| 1. |
- Graslund, S, et al.
(författare)
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Protein production and purification
- 2008
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Ingår i: Nature methods. - : Springer Science and Business Media LLC. - 1548-7105 .- 1548-7091. ; 5:2, s. 135-146
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Tidskriftsartikel (refereegranskat)
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| 2. |
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| 3. |
- Davies, R.J., et al.
(författare)
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A user driven approach to develop a cognitive prosthetic to address the unmet needs of people with mild dementia
- 2009
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Ingår i: Pervasive and Mobile Computing. - : Elsevier BV. - 1574-1192 .- 1873-1589. ; 5:3, s. 253-267
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Tidskriftsartikel (refereegranskat)abstract
- This paper aims to provide the details of the approach adopted in the development of a cognitive prosthetic aimed to help address the unmet needs of people with mild dementia. The approach adopted is based on a waterfall style approach consisting of a series of three phases each of which contributes to the progression and improvement of a cognitive prosthetic-based solution. Within each phase, distinct stages of design, development and evaluation of the cognitive solution are conducted. The current paper discusses the distinct stages conducted in the first phase of the project which resulted in the design and development of a user driven solution based on the needs of 17 patient/carer dyads across three trial sites.
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| 4. |
- Jallow, Muminatou, et al.
(författare)
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Genome-wide and fine-resolution association analysis of malaria in West Africa.
- 2009
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; , s. 657-665
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Tidskriftsartikel (refereegranskat)abstract
- We report a genome-wide association (GWA) study of severe malaria in The Gambia. The initial GWA scan included 2,500 children genotyped on the Affymetrix 500K GeneChip, and a replication study included 3,400 children. We used this to examine the performance of GWA methods in Africa. We found considerable population stratification, and also that signals of association at known malaria resistance loci were greatly attenuated owing to weak linkage disequilibrium (LD). To investigate possible solutions to the problem of low LD, we focused on the HbS locus, sequencing this region of the genome in 62 Gambian individuals and then using these data to conduct multipoint imputation in the GWA samples. This increased the signal of association, from P = 4 x 10(-7) to P = 4 x 10(-14), with the peak of the signal located precisely at the HbS causal variant. Our findings provide proof of principle that fine-resolution multipoint imputation, based on population-specific sequencing data, can substantially boost authentic GWA signals and enable fine mapping of causal variants in African populations.
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| 5. |
- Menzel, Annette, et al.
(författare)
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European phenological response to climate change matches the warming pattern
- 2006
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Ingår i: Global Change Biology. - 1354-1013 .- 1365-2486. ; 12:10, s. 1969-1976
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Tidskriftsartikel (refereegranskat)abstract
- Global climate change impacts can already be tracked in many physical and biological systems; in particular, terrestrial ecosystems provide a consistent picture of observed changes. One of the preferred indicators is phenology, the science of natural recurring events, as their recorded dates provide a high-temporal resolution of ongoing changes. Thus, numerous analyses have demonstrated an earlier onset of spring events for mid and higher latitudes and a lengthening of the growing season. However, published single-site or single-species studies are particularly open to suspicion of being biased towards predominantly reporting climate change-induced impacts. No comprehensive study or meta-analysis has so far examined the possible lack of evidence for changes or shifts at sites where no temperature change is observed. We used an enormous systematic phenological network data set of more than 125000 observational series of 542 plant and 19 animal species in 21 European countries (1971-2000). Our results showed that 78% of all leafing, flowering and fruiting records advanced (30% significantly) and only 3% were significantly delayed, whereas the signal of leaf colouring/fall is ambiguous. We conclude that previously published results of phenological changes were not biased by reporting or publication predisposition: the average advance of spring/summer was 2.5 days decade -1 in Europe. Our analysis of 254 mean national time series undoubtedly demonstrates that species' phenology is responsive to temperature of the preceding months (mean advance of spring/summer by 2.5 days °C -1, delay of leaf colouring and fall by 1.0 day °C -1). The pattern of observed change in spring efficiently matches measured national warming across 19 European countries (correlation coefficient r = -0.69, P < 0.001).
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| 6. |
- Hallberg, Josef, et al.
(författare)
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HomeRuleML : a model for the exchange of decision support rules within smart environments
- 2007
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Ingår i: IEEE International Conference on Automation Science and Engineering, 2007. - Piscataway, NJ : IEEE Communications Society. - 1424411548 - 9781424411542 ; , s. 513-520
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Konferensbidrag (refereegranskat)abstract
- The demands for smart environments, which can help to facilitate as well as monitor independent living are increasing. With this comes a desire for decision support rules to process data recorded from such environments. However, testing and evaluating rules can be both time-consuming and indeed stressful for the inhabitants. Within this paper we propose a model, referred to as HomeRuleML, for representing decision support rules for smart environments. The motivating factor behind such a proposal is to provide a widely and freely accessible set of rules which can be openly used and exchanged within the research domain and beyond. This model has the potential to decrease the time required for deployment, and inevitability improve the inhabitants' quality of life. In the paper we explain in detail the structure of adopting this approach and also provide an indication of the typical types of software tools required for its use.
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| 7. |
- Nugent, C.D., et al.
(författare)
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The development of personalised cognitive prosthetics
- 2008
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Ingår i: Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. - Piscataway, NJ : IEEE Communications Society. ; , s. 787-790
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Konferensbidrag (refereegranskat)abstract
- Persons suffering from mild dementia can benefit from a form of cognitive prosthetic which can be used to assist them with their day to day activities. Within our current work we are aiming to develop a successful user-validated cognitive prosthetic for persons with mild dementia. We have devised a three phased waterfall methodology to support our developments. Based on the evaluation of the first of these phases which involved the processes of user requirements gathering, prototype development and evaluation of in situ deployment of the technology we have been able to guide the technical development within the second phase of our work. Within this paper we provide an overview of the first phase of our methodology and demonstrate how we have used the results from this to guide the second phase of our work, especially with regards to the notion of personalisation.
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