| 1. |
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| 2. |
- Felsberg, Michael, et al.
(författare)
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The Thermal Infrared Visual Object Tracking VOT-TIR2015 Challenge Results
- 2015
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Ingår i: Proceedings of the IEEE International Conference on Computer Vision. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781467383905 ; , s. 639-651
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Konferensbidrag (refereegranskat)abstract
- The Thermal Infrared Visual Object Tracking challenge 2015, VOTTIR2015, aims at comparing short-term single-object visual trackers that work on thermal infrared (TIR) sequences and do not apply prelearned models of object appearance. VOT-TIR2015 is the first benchmark on short-term tracking in TIR sequences. Results of 24 trackers are presented. For each participating tracker, a short description is provided in the appendix. The VOT-TIR2015 challenge is based on the VOT2013 challenge, but introduces the following novelties: (i) the newly collected LTIR (Linköping TIR) dataset is used, (ii) the VOT2013 attributes are adapted to TIR data, (iii) the evaluation is performed using insights gained during VOT2013 and VOT2014 and is similar to VOT2015.
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| 3. |
- Felsberg, Michael, 1974-, et al.
(författare)
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The Thermal Infrared Visual Object Tracking VOT-TIR2016 Challenge Results
- 2016
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Ingår i: Computer Vision – ECCV 2016 Workshops. ECCV 2016.. - Cham : SPRINGER INT PUBLISHING AG. - 9783319488813 - 9783319488806 ; , s. 824-849
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Konferensbidrag (refereegranskat)abstract
- The Thermal Infrared Visual Object Tracking challenge 2016, VOT-TIR2016, aims at comparing short-term single-object visual trackers that work on thermal infrared (TIR) sequences and do not apply pre-learned models of object appearance. VOT-TIR2016 is the second benchmark on short-term tracking in TIR sequences. Results of 24 trackers are presented. For each participating tracker, a short description is provided in the appendix. The VOT-TIR2016 challenge is similar to the 2015 challenge, the main difference is the introduction of new, more difficult sequences into the dataset. Furthermore, VOT-TIR2016 evaluation adopted the improvements regarding overlap calculation in VOT2016. Compared to VOT-TIR2015, a significant general improvement of results has been observed, which partly compensate for the more difficult sequences. The dataset, the evaluation kit, as well as the results are publicly available at the challenge website.
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| 4. |
- Kristan, Matej, et al.
(författare)
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The Visual Object Tracking VOT2015 challenge results
- 2015
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Ingår i: Proceedings 2015 IEEE International Conference on Computer Vision Workshops ICCVW 2015. - : IEEE. - 9780769557205 ; , s. 564-586
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Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge 2015, VOT2015, aims at comparing short-term single-object visual trackers that do not apply pre-learned models of object appearance. Results of 62 trackers are presented. The number of tested trackers makes VOT 2015 the largest benchmark on short-term tracking to date. For each participating tracker, a short description is provided in the appendix. Features of the VOT2015 challenge that go beyond its VOT2014 predecessor are: (i) a new VOT2015 dataset twice as large as in VOT2014 with full annotation of targets by rotated bounding boxes and per-frame attribute, (ii) extensions of the VOT2014 evaluation methodology by introduction of a new performance measure. The dataset, the evaluation kit as well as the results are publicly available at the challenge website(1).
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| 5. |
- Kristan, Matej, et al.
(författare)
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The Visual Object Tracking VOT2016 Challenge Results
- 2016
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Ingår i: COMPUTER VISION - ECCV 2016 WORKSHOPS, PT II. - Cham : SPRINGER INT PUBLISHING AG. - 9783319488813 - 9783319488806 ; , s. 777-823
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Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge VOT2016 aims at comparing short-term single-object visual trackers that do not apply pre-learned models of object appearance. Results of 70 trackers are presented, with a large number of trackers being published at major computer vision conferences and journals in the recent years. The number of tested state-of-the-art trackers makes the VOT 2016 the largest and most challenging benchmark on short-term tracking to date. For each participating tracker, a short description is provided in the Appendix. The VOT2016 goes beyond its predecessors by (i) introducing a new semi-automatic ground truth bounding box annotation methodology and (ii) extending the evaluation system with the no-reset experiment.
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| 6. |
- Kristan, Matej, et al.
(författare)
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The Visual Object Tracking VOT2017 challenge results
- 2017
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Ingår i: 2017 IEEE INTERNATIONAL CONFERENCE ON COMPUTER VISION WORKSHOPS (ICCVW 2017). - : IEEE. - 9781538610343 ; , s. 1949-1972
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Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge VOT2017 is the fifth annual tracker benchmarking activity organized by the VOT initiative. Results of 51 trackers are presented; many are state-of-the-art published at major computer vision conferences or journals in recent years. The evaluation included the standard VOT and other popular methodologies and a new "real-time" experiment simulating a situation where a tracker processes images as if provided by a continuously running sensor. Performance of the tested trackers typically by far exceeds standard baselines. The source code for most of the trackers is publicly available from the VOT page. The VOT2017 goes beyond its predecessors by (i) improving the VOT public dataset and introducing a separate VOT2017 sequestered dataset, (ii) introducing a realtime tracking experiment and (iii) releasing a redesigned toolkit that supports complex experiments. The dataset, the evaluation kit and the results are publicly available at the challenge website(1).
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| 7. |
- Kristanl, Matej, et al.
(författare)
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The Seventh Visual Object Tracking VOT2019 Challenge Results
- 2019
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Ingår i: 2019 IEEE/CVF INTERNATIONAL CONFERENCE ON COMPUTER VISION WORKSHOPS (ICCVW). - : IEEE COMPUTER SOC. - 9781728150239 ; , s. 2206-2241
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Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge VOT2019 is the seventh annual tracker benchmarking activity organized by the VOT initiative. Results of 81 trackers are presented; many are state-of-the-art trackers published at major computer vision conferences or in journals in the recent years. The evaluation included the standard VOT and other popular methodologies for short-term tracking analysis as well as the standard VOT methodology for long-term tracking analysis. The VOT2019 challenge was composed of five challenges focusing on different tracking domains: (i) VOT-ST2019 challenge focused on short-term tracking in RGB, (ii) VOT-RT2019 challenge focused on "real-time" short-term tracking in RGB, (iii) VOT-LT2019 focused on long-term tracking namely coping with target disappearance and reappearance. Two new challenges have been introduced: (iv) VOT-RGBT2019 challenge focused on short-term tracking in RGB and thermal imagery and (v) VOT-RGBD2019 challenge focused on long-term tracking in RGB and depth imagery. The VOT-ST2019, VOT-RT2019 and VOT-LT2019 datasets were refreshed while new datasets were introduced for VOT-RGBT2019 and VOT-RGBD2019. The VOT toolkit has been updated to support both standard short-term, long-term tracking and tracking with multi-channel imagery. Performance of the tested trackers typically by far exceeds standard baselines. The source code for most of the trackers is publicly available from the VOT page. The dataset, the evaluation kit and the results are publicly available at the challenge website(1).
