| 1. |
- Zeggini, Eleftheria, et al.
(författare)
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Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
- 2008
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 40:5, s. 638-645
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D)(1-11). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and similar to 2.2 million SNPs (directly genotyped and imputed), followed by replication testing in an independent sample with an effective sample size of up to 53,975. We detected at least six previously unknown loci with robust evidence for association, including the JAZF1 (P=5.0 x 10(-14)), CDC123-CAMK1D (P=1.2 x 10(-10)), TSPAN8-LGR5 (P=1.1 x 10(-9)), THADA (P=1.1 x 10(-9)), ADAMTS9 (P=1.2 x 10(-8)) and NOTCH2 (P=4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D.
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| 2. |
- Chen, Li-Jen, et al.
(författare)
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Evidence of an extended electron current sheet and its neighboring magnetic island during magnetotail reconnection
- 2008
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 113:A12, s. A12213-
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Tidskriftsartikel (refereegranskat)abstract
- We have identified a spatially extended electron current sheet (ECS) and its adjacent magnetic island during a magnetotail reconnection event with no appreciable guide field. This finding is based on data from the four Cluster spacecraft and is enabled by detailed maps of electron distribution functions and DC electric fields within the diffusion region. The maps are developed using two-dimensional particle-in-cell simulations with a mass ratio m(i)/m(e) = 800. One spacecraft crossed the ECS earthward of the reconnection null and, together with the other three spacecraft, registered the following properties: (1) The ECS is colocated with a layer of bipolar electric fields normal to the ECS, pointing toward the ECS, and with a half width less than 8 electron skin depths. (2) In the inflow region up to the ECS and separatrices, electrons have a temperature anisotropy (Te-parallel to/Te-perpendicular to > 1), and the anisotropy increases toward the ECS. (3) Within about 1 ion skin depth (d(i)) above and below the ECS, the electron density decreases toward the ECS by a factor of 3-4, reaching a minimum at edges of the ECS, and has a local distinct maximum at the ECS center. (4) A di-scale magnetic island is attached to the ECS, separating it from another reconnection layer. Our simulations established that the electric field normal to the ECS is due to charge imbalance and is of the ECS scale, and ions exhibit electron-scale structures in response to this electric field.
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| 3. |
- Chen, Li-Jen, et al.
(författare)
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Multispacecraft observations of the electron current sheet, neighboring magnetic islands, and electron acceleration during magnetotail reconnection
- 2009
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Ingår i: Physics of Plasmas. - : AIP Publishing. - 1070-664X .- 1089-7674. ; 16:5, s. 056501-
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Tidskriftsartikel (refereegranskat)abstract
- Open questions concerning structures and dynamics of diffusion regions and electron acceleration in collisionless magnetic reconnection are addressed based on data from the four-spacecraft mission Cluster and particle-in-cell simulations. Using time series of electron distribution functions measured by the four spacecraft, distinct electron regions around a reconnection layer are mapped out to set the framework for studying diffusion regions. A spatially extended electron current sheet (ecs), a series of magnetic islands, and bursts of energetic electrons within islands are identified during magnetotail reconnection with no appreciable guide field. The ecs is collocated with a layer of electron-scale electric fields normal to the ecs and pointing toward the ecs center plane. Both the observed electron and ion densities vary by more than a factor of 2 within one ion skin depth north and south of the ecs, and from the ecs into magnetic islands. Within each of the identified islands, there is a burst of suprathermal electrons whose fluxes peak at density compression sites [L.-J. Chen , Nat. Phys. 4, 19 (2008)] and whose energy spectra exhibit power laws with indices ranging from 6 to 7.3. These results indicate that the in-plane electric field normal to the ecs can be of the electron scale at certain phases of reconnection, electrons and ions are highly compressible within the ion diffusion region, and for reconnection involving magnetic islands, primary electron acceleration occurs within the islands.
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| 4. |
- Chen, Li-Jen, et al.
(författare)
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Observation of energetic electrons within magnetic islands
- 2008
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Ingår i: Nature Physics. - : Nature Publishing Group. - 1745-2473 .- 1745-2481. ; 4:1, s. 19-23
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Tidskriftsartikel (refereegranskat)abstract
- Magnetic reconnection is the underlying process that releases impulsively an enormous amount of magnetic energy(1) in solar flares(2,3), flares on strongly magnetized neutron stars(4) and substorms in the Earth's magnetosphere(5). Studies of energy release during solar flares, in particular, indicate that up to 50% of the released energy is carried by accelerated 20-100 keV suprathermal electrons(6-8). How so many electrons can gain so much energy during reconnection has been a long-standing question. A recent theoretical study suggests that volume-filling contracting magnetic islands formed during reconnection can produce a large number of energetic electrons(9). Here we report the first evidence of the link between energetic electrons and magnetic islands during reconnection in the Earth's magnetosphere. The results indicate that energetic electron fluxes peak at sites of compressed density within islands, which imposes a new constraint on theories of electron acceleration.
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