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Gas6 promotes infla...
Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes
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Tjwa, Marc (author)
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Ido-Martin, Lola Bell (author)
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Lin, Yuan (author)
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Lutgens, Esther (author)
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Plaisance, Stephane (author)
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Bono, Francoise (author)
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Delesque-Touchard, Nathalie (author)
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Herve, Caroline (author)
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Moura, Rute (author)
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Billiau, An D (author)
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Aparicio, Cristina (author)
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Levi, Marcel (author)
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Daemen, Mat (author)
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Dewerchin, Mieke (author)
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Lupu, Florea (author)
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Arnout, Jef (author)
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Herbert, Jean-Marc (author)
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Waer, Mark (author)
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- Garcia de Frutos, Pablo (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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- Dahlbäck, Björn (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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Carmeliet, Peter (author)
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Hoylaerts, Marc F (author)
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Moons, Lieve (author)
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(creator_code:org_t)
- American Society of Hematology, 2008
- 2008
- English.
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In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 111:8, s. 4096-4105
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Abstract
Subject headings
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- The role of Gas6 in enclothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and enclothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart transplantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Blood
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- By the author/editor
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Tjwa, Marc
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Ido-Martin, Lola ...
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Lin, Yuan
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Lutgens, Esther
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Plaisance, Steph ...
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Bono, Francoise
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show more...
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Delesque-Touchar ...
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Herve, Caroline
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Moura, Rute
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Billiau, An D
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Aparicio, Cristi ...
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Levi, Marcel
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Daemen, Mat
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Dewerchin, Mieke
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Lupu, Florea
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Arnout, Jef
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Herbert, Jean-Ma ...
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Waer, Mark
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Garcia de Frutos ...
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Dahlbäck, Björn
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Carmeliet, Peter
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Hoylaerts, Marc ...
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Moons, Lieve
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Blood
- By the university
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Lund University