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IGFBP-7 and Outcome...
IGFBP-7 and Outcomes in Heart Failure With Reduced Ejection Fraction : Findings From DAPA-HF.
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Adamson, Carly (författare)
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Welsh, Paul (författare)
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Docherty, Kieran F. (författare)
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visa fler...
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de Boer, Rudolf A. (författare)
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Diez, Mirta (författare)
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Drozdz, Jaroslaw (författare)
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Dukat, Andre (författare)
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Inzucchi, Silvio E. (författare)
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Kober, Lars (författare)
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Kosiborod, Mikhail N. (författare)
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- Ljungman, Charlotta, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Martinez, Felipe A. (författare)
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Ponikowski, Piotr (författare)
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Sabatine, Marc S. (författare)
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Morrow, David A. (författare)
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Lindholm, Daniel (författare)
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Hammarstedt, Ann (författare)
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Boulton, David W. (författare)
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Greasley, Peter J. (författare)
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Langkilde, Anna Maria (författare)
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Solomon, Scott D. (författare)
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Sattar, Naveed (författare)
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McMurray, John J. V. (författare)
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Jhund, Pardeep S. (författare)
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- Engelska.
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Ingår i: JACC. Heart failure. - : Elsevier BV. - 2213-1779 .- 2213-1787. ; 11:3, s. 291-304
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Insulin-like growth factor-binding protein-7 (IGFBP-7) has been proposed as a potential prognostic biomarker in heart failure (HF), but the association between elevation in IGFBP-7 and HF outcomes in ambulant patients with heart failure with reduced ejection fraction (HFrEF) is unknown. OBJECTIVES: The authors addressed this question in a post hoc analysis of the DAPA-HF (Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure) trial. METHODS: The primary outcome was a composite of cardiovascular death or a worsening HF event. The risk of adverse outcome was compared across tertiles of IGFBP-7 concentration by means of Cox proportional hazard models adjusted for N-terminal pro-B- type natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hsTnT). The efficacy of randomized treatment across IGFBP-7 tertiles was assessed. Change in IGFBP-7 at 12 months was compared with the use of geometric means. RESULTS: A total of 3,158 patients had IGFBP-7 measured at baseline, and 2,493 had a repeated measure at 12 months. Patients in the highest tertile of IGFBP-7 had evidence of more advanced HFrEF. The adjusted HR for the primary endpoint in tertile 3, compared with tertile 1, was 1.48 (95% CI: 1.17-1.88). There was no modification of the benefit of dapagliflozin by baseline IGFBP-7 (P interaction = 0.34). Dapagliflozin did not change IGFBP-7 levels over 1 year (P = 0.34). CONCLUSIONS: Higher IGFBP-7 in patients with HFrEF was associated with worse clinical profile and an increased risk of adverse clinical outcomes. IGFBP-7 provided prognostic information incremental to clinical variables, NT-proBNP, and hsTnT. The benefit of dapagliflozin was not modulated by IGFBP-7 level. (Study to Evaluate the Effect of Dapagliflozin on the Incidence of Worsening Heart Failure or Cardiovascular Death in Patients With Chronic Heart Failure [DAPA-HF]; NCT03036124).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- *Heart Failure/drug therapy
- *Ventricular Dysfunction
- Left
- biomarker
- dapagliflozin
- heart failure
- Humans
- Insulin-Like Growth Factor Binding Proteins
- insulin-like growth factor-binding protein-7
- Proportional Hazards Models
- SGLT2 inhibitor
- Stroke Volume
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Adamson, Carly
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Welsh, Paul
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Docherty, Kieran ...
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de Boer, Rudolf ...
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Diez, Mirta
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Drozdz, Jaroslaw
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visa fler...
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Dukat, Andre
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Inzucchi, Silvio ...
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Kober, Lars
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Kosiborod, Mikha ...
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Ljungman, Charlo ...
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Martinez, Felipe ...
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Ponikowski, Piot ...
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Sabatine, Marc S ...
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Morrow, David A.
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Lindholm, Daniel
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Hammarstedt, Ann
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Boulton, David W ...
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Greasley, Peter ...
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Langkilde, Anna ...
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Solomon, Scott D ...
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Sattar, Naveed
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McMurray, John J ...
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Jhund, Pardeep S ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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JACC. Heart fail ...
- Av lärosätet
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Uppsala universitet
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Göteborgs universitet