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| 8. |
- Lai, Kuei-Hung, et al.
(författare)
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Antileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90
- 2016
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Two new scalarane sesterterpenoids, 12 beta-(3'beta-hydroxybutanoyloxy)-20,24-dimethyl-24-oxo-scalara-16-en-25-al (1) and 12 beta-(3'beta-hydroxypentanoyloxy)-20,24-dimethyl-24-oxo-scalara-16-en-25-al (2), along with one known tetraprenyltoluquinol-related metabolite (3), were isolated from the sponge Carteriospongia sp. In leukemia Molt 4 cells, 1 at 0.0625 mu g/mL (125 nM) triggered mitochondrial membrane potential (MMP) disruption and apoptosis showing more potent effect than 2 and 3. The isolates inhibited topoisomerase II alpha expression. The apoptotic-inducing effect of 3 was supported by the in vivo experiment through suppressing the volume of xenograft tumor growth (47.58%) compared with the control. Compound 1 apoptotic mechanism of action in Molt 4 cells was further elucidated through inducing ROS generation, calcium release and ER stress. Using the molecular docking analysis, 1 exhibited more binding affinity to N-terminal ATP-binding pocket of Hsp90 protein than 17-AAG, a standard Hsp90 inhibitor. The expression of Hsp90 client proteins, Akt, p70(S6k), NF kappa B, Raf-1, p-GSK3 beta, and XIAP, MDM 2 and Rb2, and CDK4 and Cyclin D3, HIF1 and HSF1 were suppressed by the use of 1. However, the expression of Hsp70, acetylated tubulin, and activated caspase 3 were induced after 1 treatment. Our results suggested that the proapoptotic effect of the isolates is mediated through the inhibition of Hsp90 and topoisomerase activities.
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| 9. |
- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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| 10. |
- Cheng, Ran, et al.
(författare)
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In Vitro and in Vivo Evaluation of C-11-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies
- 2018
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Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 61:6, s. 2278-2291
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Tidskriftsartikel (refereegranskat)abstract
- Monoacylglycerol lipase (MAGL) is the principle enzyme for metabolizing endogenous cannabinoid ligand 2-arachidonoyglycerol (2-AG). Blockade of MAGL increases 2-AG levels, resulting in subsequent activation of the endocannabinoid system, and has emerged as a novel therapeutic strategy to treat drug addiction, inflammation, and neurodegenerative diseases. Herein we report a new series of MAGL inhibitors, which were radiolabeled by site-specific labeling technologies, including C-11-carbonylation and spirocyclic iodonium ylide (SCIDY) radio fluorination. The lead compound [C-11]10 (MAGL-0519) demonstrated high specific binding and selectivity in vitro and in vivo. We also observed unexpected washout kinetics with these irreversible radiotracers, in which in vivo evidence for turnover of the covalent residue was unveiled between MAGL and azetidine carboxylates. This work may lead to new directions for drug discovery and PET tracer development based on azetidine carboxylate inhibitor scaffold.
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| 11. |
- Danaei, Goodarz, et al.
(författare)
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Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331288 participants
- 2015
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Ingår i: The Lancet Diabetes & Endocrinology. - 2213-8595 .- 2213-8587. ; 3:8, s. 624-637
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Tidskriftsartikel (refereegranskat)abstract
- Background Diabetes has been defined on the basis of different biomarkers, including fasting plasma glucose (FPG), 2-h plasma glucose in an oral glucose tolerance test (2hOGTT), and HbA(1c). We assessed the effect of different diagnostic definitions on both the population prevalence of diabetes and the classification of previously undiagnosed individuals as having diabetes versus not having diabetes in a pooled analysis of data from population-based health examination surveys in different regions. Methods We used data from 96 population-based health examination surveys that had measured at least two of the biomarkers used for defining diabetes. Diabetes was defined using HbA(1c) (HbA(1c) >= 6 . 5% or history of diabetes diagnosis or using insulin or oral hypoglycaemic drugs) compared with either FPG only or FPG-or-2hOGTT definitions (FPG >= 7 . 0 mmol/L or 2hOGTT >= 11 . 1 mmol/L or history of diabetes or using insulin or oral hypoglycaemic drugs). We calculated diabetes prevalence, taking into account complex survey design and survey sample weights. We compared the prevalences of diabetes using different definitions graphically and by regression analyses. We calculated sensitivity and specificity of diabetes diagnosis based on HbA1c compared with diagnosis based on glucose among previously undiagnosed individuals (ie, excluding those with history of diabetes or using insulin or oral hypoglycaemic drugs). We calculated sensitivity and specificity in each survey, and then pooled results using a random-effects model. We assessed the sources of heterogeneity of sensitivity by meta-regressions for study characteristics selected a priori. Findings Population prevalence of diabetes based on FPG- or-2hOGTT was correlated with prevalence based on FPG alone (r= 0 . 98), but was higher by 2-6 percentage points at different prevalence levels. Prevalence based on HbA(1c) was lower than prevalence based on FPG in 42 . 8% of age-sex-survey groups and higher in another 41 . 6%; in the other 15 . 6%, the two definitions provided similar prevalence estimates. The variation across studies in the relation between glucose-based and HbA(1c)-based prevalences was partly related to participants' age, followed by natural logarithm of per person gross domestic product, the year of survey, mean BMI, and whether the survey population was national, subnational, or from specific communities. Diabetes defined as HbA(1c) 6 . 5% or more had a pooled sensitivity of 52 . 8% (95% CI 51 . 3-54 . 3%) and a pooled specificity of 99 . 74% (99 . 71-99 . 78%) compared with FPG 7 . 0 mmol/L or more for diagnosing previously undiagnosed participants; sensitivity compared with diabetes defined based on FPG-or-2hOGTT was 30 . 5% (28 . 7-32 . 3%). None of the preselected study-level characteristics explained the heterogeneity in the sensitivity of HbA(1c) versus FPG. Interpretation Different biomarkers and definitions for diabetes can provide different estimates of population prevalence of diabetes, and differentially identify people without previous diagnosis as having diabetes. Using an HbA(1c)-based definition alone in health surveys will not identify a substantial proportion of previously undiagnosed people who would be considered as having diabetes using a glucose-based test.
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| 12. |
- Du, Jinfeng, et al.
