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| 3. |
- Bender, A. N., et al.
(författare)
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Galaxy cluster scaling relations measured with APEX-SZ
- 2016
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 460:4, s. 3432-3446
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Tidskriftsartikel (refereegranskat)abstract
- We present thermal Sunyaev-Zel'dovich effect (SZE) measurements for 42 galaxy clusters observed at 150 GHz with the APEX-SZ experiment. For each cluster, we model the pressure profile and calculate the integrated Comptonization Y to estimate the total thermal energy of the intraclustermedium (ICM). We compare the measured Y values to X-ray observables of the ICM from the literature (cluster gas mass M-gas, temperature T-X, and Y-X = MgasTX) that relate to total cluster mass. We measure power-law scaling relations, including an intrinsic scatter, between the SZE and X-ray observables for three subsamples within the set of 42 clusters that have uniform X-ray analysis in the literature. We observe that differences between these X-ray analyses introduce significant variance into the measured scaling relations, particularly affecting the normalization. For all three subsamples, we find results consistent with a selfsimilarmodel of cluster evolution dominated by gravitational effects. Comparing to predictions from numerical simulations, these scaling relations prefer models that include cooling and feedback in the ICM. Lastly, we measure an intrinsic scatter of similar to 28 per cent in the Y - Y-X scaling relation for all three subsamples.
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| 4. |
- Dahlin, Anna M., 1979-, et al.
(författare)
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Genetic Variants in the 9p21.3 Locus Associated with Glioma Risk in Children, Adolescents, and Young Adults : A Case-Control Study
- 2019
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 28:7, s. 1252-1258
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Tidskriftsartikel (refereegranskat)abstract
- Background: Genome-wide association studies have identified germline genetic variants in 25 genetic loci that increase the risk of developing glioma in adulthood. It is not known if these variants increase the risk of developing glioma in children and adolescents and young adults (AYA). To date, no studies have performed genome-wide analyses to find novel genetic variants associated with glioma risk in children and AYA.Methods: We investigated the association between 8,831,628 genetic variants and risk of glioma in 854 patients diagnosed up to the age of 29 years and 3,689 controls from Sweden and Denmark. Recruitment of patients and controls was population based. Genotyping was performed using Illumina BeadChips, and untyped variants were imputed with IMPUTE2. We selected 41 established adult glioma risk variants for detailed investigation.Results: Three adult glioma risk variants, rs634537, rs2157719, and rs145929329, all mapping to the 9p21.3 (CDKN2B-AS1) locus, were associated with glioma risk in children and AYA. The strongest association was seen for rs634537 (odds ratioG = 1.21; 95% confidence interval = 1.09–1.35; P = 5.8 × 10−4). In genome-wide analysis, an association with risk was suggested for 129 genetic variants (P <1 × 10−5).Conclusions: Carriers of risk alleles in the 9p21.3 locus have an increased risk of glioma throughout life. The results from genome-wide association analyses require validation in independent cohorts.Impact: Our findings line up with existing evidence that some, although not all, established adult glioma risk variants are associated with risk of glioma in children and AYA. Validation of results from genome-wide analyses may reveal novel susceptibility loci for glioma in children and AYA.
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| 10. |
- Arrowsmith, CH, et al.
(författare)
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The promise and peril of chemical probes
- 2015
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Ingår i: Nature chemical biology. - : Springer Science and Business Media LLC. - 1552-4469 .- 1552-4450. ; 11:8, s. 536-541
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Tidskriftsartikel (refereegranskat)
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| 11. |
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| 12. |
- Beckman, K., et al.
(författare)
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Impulsive suicide attempts among young people-A prospective multicentre cohort study in Sweden
- 2019
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Ingår i: Journal of Affective Disorders. - : Elsevier BV. - 0165-0327 .- 1573-2517. ; 243, s. 421-426
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Tidskriftsartikel (refereegranskat)abstract
- Background: We aimed to compare the prevalence of impulsive suicide attempts (ISA) among young adults and those over 25 who present at hospital in connection with attempted suicide. We also aimed to identify factors associated with ISA in young adults and to assess medical severity as well as the probability of repeated suicide attempts in this age group. Method: A prospective multicentre cohort study included hospital known cases of suicide attempt (N = 666). The prevalence of ISA was compared between young adults (18-25) and adults aged > 26. We used logistic regression models to identify factors associated with ISA, associations of ISA with high medical severity and prediction of new fatal or non-fatal suicide attempts within 6 months. Results: 43.7% of the young patients had made an ISA, and 30.2% among those aged > 26 (p = 0.001). Among the young, substance use disorder was associated with ISA; crude odds ratio (OR) 2.0 (1.0-4.2), and adjusted OR 2.1 (0.99-4.4). Affective disorder and unemployment/sickness absence implied lower odds of ISA. ISA resulted in injuries of high medical severity as often as more planned attempts and non-fatal or fatal repetition within 6 months was equally common (30%) in both groups. Limitations: The study was set in psychiatric emergency services, which limits the generalizability. Conclusions: Clinicians should acknowledge that suicide attempts among youth often occur without previous planning and may result in medically severe injuries. The probability of new fatal or non-fatal suicide attempts should be kept in mind also after an impulsive suicide attempt.
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| 13. |
- Dahlin, Anna M., et al.
