percentile of daily maximum temperatures will increase by about 1.5A degrees C, and the 10th of daily minimum temperatures will increase by about 2A degrees C during the period 2011-35 relative to 1980-99.
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| 40. |
- Fu, C., et al.
(författare)
-
Optimization of stiffness for isotropic conductive adhesives
- 2010
-
Ingår i: 2010 International Symposium on Advanced Packaging Materials: Microtech, APM '10. - 9781424467563 ; , s. 29-33
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- With the rapid developments of electronic packaging, there is an increasing demand on high performance isotropic conductive adhesives (ICAs). However, the traditional ICAs are brittle, sensitive for crack formation and delamination, which is one of the major drawbacks that limits their use in a wide range of applications. Therefore great efforts have been made to make conductive adhesives more flexible. The present work aims at studying of several chemicals in terms of flexibilizing materials to modify the stiffuess modulus of the conductive adhesives. The effect of the flexibilizers has been characterized by different methods, such as Differential Scanning Calorimetry (DSC), Dynamic Mechanical Analysis (DMA), Thermogravimetric Analysis (TGA), etc. Moreover, the electrical resistance, thermal conductivity and viscosity are also measured in various conditions. Experimental results indicate that one of the flexibilizing materials using flexible ester-linkage is particular of interest as it offers low electrical resistance, high thermal performance and low modulus without decreasing glass transition temperature (Tg) and influencing curing and decomposition conditions. ©2010 IEEE.
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| 41. |
- Fu, H. S., et al.
(författare)
-
First observation of rising-tone magnetosonic waves
- 2014
-
Ingår i: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 41:21, s. 7419-7426
-
Tidskriftsartikel (refereegranskat)abstract
- Magnetosonic (MS) waves are linearly polarized emissions confined near the magnetic equator with wave normal angle near 90 degrees and frequency below the lower hybrid frequency. Such waves, also termed equatorial noise, were traditionally known to be "temporally continuous" in their time-frequency spectrogram. Here we show for the first time that MS waves actually have discrete wave elements with rising-tone features in their spectrogram. The frequency sweep rate of MS waves, similar to 1 Hz/s, is between that of chorus and electromagnetic ion cyclotron (EMIC) waves. For the two events we analyzed, MS waves occur outside the plasmapause and cannot penetrate into the plasmasphere; their power is smaller than that of chorus. We suggest that the rising-tone feature of MS waves is a consequence of nonlinear wave-particle interaction, as is the case with chorus and EMIC waves.
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| 42. |
- Fu, Jian, et al.
(författare)
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A reconstruction method for cone-beam differential x-ray phase-contrast computed tomography
- 2012
-
Ingår i: Optics Express. - 1094-4087. ; 20:19, s. 21512-21519
-
Tidskriftsartikel (refereegranskat)abstract
- Most existing differential phase-contrast computed tomography (DPC-CT) approaches are based on three kinds of scanning geometries, described by parallel-beam, fan-beam and cone-beam. Due to the potential of compact imaging systems with magnified spatial resolution, cone-beam DPC-CT has attracted significant interest. In this paper, we report a reconstruction method based on a back-projection filtration (BPF) algorithm for cone-beam DPC-CT. Due to the differential nature of phase contrast projections, the algorithm restrains from differentiation of the projection data prior to back-projection, unlike BPF algorithms commonly used for absorption-based CT data. This work comprises a numerical study of the algorithm and its experimental verification using a dataset measured with a three-grating interferometer and a micro-focus x-ray tube source. Moreover, the numerical simulation and experimental results demonstrate that the proposed method can deal with several classes of truncated cone-beam datasets. We believe that this feature is of particular interest for future medical cone-beam phase-contrast CT imaging applications. (C) 2012 Optical Society of America
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| 43. |
- Fu, Jian, et al.
(författare)
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An algebraic iterative reconstruction technique for differential X-ray phase-contrast computed tomography
- 2013
-
Ingår i: Zeitschrift für Medizinische Physik. - : Elsevier BV. - 1876-4436 .- 0939-3889. ; 23:3, s. 186-193
-
Tidskriftsartikel (refereegranskat)abstract
- Iterative reconstruction has a wide spectrum of proven advantages in the field of conventional X-ray absorption-based computed tomography (CT). In this paper, we report on an algebraic iterative reconstruction technique for grating-based differential phase-contrast CT (DPC-CT). Due to the differential nature of DPC-CT projections, a differential operator and a smoothing operator are added to the iterative reconstruction, compared to the one commonly used for absorption-based CT data. This work comprises a numerical study of the algorithm and its experimental verification using a dataset measured at a two-grating interferometer setup. Since the algorithm is easy to implement and allows for the extension to various regularization possibilities, we expect a significant impact of the method for improving future medical and industrial DPC-CT applications.