(författare)
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Scalable Capacity Bounding Models for Wireless Networks
- 2016
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Ingår i: IEEE Transactions on Information Theory. - : IEEE Press. - 0018-9448 .- 1557-9654. ; 62:1, s. 208-229
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Tidskriftsartikel (refereegranskat)abstract
- The framework of network equivalence theory developed by Koetter et al. introduces a notion of channel emulation to construct noiseless networks as upper (respectively, lower) bounding models, which can be used to calculate the outer (respectively, inner) bounds for the capacity region of the original noisy network. Based on the network equivalence framework, this paper presents scalable upper and lower bounding models for wireless networks with potentially many nodes. A channel decoupling method is proposed to decompose wireless networks into decoupled multiple-access channels and broadcast channels. The upper bounding model, consisting of only point-to-point bit pipes, is constructed by first extending the one-shot upper bounding models developed by Calmon et al. and then integrating them with network equivalence tools. The lower bounding model, consisting of both point-to-point and point-to-points bit pipes, is constructed based on a two-step update of the lower bounding models to incorporate the broadcast nature of wireless transmission. The main advantages of the proposed methods are their simplicity and the fact that they can be extended easily to large networks with a complexity that grows linearly with the number of nodes. It is demonstrated that the resulting upper and lower bounds can approach the capacity in some setups.
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| 13. |
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| 14. |
- Du, Rong, 1989-, et al.
(författare)
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Energy efficient monitoring of water distribution networks via compressive sensing
- 2015
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Ingår i: 2015 IEEE International Conference on Communications (ICC). - : IEEE conference proceedings. - 9781467364324 ; , s. 6681-6686
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Konferensbidrag (refereegranskat)abstract
- The recent development of low cost wireless sensors enables water monitoring through dense wireless sensor networks (WSN). Sensor nodes are battery powered devices, and hence their limited energy resources have to be optimally managed. The latest advancements in compressive sensing (CS) provide ample promise to increase WSNs lifetime by limiting the amount of measurements that have to be collected. Additional energy savings can be achieved through CS-based scheduling schemes that activate only a limited number of sensors to sense and transmit their measurements, whereas the rest are turned off. The ultimate objective is to maximize network lifetime without sacrificing network connectivity and monitoring performance. This problem can be approximated by an energy balancing approach that consists of multiple simpler subproblems, each of which corresponds to a specific time period. Then, the sensors that should be activated within a given period can be optimally derived through dynamic programming. The complexity of the proposed CS-based scheduling scheme is characterized and numerical evaluation reveals that it achieves comparable monitoring performance by activating only a fraction of the sensors.
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| 15. |
- Du, Rong, et al.
(författare)
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Energy Efficient Sensor Activation for Water Distribution Networks Based on Compressive Sensing
- 2015
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Ingår i: IEEE Journal on Selected Areas in Communications. - : IEEE. - 0733-8716 .- 1558-0008. ; 33:12, s. 2997-3010
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Tidskriftsartikel (refereegranskat)abstract
- The recent development of low cost wireless sensors enables novel internet-of-things (IoT) applications, such as the monitoring of water distribution networks. In such scenarios, the lifetime of the wireless sensor network (WSN) is a major concern, given that sensor node replacement is generally inconvenient and costly. In this paper, a compressive sensing-based scheduling scheme is proposed that conserves energy by activating only a small subset of sensor nodes in each timeslot to sense and transmit. Compressive sensing introduces a cardinality constraint that makes the scheduling optimization problem particularly challenging. Taking advantage of the network topology imposed by the IoT water monitoring scenario, the scheduling problem is decomposed into simpler subproblems, and a dynamic-programming-based solution method is proposed. Based on the proposed method, a solution algorithm is derived, whose complexity and energy-wise performance are investigated. The complexity of the proposed algorithm is characterized and its performance is evaluated numerically via an IoT emulator of water distribution networks. The analytical and numerical results show that the proposed algorithm outperforms state-of-the-art approaches in terms of energy consumption, network lifetime, and robustness to sensor node failures. It is argued that the derived solution approach is general and it can be potentially applied to more IoT scenarios such as WSN scheduling in smart cities and intelligent transport systems.
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| 16. |
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| 17. |
- Du, Rong, et al.
(författare)
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Joint node deployment and wireless energy transfer scheduling for immortal sensor networks
- 2017
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Ingår i: 2017 15th International Symposium on Modeling and Optimization in Mobile, Ad Hoc, and Wireless Networks, WiOpt 2017. - : Institute of Electrical and Electronics Engineers (IEEE). - 9783901882906
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Konferensbidrag (refereegranskat)abstract
- The lifetime of a wireless sensor network (WSN) is limited by the lifetime of the individual sensor nodes. A promising technique to extend the lifetime of the nodes is wireless energy transfer. The WSN lifetime can also be extended by exploiting the redundancy in the nodes' deployment, which allows the implementation of duty-cycling mechanisms. In this paper, the joint problem of optimal sensor node deployment and WET scheduling is investigated. Such a problem is formulated as an integer optimization whose solution is challenging due to the binary decision variables and non-linear constraints. To solve the problem, an approach based on two steps is proposed. First, the necessary condition for which the WSN is immortal is established. Based on this result, an algorithm to solve the node deployment problem is developed. Then, the optimal WET scheduling is given by a scheduling algorithm. The WSN is shown to be immortal from a networking point of view, given the optimal deployment and WET scheduling. Theoretical results show that the proposed algorithm achieves the optimal node deployment in terms of the number of deployed nodes. In the simulation, it is shown that the proposed algorithm reduces significantly the number of nodes to deploy compared to a random-based approach. The results also suggest that, under such deployment, the optimal scheduling and WET can make WSNs immortal.
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| 18. |
- Du, Rong, et al.
(författare)
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Lifetime Maximization for Sensor Networks with Wireless Energy Transfer
- 2016
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Ingår i: 2016 IEEE International Conference on Communications, ICC 2016. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781479966646 ; , s. 20-25
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Konferensbidrag (refereegranskat)abstract
- In Wireless Sensor Networks (WSNs), to supply energy to the sensor nodes, wireless energy transfer (WET) is a promising technique. One of the most efficient procedures to transfer energy to the sensor nodes consists in using a sharp wireless energy beam from the base station to each node at a time. A natural fundamental question is what is the lifetime ensured by WET and how to maximize the network lifetime by scheduling the transmissions of the energy beams. In this paper, such a question is addressed by posing a new lifetime maximization problem for WET enabled WSNs. The binary nature of the energy transmission process introduces a binary constraint in the optimization problem, which makes challenging the investigation of the fundamental properties of WET and the computation of the optimal solution. The sufficient condition for which the WET makes WSNs immortal is established as function of the WET parameters. When such a condition is not met, a solution algorithm to the maximum lifetime problem is proposed. The numerical results show that the lifetime achieved by the proposed algorithm increases by about 50% compared to the case without WET, for a WSN with a small to medium size number of nodes. This suggests that it is desirable to schedule WET to prolong lifetime of WSNs having small or medium network sizes.