(författare)
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CCND2, CTNNB1, DDX3X, GLI2, SMARCA4, MYC, MYCN, PTCH1, TP53, and MLL2 gene variants and risk of childhood medulloblastoma
- 2015
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Ingår i: Journal of Neuro-Oncology. - : Springer Science and Business Media LLC. - 0167-594X .- 1573-7373. ; 125:1, s. 75-78
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Tidskriftsartikel (refereegranskat)abstract
- Recent studies have described a number of genes that are frequently altered in medulloblastoma tumors and that have putative key roles in the development of the disease. We hypothesized that common germline genetic variations in these genes may be associated with medulloblastoma development. Based on recent publications, we selected 10 genes that were frequently altered in medulloblastoma: CCND2, CTNNB1, DDX3X, GLI2, SMARCA4, MYC, MYCN, PTCH1, TP53, and MLL2 (now renamed as KMT2D). Common genetic variants (single nucleotide polymorphisms) annotating these genes (n = 221) were genotyped in germline DNA (neonatal dried blood spot samples) from 243 childhood medulloblastoma cases and 247 control subjects from Sweden and Denmark. Eight genetic variants annotating three genes in the sonic hedgehog signaling pathway; CCND2, PTCH1, and GLI2, were found to be associated with the risk of medulloblastoma (P (combined) < 0.05). The findings were however not statistically significant following correction for multiple testing by the very stringent Bonferroni method. The results do not support our hypothesis that common germline genetic variants in the ten studied genes are associated with the risk of developing medulloblastoma.
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| 14. |
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| 15. |
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| 16. |
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| 17. |
- Lindefeldt, M, et al.
(författare)
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The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy
- 2019
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Ingår i: NPJ biofilms and microbiomes. - : Springer Science and Business Media LLC. - 2055-5008. ; 5:1, s. 5-
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Tidskriftsartikel (refereegranskat)abstract
- The gut microbiota has been linked to various neurological disorders via the gut–brain axis. Diet influences the composition of the gut microbiota. The ketogenic diet (KD) is a high-fat, adequate-protein, low-carbohydrate diet established for treatment of therapy-resistant epilepsy in children. Its efficacy in reducing seizures has been confirmed, but the mechanisms remain elusive. The diet has also shown positive effects in a wide range of other diseases, including Alzheimer’s, depression, autism, cancer, and type 2 diabetes. We collected fecal samples from 12 children with therapy-resistant epilepsy before starting KD and after 3 months on the diet. Parents did not start KD and served as diet controls. Applying shotgun metagenomic DNA sequencing, both taxonomic and functional profiles were established. Here we report that alpha diversity is not changed significantly during the diet, but differences in both taxonomic and functional composition are detected. Relative abundance of bifidobacteria as well as E. rectale and Dialister is significantly diminished during the intervention. An increase in relative abundance of E. coli is observed on KD. Functional analysis revealed changes in 29 SEED subsystems including the reduction of seven pathways involved in carbohydrate metabolism. Decomposition of these shifts indicates that bifidobacteria and Escherichia are important contributors to the observed functional shifts. As relative abundance of health-promoting, fiber-consuming bacteria becomes less abundant during KD, we raise concern about the effects of the diet on the gut microbiota and overall health. Further studies need to investigate whether these changes are necessary for the therapeutic effect of KD.
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| 18. |
- Lindh, ÅU, et al.
(författare)
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A Comparison of Suicide Risk Scales in Predicting Repeat Suicide Attempt and Suicide: A Clinical Cohort Study
- 2019
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Ingår i: The Journal of clinical psychiatry. - : Physicians Postgraduate Press. - 1555-2101 .- 0160-6689. ; 80:6
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To compare the predictive accuracy of the Suicide Intent Scale (SIS), the Suicide Assessment Scale (SUAS), the Karolinska Interpersonal Violence Scale (KIVS), and the Columbia-Suicide Severity Rating Scale (C-SSRS) for suicide attempts and suicides within 3 and 12 months of an episode of self-harm. METHODS: This prospective multicenter cohort study included patients (N = 804) aged 18-95 years with a recent episode of self-harm assessed in psychiatric emergency settings from April 2012 to April 2016. Suicide attempts and suicides were identified in medical records and in the National Cause of Death Register. Receiver operating characteristic curves were constructed, and accuracy statistics were calculated. A sensitivity of at least 80% combined with a specificity of at least 50% were considered minimally acceptable. RESULTS: At least 1 suicide attempt was recorded for 216 participants during follow-up, and 19 participants died by suicide. The SUAS and C-SSRS were better than chance in classifying the 114 suicide attempts occurring within the first 3 months; a C-SSRS score ≥ 27 yielded a sensitivity/specificity of 79.8%/51.5% (P < .001). During 1-year follow-up, the SUAS and C-SSRS also performed better than chance, but no cutoff on either instrument gave a sensitivity/specificity of ≥ 80%/≥ 50%. The SIS was the only instrument that could classify suicides correctly. At 3 months, the area under the curve (AUC) was 0.94 (95% CI, 0.89-0.99), and a score ≥ 21 predicted suicide with a sensitivity/specificity of 100%/81.9%, based on only 4 suicides. At 1-year follow-up, the AUC was 0.74 (95% CI, 0.61-0.87), and a score ≥ 17 predicted suicide with a sensitivity/specificity of 72.2%/57.9%. CONCLUSIONS: Instruments that predicted nonfatal repeat suicide attempts did not predict suicide and vice versa. With the possible exception of the prediction of suicide by the SIS in a short time frame, the specificity of these instruments was low, giving them a limited relevance in the prediction of suicidal behaviors. © Copyright 2019 Physicians Postgraduate Press, Inc.
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| 19. |
- Malehmir, Alireza, et al.
(författare)
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Near-Surface Geophysical Characterization of Areas Prone to Natural Hazards : A Review of the Current and Perspective on the Future
- 2016
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Ingår i: Advances in Geophysics. - : Elsevier. - 0065-2687 .- 2162-7622. ; 57, s. 51-146
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Tidskriftsartikel (refereegranskat)abstract
- Natural hazards such as landslides, floods, rockfalls, earthquakes, volcanic eruptions, sinkholes, and snow avalanches represent potential risks to our infrastructures, properties, and lives. That potential will continue to escalate with current and continued human encroachment into risk areas. With the help of geophysical techniques many of those risks can be better understood and quantified, thereby minimized and at least partly mitigated through accurate, site-specific, and proper planning and engineering. On occasions these hazards simply cannot be avoided, but better characterization and therefore understanding of the subsurface geology and natural processes responsible for the threats is possible through integration of various cost-effective geophysical methods with relevant geotechnical, geomechanical, and hydrogeological methods. With the enhanced characterization possible when geophysics is incorporated into natural hazard analysis, potential risks can be better quantified and remediation plans tuned to minimize the threat most natural hazards present to civilizations. In this article we will first review common geophysical methods that can be and have been utilized in studying natural hazard prone areas, then we provide selected case studies and approaches using predominantly our own examples, and finally a look into the future detailing how these methods and technologies can be better implemented and thereby more time- and cost-effective and provide improved results.