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| 44. |
- Fu, Juan, et al.
(författare)
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Analysis of Self-Pressurization Phenomenon in a Cryogenic Fluid Storage Tank With VOF Method
- 2014
-
Ingår i: Proceedings of ASME 2013 International Mechanical Engineering Congress and Exposition. - 9780791856178 ; 1, s. 001-020
-
Konferensbidrag (refereegranskat)abstract
- The self-pressurization phenomenon is studied numerically with the Volume of Fluid (VOF) method in a cryogenic fluid tank. Heat and mass transfer modelling is used for the phase change calculation at the interface. Transient simulations of the vaporization and pressure rise in a cylindrical liquid hydrogen tank are performed. The computations are carried out by using the CFD software package, Ansys Fluent, and an in-house developed code to calculate the source term associated with the phase change. Effects of the heat flux, fill level and gravity acceleration are investigated. Numerical results indicate that the pressure starts to rise after a certain time of sidewall heating and pressure rises gradually once the vaporization occurs. The rise rate increases as time elapses and is larger at higher heat flux at the same time. Multiple loops are observed in the fluid flow and thermal stratification is developed. The stratification degree is nearly the same for different fill levels at the same heat flux while the pressure rise rate increases as the fill fraction becomes larger. High temperature area appears when the fluid mixing becomes weaker as gravity acceleration decreases. Heat transfer turns to nucleate boiling at the wall from convection. as evaporation occurs at the interface.
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| 45. |
- Fu, Jian, et al.
(författare)
-
Helical differential X-ray phase-contrast computed tomography.
- 2014
-
Ingår i: Physica Medica. - : Elsevier BV. - 1120-1797. ; 30:3, s. 374-379
-
Tidskriftsartikel (refereegranskat)abstract
- We report on the first experimental results of helical differential phase-contrast computed tomography (helical DPC-CT) with a laboratory X-ray tube source and a Talbot-Lau grating interferometer. The results experimentally verify the feasibility of helical data acquisition and reconstruction in phase-contrast imaging, in analogy to its use in clinical CT systems. This allows fast and continuous volumetric scans for long objects with lengths exceeding the dimension of the detector. Since helical CT revolutionized the field of medical CT several years ago, we anticipate that this method will bring the same significant impact on the future medical and industrial applications of X-ray DPC-CT.
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| 46. |
- Fu, Juan, et al.
(författare)
-
Influence of wall ribs on the thermal stratification and self-pressurization in a cryogenic liquid tank
- 2014
-
Ingår i: Applied Thermal Engineering. - : Elsevier BV. - 1359-4311. ; 73:2, s. 1421-1431
-
Tidskriftsartikel (refereegranskat)abstract
- Self-pressurization in a cylindrical ribbed tank which is partially filled with liquid hydrogen is investigated numerically under different rib spacing-to-height ratios. The Volume of Fluid (VOF) method is employed as well as a phase change model. Appropriate models are incorporated into the Ansys Fluent by the user-defined functions to carry out the computations. The ribbed surface is modeled as a finned surface and a conjugate transient heat transfer problem is formulated for predicting fluid flow currents and heat transfer. The effect of rib material and shapes is also studied. Numerical results indicate that the pressure rise can be reduced by ribs mounted on the tank wall. This phenomenon is more pronounced as the rib spacing-to-height ratio is reduced. A vortex is observed in the downstream region of each rib when the spacing-to-height has a relatively high value. Evaporation occurs as time elapses due to heat accumulation at the rib surfaces. Pressure starts to rise later with high thermal conductivity ribs and becomes higher with low thermal conductivity ribs when the ribs are of identical configuration in geometry. The final pressure rise seems to be monotonically versus increasing time. The semicircular ribs perform better than rectangular ones in control of the pressure rise and thermal stratification for identical cross sectional area and if the locations are kept the same. (C) 2014 Elsevier Ltd. All rights reserved.
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| 47. |
- Fu, Jianxin, et al.
(författare)
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Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice.