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| 19. |
- Du, Rong, et al.
(författare)
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On Maximizing Sensor Network Lifetime by Energy Balancing
- 2018
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Ingår i: IEEE Transactions on Control of Network Systems. - : Institute of Electrical and Electronics Engineers (IEEE). - 2325-5870. ; 5:3
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Tidskriftsartikel (refereegranskat)abstract
- Many physical systems, such as water/electricity distribution networks, are monitored by battery-powered wireless-sensor networks (WSNs). Since battery replacement of sensor nodes is generally difficult, long-term monitoring can be only achieved if the operation of the WSN nodes contributes to long WSN lifetime. Two prominent techniques to long WSN lifetime are 1) optimal sensor activation and 2) efficient data gathering and forwarding based on compressive sensing. These techniques are feasible only if the activated sensor nodes establish a connected communication network (connectivity constraint), and satisfy a compressive sensing decoding constraint (cardinality constraint). These two constraints make the problem of maximizing network lifetime via sensor node activation and compressive sensing NP-hard. To overcome this difficulty, an alternative approach that iteratively solves energy balancing problems is proposed. However, understanding whether maximizing network lifetime and energy balancing problems are aligned objectives is a fundamental open issue. The analysis reveals that the two optimization problems give different solutions, but the difference between the lifetime achieved by the energy balancing approach and the maximum lifetime is small when the initial energy at sensor nodes is significantly larger than the energy consumed for a single transmission. The lifetime achieved by energy balancing is asymptotically optimal, and that the achievable network lifetime is at least 50% of the optimum. Analysis and numerical simulations quantify the efficiency of the proposed energy balancing approach.
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| 20. |
- Du, Rong, et al.
(författare)
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Optimal Energy Beamforming and Data Routing for Immortal Wireless Sensor Networks
- 2017
-
Ingår i: IEEE International Conference on Communications. - : Institute of Electrical and Electronics Engineers (IEEE). - 1550-3607. - 9781467389990
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Konferensbidrag (refereegranskat)abstract
- Wireless sensor networks (WSNs) consist of energy limited sensor nodes, which limits the network lifetime. Such a lifetime can be prolonged by employing the emerging technology of wireless energy transfer (WET). In WET systems, the sensor nodes can harvest wireless energy from wireless charger, which can use energy beamforming to improve the efficiency. In this paper, a scenario where dedicated wireless chargers with multiple antennas use energy beamforming to charge sensor nodes is considered. The energy beamforming is coupled with the energy consumption of sensor nodes in terms of data routing, which is one novelty of the paper. The energy beamforming and the data routing are jointly optimized by a non-convex optimization problem. This problem is transformed into a semidefinite optimization problem, for which strong duality is proved, and thus the optimal solution exists. It is shown that the optimal solution of the semi-definite programming problem allows to derive the optimal solution of the original problem. The analytical and numerical results show that optimal energy beamforming gives two times better monitoring performance than that of WET without using energy beamforming.
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| 21. |
- Du, Rong, 1989-
(författare)
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Optimal Networking in Wirelessly Powered Sensor Networks
- 2018
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Wireless sensor networks (WSNs) are nowadays widely used for the long-term monitoring of small or large regions, such as lakes, forests, cities, and industrial areas. The performance of a WSN typically consists of two aspects: i) the monitoring performance, e.g., the accuracy and the timeliness of the measurements or estimations produced by the sensor nodes of the WSN; and ii) the lifetime, i.e., how long the WSN can sustain such a performance. Naturally, we would like to have the monitoring performance as good as possible, and the lifetime as long as possible. However, in traditional WSNs, the sensor nodes generally have limited resources, especially in terms of battery capacity. If the nodes make measurements and report them frequently for a good monitoring performance, they drain their batteries and this leads to a severely shortened network lifetime. Conversely, the sensors can have a longer lifetime by sacrificing the monitoring performance. It shows the inherent trade-off between the monitoring performance and the lifetime in WSNs.We can overcome the limitations of the trade-off described above by wireless energy transfer (WET), where we can provide the sensor nodes with additional energy remotely. The WSNs with WET are called wirelessly powered sensor networks (WPSNs). In a WPSN, dedicated energy sources, e.g., static base stations or mobile chargers, transmit energy via radio frequency (RF) waves to the sensor nodes. The nodes can store the energy in their rechargeable batteries and use it later when it is needed. In so doing, they can use more energy to perform the sensing tasks. Thus, WET is a solution to improve the monitoring performance and lifetime at the same time. As long as the nodes receive more energy than they consume, it is possible that the WSN be immortal, which is impossible in traditional WSNs. Although WPSNs can potentially break the trade-off between monitoring performance and lifetime, they also bring many fundamental design and performance analysis challenges. Due to the safety issues, the power that the dedicated energy sources can use is limited. The propagation of the RF waves suffers high path losses. Therefore, the energy received by the sensor nodes is much less than the energy transmitted from the sources. As a result, to have a good WSN performance, we should optimize the energy transmission on the energy source side and the energy consumption on the nodes side. Compared to the traditional WSN scenarios where we can only optimize the sensing and data communication strategies, in WPSNs, we have an additional degree of freedom, i.e., the optimization of the energy transmission strategies. This aspect brings new technical challenges and problems that have not been studied in the traditional WSNs. Several novel research questions arise, such as when and how to transmit the energy, and which energy source should transmit. Such questions are not trivial especially when we jointly consider the energy consumption part.This thesis contributes to answer the questions above. It consists of three contributions as follows.In the first contribution, we consider a WPSN with single energy base stations (eBS) and multiple sensor nodes to monitor several separated areas of interest. The eBS has multiple antennas, and it uses energy beamforming to transmit energy to the nodes. Notice that, if we deploy multiple sensor nodes at the same area, these nodes may receive the energy from the eBS at the same time and they can reduce the energy consumption by applying sleep/awake mechanism. Therefore, we jointly study the deployment of the nodes, the energy transmission of the eBS, and the node activation. The problem is an integer optimization, and we decouple the problem into a node deployment problem and a scheduling problem. We provide a greedy-based algorithm to solve the problem, and show its performance in terms of optimality.The second contribution of the thesis starts by noticing that wireless channel state information (CSI) is important for energy beamforming. The more energy that an eBS spends in channel acquisition, the more accurate CSI it will have, thus improving the energy beamforming performance. However, if the eBS spends too much energy on channel acquisition, it will have less energy for WET, which might reduce the energy that is received by the sensor nodes. We thus investigate how much energy the eBS should spend in channel acquisition, i.e., we study the power allocation problem in channel acquisition and energy beamforming for WPSNs. We consider the general optimal channel acquisition and show that the problem is non-convex. Based on the idea of bisection search, we provide an algorithm to find the optimal solution for the single eBS cases, and a closed-form solution for the case where the eBS uses orthogonal pilot transmission, least-square channel estimation, and maximum ratio transmission for WET. The simulations show that the algorithm converges fast, and the performance is close to the theoretical upper bound.In the third contribution, we consider a joint energy beamforming and data routing problem for WPSNs. More specifically, we investigate the WPSNs consisting of multiple eBSs, multiple sensor nodes, and a sink node. Based on the received energy, the sensor nodes need to decide how to route their data. The problem aims at maximizing the minimum sensing rate of the sensor nodes while guaranteeing that the received energy of each node is no less than that is consumed. Such a problem is non-convex, and we provide a centralized solution algorithm based on a semi-definite programming transformation. We extend this approach with a distributed algorithm using alternating direction method of multipliers (ADMM). We prove that the centralized algorithm achieves the optimal energy beamforming and routing, and we show by simulation that the distributed one converges to the optimal solution. Additionally, for the cases where the energy beamforming options are pre-determined, we study the problem of finding the energy that should be spent on each vector. We observe that, if the pre-determined beamforming options are chosen wisely, their performance is close to the optimal.The results of the thesis show that WET can prolong the lifetime of WSNs, and even make them work sufficiently long for general monitoring applications. More importantly, we should optimize the WPSN by considering both the energy provision and the energy consumption part. The studies of the thesis have the potential to be used in many Internet of Things (IoT) systems in smart cities, such as water distribution lines and building monitoring.
