| 1. |
- Windhorst, Rogier A., et al.
(författare)
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JWST PEARLS. Prime extragalactic areas for reionization and lensing science : project overview and first results
- 2023
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Ingår i: Astronomical Journal. - : Institute of Physics (IOP). - 0004-6256 .- 1538-3881. ; 165:1
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Tidskriftsartikel (refereegranskat)abstract
- We give an overview and describe the rationale, methods, and first results from NIRCam images of the JWST “Prime Extragalactic Areas for Reionization and Lensing Science” (PEARLS) project. PEARLS uses up to eight NIRCam filters to survey several prime extragalactic survey areas: two fields at the North Ecliptic Pole (NEP); seven gravitationally lensing clusters; two high redshift protoclusters; and the iconic backlit VV 191 galaxy system to map its dust attenuation. PEARLS also includes NIRISS spectra for one of the NEP fields and NIRSpec spectra of two high-redshift quasars. The main goal of PEARLS is to study the epoch of galaxy assembly, active galactic nucleus (AGN) growth, and First Light. Five fields—the JWST NEP Time-Domain Field (TDF), IRAC Dark Field, and three lensing clusters—will be observed in up to four epochs over a year. The cadence and sensitivity of the imaging data are ideally suited to find faint variable objects such as weak AGN, high-redshift supernovae, and cluster caustic transits. Both NEP fields have sightlines through our Galaxy, providing significant numbers of very faint brown dwarfs whose proper motions can be studied. Observations from the first spoke in the NEP TDF are public. This paper presents our first PEARLS observations, their NIRCam data reduction and analysis, our first object catalogs, the 0.9–4.5 μm galaxy counts and Integrated Galaxy Light. We assess the JWST sky brightness in 13 NIRCam filters, yielding our first constraints to diffuse light at 0.9–4.5 μm. PEARLS is designed to be of lasting benefit to the community.
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| 2. |
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| 3. |
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| 4. |
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| 5. |
- Duncan, Rebecca
(författare)
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Decolonial Gothic : Beyond the Postcolonial in Gothic Studies
- 2022
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Ingår i: Gothic Studies. - : Edingburgh University Press. - 1362-7937 .- 2050-456X. ; 24:3, s. 304-322
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Tidskriftsartikel (refereegranskat)abstract
- This article theorises decolonial Gothic as a novel approach to Gothic fiction from formerly colonised regions and communities. It responds to an emerging body of Gothic production, which situates itself in a world shaped by persistently racialised distributions of social and environmental precarity, and where colonial power is thus an enduring material reality. To address such fiction, the article proposes, requires a reassessment of the hauntological frameworks through which Gothic and the (post)colonial have hitherto been brought into contact. Forged in the cultural climate of late-twentieth-century postmodernity, these hinge on the assumption of an epochal break, which renders colonial history a thing of the past; thus, they fall short of narratives that engage with active formations of colonial power. Accordingly, the article outlines an alternative approach, positioning Gothic fiction in the context of the capitalist world-system, which – into the present – is structured by colonial categories of race, heteropatriarchal categories of gender, and instrumentalising discourses of nature as plunderable resource.
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| 6. |
- Duncan, Rebecca, et al.
(författare)
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Decolonising the COVID-19 pandemic : On Being in this Together
- 2021
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Ingår i: Approaching Religion. - : Approaching Religion. - 1799-3121. ; 11:2, s. 115-131
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Tidskriftsartikel (refereegranskat)abstract
- At its inception, the COVID-19 pandemic was described as something inherently new, capable of crossing and erasing the economic, racial, gendered, and religious divides that stratify societies around the world. However, the ongoing pandemic is not new or egalitarian, but fuelled by, and fuelling, crises already under way on a global scale. In this article we examine on the one hand the relationship between the pandemic and still-active formations of racialised and gendered power, and on the other the pandemic's inextricability from a dispersed and uneven planetary emergency. As the environmental historian Jason W. Moore notes, this emergency disproportionately affects ‘women, people of colour and (neo)colonial populations’ (2019: 54), and the effects of COVID-19 are similarly unevenly allocated.