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| 20. |
- Ronczka, M., et al.
(författare)
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Geophysical Site Investigation at Dalby-Önneslov Using Joint Inversion
- 2017
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Ingår i: 23rd European Meeting of Environmental and Engineering Geophysics. - Netherlands : EAGE Publications BV. - 9789462822238
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Konferensbidrag (refereegranskat)abstract
- A geophysical site investigation using ERT and refraction seismic was done to detect the bedrock interface and possible weakness zones. For the purpose of a more realistic subsurface model a joint inversion was done.
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| 21. |
- Rydberg Sterner, Therese, et al.
(författare)
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The Gothenburg H70 Birth cohort study 2014-16: design, methods and study population.
- 2019
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Ingår i: European journal of epidemiology. - : Springer Science and Business Media LLC. - 1573-7284 .- 0393-2990. ; 34:2, s. 191-209
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Tidskriftsartikel (refereegranskat)abstract
- To improve health care for older persons, we need to learn more about ageing, e.g. identify protective factors and early markers for diseases. The Gothenburg H70 Birth Cohort Studies (the H70 studies) are multidisciplinary epidemiological studies examining representative birth cohorts of older populations in Gothenburg, Sweden. So far, six birth cohorts of 70-year-olds have been examined over time, and examinations have been virtually identical between studies. This paper describes the study procedures for the baseline examination of the Birth cohort 1944, conducted in 2014-16. In this study, all men and women born 1944 on specific dates, and registered as residents in Gothenburg, were eligible for participation (n=1839). A total of 1203 (response rate 72.2%; 559 men and 644 women; mean age 70.5years) agreed to participate in the study. The study comprised sampling of blood and cerebrospinal fluid, psychiatric, cognitive, and physical health examinations, examinations of genetics and family history, use of medications, social factors, functional ability and disability, physical fitness and activity, body composition, lung function, audiological and ophthalmological examinations, diet, brain imaging, as well as a close informant interview, and qualitative studies. As in previous examinations, data collection serves as a basis for future longitudinal follow-up examinations. The research gained from the H70 studies has clinical relevance in relation to prevention, early diagnosis, clinical course, experience of illness, understanding pathogenesis and prognosis. Results will increase our understanding of ageing and inform service development, which may lead to enhanced quality of care for older persons.
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| 22. |
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| 23. |
- Aludden, H. C., et al.
(författare)
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Lateral ridge augmentation with Bio-Oss alone or Bio-Oss mixed with particulate autogenous bone graft: a systematic review
- 2017
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Ingår i: International Journal of Oral and Maxillofacial Surgery. - : Elsevier BV. - 0901-5027. ; 46:8, s. 1030-1038
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this systematic review was to test the hypothesis of no difference in implant treatment outcomes when using Bio-Oss alone or Bio-Oss mixed with particulate autogenous bone grafts for lateral ridge augmentation. A search of the MEDLINE, Cochrane Library, and Embase databases in combination with a hand-search of relevant journals was conducted. Human studies published in English from 1 January 1990 to 1 May 2016 were included. The search provided 337 titles and six studies fulfilled the inclusion criteria. Considerable variation prevented a meta-analysis from being performed. The two treatment modalities have never been compared within the same study. Non-comparative studies demonstrated a 3-year implant survival of 96% with 50% Bio-Oss mixed with 50% autogenous bone graft. Moreover, Bio-Oss alone or Bio-Oss mixed with autogenous bone graft seems to increase the amount of newly formed bone as well as the width of the alveolar process. Within the limitations of this systematic review, lateral ridge augmentation with Bio-Oss alone or in combination with autogenous bone graft seems to induce newly formed bone and increase the width of the alveolar process, with high short-term implant survival. However, long-term studies comparing the two treatment modalities are needed before final conclusions can be drawn.
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| 24. |
- Andersson, Ulrika, et al.
(författare)
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The association between longer relative leukocyte telomere length and risk of glioma is independent of the potentially confounding factors allergy, BMI, and smoking
- 2019
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Ingår i: Cancer Causes and Control. - : Springer. - 0957-5243 .- 1573-7225. ; 30:2, s. 177-185
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Previous studies have suggested an association between relative leukocyte telomere length (rLTL) and glioma risk. This association may be influenced by several factors, including allergies, BMI, and smoking. Previous studies have shown that individuals with asthma and allergy have shortened relative telomere length, and decreased risk of glioma. Though, the details and the interplay between rLTL, asthma and allergies, and glioma molecular phenotype is largely unknown. Methods: rLTL was measured by qPCR in a Swedish population-based glioma case–control cohort (421 cases and 671 controls). rLTL was related to glioma risk and health parameters associated with asthma and allergy, as well as molecular events in glioma including IDH1 mutation, 1p/19q co-deletion, and EGFR amplification. Results: Longer rLTL was associated with increased risk of glioma (OR = 1.16; 95% CI 1.02–1.31). Similar to previous reports, there was an inverse association between allergy and glioma risk. Specific, allergy symptoms including watery eyes was most strongly associated with glioma risk. High body mass index (BMI) a year prior diagnosis was significantly protective against glioma in our population. Adjusting for allergy, asthma, BMI, and smoking did not markedly change the association between longer rLTL and glioma risk. rLTL among cases was not associated with IDH1 mutation, 1p/19q co-deletion, or EGFR amplification, after adjusting for age at diagnosis and sex. Conclusions: In this Swedish glioma case–control cohort, we identified that long rLTL increases the risk of glioma, an association not confounded by allergy, BMI, or smoking. This highlights the complex interplay of the immune system, rLTL and cancer risk.
