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- Hillier, Ladeana W, et al.
(författare)
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Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
- 2004
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Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 432:7018, s. 695-716
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Tidskriftsartikel (refereegranskat)abstract
- We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genome sequenced, the draft sequence of its genome--composed of approximately one billion base pairs of sequence and an estimated 20,000-23,000 genes--provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes. For example, the evolutionary distance between chicken and human provides high specificity in detecting functional elements, both non-coding and coding. Notably, many conserved non-coding sequences are far from genes and cannot be assigned to defined functional classes. In coding regions the evolutionary dynamics of protein domains and orthologous groups illustrate processes that distinguish the lineages leading to birds and mammals. The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture.
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- Davies, SJ, et al.
(författare)
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Icodextrin improves the fluid status of peritoneal dialysis patients: Results of a double-blind randomized controlled trial
- 2003
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Ingår i: Journal of the American Society of Nephrology. - 1046-6673. ; 14:9, s. 2338-2344
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Tidskriftsartikel (refereegranskat)abstract
- Worsening fluid balance results in reduced technique and patient survival in peritoneal dialysis. Under these conditions, the glucose polymer icodextrin is known to enhance ultrafiltration in the long dwell. A multicenter, randomized, double-blind, controlled trial was undertaken to compare icodextrin versus 2.27% glucose to establish whether icodextrin improves fluid status. Fifty patients with urine output <750 ml/d, high solute transport, and either treated hypertension or untreated BP >140/90 mmHg, or a requirement for the equivalent of all 2.27% glucose exchanges, were randomized 1: 1 and evaluated at 1, 3, and 6 mo. Members of the icodextrin group lost weight, whereas the control group gained weight. Similar differences in total body water were observed, largely explained by reduced extracellular fluid volume in those receiving icodextrin, who also achieved better ultrafiltration and total sodium losses at 3 mo (P < 0.05) and had better maintenance of urine volume at 6 mo (P = 0.039). In patients fulfilling the study's inclusion criteria, the use of icodextrin, when compared with 2.27% glucose, in the long exchange improves fluid removal and status in peritoneal dialysis. This effect is apparent within I mo of commencement and was sustained for 6 mo without harmful effects on residual renal function.
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- Gennery, A. R., et al.
(författare)
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Treatment of CD40 ligand deficiency by hematopoietic stem cell transplantation: a survey of the European experience, 1993-2002
- 2004
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 103:3, s. 1152-7
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Tidskriftsartikel (refereegranskat)abstract
- CD40 ligand (CD40L) deficiency causes recurrent sinopulmonary infection, Pneumocystis carinii pneumonia, and Cryptosporidium parvum infection. Approximately 40% to 50% of patients survive to the third decade: long-term survival is unclear. Hematopoietic stem cell transplantation (HSCT) is curative. We present a retrospective analysis of 38 European patients undergoing HSCT for CD40L deficiency in 8 European countries between 1993 and 2002. Donor stem cell source included 14 HLA-identical siblings, 22 unrelated donors, and 2 phenotypically matched parental stem cells (12 T-cell depleted). Of the patients, 34 engrafted and 26 (68%) survived; 3 had autologous reconstitution, 22 (58%) were cured, and 1 engrafted but has poor T-cell immune reconstitution. There were 18 evaluated patients who responded to vaccination. Of the patients, 12 (32%) died from infection-related complications, with severe cryptosporidiosis in 6. Grades 2 to 4 graft-versus-host disease (GvHD) associated with infection occurred in 6 of 12 fatal cases. HSCT cured 58% of patients, 72% of those without hepatic disease. Early T-cell function following whole marrow HSCT may limit cryptosporidial disease, but survival was similar after T-cell-depleted HSCT. Preexisting lung damage was the most important adverse risk factor. Further studies will determine optimal timing and type of HSCT.
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- Lindén, Anita, et al.
(författare)
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Special Considerations for Navigation and Interaction in Virtual Environments for People with Brain Injury
- 2000
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Ingår i: Proceedings of the 3rd International Conference on Disability, Virtual Reality & Associated Technologies. ; , s. 287-296
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Konferensbidrag (refereegranskat)abstract
- When a Virtual Environment (VE) is designed, decisions regarding the navigation of the viewpoint, interaction with objects, and the behavior of the VE itself are made. Each of these can affect the usability and the cognitive load on the user. A VE that had previously been constructed as a prototype tool for the assessment of brain injury has been studied to establish the consequences of such design decisions. Six people, two with brain injury, have used the VE to perform a specific task (brewing coffee) a total of ten times over two sessions separated by a week. These trials were video recorded and analysed. Results and implications are presented and discussed.
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- Semadeni Davies, Annette, et al.
(författare)
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Estimating latent heat over a melting arctic snow cover
- 2004
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Ingår i: Nordic Hydrology. - 0029-1277. ; 35:3, s. 175-190
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Tidskriftsartikel (refereegranskat)abstract
- The latent heat flux over snow near Ny-Alesund, Spitsbergen, was investigated for the 1999 snowmelt season to assess different methods of modelling the flux. Snow evaporation had hitherto been estimated as the residual of plot water balance calculations and was subject to measurement errors: hence a modelling solution was sought to make use of existing data. Precipitation, snow depth and albedo we.-e measured daily. Runoff from the plots was recorded continuously. Wind speed, relative humidity and air temperature were measured at two levels (2 and 10 m) every 10 minutes; wind direction was noted hourly. Three models which simulate latent heat were assessed against evaporation and condensation measured by weighing several snow-filled containers each day. Two employ the bulk profile method (within the SNTHERM and CROCUS snowmelt models), while the third is the aerodynamic profile method (APM). Each follows tie measured evaporation until snow-free patches develop after which the APM predicts evaporation whereas the snowmelt models predict condensation. The effect of wind is also noted. A major conclusion of this work is that the complexity of the land surface/atmosphere interactions, particularly when the snow cover breaks up, precludes the use of simple models for determining latent heat.
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