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| 7. |
- Duncan, Rebecca
(författare)
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Fiction from the Data Frontier
- 2024
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Ingår i: Interventions. - : Taylor & Francis Group. - 1369-801X .- 1469-929X.
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Tidskriftsartikel (refereegranskat)
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| 8. |
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| 9. |
- Duncan, Rebecca
(författare)
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Haunted Technonature : Anthropocene Coloniality in Ng Yi-Sheng’s Lion City
- 2021
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Ingår i: Haunted Nature. - Cham : Palgrave Macmillan. - 9783030818685 - 9783030818692 - 9783030818715 ; , s. 135-158
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Bokkapitel (refereegranskat)abstract
- This chapter moves away from the established strand of literary ecocriticism in which haunted nature is situated in the Anthropocene and instead examines how Anthropocene thinking itself becomes subject to haunting in speculative fiction. To make this argument, it focuses on Ng Yi-Sheng’s collection Lion City (2018): a text that maps connections between Singapore’s colonial history and the nation’s contemporary status as a model for climate survival through geoengineering and “technonature.” This analysis proposes that rather than mobilizing the speculative to describe human effects on the biosphere (as much criticism suggests), Ng’s tales excavate legacies of environmental injustice repressed by the paradigm of anthropogenesis. In doing so, the narrative critiques Anthropocene accounts of emergency and highlights the necessity of decolonizing the narrative of crisis itself.
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| 10. |
- Duncan, Rebecca, et al.
(författare)
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Introduction : The Body in Postcolonial Fiction after the Millennium
- 2020
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Ingår i: Interventions. - : Taylor & Francis Group. - 1369-801X .- 1469-929X. ; 22:5, s. 587-605
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Since the turn of the millennium, debates in postcolonial studies and world literature have repeatedly shown the realities of empire to be continuing, immediate and visceral. What has been overlooked thus far are the ways in which the bodily has re-emerged in postcolonial cultural production as a receptor to, and vocabulary for, these immanent violences. Fictions from across the global south are drawing with apparently increasing frequency on corporeal lexica in their imaginings of on-going imperial circumstances. At the same time, the new millennium has witnessed the rise, in multiple postcolonial contexts, of speculative genres - science fiction and horror pre-eminent among them - to which the body is central. Together, all of this suggests the need for renewed reflection on the poetics and functions of the bodily in contemporary fictional engagements with empire. This special issue takes up this imperative. Our interest lies with the grammars and technologies offered by the corporeal in postcolonial cultural production since the millennium, and in the possibilities and limitations of these bodily registers. Over the course of this introduction, we outline the material, narrative and theoretical contexts within which we see the body re-emerging as a site of renewed critical and literary or cinematic potential. We return to established analytical categories for the corporeal in postcolonial literary studies, and show that current fictional handlings of the body and embodiment appear resistant to interpretation via these rubrics. Taking our cue both from a materialist theoretical (re)turn that corresponds to the turn of the millennium and from aesthetic developments in literature and film of the same period, we go on to lay the groundwork for an approach to the body as this is currently emerging in contemporary postcolonial and peripheral imaginaries.
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| 11. |
- Duncan, Rebecca
(författare)
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Introduction : Decolonising Gothic
- 2022
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Ingår i: Gothic Studies. - : Edingburgh University Press. - 1362-7937 .- 2050-456X. ; 24:3, s. 219-227
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This introduction to the special issue – ‘Decolonising Gothic’ – provides an overview of major existing approaches to gothic in the international context – namely postcolonial- and globalgothic – and highlights developments in contemporary Gothic production that demand a critical shift beyond these frameworks. The article outlines decolonial thinking as one productive response to this situation, and reflects both on what it might mean to ‘decolonise’ Gothic Studies, and on Gothic fiction’s own decolonising possibilities. The article concludes by introducing the essays collected in the special issue, foregrounding how each takes up the questions of decoloniality and decolonising in relation to gothic imaginaries from different regions of the world.