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| 25. |
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| 26. |
- Beckman, K., et al.
(författare)
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Mental illness and suicide after self-harm among young adults : long-term follow-up of self-harm patients, admitted to hospital care, in a national cohort
- 2016
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Ingår i: Psychological Medicine. - Nww York, USA : Cambridge University Press. - 0033-2917 .- 1469-8978. ; 46:16, s. 3397-3405
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Tidskriftsartikel (refereegranskat)abstract
- Background: Self-harm among young adults is a common and increasing phenomenon in many parts of the world. The long-term prognosis after self-harm at young age is inadequately known. We aimed to estimate the risk of mental illness and suicide in adult life after self-harm in young adulthood and to identify prognostic factors for adverse outcome.Method: We conducted a national population-based matched case-cohort study. Patients aged 18-24 years (n = 13 731) hospitalized after self-harm between 1990 and 2003 and unexposed individuals of the same age (n = 137 310 ) were followed until December 2009. Outcomes were suicide, psychiatric hospitalization and psychotropic medication in short-term (1-5 years) and long-term (>5 years) follow-up.Results: Self-harm implied an increased relative risk of suicide during follow-up [hazard ratio (HR) 16.4, 95% confidence interval (CI) 12.9-20.9). At long-term follow-up, 20.3% had psychiatric hospitalizations and 51.1% psychotropic medications, most commonly antidepressants and anxiolytics. There was a six-fold risk of psychiatric hospitalization (HR 6.3, 95% CI 5.8-6.8) and almost three-fold risk of psychotropic medication (HR 2.8, 95% CI 2.7-3.0) in long-term follow-up. Mental disorder at baseline, especially a psychotic disorder, and a family history of suicide were associated with adverse outcome among self-harm patients.Conclusion: We found highly increased risks of future mental illness and suicide among young adults after self-harm. A history of a mental disorder was an important indicator of long-term adverse outcome. Clinicians should consider the substantially increased risk of suicide among self-harm patients with psychotic disorders.
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| 27. |
- Beckman, K., et al.
(författare)
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Method of self-harm in adolescents and young adults and risk of subsequent suicide
- 2018
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Ingår i: Journal of Child Psychology and Psychiatry. - : Wiley. - 0021-9630 .- 1469-7610. ; 59:9, s. 948-956
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Tidskriftsartikel (refereegranskat)abstract
- Background: Self-harm is common in youth and an important risk factor for suicide. Certain self-harm methods might indicate a higher risk of suicide. The main aim of this study was to determine whether some methods of self-harm in adolescents (10-17 years) and young adults (18-24 years) are associated with a particularly high risk of suicide. A secondary aim was to ascertain how different self-harm methods might affect the probability of psychiatric follow up. Method: Five Swedish registers were linked in a national population-based cohort study. All nonfatal self-harm events recorded in specialist health care, excluding psychiatry and primary care services, among 10-24 year olds between 2000 and 2009 were included. Methods were classified as poisoning, cutting/piercing, violent method (gassing, hanging, strangulation/suffocation, drowning, jumping and firearms), other and multiple methods. Hazard Ratios (HR) for suicide were calculated in Cox regression models for each method with poisoning as the reference. Odds Ratios (OR) for psychiatric inpatient care were determined in logistic regression models. Analyses were adjusted for important covariates and stratified by age group and treatment setting (inpatient/outpatient). Results: Among adolescents with initial medical hospitalisation, use of a violent method was associated with a near eightfold increase in HR for suicide compared to self-poisoning in the adjusted analysis [HR 7.8; 95% confidence interval (CI) 3.2-19.0]. Among hospitalised young adult women, adjusted HRs were elevated fourfold for both cutting [4.0 (1.9-8.8)] and violent methods [3.9 (1.5-10.6)]. Method of self-harm did not affect suicide risk in young adult men. Adolescents using violent methods had an increased probability of psychiatric inpatient care following initial treatment for self harm. Conclusions: Violent self-harm requiring medical hospitalisation may signal particularly high risk of future suicide in adolescents (both sexes) and in young adult women. For the latter group this is the case for cutting requiring hospitalisation as well.
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| 28. |
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| 29. |
- Dahlin, Anna M., et al.
(författare)
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Relation between Established Glioma Risk Variants and DNA Methylation in the Tumor
- 2016
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Ingår i: PLOS ONE. - : Public library science. - 1932-6203. ; 11:10
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies and candidate gene studies have identified several genetic variants that increase glioma risk. The majority of these variants are non-coding and the mechanisms behind the increased risk in carriers are not known. In this study, we hypothesize that some of the established glioma risk variants induce aberrant DNA methylation in the developing tumor, either locally (gene-specific) or globally (genome-wide). In a pilot data set including 77 glioma patients, we used Illumina beadchip technology to analyze genetic variants in blood and DNA methylation in matched tumor samples. To validate our findings, we used data from the Cancer Genome Atlas, including 401 glioblastoma patients. Consensus clustering identified the glioma CpG island methylator phenotype (gCIMP) and two additional subgroups with distinct patterns of global DNA methylation. In the pilot dataset, gCIMP was associated with two genetic variants in CDKN2B-AS1, rs1412829 and rs4977756 (9p21.3, p = 8.1 x 10(-7) and 4.8 x 10(-5), respectively). The association was in the same direction in the TCGA dataset, although statistically significant only when combining individuals with AG and GG genotypes. We also investigated the relation between glioma risk variants and DNA methylation in the promoter region of genes located within 30 kb of each variant. One association in the pilot dataset, between the TERT risk variant rs2736100 and lower methylation of cg23827991 (in TERT; p = 0.001), was confirmed in the TCGA dataset (p = 0.001). In conclusion, we found an association between rs1412829 and rs4977756 (9p21.3, CDKN2B-AS1) and global DNA methylation pattern in glioma, for which a trend was seen also in the TCGA glioblastoma dataset. We also found an association between rs2736100 (in TERT) and levels of methylation at cg23827991 (localized in the same gene, 3.3 kbp downstream of the risk variant), which was validated in the TCGA dataset. Except for this one association, we did not find strong evidence for gene-specific DNA methylation mediated by glioma risk variants.
