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| 2. |
- Charlton, M, et al.
(författare)
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Antiparticle sources for antihydrogen production and trapping
- 2011
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Ingår i: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6596. ; 262, s. 012001-
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Tidskriftsartikel (refereegranskat)abstract
- Sources of positrons and antiprotons that are currently used for the formation of antihydrogen with low kinetic energies are reviewed, mostly in the context of the ALPHA collaboration and its predecessor ATHENA. The experiments were undertaken at the Antiproton Decelerator facility, which is located at CERN. Operations performed on the clouds of antiparticles to facilitate their mixing to produce antihydrogen are described. These include accumulation, cooling and manipulation. The formation of antihydrogen and some of the characteristics of the anti-atoms that are created are discussed. Prospects for trapping antihydrogen in a magnetic minimum trap, as envisaged by the ALPHA collaboration, are reviewed.
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| 3. |
- Charman, Tony, et al.
(författare)
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The EU-AIMS Longitudinal European Autism Project (LEAP) : clinical characterisation.
- 2017
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Ingår i: Molecular Autism. - : Springer Science and Business Media LLC. - 2040-2392. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes the clinical characteristics of the LEAP cohort and examines age, sex and IQ differences in ASD core symptoms and common co-occurring psychiatric symptoms. A companion paper describes the overall design and experimental protocol and outlines the strategy to identify stratification biomarkers.METHODS: From six research centres in four European countries, we recruited 437 children and adults with ASD and 300 controls between the ages of 6 and 30 years with IQs varying between 50 and 148. We conducted in-depth clinical characterisation including a wide range of observational, interview and questionnaire measures of the ASD phenotype, as well as co-occurring psychiatric symptoms.RESULTS: The cohort showed heterogeneity in ASD symptom presentation, with only minimal to moderate site differences on core clinical and cognitive measures. On both parent-report interview and questionnaire measures, ASD symptom severity was lower in adults compared to children and adolescents. The precise pattern of differences varied across measures, but there was some evidence of both lower social symptoms and lower repetitive behaviour severity in adults. Males had higher ASD symptom scores than females on clinician-rated and parent interview diagnostic measures but not on parent-reported dimensional measures of ASD symptoms. In contrast, self-reported ASD symptom severity was higher in adults compared to adolescents, and in adult females compared to males. Higher scores on ASD symptom measures were moderately associated with lower IQ. Both inattentive and hyperactive/impulsive ADHD symptoms were lower in adults than in children and adolescents, and males with ASD had higher levels of inattentive and hyperactive/impulsive ADHD symptoms than females.CONCLUSIONS: The established phenotypic heterogeneity in ASD is well captured in the LEAP cohort. Variation both in core ASD symptom severity and in commonly co-occurring psychiatric symptoms were systematically associated with sex, age and IQ. The pattern of ASD symptom differences with age and sex also varied by whether these were clinician ratings or parent- or self-reported which has important implications for establishing stratification biomarkers and for their potential use as outcome measures in clinical trials.
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| 4. |
- Ciuk Karlsson, Susanna
(författare)
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Simulating water and pollutant transport in bark, charcoal and sand filters for greywater treatment
- 2015
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- A septic tank combined with a sand filter is the most common onsite wastewater treatment system worldwide, since it is a simple, lowcost and reliable treatment method. Alternatives to sand in filters could be advantageous in terms of availability of material and enhanced treatment properties. In this study, flow dynamics and pollutant transport in three filter materials; sand, pine bark and activated charcoal, intermittently dosed with artificial greywater, were simulated using the HYDRUS wetland module. The simulated results were compared with observations from laboratory filters and model hydraulic and microbial parameters were calibrated. Emphasis was placed on simulating the removal of organic pollutants by each filter type. Furthermore, for the bark and charcoal filters, removal of organic matter was simulated for different hydraulic and organic loading rates (HLR = 32 and 64 l m⁻² day⁻¹ and OLR = 13-6 and 28 g BOD₅ m⁻² day⁻¹). Comparing simulated with measured cumulated effluent volume, the normalised root mean square error for all three filter materials was small (0.7-3.5%). The simulated bark filter COD removal in different loading regimes (HLR = 32 and 64 l m⁻² day⁻¹, OLR = 13-16 and 28 g BOD₅ m⁻² day⁻¹) was overestimated by 13-20 percentage points compared with the measured values. When release of organic matter from the bark material itself was accounted for, the difference was reduced to 2-10 percentage points. Simulation of the charcoal filter demonstrated 94 and 91 % removal of COD for HLR = 32 and OLR = 13 - 16 g BOD₅ m⁻² day⁻¹, which compared well with the measured values, 95 ± 2 % and 89 ± 11 %, respectively. However, simulated COD removal for Run 2 (70%) and Run 5 (72%) was low compared with the measured values (90 ± 7 and 84 ± 4 %). The measured sand filter effluent concentration of COD was 245 mg l⁻¹ and the simulated effluent concentration of COD was 134 mg l⁻¹ for HLR = 32 and OLR = 14 g BOD₅ m⁻² day⁻¹. After including an effect of water flow along the column wall in the model, the simulated effluent concentration of COD was 337 mg l⁻¹. These simulations of bark, charcoal and sand filters improved understanding of filter functions and identified possible filter design developments.
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| 5. |
- Ciuk Karlsson, Susanna, et al.
(författare)
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Simulation and verification of hydraulic properties and organic matter degradation in sand filters for greywater treatment
- 2015
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Ingår i: Water Science and Technology. - : IWA Publishing. - 0273-1223 .- 1996-9732. ; 71, s. 426-433
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Tidskriftsartikel (refereegranskat)abstract
- To evaluate the treatment performance of vertical flow sand filters, the HYDRUS wetland module was used to simulate treatment in an experimental set-up. The laboratory filters were intermittently dosed with artificial greywater at a hydraulic loading rate of 0.032 m(3) m(-2) day(-1) and an organic loading rate of 0.014 kg BOD5 m(-2) day(-1). The hydraulic properties of the filter were characterised, as were inflow and outflow concentrations of chemical oxygen demand (COD), biochemical oxygen demand (BOD), ammonia, nitrate and total nitrogen. The inverse simulation function of the HYDRUS software was used to calibrate the water flow model. The observed effect of water flowing faster along the column wall was included in the inverse simulations. The biokinetic model was calibrated by fitting heterotrophic biomass growth to measurements of potential respiration rate. Emphasis was put on simulating outflow concentrations of organic pollutants. The simulations were conducted using three models of varying degree of calibration effort and output accuracy. The effluent concentration was 245 mg COD L-1 for the laboratory filters, 134 mg COD mg L-1 for the model excluding wall flow effects and 338 mg COD mg L-1 for the model including wall flow effects.
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| 6. |
- Konkoli, Zoran, 1966, et al.
(författare)
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Philosophy of computation
- 2018
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Ingår i: Natural Computing Series. - Cham : Springer International Publishing. - 1619-7127. ; , s. 153-184
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Unconventional computation emerged as a response to a series of technological and societal challenges. The main source of these challenges is the expected collapse of Moore’s law. It is very likely that the existing trend of building faster digital information processing machines will come to an end. This chapter provides a broad philosophical discussion of what might be needed to construct a theoretical machinery that could be used to understand the obstacles and identify the alternative designs. The key issue that has been addressed is simple to formulate: given a physical system, what can it compute? There is an enormous conceptual depth to this question and some specific aspects are systematically discussed. The discussion covers digital philosophy of computation, two reasons why rocks cannot be used for computation are given, a new depth to the ontology of number, and the ensemble computation inspired by recent understanding of the computing ability of living cell aggregates.
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