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| 12. |
- Duncan, Rebecca
(författare)
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Introduction : Globalgothic Beyond Globalisation
- 2023
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Ingår i: The Edinburgh Companion to Globalgothic. - Edinburgh : Edinburgh University Press. - 9781399510585 - 9781399510608 ; , s. 1-22
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Bokkapitel (refereegranskat)
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| 13. |
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| 14. |
- Duncan, Rebecca
(författare)
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Planetary Gothic : An Invitation
- 2023
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Ingår i: The Edinburgh Companion to Globalgothic. - Edinburgh : Edinburgh University Press. - 9781399510585 - 9781399510608 ; , s. 485-494
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Bokkapitel (refereegranskat)
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| 15. |
- Duncan, Rebecca, et al.
(författare)
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The Emergency Has Already Happened
- 2023
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Ingår i: Environment and History. - : White Horse Press. - 0967-3407 .- 1752-7023. ; 29:4, s. 476-482
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Tidskriftsartikel (refereegranskat)
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| 16. |
- Duncan, Rebecca
(författare)
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Writing Ecological Revolution from Millennial South Africa : History, Nature and the Postapartheid Present
- 2020
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Ingår i: Ariel. - : Johns Hopkins University Press. - 0004-1327. ; 51:4, s. 65-97
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Tidskriftsartikel (refereegranskat)abstract
- This article does two key things. Firstly, it offers a perspective on histories of South African political economy refracted through the lens of "world-ecological" thinking (Moore, Capitalism 2-5). It maps the organisations of institutionalised apartheid and the liberal democracy that has succeeded it in terms of capital's cyclical regimentations of nature. This approach sheds new light on the entanglements of politics, economics, and environments, which, in specific ways over the course of the twentieth century and into the millennial present, have shaped and characterised unevenness in South Africa. Secondly, in light of these ideas, the article considers Zinaid Meeran's Tanuki Ichiban (2012), Henrietta Rose-Innes' Nineveh (2011), and Lauren Beukes' Maryland (2008), twenty-first-century texts exemplary of an increasingly prominent "speculative" impulse in contemporary South African literary production. I situate the extraordinary human and extra-human vocabularies of these fictions as responsive to shifting historical constructions of "Nature" in neoliberalising South Africa. I further argue that the narratives are sensitive to the structures of these historical and ongoing regimentations-to how they concatenate and overlay one another in the millennial present. Finally, I suggest that with recourse to speculative poetics, the texts seek to offer alternative conceptual vocabularies to those from which systematic violences continue to proceed.
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| 17. |
- Ercan, Ayse Bahar, et al.
(författare)
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Clinical and biological landscape of constitutional mismatch-repair deficiency syndrome: an International Replication Repair Deficiency Consortium cohort study.
- 2024
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Ingår i: The Lancet Oncology. - 1470-2045. ; 25:5, s. 668-682
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Tidskriftsartikel (refereegranskat)abstract
- Constitutional mismatch repair deficiency (CMMRD) syndrome is a rare and aggressive cancer predisposition syndrome. Because a scarcity of data on this condition contributes to management challenges and poor outcomes, we aimed to describe the clinical spectrum, cancer biology, and impact of genetics on patient survival in CMMRD.In this cohort study, we collected cross-sectional and longitudinal data on all patients with CMMRD, with no age limits, registered with the International Replication Repair Deficiency Consortium (IRRDC) across more than 50 countries. Clinical data were extracted from the IRRDC database, medical records, and physician-completed case record forms. The primary objective was to describe the clinical features, cancer spectrum, and biology of the condition. Secondary objectives included estimations of cancer incidence and of the impact of the specific mismatch-repair gene and genotype on cancer onset and survival, including after cancer surveillance and immunotherapy interventions.We analysed data from 201 patients (103 males, 98 females) enrolled between June 5, 2007 and Sept 9, 2022. Median age at diagnosis of CMMRD or a related cancer was 8·9 years (IQR 5·9-12·6), and median follow-up from diagnosis was 7·2 years (3·6-14·8). Endogamy among minorities and closed communities contributed to high homozygosity within countries with low consanguinity. Frequent dermatological manifestations (117 [93%] of 126 patients with complete data) led to a clinical overlap with neurofibromatosis type 1 (35 [28%] of 126). 