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| 30. |
- Dahlin, JS, et al.
(författare)
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A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice
- 2018
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 131:21, s. E1-E11
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Tidskriftsartikel (refereegranskat)abstract
- Single-cell transcriptional landscape of 44 802 hematopoietic stem/progenitor cells defines entry points to 8 different blood lineages. Comparison with 13 815 c-Kit mutant cells identifies pleiotropic changes in cell type abundance and underlying molecular profiles.
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| 31. |
- Dahlin, M, et al.
(författare)
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The gut microbiome and epilepsy
- 2019
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Ingår i: EBioMedicine. - : Elsevier BV. - 2352-3964. ; 44, s. 741-746
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Tidskriftsartikel (refereegranskat)
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| 32. |
- Dahlin, T., et al.
(författare)
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Urban underwater ERT for site investigation in lake Mälaren, Sweden
- 2016
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Ingår i: 22nd European Meeting of Environmental and Engineering Geophysics, Near Surface Geoscience 2016.
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Konferensbidrag (refereegranskat)abstract
- An underwater ERT survey was made along a planned road tunnel for The Stockholm Bypass Project (Förbifart Stockholm). The aim was to assess the ability to identify variations in the depth of the bottom sediments, as well as variations in rock quality and the possible presence of weak zones in the rock. Reference data from a seismic survey and geotechnical drilling was used for evaluation the result. An underwater layout of 121 underwater and 37 land based electrodes at a separation of 5 m was used. Repeated measurements were made to assess the temporal variation in urban noise, which lead to doing the actual survey during the quiet night hours. The resistivity data are of good quality and the inversion results in low residuals. The invested section shows a low resistivity layer corresponding to sediments on top of bedrock with varying resistivity, where the interpreted depth to bedrock is in good accordance with the reference data. A major low resistive zone corresponds well with poor quality rock according to drilling and a low velocity zone.
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| 33. |
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| 34. |
- Ghasimi, Soma, et al.
(författare)
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Genetic risk variants in the CDKN2A/B, RTEL1 and EGFR genes are associated with somatic biomarkers in glioma
- 2016
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Ingår i: Journal of Neuro-Oncology. - : Springer Science and Business Media LLC. - 0167-594X .- 1573-7373. ; 127:3, s. 483-492
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Tidskriftsartikel (refereegranskat)abstract
- During the last years, genome wide association studies have discovered common germline genetic variants associated with specific glioma subtypes. We aimed to study the association between these germline risk variants and tumor phenotypes, including copy number aberrations and protein expression. A total of 91 glioma patients were included. Thirteen well known genetic risk variants in TERT, EGFR, CCDC26, CDKN2A, CDKN2B, PHLDB1, TP53, and RTEL1 were selected for investigation of possible correlations with the glioma somatic markers: EGFR amplification, 1p/19q codeletion and protein expression of p53, Ki-67, and mutated IDH1. The CDKN2A/B risk variant, rs4977756, and the CDKN2B risk variant, rs1412829 were inversely associated (p = 0.049 and p = 0.002, respectively) with absence of a mutated IDH1, i.e., the majority of patients homozygous for the risk allele showed no or low expression of mutated IDH1. The RTEL1 risk variant, rs6010620 was associated (p = 0.013) with not having 1p/19q codeletion, i.e., the majority of patients homozygous for the risk allele did not show 1p/19q codeletion. In addition, the EGFR risk variant rs17172430 and the CDKN2B risk variant rs1412829, both showed a trend for association (p = 0.055 and p = 0.051, respectively) with increased EGFR copy number, i.e., the majority of patients homozygote for the risk alleles showed chromosomal gain or amplification of EGFR. Our findings indicate that CDKN2A/B risk genotypes are associated with primary glioblastoma without IDH mutation, and that there is an inverse association between RTEL1 risk genotypes and 1p/19q codeletion, suggesting that these genetic variants have a molecular impact on the genesis of high graded brain tumors. Further experimental studies are needed to delineate the functional mechanism of the association between genotype and somatic genetic aberrations.
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| 35. |
- Ivanova, Ekaterina, et al.
(författare)
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Guided and unguided CBT for social anxiety disorder and/or panic disorder via the Internet and a smartphone application
- 2015
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Ingår i: Abstracts from the 7th Swedish Congress on internet interventions (SWEsrii). - Linköping : Linköping University Press. ; , s. 9-9
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Background: As Acceptance and Commitment Therapy (ACT) becomes a part of the clinical practice, the interest for alternative ways of providing it continue to grow. Internet-based CBT, both guided and unguided, has proved to be effective for the treatment of a wide range of psychiatric disorders, including anxiety disorders. Moreover, the tremendous accessibility of smartphones makes them a potentially powerful instrument for providing psychological treatment. The purpose of this study was to investigate the effects of an Internet-based ACT-program for social anxiety disorder and panic disorder using both computers and smartphones, and with and without therapist support. Method: The participants were recruited from the general public by filling out an online screening form, which consisted of LSAS, PDSS-SR, GAD-7, PHQ-9, QOLI (the scales later served as outcome measures) and demographic questions. The individuals who met the inclusion criteria were contacted for a diagnostic telephone interview. The 152 people chosen for participation were then randomized into two treatment groups (guided and unguided) and a waiting list control group. The participants in the treatment groups were given access to an Internet-provided ACT-based treatment program consisting of 8 modules, as well as a smartphone application with content that corresponded to the Internet treatment program. Additionally, the participants in the guided group received minimum therapist support (15 min/week) through the smartphone application from psychology students undergoing their clinical training. The participants worked with the program for 10 weeks. They were evaluated twice during treatment, once after completing treatment, and once again 12-months later as a follow-up measure. A mixed effect model was used to analyze the data. Results: Regardless of diagnosis, as a whole the treated groups showed significant decreases in anxiety, with a moderate within-group effect size. This improvement appeared to be maintained when the groups were evaluated again during the follow-up. The participants suffering primarily from social anxiety disorder showed significant improvements, with moderate within-group effect sizes in both the guided (Cohen's d = 0.79) and unguided group (Cohen's d = 0.71). This improvement also appeared to be maintained when these participants were evaluated during the follow-up. No significant changes were observed in the symptoms of the participants suffering primarily from panic disorder. Discussion: Internet-delivered ACT-based treatment provided via both computer and smartphone can be effective for reducing general anxiety symptoms, as well as social anxiety symptoms. The guided treatment was not clearly superior to the unguided treatment. Some of the study’s uncertainties are likely due to the presence of a large number of different components, which made it difficult to isolate the effects of each individual component.