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| 22. |
- Du, Rong, 1989-, et al.
(författare)
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Optimal Node Deployment and Energy Provision for Wirelessly Powered Sensor Networks
- 2018
-
Ingår i: IEEE Journal on Selected Areas in Communications. - : IEEE Press. - 0733-8716 .- 1558-0008. ; 37:2, s. 407-423
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Tidskriftsartikel (refereegranskat)abstract
- In a typical wirelessly powered sensor network (WPSN), wireless chargers provide energy to sensor nodes by using wireless energy transfer (WET). The chargers can greatly improve the lifetime of a WPSN using energy beamforming by a proper charging scheduling of energy beams. However, the supplied energy still may not meet the demand of the energy of the sensor nodes. This issue can be alleviated by deploying redundant sensor nodes, which not only increase the total harvested energy, but also decrease the energy consumption per node provided that an efficient scheduling of the sleep/awake of the nodes is performed. Such a problem of joint optimal sensor deployment, WET scheduling, and node activation is posed and investigated in this paper. The problem is an integer optimization that is challenging due to the binary decision variables and non-linear constraints. Based on the analysis of the necessary condition such that the WPSN be immortal, we decouple the original problem into a node deployment problem and a charging and activation scheduling problem. Then, we propose an algorithm and prove that it achieves the optimal solution under a mild condition. The simulation results show that the proposed algorithm reduces the needed nodes to deploy by approximately 16%, compared to a random-based approach. The simulation also shows if the battery buffers are large enough, the optimality condition will be easy to meet.
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| 23. |
- Du, Rong, 1989-, et al.
(författare)
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Poster : On the immortality of wireless sensor networks by wireless energy transfer — a node deployment perspective
- 2017
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Ingår i: International Conference on Embedded Wireless Systems and Networks. - : Junction Publishing. ; , s. 206-207
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Konferensbidrag (refereegranskat)abstract
- The lifetime of wireless sensor networks (WSNs) can be substantially extended by transferring energy wirelessly to the sensor nodes. In this poster, a wireless energy transfer (WET) enabled WSN is presented, where a base station transfers energy wirelessly to the sensor nodes that are deployed in several regions of interest, to supply them with energy to sense and to upload data. The WSN lifetime can be extended by deploying redundant sensor nodes, which allows the implementation of duty-cycling mechanisms to reduce nodes’ energy consumption. In this context, a problem on sensor node deployment naturally arises, where one needs to determine how many sensor nodes to deploy in each region such that the total number of nodes is minimized, and the WSN is immortal. The problem is formulated as an integer optimization, whose solution is challenging due to the binary decision variables and a non-linear constraint. A greedybased algorithm is proposed to achieve the optimal solution of such deployment problem. It is argued that such scheme can be used in monitoring systems in smart cities, such as smart buildings and water lines.
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| 24. |
- Du, Rong, 1989-, et al.
(författare)
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The sensable city : A survey on the deployment and management for smart city monitoring
- 2019
-
Ingår i: IEEE Communications Surveys and Tutorials. - : IEEE. - 1553-877X. ; 21:2, s. 1533-1560
-
Tidskriftsartikel (refereegranskat)abstract
- In last two decades, various monitoring systems have been designed and deployed in urban environments, toward the realization of the so called smart cities. Such systems are based on both dedicated sensor nodes, and ubiquitous but not dedicated devices such as smart phones and vehicles’ sensors. When we design sensor network monitoring systems for smart cities, we have two essential problems: node deployment and sensing management. These design problems are challenging, due to large urban areas to monitor, constrained locations for deployments, and heterogeneous type of sensing devices. There is a vast body of literature from different disciplines that have addressed these challenges. However, we do not have yet a comprehensive understanding and sound design guidelines. This article addresses such a research gap and provides an overview of the theoretical problems we face, and what possible approaches we may use to solve these problems. Specifically, this paper focuses on the problems on both the deployment of the devices (which is the system design/configuration part) and the sensing management of the devices (which is the system running part). We also discuss how to choose the existing algorithms in different type of monitoring applications in smart cities, such as structural health monitoring, water pipeline networks, traffic monitoring. We finally discuss future research opportunities and open challenges for smart city monitoring.
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| 25. |
- Du, Rong, 1989-, et al.
