Sökning: WFRF:(Chung Lorinda S.)
> (2024) >
Xist ribonucleoprot...
Xist ribonucleoproteins promote female sex-biased autoimmunity
-
- Dou, Diana R. (författare)
- Center for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
-
- Zhao, Yanding (författare)
- Center for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
-
- Belk, Julia A. (författare)
- Center for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
-
visa fler...
-
- Zhao, Yang (författare)
- Center for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
-
- Casey, Kerriann M. (författare)
- Department of Comparative Medicine, Stanford University, Stanford, CA, USA
-
- Chen, Derek C. (författare)
- Center for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
-
- Li, Rui (författare)
- Center for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
-
- Yu, Bingfei (författare)
- Center for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
-
- Srinivasan, Suhas (författare)
- Center for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
-
- Abe, Brian T. (författare)
- Center for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
-
- Kraft, Katerina (författare)
- Center for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA
-
- Hellström, Cecilia (författare)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
-
- Sjöberg, Ronald (författare)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
-
- Chang, Sarah (författare)
- Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA
-
- Feng, Allan (författare)
- Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA
-
- Goldman, Daniel W. (författare)
- Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
-
- Shah, Ami A. (författare)
- Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
-
- Petri, Michelle (författare)
- Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
-
- Chung, Lorinda S. (författare)
- Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA
-
- Fiorentino, David F. (författare)
- Department of Dermatology, Stanford University School of Medicine, Redwood City, CA, USA
-
- Käller Lundberg, Emma (författare)
- KTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,Departments of Bioengineering and Pathology, Stanford University, Stanford, CA, USA
-
- Wutz, Anton (författare)
- Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
-
- Utz, Paul J. (författare)
- Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA
-
- Chang, Howard Y. (författare)
- Center for Personal Dynamic Regulomes, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2024
- 2024
- Engelska.
-
Ingår i: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 187:3, s. 16-733
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Autoimmune diseases disproportionately affect females more than males. The XX sex chromosome complement is strongly associated with susceptibility to autoimmunity. Xist long non-coding RNA (lncRNA) is expressed only in females to randomly inactivate one of the two X chromosomes to achieve gene dosage compensation. Here, we show that the Xist ribonucleoprotein (RNP) complex comprising numerous autoantigenic components is an important driver of sex-biased autoimmunity. Inducible transgenic expression of a non-silencing form of Xist in male mice introduced Xist RNP complexes and sufficed to produce autoantibodies. Male SJL/J mice expressing transgenic Xist developed more severe multi-organ pathology in a pristane-induced lupus model than wild-type males. Xist expression in males reprogrammed T and B cell populations and chromatin states to more resemble wild-type females. Human patients with autoimmune diseases displayed significant autoantibodies to multiple components of XIST RNP. Thus, a sex-specific lncRNA scaffolds ubiquitous RNP components to drive sex-biased immunity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- autoantibody
- autoimmunity
- long non-coding RNA
- RNA binding protein
- XIST
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Cell
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Dou, Diana R.
-
Zhao, Yanding
-
Belk, Julia A.
-
Zhao, Yang
-
Casey, Kerriann ...
-
Chen, Derek C.
-
visa fler...
-
Li, Rui
-
Yu, Bingfei
-
Srinivasan, Suha ...
-
Abe, Brian T.
-
Kraft, Katerina
-
Hellström, Cecil ...
-
Sjöberg, Ronald
-
Chang, Sarah
-
Feng, Allan
-
Goldman, Daniel ...
-
Shah, Ami A.
-
Petri, Michelle
-
Chung, Lorinda S ...
-
Fiorentino, Davi ...
-
Käller Lundberg, ...
-
Wutz, Anton
-
Utz, Paul J.
-
Chang, Howard Y.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Medicinsk geneti ...
- Artiklar i publikationen
-
Cell
- Av lärosätet
-
Kungliga Tekniska Högskolan