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| 36. |
- Johansson, S., et al.
(författare)
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The potential of X-ray tomography and image analysis for interpretation of spectral induced polarization measurements
- 2017
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Ingår i: Conference Proceedings, 23rd European Meeting of Environmental and Engineering Geophysics. - Netherlands : EAGE Publications BV. - 9789462822238
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Konferensbidrag (refereegranskat)abstract
- The spectral induced polarization (SIP) method is a promising method for many near surface applications, including characterization of contaminated soil. In this study, SIP measurements, high-resolution X-ray tomography and image analysis are combined to investigate clean and tetrachloroethylene (PCE) contaminated sand. This is the first known combination of these methods and the aim of this paper is to demonstrate some powerful possibilities of using X-ray tomography in SIP research. X-ray tomography enables a direct visual control of the sample conditions and quantification of relevant sample properties via image analysis techniques. The image stacks from were processed with image analysis techniques, so that individual grains and PCE phases could be extracted from the sample volume. This enabled calculations of relevant sample properties such as PCE blob volumes, grain diameter,-surface area and-eccentricity as well as bulk porosity, specific surface area to pore volume and proportion of high-density grains. We conclude that the combination of SIP measurements and X-ray tomography have a great potential of increasing the understanding of SIP mechanisms in geological materials. The tomography results can be used both to calculate properties relevant for SIP interpretation as well as 3D modelling of the pore space.
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| 37. |
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| 38. |
- Kumlien, Eva, et al.
(författare)
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Treatment with neurostimulation and ketogenic diet for people with medically refractory epilepsy : Andra behandlingsalternativ vid svårbehandlad epilepsi.
- 2018
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Ingår i: Läkartidningen. - 1652-7518. ; 115:Maj
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Forskningsöversikt (refereegranskat)abstract
- For some people with medically refractory epilepsy adjunct treatment with neurostimulation and ketogenic diet can be an option. Vagal nerve stimulation, VNS, consists of chronic intermittent electrical stimulation of the vagus nerve. VNS is effective and well tolerated in adolescents and adults. There is insufficient evidence on the efficacy of deep brain stimulation, DBS, and brain-responsive neurostimulation, RNS. Ketogenic diet is an established treatment in epilepsy with an increased number of indications, especially in neurometabolic diseases, where dietary therapy can completely eliminate epilepsy and improve cognitive and motor development. Ketogenic diet is a calculated diet consisting of a high amount of fat, the daily need of protein and a minimum of carbohydrates. The fat is converted to ketone bodies and transported across the blood-brain barrier to be used as an alternative energy source in the brain. Strictly calculated menus, regular monitoring and support from a team of dietician, nurse and physician are required.
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| 39. |
- Lindh, A. U., et al.
(författare)
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Short term risk of non-fatal and fatal suicidal behaviours: the predictive validity of the Columbia-Suicide Severity Rating Scale in a Swedish adult psychiatric population with a recent episode of self-harm
- 2018
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Ingår i: Bmc Psychiatry. - : Springer Science and Business Media LLC. - 1471-244X. ; 18
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Tidskriftsartikel (refereegranskat)abstract
- Background: The Columbia-Suicide Severity Rating Scale (C-SSRS) is a relatively new instrument for the assessment of suicidal ideation and behaviour that is widely used in clinical and research settings. The predictive properties of the C-SSRS have mainly been evaluated in young US populations. We wanted to examine the instrument's predictive validity in a Swedish cohort of adults seeking psychiatric emergency services after an episode of self-harm. Methods: Prospective cohort study of patients (n = 804) presenting for psychiatric emergency assessment after an episode of self-harm with or without suicidal intent. Suicidal ideation and behaviours at baseline were rated with the C-SSRS and subsequent non-fatal and fatal suicide attempts within 6 months were identified by record review. Logistic regression was used to evaluate separate ideation items and total scores as predictors of non-fatal and fatal suicide attempts. Receiver operating characteristics (ROC) curves were constructed for the suicidal ideation (SI) intensity score and the C-SSRS total score. Results: In this cohort, the median age at baseline was 33 years, 67% were women and 68% had made at least one suicide attempt prior to the index attempt. At least one non-fatal or fatal suicide attempt was recorded during follow-up for 165 persons (20.5%). The single C-SSRS items frequency, duration and deterrents were associated with this composite outcome; controllability and reasons were not. In a logistic regression model adjusted for previous history of suicide attempt, SI intensity score was a significant predictor of a non-fatal or fatal suicide attempt (OR 1.08; 95% CI 1.03-1.12). ROC analysis showed that the SI intensity score was somewhat better than chance in correctly classifying the outcome (AUC 0.62, 95% CI 0.57-0.66). The corresponding figures for the C-SSRS total score were 0.65, 95% CI 0.60-0.69. Conclusions: The C-SSRS items frequency, duration and deterrents were associated with elevated short term risk in this adult psychiatric cohort, as were both the SI intensity score and the C-SSRS total score. However, the ability to correctly predict future suicidal behaviour was limited for both scores.