(författare)
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Towards Immortal Wireless Sensor Networks by Optimal Energy Beamforming and Data Routing
- 2018
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Ingår i: IEEE Transactions on Wireless Communications. - : Institute of Electrical and Electronics Engineers (IEEE). - 1536-1276 .- 1558-2248. ; 17:8, s. 5338-5352
-
Tidskriftsartikel (refereegranskat)abstract
- The lifetime of a wireless sensor network (WSN) determines how long the network can be used to monitor the area of interest. Hence, it is one of the most important performance metrics for WSN. The approaches used to prolong the lifetime can be briefly divided into two categories: reducing the energy consumption, such as designing an efficient routing, and providing extra energy, such as using wireless energy transfer (WET) to charge the nodes. Contrary to the previous line of work where only one of those two aspects is considered, we investigate these two together. In particular, we consider a scenario where dedicated wireless chargers transfer energy wirelessly to sensors. The overall goal is to maximize the minimum sampling rate of the nodes while keeping the energy consumption of each node smaller than the energy it receives. This is done by properly designing the routing of the sensors and the WET strategy of the chargers. Although such a joint routing and energy beamforming problem is non-convex, we show that it can be transformed into a semi-definite optimization problem (SDP). We then prove that the strong duality of the SDP problem holds, and hence, the optimal solution of the SDP problem is attained. Accordingly, the optimal solution for the original problem is achieved by a simple transformation. We also propose a lowcomplexity approach based on pre-determined beamforming directions. Moreover, based on the alternating direction method of multipliers, the distributed implementations of the proposed approaches are studied. The simulation results illustrate the significant performance improvement achieved by the proposed methods. In particular, the proposed energy beamforming scheme significantly outperforms the schemes where one does not use energy beamforming, or one does not use optimized routing. A thorough investigation of the effect of system parameters, including the number of antennas, the number of nodes, and the number of chargers, on the system performance is provided. The promising convergence behavior of the proposed distributed approaches is illustrated.
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| 26. |
- Engert, Andreas, et al.
(författare)
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The European Hematology Association Roadmap for European Hematology Research : a consensus document
- 2016
-
Ingår i: Haematologica. - Pavia, Italy : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 101:2, s. 115-208
-
Tidskriftsartikel (refereegranskat)abstract
- The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at (sic)23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.
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| 27. |
- Hsu, Yu-Ming, et al.
(författare)
-
Zoanthamine-Type Alkaloids from the Zoanthid Zoanthus kuroshio Collected in Taiwan and Their Effects on Inflammation
- 2016
-
Ingår i: Journal of natural products (Print). - : American Chemical Society (ACS). - 0163-3864 .- 1520-6025. ; 79:10, s. 2674-2680
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Tidskriftsartikel (refereegranskat)abstract
- Zoanthus kuroshio is a colorful zoanthid with a fluorescent pink oral disc and brown tentacles, which dominates certain parts of the Taiwanese and Japanese coasts. This sea anemone is a rich source of biologically active alkaloids. In the current investigation, two novel halogenated zoanthamines [5 alpha-iodozoanthenamine (1) and 11 beta-chloro-11-deoxykuroshine A (2)], along with four new zoanthamines [18-epi-kuroshine A (3), 7 alpha-hydroxykuroshine E (4), 5 alpha-methoxykuroshine E (5), and 18-epi-kuroshine E (6)], and six known compounds were isolated from Z. kuroshio. Compounds 1 and 2 are the first examples of halogenated zoanthamine-type alkaloids isolated from nature. Compounds 3 and 6 are the first zoanthamine stereoisomers with a cis-junction of the A/B rings. All isolated compounds were evaluated for their anti-inflammatory activities by measuring their effects on superoxide anion generation and elastase release by human neutrophils in response to fMLP.
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| 28. |
- Lai, Kuei-Hung, et al.
(författare)
-
Cytotoxic Lanostanoids from Poria cocos
- 2016
-
Ingår i: Journal of natural products (Print). - : American Chemical Society (ACS). - 0163-3864 .- 1520-6025. ; 79:11, s. 2805-2813
-
Tidskriftsartikel (refereegranskat)abstract
- Six new and 16 known lanostanoids were isolated from the sclerotia of Poria cocos. The structures of the new isolates were elucidated to be 16α-hydroxy-3-oxo-24-methyllanosta-5,7,9(11),24(31)-tetraen-21-oic acid (1), 3β,16α,29-trihydroxy-24-methyllanosta-7,9(11),24(31)-trien-21-oic acid (2), 3β,16α,30-trihydroxy-24-methyllanosta-7,9(11),24(31)-trien-21-oic acid (3), 3β-acetoxy-16α,24β-dihydroxylanosta-7,9(11),25-trien-21-oic acid (4), 3β,16α-dihydroxy-7-oxo-24-methyllanosta-8,24(31)-dien-21-oic acid (5), and 3α,16α-dihydroxy-7-oxo-24-methyllanosta-8,24(31)-dien-21-oic acid (6), based on extensive spectroscopic analyses. The absolute configuration of 4 was determined using Mosher's method. The antiproliferative activity of the isolated compounds (except 3 and 4) was evaluated against four leukemic cell lines (Molt 4, CCRF-CEM, HL 60, and K562). Dehydropachymic acid (9), dehydroeburicoic acid (12), pachymic acid (14), and lanosta-7,9(11),24-trien-21-oic acid (20) exhibited an antiproliferative effect on the CCRF-CEM cancer cell line with IC50 values of 2.7, 6.3, 4.9, and 13.1 μM, respectively. Both dehydropachymic acid (9) and dehydroeburicoic acid (12) showed antiproliferative effects against Molt 4 (IC50 13.8 and 14.3 μM) and HL 60 (IC50 7.3 and 6.0 μM) leukemic cell lines. Primary computational analysis using a chemical global positioning system for natural products (ChemGPS-NP) on the active lanostanoids from P. cocos suggested that targets other than topoisomerases may be involved in the antiproliferative activity.
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| 29. |
- Mestre, Humberto, et al.
(författare)
-
Aquaporin-4-dependent glymphatic solute transport in the rodent brain
- 2018
-
Ingår i: eLife. - 2050-084X. ; 7
-
Tidskriftsartikel (refereegranskat)abstract
- The glymphatic system is a brain-wide clearance pathway; its impairment contributes to the accumulation of amyloid-β. Influx of cerebrospinal fluid (CSF) depends upon the expression and perivascular localization of the astroglial water channel aquaporin-4 (AQP4). Prompted by a recent failure to find an effect of Aqp4 knock-out (KO) on CSF and interstitial fluid (ISF) tracer transport, five groups re-examined the importance of AQP4 in glymphatic transport. We concur that CSF influx is higher in wild-type mice than in four different Aqp4 KO lines and in one line that lacks perivascular AQP4 (Snta1 KO). Meta-analysis of all studies demonstrated a significant decrease in tracer transport in KO mice and rats compared to controls. Meta-regression indicated that anesthesia, age, and tracer delivery explain the opposing results. We also report that intrastriatal injections suppress glymphatic function. This validates the role of AQP4 and shows that glymphatic studies must avoid the use of invasive procedures.