339 cancers were reported in 194 (97%) of 201 patients. The cumulative cancer incidence by age 18 years was 90% (95% CI 80-99). Median time between cancer diagnoses for patients with more than one cancer was 1·9 years (IQR 0·8-3·9). Neoplasms developed in 15 organs and included early-onset adult cancers. CNS tumours were the most frequent (173 [51%] cancers), followed by gastrointestinal (75 [22%]), haematological (61 [18%]), and other cancer types (30 [9%]). Patients with CNS tumours had the poorest overall survival rates (39% [95% CI 30-52] at 10 years from diagnosis; log-rank p<0·0001 across four cancer types), followed by those with haematological cancers (67% [55-82]), gastrointestinal cancers (89% [81-97]), and other solid tumours (96% [88-100]). All cancers showed high mutation and microsatellite indel burdens, and pathognomonic mutational signatures. MLH1 or MSH2 variants caused earlier cancer onset than PMS2 or MSH6 variants, and inferior survival (overall survival at age 15 years 63% [95% CI 55-73] for PMS2, 49% [35-68] for MSH6, 19% [6-66] for MLH1, and 0% for MSH2; p<0·0001). Frameshift or truncating variants within the same gene caused earlier cancers and inferior outcomes compared with missense variants (p<0·0001). The greater deleterious effects of MLH1 and MSH2 variants as compared with PMS2 and MSH6 variants persisted despite overall improvements in survival after surveillance or immune checkpoint inhibitor interventions.The very high cancer burden and unique genomic landscape of CMMRD highlight the benefit of comprehensive assays in timely diagnosis and precision approaches toward surveillance and immunotherapy. These data will guide the clinical management of children and patients who survive into adulthood with CMMRD.The Canadian Institutes for Health Research, Stand Up to Cancer, Children's Oncology Group National Cancer Institute Community Oncology Research Program, Canadian Cancer Society, Brain Canada, The V Foundation for Cancer Research, BioCanRx, Harry and Agnieszka Hall, Meagan's Walk, BRAINchild Canada, The LivWise Foundation, St Baldrick Foundation, Hold'em for Life, and Garron Family Cancer Center.
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| 18. |
- Foley, Matt, et al.
(författare)
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Patrick McGrath and Passion : the Gothic modernism of Asylum and Beyond
- 2020
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Ingår i: Patrick McGrath and his Worlds. - London : Routledge. - 9781138311190 - 9781003007944 ; , s. 103-115
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Bokkapitel (refereegranskat)abstract
- This chapter reads Asylum (1996) and Port Mungo (2004) to suggest the centrality of passion to McGrath’s writing and, more specifically, to argue for the importance of modernist aesthetics and influences to mediating and locating these representations. There is still much to be said about the complex influences that modernism has on McGrath’s signature first-person narration and regarding the ways in which his fiction explores and critiques modernist concerns. As a starting point for further investigations, our argument makes the case that some of McGrath’s work can be understood as “gothic modernist:” that is, as drawing together modernist technique and concerns with images of gothic excess. Important intertexts for McGrath include first-person modes of narration drawn from modernism, for example from Ford Madox Ford’s The Good Solder: a Tale of Passion (1914), as well the “primtivist” turn to modernist aesthetics, evident in the writing of D. H. Lawrence, and in the post-Impressionist paintings of Paul Gauguin.
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| 19. |
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| 20. |
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Patrick McGrath and his Worlds : Madness and the Transnational Gothic
- 2020
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- Following the publication of Ghost Town (2005), a complex, globally conscious genealogy of millennial Manhattan, McGrath’s transnational status as an English author resident in New York, his pointed manipulation of British and American contexts, and his clear apprehension of imperial legacies have all come into sharper focus. By bringing together readings cognizant of this transnational and historical sensitivity with those that build on existing studies of McGrath’s engagements with the gothic and madness, Patrick McGrath and his Worlds sheds new light on an author whose imagined realities reflect the anxieties, pathologies, and power dynamics of our contemporary world order. McGrath’s fiction has been noted as parodic (The Grotesque, 1989), psychologically disturbing (Spider, 1990), and darkly sexual (Asylum, 1996). Throughout, his corpus is characterized by a preoccupation with madness and its institutions and by a nuanced relationship to the gothic. With its international range of contributors, and including a new interview with McGrath himself, this book opens up hitherto underexplored theoretical perspectives on the key concerns of McGrath’s ouevre, moving conversations around McGrath’s work decisively forward. Offering the first sustained exploration of his fiction’s transnational and world-historical dimensions, Patrick McGrath and his Worlds seeks to situate, reflect upon, and interrogate McGrath’s role as a key voice in Anglophone letters in our millennial global moment.