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| 40. |
- Loke, M. H., et al.
(författare)
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The inversion of 2-D and 3-D resistivity data from surveys in aquatic areas
- 2019
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Ingår i: EAGE-GSM 2nd Asia Pacific Meeting on Near Surface Geoscience and Engineering. - : European Association of Geoscientists & Engineers. - 9789462822740
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Konferensbidrag (refereegranskat)abstract
- Resistivity surveys are now also carried in areas covered by water. The surveys involve electrodes planted on the water bottom or on a streamer towed by a boat. As the water layer has a large effect on resistivity measurements, its effect must be accurately modelled. The water resistivity and depth to the bottom are usually independently measured with a conductivity meter and depth sounder. The upper part of a finite-element grid is used to model the water layer, including possible variations in the water resistivity with depth. We show the results from a 2-D survey in Stockholm with electrodes planted on the sea bottom. The sediment thickness from the inverse model agrees well with drilling results and a possible weak zone in the bedrock was detected. Surveys with floating electrodes do not follow a straight line due to water currents and a 3-D inversion approach is required. An example is shown from a survey in the Panama Canal where the data from 19 sub-parallel lines are collated into a 3-D data set. The inverse model shows a conductive bottom with weathered marine sedimentary rocks and a remnant of an old river channel filled with more resistive sands and gravels.
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| 41. |
- Loke, M. H., et al.
(författare)
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The use of positivity constraints in 4-D ERT inversion
- 2018
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Konferensbidrag (refereegranskat)abstract
- Time-lapse resistivity surveys are used to monitor changes in the subsurface. In some situations, it is expected the resistivity will only decrease (or vice versa) with time. The 4-D ERT inversion technique includes a temporal smoothness constraint to ensure that the resistivity changes in a smooth manner with time. However, it does not directly constrain the direction of the temporal changes in the resistivity. In some cases, the time-lapse models might show an increase in the resistivity with time in parts of the inverse model where it is expected to only decrease based on other information. We modify the 4-D ERT inversion method to remove this artefact. We first use the standard 4-D ERT inversion algorithm to generate an initial model. If the resistivity is expected to decrease with time, for the model cells that show a resistivity increase a truncation procedure is used where the resistivities of the different time models are reset to the mean value. The method of transformations is then used to ensure that the resistivities of the later time models are always less than the first model. The constraints can be applied to selected regions in the model in cases where additional information is available.
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| 42. |
- Loke, M. H., et al.
(författare)
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Time-lapse 4-D resistivity imaging inversion with positivity constraints
- 2018
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Ingår i: 24th European Meeting of Environmental and Engineering Geophysics. - : European Association of Geoscientists & Engineers. - 9789462822634
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Konferensbidrag (refereegranskat)abstract
- Time-lapse resistivity surveys are used to monitor changes in the subsurface. In some situations, it is known that the resistivity will only decrease (or increase) with time. The 4-D ERT smoothness-constrained inversion method, that includes temporal smoothness constraint, has proved to be a robust method that reduces artefacts due to noise. However, in some cases, the time-lapse inverse models might show an increase in the resistivity with time where it is only expected to decrease. We modify the 4-D ERT inverse method to include a constraint that removes this artefact. The standard 4-D ERT inversion algorithm is first used to generate an initial model. If the resistivity is expected to decrease with time, for the model cells that show a resistivity increase with time, a truncation procedure is used where the resistivities of the different time models are reset to the mean value (corresponding to zero change with time). We then use the method of transformations in the inversion method that ensures the resistivities of the later time models are always less than the first model. The constraints can be modified so that they are only applied to selected regions in the model in cases where additional information is available.
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| 43. |
- Lumetzberger, M., et al.
(författare)
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Predicting the fate of chlorinated aliphatics by hydrogeological modelling and DCIP data - Färgaren case study
- 2019
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Konferensbidrag (refereegranskat)abstract
- We present a local flow model approach for the transport and the decay of a roughly 50 year old perchloroethylene contamination at a former dry cleaning facility at Kv. Färgaren in Kristianstad that sits above the largest aquifer in Sweden. The study demonstrates an efficient workflow integrating ERT for conceptualising and calibrating a three dimensional transient, multi aquifer groundwater transport problem with a sequential first-order decay contamination where only limited sample data is available for calibration - i.e. non-ideal, real world conditions. The 3D hydraulic model geometry is based on information from ERT data. It was possible to map resistivity signatures correlated with boreholes to geological features with a high degree of accuracy. On the Färgaren site itself, a 3D IP inversion model displayed some IP effects that correlated with historical perchloroethylene source terms. The simulations provide new information regarding the vulnerability of a critical groundwater resource, filling in knowledge gaps left by traditional sampling methods. It is concluded that there is potential for long term contamination of the regional sandstone aquifer, and that the plume front may already have reached its upper layers.
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| 44. |
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| 45. |
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| 46. |
- Nivorlis, A., et al.
(författare)
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Geophysical monitoring of initiated in-situ bioremediation of chlorinated solvent contamination
- 2019
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Konferensbidrag (refereegranskat)abstract
- Contaminated ground is a severe problem which is present in many countries, and it is of great importance to find efficient solutions to deal with it. In Sweden, there is a trend in the industry to move towards alternate remediation methods and on that scope in-situ bioremediation has received a lot of attention. The main challenge with in-situ bioremediation is to verify that the treatment has the intended effect, and it is hence important to understand the changes that happen in the subsurface and monitor them over time. The scope of our work is to use geophysics to extrapolate the punctual information from groundwater and soil samples and acquire a better understanding of the changes in the subsurface during in-situ bioremediation of the contaminated soil. In this work we have made a permanent installation in one of our field sites, in Alingsås, where a pilot bioremediation test is taking place to treat the contaminated soil. The autonomous system can measure the resistivity and chargeability distribution in the subsurface. The results indicate promising correlations with the geophysical signature and the contaminant. Currently we are investigating the correlations between the groundwater samples and the time-lapse imaging acquired while working towards real-time monitoring.