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| 30. |
- Nawaz, Imran, et al.
(författare)
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Integrin α9 gene promoter is hypermethylated and downregulated in nasopharyngeal carcinoma
- 2015
-
Ingår i: Oncotarget. - Albany, NY, United States : Impact Journals LLC. - 1949-2553. ; 6:31, s. 31493-31507
-
Tidskriftsartikel (refereegranskat)abstract
- Epigenetic silencing of tumor suppressor genes (TSGs) by promoter methylation can be an early event in the multi-step process of carcinogenesis. Human chromosome 3 contains clusters of TSGs involved in many cancer types including nasopharyngeal carcinoma (NPC), the most common cancer in Southern China. Among ten candidate TSGs identified in chromosome 3 using NotI microarray, ITGA9 and WNT7A could be validated. 5-aza-2 deoxycytidine treatment restored the expression of ITGA9 and WNT7A in two NPC cell lines. Immunostaining showed strong expression of these genes in the membrane and cytoplasm of adjacent control nasopharyngeal epithelium cells, while they were weakly expressed in NPC tumor cells. The ITGA9 promoter showed marked differentially methylation between tumor and control tissue, whereas no differentially methylation could be detected for the WNT7A promoter. The expression level of ITGA9 in NPC tumors was downregulated 4.9-fold, compared to the expression in control. ITGA9 methylation was detected by methylation specific PCR (MSP) in 56% of EBV positive NPC-cases with 100% specificity. Taken together, this suggests that ITGA9 might be a TSG in NPC that is involved in tumor cell biology. The possibility of using ITGA9 methylation as a marker for early detection of NPC should further be explored.
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| 31. |
- Rong, Du
(författare)
-
Wireless Sensor Networks in Smart Cities : The Monitoring of Water Distribution Networks Case
- 2016
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The development of wireless sensor networks (WSNs) is making it possible to monitor our cities. Due to the small size of the sensor nodes, and their capabilities of transmitting data remotely, they can be deployed at locations that are not easy or impossible to access, such as the pipelines of water distribution networks (WDNs), which plays an important role in protecting environment and securing public health. The design of WSNs for WDNs faces major challenges. Generally, WSNs are resource-limited because most of the sensor nodes are battery powered. Thus, their resource allocation has to be carefully controlled. The thesis considers two prominent problems that occur when designing WSNs for WDNs: scheduling the sensing of the nodes of static WSNs, and sensor placement for mobile WSNs. These studies are reported in the thesis from three published or submitted papers. In the first paper, the scheduling of sleep/sensing for each sensor node is considered to maximize the whole WSNs lifetime while guaranteeing a monitoring performance constraint. The problem is transformed into an energy balancing problem, and solved by a dynamic programming based algorithm. It is proved that this algorithm finds one of the optimal solutions for the energy balancing problem. In the second paper, the question of how the energy balancing problem approximates the original scheduling problem is addressed. It is shown that even though these two problems are not equivalent, the gap of them is small enough. Thus, the proposed algorithm for the energy balancing problem can find a good approximation solution for the original scheduling problem. The second part of the thesis considers the use of mobile sensor nodes. Here, the limited resource is the number of available such mobile nodes. To maximize the monitoring coverage in terms of population, an optimization problem for determining the releasing locations for the mobile sensor nodes is formulated. An approximate solution algorithm based on submodular maximization is proposed and its performance is investigated. Beside WDNs, WSN applications for smart cities share a common characteristic: the area to monitor usually has a network structure. Therefore, the studies of this thesis can be potentially generalized for several IoT scenarios.
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| 32. |
- Rosenquist, Richard, et al.
(författare)
-
Clinical impact of recurrently mutated genes on lymphoma diagnostics : state-of-the-art and beyond
- 2016
-
Ingår i: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 101:9, s. 1002-1009
-
Forskningsöversikt (refereegranskat)abstract
- Similar to the inherent clinical heterogeneity of most, if not all, lymphoma entities, the genetic landscape of these tumors is markedly complex in the majority of cases, with a rapidly growing list of recurrently mutated genes discovered in recent years by next-generation sequencing technology. Whilst a few genes have been implied to have diagnostic, prognostic and even predictive impact, most gene mutations still require rigorous validation in larger, preferably prospective patient series, to scrutinize their potential role in lymphoma diagnostics and patient management. In selected entities, a predominantly mutated gene is identified in almost all cases (e.g. Waldenstrom's macroglobulinemia/lymphoplasmacytic lymphoma and hairy-cell leukemia), while for the vast majority of lymphomas a quite diverse mutation pattern is observed, with a limited number of frequently mutated genes followed by a seemingly endless tail of genes with mutations at a low frequency. Herein, the European Expert Group on NGS-based Diagnostics in Lymphomas (EGNL) summarizes the current status of this ever-evolving field, and, based on the present evidence level, segregates mutations into the following categories: i) immediate impact on treatment decisions, ii) diagnostic impact, iii) prognostic impact, iv) potential clinical impact in the near future, or v) should only be considered for research purposes. In the coming years, coordinated efforts aiming to apply targeted next-generation sequencing in large patient series will be needed in order to elucidate if a particular gene mutation will have an immediate impact on the lymphoma classification, and ultimately aid clinical decision making.
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| 33. |
- Xochelli, Aliki, et al.
(författare)
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Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations
- 2019
-
Ingår i: Journal of Pathology. - : WILEY. - 0022-3417 .- 1096-9896. ; 247:4, s. 416-421
-
Tidskriftsartikel (refereegranskat)abstract
- The B cell receptor immunoglobulin (Ig) gene repertoires of marginal zone (MZ) lymphoproliferations were analyzed in order to obtain insight into their ontogenetic relationships. Our cohort included cases with MZ lymphomas (n = 488), i.e. splenic (SMZL), nodal (NMZL) and extranodal (ENMZL), as well as provisional entities (n = 76), according to the WHO classification. The most striking Ig gene repertoire skewing was observed in SMZL. However, restrictions were also identified in all other MZ lymphomas studied, particularly ENMZL, with significantly different Ig gene distributions depending on the primary site of involvement. Cross-entity comparisons of the MZ Ig sequence dataset with a large dataset of Ig sequences (MZ-related or not; n = 65 837) revealed four major clusters of cases sharing homologous ('public') heavy variable complementarity-determining region 3. These clusters included rearrangements from SMZL, ENMZL (gastric, salivary gland, ocular adnexa), chronic lymphocytic leukemia, but also rheumatoid factors and non-malignant splenic MZ cells. In conclusion, different MZ lymphomas display biased immunogenetic signatures indicating distinct antigen exposure histories. The existence of rare public stereotypes raises the intriguing possibility that common, pathogen-triggered, immune-mediated mechanisms may result in diverse B lymphoproliferations due to targeting versatile progenitor B cells and/or operating in particular microenvironments.