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| 21. |
- Piponiot, Camille, et al.
(författare)
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Distribution of biomass dynamics in relation to tree size in forests across the world
- 2022
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Ingår i: New Phytologist. - : Wiley. - 0028-646X .- 1469-8137. ; 234, s. 1664-1677
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Tidskriftsartikel (refereegranskat)abstract
- Tree size shapes forest carbon dynamics and determines how trees interact with their environment, including a changing climate. Here, we conduct the first global analysis of among-site differences in how aboveground biomass stocks and fluxes are distributed with tree size. We analyzed repeat tree censuses from 25 large-scale (4–52 ha) forest plots spanning a broad climatic range over five continents to characterize how aboveground biomass, woody productivity, and woody mortality vary with tree diameter. We examined how the median, dispersion, and skewness of these size-related distributions vary with mean annual temperature and precipitation. In warmer forests, aboveground biomass, woody productivity, and woody mortality were more broadly distributed with respect to tree size. In warmer and wetter forests, aboveground biomass and woody productivity were more right skewed, with a long tail towards large trees. Small trees (1–10 cm diameter) contributed more to productivity and mortality than to biomass, highlighting the importance of including these trees in analyses of forest dynamics. Our findings provide an improved characterization of climate-driven forest differences in the size structure of aboveground biomass and dynamics of that biomass, as well as refined benchmarks for capturing climate influences in vegetation demographic models.
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| 22. |
- Strittmatter, Nicole, et al.
(författare)
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Method To Visualize the Intratumor Distribution and Impact of Gemcitabine in Pancreatic Ductal Adenocarcinoma by Multimodal Imaging
- 2022
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Ingår i: Analytical Chemistry. - : American Chemical Society (ACS). - 0003-2700 .- 1520-6882. ; 94:3, s. 1795-1803
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Tidskriftsartikel (refereegranskat)abstract
- Gemcitabine (dFdC) is a common treatment for pancreatic cancer; however, it is thought that treatment may fail because tumor stroma prevents drug distribution to tumor cells. Gemcitabine is a pro-drug with active metabolites generated intracellularly; therefore, visualizing the distribution of parent drug as well as its metabolites is important. A multimodal imaging approach was developed using spatially coregistered mass spectrometry imaging (MSI), imaging mass cytometry (IMC), multiplex immunofluorescence microscopy (mIF), and hematoxylin and eosin (H&E) staining to assess the local distribution and metabolism of gemcitabine in tumors from a genetically engineered mouse model of pancreatic cancer (KPC) allowing for comparisons between effects in the tumor tissue and its microenvironment. Mass spectrometry imaging (MSI) enabled the visualization of the distribution of gemcitabine (100 mg/kg), its phosphorylated metabolites dFdCMP, dFdCDP and dFdCTP, and the inactive metabolite dFdU. Distribution was compared to small-molecule ATR inhibitor AZD6738 (25 mg/kg), which was codosed. Gemcitabine metabolites showed heterogeneous distribution within the tumor, which was different from the parent compound. The highest abundance of dFdCMP, dFdCDP, and dFdCTP correlated with distribution of endogenous AMP, ADP, and ATP in viable tumor cell regions, showing that gemcitabine active metabolites are reaching the tumor cell compartment, while AZD6738 was located to nonviable tumor regions. The method revealed that the generation of active, phosphorylated dFdC metabolites as well as treatment-induced DNA damage primarily correlated with sites of high proliferation in KPC PDAC tumor tissue, rather than sites of high parent drug abundance.
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| 23. |
- Sumaila, U. Rashid, et al.
