| 1. |
- Di Filippo, Maria, et al.
(författare)
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Hydrothermal aging of carbon reinforced epoxy laminates with nanofibrous mats as toughening interlayers
- 2016
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Ingår i: Polymer degradation and stability. - : Elsevier. - 0141-3910 .- 1873-2321. ; 126, s. 188-195
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Tidskriftsartikel (refereegranskat)abstract
- Electrospun mats have been applied as toughening interlayers in high performance carbon fiber epoxy composites. While the toughening mechanism exerted by the mat at the interface is the subject of several recent studies, no investigations are reported on the aging behaviour of laminates comprising these nanostructured elements. This work investigates the influence of the combined effect of water and temperature (90 degrees C) on laminates with Nylon 6,6 electrospun membranes placed either at the middle plane only or at each interlayer. The water-uptake behaviour is modelled by a two-stage diffusion model and compared with the behaviour of the neat resin and of the laminate without mats. Interestingly, a lower water uptake is observed for the laminates with mat-modified interfaces and this is possibly due to a significantly reduced porosity. The effect of hydrothermal aging on the thermal (Tg) and mechanical properties (transverse flexural modulus and interlaminar shear strength) of the various laminates is also investigated.
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| 2. |
- Dispenza, Clelia, et al.
(författare)
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On the origin of functionalization in one-pot radiation synthesis of nanogels from aqueous polymer solutions
- 2016
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Ingår i: RSC Advances. - : Royal Society of Chemistry. - 2046-2069. ; 6:4, s. 2582-2591
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Tidskriftsartikel (refereegranskat)abstract
- Radiation-engineered poly(N-vinyl pyrrolidone) nanogels are very interesting biocompatible nanocarriers for i.v. administration of therapeutics and contrast agents for bioimaging. The manufacturing process is fast and effective, it grants excellent control of particle size and simultaneous sterilization of the formed nanogels. Interestingly, primary amino groups and carboxyl groups, useful for (bio) conjugation, are also formed in a dose-dependent fashion. In this paper, by means of both numerical simulations and experiments, the origin of nanogel size control and functionalization is investigated. This understanding offers a new dimension for the design and production of radiation-sculptured multifunctional nanocarriers from aqueous solutions of polymers.
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| 3. |
- Picone, P., et al.
(författare)
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Ionizing radiation-engineered nanogels as insulin nanocarriers for the development of a new strategy for the treatment of Alzheimer’s disease
- 2016
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Ingår i: Biomaterials. - : Elsevier. - 0142-9612 .- 1878-5905. ; 80, s. 179-194
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Tidskriftsartikel (refereegranskat)abstract
- A growing body of evidence shows the protective role of insulin in Alzheimer’s disease (AD). A nanogel system (NG) to deliver insulin to the brain, as a tool for the development of a new therapy for Alzheimer’s Disease (AD), is designed and synthetized. A carboxyl-functionalized poly(N-vinyl pyrrolidone) nanogel system produced by ionizing radiation is chosen as substrate for the covalent attachment of insulin or fluorescent molecules relevant for its characterization. Biocompatibility and hemocompatibility of the naked carrier is demonstrated. The insulin conjugated to the NG (NG-In) is protected by protease degradation and able to bind to insulin receptor (IR), as demonstrated by immunofluorescence measurements showing colocalization of NG-InFITC with IR. Moreover, after binding to the receptor, NG-In is able to trigger insulin signaling via AKT activation. Neuroprotection of NG-In against dysfunction induced by amyloid β (Aβ), a peptide mainly involved in AD, is verified. Finally, the potential of NG-In to be efficiently transported across the Blood Brain Barrier (BBB) is demonstrated. All together these results indicate that the synthesized NG-In is a suitable vehicle system for insulin deliver in biomedicine and a very promising tool to develop new therapies for neurodegenerative diseases.
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