- 2011
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Ingår i: The Journal of clinical investigation. - 1558-8238. ; 121:4, s. 1657-66
-
Tidskriftsartikel (refereegranskat)abstract
- Mucin-type O-linked oligosaccharides (O-glycans) are primary components of the intestinal mucins that form the mucus gel layer overlying the gut epithelium. Impaired expression of intestinal O-glycans has been observed in patients with ulcerative colitis (UC), but its role in the etiology of this disease is unknown. Here, we report that mice with intestinal epithelial cell-specific deficiency of core 1-derived O-glycans, the predominant form of O-glycans, developed spontaneous colitis that resembled human UC, including massive myeloid infiltrates and crypt abscesses. The colitis manifested in these mice was also characterized by TNF-producing myeloid infiltrates in colon mucosa in the absence of lymphocytes, supporting an essential role for myeloid cells in colitis initiation. Furthermore, induced deletion of intestinal core 1-derived O-glycans caused spontaneous colitis in adult mice. These data indicate a causal role for the loss of core 1-derived O-glycans in colitis. Finally, we detected a biosynthetic intermediate typically exposed in the absence of core 1 O-glycan, Tn antigen, in the colon epithelium of a subset of UC patients. Somatic mutations in the X-linked gene that encodes core 1 β1,3-galactosyltransferase-specific chaperone 1 (C1GALT1C1, also known as Cosmc), which is essential for core 1 O-glycosylation, were found in Tn-positive epithelia. These data suggest what we believe to be a new molecular mechanism for the pathogenesis of UC.
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| 48. |
- Fu, Keren, 1988, et al.
(författare)
-
Adaptive Multi-Level Region Merging for Salient Object Detection
- 2014
-
Ingår i: British Machine Vision Conference (BMVC) 2014. ; , s. 11 -
-
Konferensbidrag (refereegranskat)abstract
- Most existing salient object detection algorithms face the problem of either under or over-segmenting an image. More recent methods address the problem via multi-level segmentation. However, the number of segmentation levels is manually predetermined and only works well on specific class of images. In this paper, a new salient object detection scheme is presented based on adaptive multi-level region merging. A graph based merging scheme is developed to reassemble regions based on their shared contourstrength. This merging process is adaptive to complete contours of salient objects that can then be used for global perceptual analysis, e.g., foreground/ground separation. Such contour completion is enhanced by graph-based spectral decomposition. We show that even though simple region saliency measurements are adopted for each region, encouraging performance can be obtained after across-level integration. Experiments by comparing with 13 existing methods on three benchmark datasets including MSRA-1000, SOD and SED show the proposed method results in uniform object enhancement and achieves state-of-the-art performance.
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| 49. |
- Fu, Keren, 1988, et al.
(författare)
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Geodesic Saliency Propagation for Image Salient Region Detection
- 2013
-
Ingår i: IEEE Int'l conf. on Image Processing (ICIP 2013), Sept.15-18, Melbourne, Australia. - 9781479923410 ; , s. 3278-3282
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Konferensbidrag (refereegranskat)abstract
- This paper proposes a novel geodesic saliency propagation method where detected salient objects may be isolated from both the background and other clutters by adding global considerations in the detection process. The method transmits saliency energy from a coarse saliency map to all image parts rather than from image boundaries in conventional cases. The coarse saliency map is computed using the combination of global contrast and Harris convex hull. Superpixels from pre-segmented image are used as pre-processing to further enhance the efficiency. The proposed propagation is geodesic distance assisted and retains the local connectivity of objects. It is capable of rendering a uniform saliency map while suppressing the background, leading to salient objects being popped out. Experiments were conducted on a benchmark dataset, visual comparisons and performance evaluations with eight existing methods have shown that the proposed method is robust and achieves the state-of-the-art performance.
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| 50. |
- Fu, Keren, 1988, et al.
(författare)
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One-class support vector machine-assisted robust tracking
- 2013
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Ingår i: Journal of Electronic Imaging. - 1560-229X .- 1017-9909. ; 22:2, s. 11-
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Tidskriftsartikel (refereegranskat)abstract
- Recently, tracking is regarded as a binary classification problem by discriminative tracking methods. However, such binary classification may not fully handle the outliers, which may cause drifting. We argue that tracking may be regarded as one-class problem, which avoids gathering limited negative samples for background description. Inspired by the fact the positive feature space generatedby one-class support vector machine (SVM) is bounded by a closed hyper sphere, we propose a tracking method utilizing one-class SVMs that adopt histograms of oriented gradient and 2bit binary patterns as features. Thus, it is called the one-class SVM tracker (OCST). Simultaneously, an efficient initialization and online updating scheme is proposed. Extensive experimental results prove that OCST outperforms some state-of-the-art discriminative tracking methods that tackle the problem using binary classifiers on providing accurate tracking and alleviating serious drifting.
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