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| 47. |
- Nivorlis, A., et al.
(författare)
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Monitoring of in situ remediation with the direct current time-domain induced polarization method
- 2018
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Ingår i: 24th European Meeting of Environmental and Engineering Geophysics. - : European Association of Geoscientists & Engineers. - 9789462822634
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Konferensbidrag (refereegranskat)abstract
- In Alingsås, a dry-cleaning facility was operated for many years, and huge amounts of the solvent PCE was spilled into the ground. This contributed to an increasing concentration of PCE over the years until the use of PCE was stopped, resulting in the formation of a DNAPL plume beneath the building. Treatment of contaminated soils in Sweden often includes excavation and landfilling, however in Alingsås this is not applicable. In situ remediation methods (thermal, biological, chemical) are the only alternative however, there is a need for tools to monitor the effectiveness of those methods. One method of particular interest in this context is the Direct Current time-domain Induced Polarization (DCIP). For that purpose, a fully autonomous and automatic monitoring system was installed in Alingsås, to perform frequent automated measurements and to provide information about the changes in the subsurface. The geophysical data should be ideally acquired, analyzed and verified with automated routines as part of a larger monitoring system. It is of great importance, especially in the early stage, to verify events that appear to show interesting changes with sampling data to evaluate the level of reliability of the system.
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| 48. |
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| 49. |
- Osman, Ayman A. M., et al.
(författare)
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Autophagy in the posterior interosseous nerve of patients with type 1 and type 2 diabetes mellitus: an ultrastructural study
- 2015
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 1432-0428 .- 0012-186X. ; 58:3, s. 625-632
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Tidskriftsartikel (refereegranskat)abstract
- We addressed the question of whether the autophagy pathway occurs in human peripheral nerves and whether this pathway is associated with peripheral neuropathy in diabetes mellitus. By using electron microscopy, we evaluated the presence of autophagy-related structures and neuropathy in the posterior interosseous nerve of patients who had undergone carpal tunnel release and had type 1 or type 2 diabetes mellitus, and in patients with no diabetes (controls). Autophagy-related ultrastructures were observed in the samples taken from all patients of the three groups. The number of autophagy-associated structures was significantly higher (p < 0.05) in the nerves of patients with type 1 than type 2 diabetes. Qualitative and quantitative evaluations of fascicle area, diameter of myelinated and unmyelinated nerve fibres, the density of myelinated and unmyelinated fibres and the g-ratio of myelinated fibres were performed. We found degeneration and regeneration of a few myelinated axons in controls, and a well-developed neuropathy with the loss of large myelinated axons and the presence of many small ones in patients with diabetes. The pathology in type 1 diabetes was more extensive than in type 2 diabetes. The results of this study show that the human peripheral nerves have access to the autophagy machinery, and this pathway may be regulated differently in type 1 and type 2 diabetes; insulin, presence of extensive neuropathy, and/or other factors such as duration of diabetes and HbA(1c) level may underlie this differential regulation.
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| 50. |
- Othman, Amal, et al.
(författare)
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Hydrogeophysical and hydrochemical characteristics of Pliocene groundwater aquifer at the area northwest El Sadat city, West Nile Delta, Egypt
- 2019
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Ingår i: Journal of African Earth Sciences. - : Elsevier BV. - 1464-343X. ; 150, s. 1-11
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Tidskriftsartikel (refereegranskat)abstract
- Due to the overpopulation in the main cities and shortage of water in Egypt, finding new possible reclamation areas becomes an urgent necessity. The area northwest of El Sadat city can be considered one of the most promising new reclamation areas. This study focuses on detecting the groundwater aquifers, delineating the best localities to drill groundwater boreholes, and evaluation of the groundwater quality. To achieve these goals, an integrated study of vertical electric sounding (VES), time domain electromagnetic (TEM) sounding, and hydrochemical analyses has been executed. The results show that the Pliocene aquifer is the main groundwater aquifer in the survey area where it is divided into two sub-aquifers. The first aquifer is encountered at depth ranging from 30 m to 70 m, where it's thickness range is 20–60 m and its resistivity is varying from 28 to 70 Ωm. The second aquifer is recorded at depth range from 95 m to 135 m with resistivity values of 33–57 Ωm. Moreover, the suitability of 57 groundwater boreholes for drinking and irrigation purposes was assessed as they were compared with the known standard guidelines values. Piper's tri-linear diagram shows the dominance of Alkaline earth (Ca2++Mg2+) and strong acids (SO4 2−+ Cl−) in most of the water samples. According to the concentrations of major ions, the water types in the area are: Ca–HCO3 (22.8%), Ca–SO4 (17.5%), Na–SO4 (15.8%), Na–Cl (14.0%), Ca–Cl (14.0%), Na–HCO3 (10.5%), Mg–HCO3 (3.5%), and Mg–SO4 (1.8%). The electric conductivity (EC) and the total dissolved solids (TDS) values suggest fresh to brackish water. The groundwater is classified according to its total hardness (TH) based on the calcium carbonate concentration into moderately hard, hard and very hard water. Water quality indices such sodium adsorption ratio (SAR), sodium content (SC), permeability index (PI), and residual sodium carbonate (RSC) were considered to evaluate the groundwater quality for agricultural activities. These parameters suggest a safe and suitable groundwater for agricultural activities. Before exploitation further studies are however essential in order to establish a sustainable level of abstraction from the aquifer, as well as assessing the vulnerability to protect it from pollution.
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