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| 34. |
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| 35. |
- Yang, Guang, et al.
(författare)
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Maximum Throughput Path Selection with Random Blockage for Indoor 60 GHz Relay Networks
- 2015
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Ingår i: IEEE Transactions on Communications. - : IEEE Press. - 0090-6778 .- 1558-0857. ; 63:10, s. 3511-3524
-
Tidskriftsartikel (refereegranskat)abstract
- Indoor communications in the 60 GHz band is capable to support multi-gigabit wireless access thanks to the abundant spectrum and the possibility of using dense antenna arrays. However, the high directivity and penetration loss make it vulnerable to blockage events which can be frequent in indoor environments. Given network topology information in sufficient precision, we investigate the average throughput and outage probability when the connection between any two nodes can be established either via the line-of-sight (LOS) link, through a reflection link, or by a half-duplex relay node. We model the reflection link as an LOS with extra power loss and derive the closed-form expression for the relative reflection loss. For networks with a central coordinator and multiple relays, we also propose a generic algorithm, maximum throughput path selection (MTPS), to select the optimal path that maximizes the throughput. The complexity of the MTPS algorithm is O(n2) for networks equipped with n relays, whereas a brute-forced algorithm has complexity of O(n · n!). Numerical results show that increasing the number of relays can significantly increase the average throughput and decrease the outage probability, and resorting to reflection paths provides significant gains when the probability of link blockage is high.
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| 36. |
- Zeng, Ming, et al.
(författare)
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Computation Rate Maximization for Wireless Powered Mobile Edge Computing with NOMA
- 2019
-
Ingår i: Proceedings 20th IEEE International Symposium on a World of Wireless, Mobile and Multimedia Networks (IEEE WoWMoM 2019). - : IEEE. - 9781728102702 - 9781728102719
-
Konferensbidrag (refereegranskat)abstract
- In this paper, we consider a mobile edge computing (MEC) network, that is wirelessly powered. Each user harvests wireless energy and follows a binary computation offloading policy, i.e., it either executes the task locally or offloads it to the MEC as a whole. For the offloading users, non-orthogonal multiple access (NOMA) is adopted for information transmission. We consider rate-adaptive computational tasks and aim at maximizing the sum computation rate of all users by jointly optimizing the individual computing mode selection (local computing or offloading), the time allocations for energy transfer and for information transmission, together with the local computing speed or the transmission power level. The major difficulty of the rate maximization problem lies in the combinatorial nature of the multiuser computing mode selection and its involved coupling with the time allocation. We also study the case where the offloading users adopt time division multiple access (TDMA) as a benchmark, and derive the optimal time sharing among the users. We show that the maximum achievable rate is the same for the TDMA and the NOMA system, and in the case of NOMA it is independent from the decoding order, which can be exploited to improve system fairness. To maximize the sum computation rate, for the mode selection we propose a greedy solution based on the wireless channel gains, combined with the optimal allocation of energy transfer time. Numerical results show that the proposed solution maximizes the computation rate in homogeneous networks, and binary offloading leads to significant gains. Moreover, NOMA increases the fairness of rate distribution among the users significantly, when compared with TDMA.
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| 37. |
- Zhou, Bin, et al.
(författare)
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Worldwide trends in diabetes since 1980: A pooled analysis of 751 population-based studies with 4.4 million participants
- 2016
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Ingår i: The Lancet. - : Elsevier B.V.. - 0140-6736 .- 1474-547X. ; 387:10027, s. 1513-1530
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Tidskriftsartikel (refereegranskat)abstract
- Background: One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are aff ecting the number of adults with diabetes.Methods: We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence-defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs-in 200 countries and territories in 21 regions, by sex and from 1980 to 2014. We also calculated the posterior probability of meeting the global diabetes target if post-2000 trends continue.Findings: We used data from 751 studies including 4372000 adults from 146 of the 200 countries we make estimates for. Global age-standardised diabetes prevalence increased from 4.3% (95% credible interval 2.4-17.0) in 1980 to 9.0% (7.2-11.1) in 2014 in men, and from 5.0% (2.9-7.9) to 7.9% (6.4-9.7) in women. The number of adults with diabetes in the world increased from 108 million in 1980 to 422 million in 2014 (28.5% due to the rise in prevalence, 39.7% due to population growth and ageing, and 31.8% due to interaction of these two factors). Age-standardised adult diabetes prevalence in 2014 was lowest in northwestern Europe, and highest in Polynesia and Micronesia, at nearly 25%, followed by Melanesia and the Middle East and north Africa. Between 1980 and 2014 there was little change in age-standardised diabetes prevalence in adult women in continental western Europe, although crude prevalence rose because of ageing of the population. By contrast, age-standardised adult prevalence rose by 15 percentage points in men and women in Polynesia and Micronesia. In 2014, American Samoa had the highest national prevalence of diabetes (>30% in both sexes), with age-standardised adult prevalence also higher than 25% in some other islands in Polynesia and Micronesia. If post-2000 trends continue, the probability of meeting the global target of halting the rise in the prevalence of diabetes by 2025 at the 2010 level worldwide is lower than 1% for men and is 1% for women. Only nine countries for men and 29 countries for women, mostly in western Europe, have a 50% or higher probability of meeting the global target.Interpretation: Since 1980, age-standardised diabetes prevalence in adults has increased, or at best remained unchanged, in every country. Together with population growth and ageing, this rise has led to a near quadrupling of the number of adults with diabetes worldwide. The burden of diabetes, both in terms of prevalence and number of adults aff ected, has increased faster in low-income and middle-income countries than in high-income countries.
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| 38. |
- Aad, G., et al.
(författare)
-
- 2016
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Ingår i: Journal of High Energy Physics. - : Springer. - 1029-8479 .- 1126-6708. ; :1
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Tidskriftsartikel (refereegranskat)
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| 39. |
- Aad, G., et al.
(författare)
-
- 2015
-
Ingår i: Journal of High Energy Physics. - : Springer. - 1029-8479 .- 1126-6708. ; :12
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Tidskriftsartikel (refereegranskat)
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| 40. |
- Aad, G., et al.
(författare)
-
- 2016
-
Ingår i: Physical Review D. Particles and fields. - : American Physical Society. - 0556-2821 .- 1089-4918. ; 93:1
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Tidskriftsartikel (refereegranskat)
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| 41. |
-
- 2017
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Ingår i: Physical Review D. - 2470-0010 .- 2470-0029. ; 96:2
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Tidskriftsartikel (refereegranskat)
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