(författare)
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WTO must ban harmful fisheries subsidies
- 2021
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 374:6567, s. 544-544
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 24. |
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| 25. |
- Wulf Hanson, Sarah, et al.
(författare)
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A global systematic analysis of the occurrence, severity, and recovery pattern of long COVID in 2020 and 2021
- 2022
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Importance: While much of the attention on the COVID-19 pandemic was directed at the daily counts of cases and those with serious disease overwhelming health services, increasingly, reports have appeared of people who experience debilitating symptoms after the initial infection. This is popularly known as long COVID.Objective: To estimate by country and territory of the number of patients affected by long COVID in 2020 and 2021, the severity of their symptoms and expected pattern of recovery.Design: We jointly analyzed ten ongoing cohort studies in ten countries for the occurrence of three major symptom clusters of long COVID among representative COVID cases. The defining symptoms of the three clusters (fatigue, cognitive problems, and shortness of breath) are explicitly mentioned in the WHO clinical case definition. For incidence of long COVID, we adopted the minimum duration after infection of three months from the WHO case definition. We pooled data from the contributing studies, two large medical record databases in the United States, and findings from 44 published studies using a Bayesian meta-regression tool. We separately estimated occurrence and pattern of recovery in patients with milder acute infections and those hospitalized. We estimated the incidence and prevalence of long COVID globally and by country in 2020 and 2021 as well as the severity-weighted prevalence using disability weights from the Global Burden of Disease study.Results: Analyses are based on detailed information for 1906 community infections and 10526 hospitalized patients from the ten collaborating cohorts, three of which included children. We added published data on 37262 community infections and 9540 hospitalized patients as well as ICD-coded medical record data concerning 1.3 million infections. Globally, in 2020 and 2021, 144.7 million (95% uncertainty interval [UI] 54.8-312.9) people suffered from any of the three symptom clusters of long COVID. This corresponds to 3.69% (1.38-7.96) of all infections. The fatigue, respiratory, and cognitive clusters occurred in 51.0% (16.9-92.4), 60.4% (18.9-89.1), and 35.4% (9.4-75.1) of long COVID cases, respectively. Those with milder acute COVID-19 cases had a quicker estimated recovery (median duration 3.99 months [IQR 3.84-4.20]) than those admitted for the acute infection (median duration 8.84 months [IQR 8.10-9.78]). At twelve months, 15.1% (10.3-21.1) continued to experience long COVID symptoms.Conclusions and relevance: The occurrence of debilitating ongoing symptoms of COVID-19 is common. Knowing how many people are affected, and for how long, is important to plan for rehabilitative services and support to return to social activities, places of learning, and the workplace when symptoms start to wane.Key Points: Question: What are the extent and nature of the most common long COVID symptoms by country in 2020 and 2021?Findings: Globally, 144.7 million people experienced one or more of three symptom clusters (fatigue; cognitive problems; and ongoing respiratory problems) of long COVID three months after infection, in 2020 and 2021. Most cases arose from milder infections. At 12 months after infection, 15.1% of these cases had not yet recovered.Meaning: The substantial number of people with long COVID are in need of rehabilitative care and support to transition back into the workplace or education when symptoms start to wane.
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| 26. |
- Wulf Hanson, Sarah, et al.
(författare)
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Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021
- 2022
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Ingår i: Journal of the American Medical Association (JAMA). - : American Medical Association (AMA). - 0098-7484 .- 1538-3598. ; 328:16, s. 1604-1615
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Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE: Some individuals experience persistent symptoms after initial symptomatic SARS-CoV-2 infection (often referred to as Long COVID).OBJECTIVE: To estimate the proportion of males and females with COVID-19, younger or older than 20 years of age, who had Long COVID symptoms in 2020 and 2021 and their Long COVID symptom duration.DESIGN, SETTING, AND PARTICIPANTS: Bayesian meta-regression and pooling of 54 studies and 2 medical record databases with data for 1.2 million individuals (from 22 countries) who had symptomatic SARS-CoV-2 infection. Of the 54 studies, 44 were published and 10 were collaborating cohorts (conducted in Austria, the Faroe Islands, Germany, Iran, Italy, the Netherlands, Russia, Sweden, Switzerland, and the US). The participant data were derived from the 44 published studies (10 501 hospitalized individuals and 42 891 nonhospitalized individuals), the 10 collaborating cohort studies (10 526 and 1906), and the 2 US electronic medical record databases (250 928 and 846 046). Data collection spanned March 2020 to January 2022.EXPOSURES: Symptomatic SARS-CoV-2 infection.MAIN OUTCOMES AND MEASURES: Proportion of individuals with at least 1 of the 3 self-reported Long COVID symptom clusters (persistent fatigue with bodily pain or mood swings; cognitive problems; or ongoing respiratory problems) 3 months after SARS-CoV-2 infection in 2020 and 2021, estimated separately for hospitalized and nonhospitalized individuals aged 20 years or older by sex and for both sexes of nonhospitalized individuals younger than 20 years of age.RESULTS: A total of 1.2 million individuals who had symptomatic SARS-CoV-2 infection were included (mean age, 4-66 years; males, 26%-88%). In the modeled estimates, 6.2% (95% uncertainty interval [UI], 2.4%-13.3%) of individuals who had symptomatic SARS-CoV-2 infection experienced at least 1 of the 3 Long COVID symptom clusters in 2020 and 2021, including 3.2% (95% UI, 0.6%-10.0%) for persistent fatigue with bodily pain or mood swings, 3.7% (95% UI, 0.9%-9.6%) for ongoing respiratory problems, and 2.2% (95% UI, 0.3%-7.6%) for cognitive problems after adjusting for health status before COVID-19, comprising an estimated 51.0% (95% UI, 16.9%-92.4%), 60.4% (95% UI, 18.9%-89.1%), and 35.4% (95% UI, 9.4%-75.1%), respectively, of Long COVID cases. The Long COVID symptom clusters were more common in women aged 20 years or older (10.6% [95% UI, 4.3%-22.2%]) 3 months after symptomatic SARS-CoV-2 infection than in men aged 20 years or older (5.4% [95% UI, 2.2%-11.7%]). Both sexes younger than 20 years of age were estimated to be affected in 2.8% (95% UI, 0.9%-7.0%) of symptomatic SARS-CoV-2 infections. The estimated mean Long COVID symptom cluster duration was 9.0 months (95% UI, 7.0-12.0 months) among hospitalized individuals and 4.0 months (95% UI, 3.6-4.6 months) among nonhospitalized individuals. Among individuals with Long COVID symptoms 3 months after symptomatic SARS-CoV-2 infection, an estimated 15.1% (95% UI, 10.3%-21.1%) continued to experience symptoms at 12 months.CONCLUSIONS AND RELEVANCE: This study presents modeled estimates of the proportion of individuals with at least 1 of 3 self-reported Long COVID symptom clusters (persistent fatigue with bodily pain or mood swings; cognitive problems; or ongoing respiratory problems) 3 months after symptomatic SARS-CoV-2 infection.
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| 27. |
- Öhrman, Caroline, et al.
(författare)
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Reorganized Genomic Taxonomy of Francisellaceae Enables Design of Robust Environmental PCR Assays for Detection of Francisella tularensis
- 2021
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Ingår i: Microorganisms. - : MDPI. - 2076-2607. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- In recent years, an increasing diversity of species has been recognized within the family Francisellaceae. Unfortunately, novel isolates are sometimes misnamed in initial publications or multiple sources propose different nomenclature for genetically highly similar isolates. Thus, unstructured and occasionally incorrect information can lead to confusion in the scientific community. Historically, detection of Francisella tularensis in environmental samples has been challenging due to the considerable and unknown genetic diversity within the family, which can result in false positive results. We have assembled a comprehensive collection of genome sequences representing most known Francisellaceae species/strains and restructured them according to a taxonomy that is based on phylogenetic structure. From this structured dataset, we identified a small number of genomic regions unique to F. tularensis that are putatively suitable for specific detection of this pathogen in environmental samples. We designed and validated specific PCR assays based on these genetic regions that can be used for the detection of F. tularensis in environmental samples, such as water and air filters.
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